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https://www.readbyqxmd.com/read/27375383/intraoperative-effect-of-dexmedetomidine-infusion-during-living-donor-liver-transplantation-a-randomized-control-trial
#1
E Sayed, K A Yassen
BACKGROUND: Dexmedetomidine hydrochloride (Dex) is a useful adjuvant for general anesthesia. The aim was to evaluate the effects of Dex infusion during living donors liver transplantation (LDLT) on the general anesthetic requirements, hemodynamics, oxygen consumption (VO2), and CO2 production (VCO2). MATERIALS AND METHODS: Forty LDLT recipients were allocated randomly to receive either Dex (0.2-0.7 μg/kg/h) or placebo (control [C]). Patient state index (PSI), SEDLine monitored anesthesia depth (25-50) with desflurane (Des) % and fentanyl altered accordingly...
July 2016: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/27159066/the-feasibility-and-utility-of-continuous-sleep-monitoring-in-critically-ill-patients-using-a-portable-electroencephalography-monitor
#2
Susana Vacas, Erin McInrue, Michael A Gropper, Mervyn Maze, Rochelle Zak, Eunjung Lim, Jacqueline M Leung
BACKGROUND: Sleep disruption in critically ill adults can result in acute decrements in cognitive function, including delirium, but it is underdiagnosed in the setting of the intensive care unit (ICU). Although sleep stages can be assessed by polysomnography (PSG), acquisition and interpretation of PSG is costly, is labor intensive, is difficult to do over an extended period of time with critically ill patients (multiple days of continuous recording), and may interfere with patient care...
July 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27066478/trapp-complexes-in-secretion-and-autophagy
#3
REVIEW
Jane J Kim, Zhanna Lipatova, Nava Segev
TRAPP is a highly conserved modular multi-subunit protein complex. Originally identified as a "transport protein particle" with a role in endoplasmic reticulum-to-Golgi transport, its multiple subunits and their conservation from yeast to humans were characterized in the late 1990s. TRAPP attracted attention when it was shown to act as a Ypt/Rab GTPase nucleotide exchanger, GEF, in the 2000s. Currently, three TRAPP complexes are known in yeast, I, II, and III, and they regulate two different intracellular trafficking pathways: secretion and autophagy...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/26364193/propofol-and-non-propofol-based-sedation-for-outpatient-colonoscopy-prospective-comparison-of-depth-of-sedation-using-an-eeg-based-sedline-monitor
#4
Basavana Goudra, Preet Mohinder Singh, Gowri Gouda, Anuradha Borle, Augustus Carlin, Avantika Yadwad
Propofol is a popular anesthetic sedative employed in colonoscopy. It is known to increase the patient satisfaction and improve throughput. However, there are concerns among the clinicians with regard to the depth of sedation, as a deeper degree of sedation is known to increase the incidence of aspiration and other adverse events. So we planned to compare the depth of sedation between propofol and non-propofol based sedation in patients undergoing outpatient colonoscopy, as measured by an electroencephalogram (EEG) based monitor SEDLine monitor (SedlineInc...
October 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/24841781/a-novel-nonsense-mutation-in-the-sedlin-gene-sedl-causes-severe-spondyloepiphyseal-dysplasia-tarda-in-a-five-generation-chinese-pedigree
#5
X Y Xia, J Yu, W W Li, N Li, Q Y Wu, X Zhou, Y X Cui, X J Li
Spondyloepiphyseal dysplasia tarda (SEDT) is an X-linked recessive osteochondrodysplasia characterized by disproportionately short stature and degenerative joint disease. The objective of this study was to describe a novel nonsense mutation in the sedlin gene (SEDL) causing severe SEDT in a large Chinese pedigree. The clinical features of all affected individuals and female carriers were presented. Four affected males of the family were diagnosed with SEDT according to their clinical and radiological features...
2014: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/24329977/trs20-is-required-for-trapp-iii-complex-assembly-at-the-pas-and-its-function-in-autophagy
#6
David Taussig, Zhanna Lipatova, Nava Segev
The modular TRAPP complex acts as a guanine-nucleotide exchange factor (GEF) for Ypt/Rab GTPases. Whereas TRAPP I and TRAPP II regulate the exocytic pathway, TRAPP III functions in autophagy. The TRAPP subunit Trs20 is not required for assembly of core TRAPP or its Ypt1 GEF activity. Interestingly, mutations in the human functional ortholog of Trs20, Sedlin, cause spondyloepiphyseal dysplasia tarda (SEDT), a cartilage-specific disorder. We have shown that Trs20 is required for TRAPP II assembly and identified a SEDT-linked mutation, Trs20-D46Y, which causes a defect in this process...
March 2014: Traffic
https://www.readbyqxmd.com/read/23656395/whole-exome-sequencing-and-functional-studies-identify-an-intronic-mutation-in-trappc2-that-causes-sedt
#7
E E Davis, J H Savage, J R Willer, Y-H Jiang, M Angrist, A Androutsopoulos, N Katsanis
Skeletal dysplasias are challenging to diagnose because of their phenotypic variability, genetic heterogeneity, and diverse inheritance patterns. We conducted whole exome sequencing of a Turkish male with a suspected X-linked skeletal dysplasia of unknown etiology as well as his unaffected mother and maternal uncle. Bioinformatic filtering of variants implicated in skeletal system development revealed a novel hemizygous mutation, c.341-(11_9)delAAT, in an intron of TRAPPC2, the causative locus of spondyloepiphyseal dysplasia tarda (SEDT)...
