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https://www.readbyqxmd.com/read/26796134/four-cases-of-investigational-therapy-with-interleukin-11-against-acute-myocardial-infarction
#1
Masashi Nakagawa, Yasuko Owada, Yasukatsu Izumi, Shinichi Nonin, Kenichi Sugioka, Daisaku Nakatani, Shinichi Iwata, Kazuki Mizutani, Satoshi Nishimura, Asahiro Ito, Suwako Fujita, Takashi Daimon, Yoshiki Sawa, Masanori Asakura, Makiko Maeda, Yasushi Fujio, Minoru Yoshiyama
We describe four cases of the patients with ST-elevation myocardial infarction (STEMI) that were treated with interleukin-11 (IL-11), a cardioprotective cytokine. Recombinant human IL-11 (rhIL-11), was intravenously administered to two cases at low dose (6 µg/kg) and to two at high dose (25 µg/kg). The cytokine administration started just after the coronary occlusion was confirmed by coronary angiography (CAG), taking 3 h. Following CAG, percutaneous coronary intervention (PCI) was performed as a standard therapy...
September 2016: Heart and Vessels
https://www.readbyqxmd.com/read/25987195/near-infrared-spectroscopy-hemoglobin-index-measurement-during-fluid-challenge-a-prospective-study-in-cardiac-surgery-patients
#2
Olivier Rebet, Marc-Olivier Fischer, Guillaume Zamparini, Jean-Louis Gérard, Jean-Luc Fellahi, Jean-Luc Hanouz
OBJECTIVE: Little is known about changes in near-infrared spectroscopy-derived tissue hemoglobin index (HbI). The authors tested the hypothesis that absolute values and changes in brain hemoglobin index (HbIb) and skeletal muscle hemoglobin index (HbIm) could differ from the reference arterial hemoglobin (Hb) during fluid challenge. DESIGN: A prospective, monocenter observational study. SETTING: A 16-bed cardiac surgical intensive care unit in a teaching university hospital...
August 2015: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/25887259/increase-in-cerebral-oxygenation-during-advanced-life-support-in-out-of-hospital-patients-is-associated-with-return-of-spontaneous-circulation
#3
Cornelia Genbrugge, Ingrid Meex, Willem Boer, Frank Jans, René Heylen, Bert Ferdinande, Jo Dens, Cathy De Deyne
INTRODUCTION: By maintaining sufficient cerebral blood flow and oxygenation, the goal of cardiopulmonary resuscitation (CPR) is to preserve the pre-arrest neurological state. To date, cerebral monitoring abilities during CPR have been limited. Therefore, we investigated the time-course of cerebral oxygen saturation values (rSO₂) during advanced life support in out-of-hospital cardiac arrest. Our primary aim was to compare rSO₂ values during advanced life support from patients with return of spontaneous circulation (ROSC) to patients who did not achieve ROSC...
2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25777922/increase-in-cerebral-oxygenation-during-advanced-life-support-in-out-of-hospital-patients-is-associated-with-return-of-spontaneous-circulation
#4
Cornelia Genbrugge, Ingrid Meex, Willem Boer, Frank Jans, René Heylen, Bert Ferdinande, Jo Dens, Cathy De Deyne
INTRODUCTION: By maintaining sufficient cerebral blood flow and oxygenation, the goal of cardiopulmonary resuscitation (CPR) is to preserve the pre-arrest neurological state. To date, cerebral monitoring abilities during CPR have been limited. Therefore, we investigated the time-course of cerebral oxygen saturation values (rSO2) during advanced life support in out-of-hospital cardiac arrest. Our primary aim was to compare rSO2 values during advanced life support from patients with return of spontaneous circulation (ROSC) to patients who did not achieve ROSC...
December 2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25649718/evaluation-of-near-infrared-spectroscopy-under-apnea-dependent-hypoxia-in-humans
#5
Lars Eichhorn, Felix Erdfelder, Florian Kessler, Jonas Doerner, Marcus O Thudium, Rainer Meyer, Richard K Ellerkmann
In this study we investigated the responsiveness of near-infrared spectroscopy (NIRS) recordings measuring regional cerebral tissue oxygenation (rSO2) during hypoxia in apneic divers. The goal was to mimic dynamic hypoxia as present during cardiopulmonary resuscitation, laryngospasm, airway obstruction, or the "cannot ventilate cannot intubate" situation. Ten experienced apneic divers performed maximal breath hold maneuvers under dry conditions. SpO2 was measured by Masimo™ pulse oximetry on the forefinger of the left hand...
December 2015: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/25286829/monitoring-of-cerebral-oxygen-saturation-during-resuscitation-in-out-of-hospital-cardiac-arrest-a-feasibility-study-in-a-physician-staffed-emergency-medical-system
#6
Jens-Christian Schewe, Marcus O Thudium, Jochen Kappler, Folkert Steinhagen, Lars Eichhorn, Felix Erdfelder, Ulrich Heister, Richard Ellerkmann
BACKGROUND: Despite recent advances in resuscitation algorithms, neurological injury after cardiac arrest due to cerebral ischemia and reperfusion is one of the reasons for poor neurological outcome. There is currently no adequate means of measuring cerebral perfusion during cardiac arrest. It was the aim of this study to investigate the feasibility of measuring near infrared spectroscopy (NIRS) as a potential surrogate parameter for cerebral perfusion in patients with out-of-hospital resuscitations in a physician-staffed emergency medical service...
2014: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/25280485/study-protocol-for-the-phantom-study-prehospital-assessment-of-noninvasive-tissue-oximetry-monitoring
#7
Andrew Weatherall, Alan Garner, Nigel Lovell, Stephen Redmond, Anna Lee, Justin Skowno, Jonathan Egan
BACKGROUND: Traumatic brain injury is a major cause of mortality and morbidity worldwide. It can be worsened by secondary injury particularly with hypoxia or hypotension. Current prehospital guidelines emphasise regular measurement of peripheral oxygen saturation and blood pressure but there is no monitor in use to provide direct information relating to blood flow or oxygen delivery to the brain tissue. This prospective cohort study will assess the utility of near-infrared spectroscopy monitoring in prehospital medicine in demonstrating injury, pathophysiology and associations with long-term functional outcomes...
2014: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/25135523/in-vivo-tmrna-protection-by-smpb-and-pre-ribosome-binding-conformation-in-solution
#8
Ehsan Ranaei-Siadat, Cécile Mérigoux, Bili Seijo, Luc Ponchon, Jean-Michel Saliou, Julie Bernauer, Sarah Sanglier-Cianférani, Fréderic Dardel, Patrice Vachette, Sylvie Nonin-Lecomte
TmRNA is an abundant RNA in bacteria with tRNA and mRNA features. It is specialized in trans-translation, a translation rescuing system. We demonstrate that its partner protein SmpB binds the tRNA-like region (TLD) in vivo and chaperones the fold of the TLD-H2 region. We use an original approach combining the observation of tmRNA degradation pathways in a heterologous system, the analysis of the tmRNA digests by MS and NMR, and co-overproduction assays of tmRNA and SmpB. We study the conformation in solution of tmRNA alone or in complex with one SmpB before ribosome binding using SAXS...
October 2014: RNA
https://www.readbyqxmd.com/read/24847771/comparison-of-four-near-infrared-spectroscopy-devices-shows-that-they-are-only-suitable-for-monitoring-cerebral-oxygenation-trends-in-preterm-infants
#9
COMPARATIVE STUDY
Anna Schneider, Bernd Minnich, Edda Hofstätter, Christof Weisser, Erna Hattinger-Jürgenssen, Martin Wald
AIM: Measuring cerebral oxygenation using near-infrared spectroscopy (NIRS) has taken on an increasingly important role in the field of neonatology. Several companies have already developed commercial devices, and more publications are reporting absolute boundary values or percentiles for neonates. We compared four commercially used devices to discover whether they provided consistent results in the same patients. METHODS: We recruited nine preterm infants and tested them for 2 h, using sensors from two different devices...
September 2014: Acta Paediatrica
https://www.readbyqxmd.com/read/24375561/giant-mycotic-coronary-aneurysm-associated-with-late-stent-infection
#10
Shinichi Nonin, Takao Hasegawa, Hidekazu Hirai, Shigefumi Suehiro, Minoru Yoshiyama
No abstract text is available yet for this article.
June 2014: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/24247475/a-feasibility-study-of-cerebral-oximetry-during-in-hospital-mechanical-and-manual-cardiopulmonary-resuscitation
#11
Sam Parnia, Asad Nasir, Anna Ahn, Hanan Malik, Jie Yang, Jiawen Zhu, Francis Dorazi, Paul Richman
OBJECTIVE: A major hurdle limiting the ability to improve the quality of resuscitation has been the lack of a noninvasive real-time detection system capable of monitoring the quality of cerebral and other organ perfusion, as well as oxygen delivery during cardiopulmonary resuscitation. Here, we report on a novel system of cerebral perfusion targeted resuscitation. DESIGN: An observational study evaluating the role of cerebral oximetry (Equanox; Nonin, Plymouth, MI, and Invos; Covidien, Mansfield, MA) as a real-time marker of cerebral perfusion and oxygen delivery together with the impact of an automated mechanical chest compression system (Life Stat; Michigan Instruments, Grand Rapids, MI) on oxygen delivery and return of spontaneous circulation following in-hospital cardiac arrest...
April 2014: Critical Care Medicine
https://www.readbyqxmd.com/read/24110647/vcsel-based-wearable-continuously-monitoring-pulse-oximeter
#12
Daniel Kollmann, William K Hogan, Charles Steidl, Mary K Hibbs-Brenner, Daniel S Hedin, Patrick A Lichter
We present the development of a novel pulse oximeter based on low power, low cost, Vertical Cavity Surface Emitting Laser (VCSEL) technology. This new design will help address a need to perform regular measurements of pulse oximetry for patients with chronic obstructive pulmonary disease. VCSELs with wavelengths suitable for pulse oximetry were developed and packaged in a PLCC package for a low cost solution that is easy to integrate into a pulse oximeter design. The VCSELs were integrated into a prototype pulse oximeter that is unobtrusive and suitable for long term wearable use...
2013: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/24110327/ultra-low-cost-clinical-pulse-oximetry
#13
Christian L Petersen, Heng Gan, Martin J MacInnis, Guy A Dumont, J Mark Ansermino
An ultra-low-cost pulse oximeter is presented that interfaces a conventional clinical finger sensor with a mobile phone through the headset jack audio interface. All signal processing is performed using the audio subsystem of the phone. In a preliminary volunteer study in a hypoxia chamber, we compared the oxygen saturation obtained with the audio pulse oximeter against a commercially available (and FDA approved) reference pulse oximeter (Nonin Xpod). Good agreement was found between the outputs of the two devices...
2013: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/24023027/factors-affecting-the-performance-of-5-cerebral-oximeters-during-hypoxia-in-healthy-volunteers
#14
RANDOMIZED CONTROLLED TRIAL
Philip E Bickler, John R Feiner, Mark D Rollins
BACKGROUND: Cerebral oximetry is a noninvasive optical technology that measures frontal cortex blood hemoglobin-oxygen saturation. Commercially available cerebral oximeters have not been evaluated independently. Unlike pulse oximeters, there are currently no Food and Drug Administration standards for performance or accuracy. We tested the hypothesis that cerebral oximeters accurately measure a fixed ratio of the oxygen saturation in cerebral mixed venous and arterial blood. METHODS: We evaluated the performance of 5 commercially available cerebral oximeters: the EQUANOX® 7600 in 3- and 4-wavelength versions (Nonin Medical, Plymouth, MN), FORE-SIGHT® (Casmed, Branford, CT), INVOS® 5100C (Covidien, Boulder, CO), and the NIRO-200NX® (Hamamatsu Photonics, Hamamatsu City, Japan) during stable isocapnic hypoxia in volunteers...
October 2013: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/23990288/peripheral-tissue-oximetry-comparing-three-commercial-near-infrared-spectroscopy-oximeters-on-the-forearm
#15
COMPARATIVE STUDY
Simon Hyttel-Sorensen, Trine Witzner Hessel, Gorm Greisen
Estimation of regional tissue oxygenation (rStO2) by near infrared spectroscopy enables non-invasive end-organ oxygen balance monitoring and could be a valuable tool in intensive care. However, the diverse absolute values and dynamics of different devices, and overall poor repeatability of measurements are a problem. The aim of the present study is to test the hypothesis that INVOS 5100C, FORE-SIGHT and NONIN EQUANOX 7600 have similar properties concerning absolute values, repeatability, and sensitivity to changes in rStO2...
April 2014: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/23804766/co-expression-of-rna-protein-complexes-in-escherichia-coli-and-applications-to-rna-biology
#16
Luc Ponchon, Marjorie Catala, Bili Seijo, Marguerite El Khouri, Frédéric Dardel, Sylvie Nonin-Lecomte, Carine Tisné
RNA has emerged as a major player in many cellular processes. Understanding these processes at the molecular level requires homogeneous RNA samples for structural, biochemical and pharmacological studies. We previously devised a generic approach that allows efficient in vivo expression of recombinant RNA in Escherichia coli. In this work, we have extended this method to RNA/protein co-expression. We have engineered several plasmids that allow overexpression of RNA-protein complexes in E. coli. We have investigated the potential of these tools in many applications, including the production of nuclease-sensitive RNAs encapsulated in viral protein pseudo-particles, the co-production of non-coding RNAs with chaperone proteins, the incorporation of a post-transcriptional RNA modification by co-production with the appropriate modifying enzyme and finally the production and purification of an RNA-His-tagged protein complex by nickel affinity chromatography...
August 2013: Nucleic Acids Research
https://www.readbyqxmd.com/read/23689486/progressive-endothelial-damage-revealed-by-multilevel-von-willebrand-factor-plasma-concentrations-in-atrial-fibrillation-patients
#17
Alina Scridon, Nicolas Girerd, Lucia Rugeri, Emilie Nonin-Babary, Philippe Chevalier
AIMS: Abnormal plasma concentrations of von Willebrand factor (vWF), a marker of prothrombotic risk, have been found in atrial fibrillation (AF) patients, but the extent of this variation is not clear. This study aimed to investigate the effect of different clinical forms of AF on plasma concentrations of vWF at different levels of the circulatory tree, both intracardiac and extracardiac. METHODS AND RESULTS: Peripheral (Pf), left atrial (LA), and coronary sinus (CS) blood samples were obtained during cardiac catheterization from 52 patients with paroxysmal AF (PAF), 36 with persistent AF (PsAF), and 17 control subjects (Ct) with left-sided accessory pathway Wolff-Parkinson-White syndrome...
November 2013: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/23603891/rna-methyltransferase-trma-is-a-dual-specific-enzyme-responsible-for-c5-methylation-of-uridine-in-both-tmrna-and-trna
#18
Ehsan Ranaei-Siadat, Céline Fabret, Bili Seijo, Frédéric Dardel, Henri Grosjean, Sylvie Nonin-Lecomte
In bacteria, trans-translation rescues stalled ribosomes by the combined action of tmRNA (transfer-mRNA) and its associated protein SmpB. The tmRNA 5' and 3' ends fold into a tRNA-like domain (TLD), which shares structural and functional similarities with tRNAs. As in tRNAs, the UUC sequence of the T-arm of the TLD is post-transcriptionally modified to m (5)UψC. In tRNAs of gram-negative bacteria, formation of m (5)U is catalyzed by the SAM-dependent methyltransferase TrmA, while formation of m (5)U at two different positions in rRNA is catalyzed by distinct site-specific methyltransferases RlmC and RlmD...
April 2013: RNA Biology
https://www.readbyqxmd.com/read/23439275/cerebral-oximetry-in-cardiac-and-major-vascular-surgery
#19
G W Fischer, G Silvay
We describe the development and current applications of cerebral oximetry (based on near-infrared reflectance spectroscopy) that can be used during cardiac and major vascular surgery to determined brain tissue oxygen saturation. There are presently three cerebral oximetry devices with FDA approval in the United States to measure and monitor cerebral tissue oxygen saturation. 1. INVOS (Somanetics Corporation, Troy, MI - recently COVIDIEN, Boulder, CO); FORE-SIGHT (CAS Medical Systems, Inc. Branford, CT); EQUANOX (Nonin Medical Inc...
2010: HSR Proceedings in Intensive Care & Cardiovascular Anesthesia
https://www.readbyqxmd.com/read/23434169/measuring-arterial-oxygenation-in-a-high-altitude-field-environment-comparing-portable-pulse-oximetry-with-blood-gas-analysis
#20
COMPARATIVE STUDY
Elliot M Ross, Michael J Matteucci, Matthew Shepherd, Matthew Barker, Lance Orr
OBJECTIVE: High altitude environments present unique medical treatment challenges. Medical providers often use small portable pulse oximetry devices to help guide their clinical decision making. A significant body of high altitude research is based on the use of these devices to monitor hypoxia, yet there is a paucity of evidence that these devices are accurate in these environments. We studied whether these devices perform accurately and reliably under true mountain conditions. METHODS: Healthy unacclimatized active-duty military volunteers participating in mountain warfare training at 2100 m (6900 feet) above sea level were evaluated with several different pulse oximetry devices while in a cold weather, high altitude field environment and then had arterial blood gases (ABG) drawn using an i-STAT for comparison...
June 2013: Wilderness & Environmental Medicine
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