April 2014: Clinical Genetics
https://www.readbyqxmd.com/read/23465091/trs20-is-required-for-trapp-ii-assembly
#8
David Taussig, Zhanna Lipatova, Jane J Kim, Xuiqi Zhang, Nava Segev
The modular TRAPP complexes act as nucleotide exchangers to activate the Golgi Ypt/Rab GTPases, Ypt1 and Ypt31/Ypt32. In yeast, TRAPP I acts at the cis-Golgi and its assembly and structure are well characterized. In contrast, TRAPP II acts at the trans-Golgi and is poorly understood. Especially puzzling is the role of Trs20, an essential TRAPP I/II subunit required neither for the assembly of TRAPP I nor for its Ypt1-exchange activity. Mutations in Sedlin, the human functional ortholog of Trs20, cause the cartilage-specific disorder SEDT...
June 2013: Traffic
https://www.readbyqxmd.com/read/23019651/sedlin-controls-the-er-export-of-procollagen-by-regulating-the-sar1-cycle
#9
Rossella Venditti, Tiziana Scanu, Michele Santoro, Giuseppe Di Tullio, Alexander Spaar, Renato Gaibisso, Galina V Beznoussenko, Alexander A Mironov, Alexander Mironov, Leopoldo Zelante, Maria Rosaria Piemontese, Angelo Notarangelo, Vivek Malhotra, Barbara M Vertel, Cathal Wilson, Maria Antonietta De Matteis
Newly synthesized proteins exit the endoplasmic reticulum (ER) via coat protein complex II (COPII) vesicles. Procollagen (PC), however, forms prefibrils that are too large to fit into typical COPII vesicles; PC thus needs large transport carriers, which we term megacarriers. TANGO1 assists PC packing, but its role in promoting the growth of megacarriers is not known. We found that TANGO1 recruited Sedlin, a TRAPP component that is defective in spondyloepiphyseal dysplasia tarda (SEDT), and that Sedlin was required for the ER export of PC...
September 28, 2012: Science
https://www.readbyqxmd.com/read/21830049/titration-of-sevoflurane-in-elderly-patients-blinded-randomized-clinical-trial-in-non-cardiac-surgery-after-beta-adrenergic-blockade
#10
RANDOMIZED CONTROLLED TRIAL
David R Drover, Clifford Schmiesing, Anthea F Buchin, H Rick Ortega, Jonathan W Tanner, Joshua H Atkins, Alex Macario
BACKGROUND: Monitoring depth of anesthesia via the processed electroencephalogram (EEG) has been found useful in reducing the amount of anesthetic drugs, optimizing wake-up times, and, in some studies, reducing awareness. Our goal was to determine if titrating sevoflurane as the maintenance anesthetic to a depth of anesthesia monitor (SEDLine™, Masimo, CA) would shorten time to extubation in elderly patients undergoing non-cardiac surgery while on beta-adrenergic blockade. This patient population was selected because the usual cardiovascular signs of inadequate general anesthesia may be masked by beta-blocker therapy...
June 2011: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/21738291/evaluation-of-the-sedline-to-improve-the-safety-and-efficiency-of-conscious-sedation
#11
Thomas D Caputo, Michael A E Ramsay, Jeffrey A Rossmann, M Miles Beach, Garth R Griffiths, Benjamin Meyrat, James B Barnes, David G Kerns, Brad Crump, Barnett Bookatz, Paul Ezzo
Brain function monitors have improved safety and efficiency in general anesthesia; however, they have not been adequately tested for guiding conscious sedation for periodontal surgical procedures. This study evaluated the patient state index (PSI) obtained from the SEDline monitor (Sedline Inc., San Diego, CA) to determine its capacity to improve the safety and efficiency of intravenous conscious sedation during outpatient periodontal surgery. Twenty-one patients at the periodontics clinic of Baylor College of Dentistry were admitted to the study in 2009 and sedated to a moderate level using midazolam and fentanyl during periodontal surgery...
July 2011: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/20498720/sedlin-forms-homodimers-characterisation-of-sedlin-mutations-and-their-interactions-with-transcription-factors-mbp1-pitx1-and-sf1
#12
Jeshmi Jeyabalan, M Andrew Nesbit, Juris Galvanovskis, Richard Callaghan, Patrik Rorsman, Rajesh V Thakker
BACKGROUND: SEDLIN, a 140 amino acid subunit of the Transport Protein Particle (TRAPP) complex, is ubiquitously expressed and interacts with the transcription factors c-myc promoter-binding protein 1 (MBP1), pituitary homeobox 1 (PITX1) and steroidogenic factor 1 (SF1). SEDLIN mutations cause X-linked spondyloepiphyseal dysplasia tarda (SEDT). METHODOLOGY/PRINCIPAL FINDINGS: We investigated the effects of 4 missense (Asp47Tyr, Ser73Leu, Phe83Ser and Val130Asp) and the most C-terminal nonsense (Gln131Stop) SEDT-associated mutations on interactions with MBP1, PITX1 and SF1 by expression in COS7 cells...
May 14, 2010: PloS One
https://www.readbyqxmd.com/read/20108251/interaction-of-sedlin-with-pam14
#13
Xiaoying Liu, Yunfei Wang, Hengrui Zhu, Qinghui Zhang, Xin Xing, Biao Wu, Lihua Song, Libin Fan
Sedlin is an evolutionarily conserved and ubiquitously expressed protein that is encoded by the gene SEDL. Mutations in the latter are known to be causative for spondyloepiphyseal dysplasia tarda. However, the mechanism underlying this remains unclear. We have previously shown that Sedlin interacts with the intracellular chloride channel proteins CLIC1 and CLIC2 in the cytoplasm. In this report we show that Sedlin is also physically associated with protein associated with MRG 14 kDa (PAM14), a nuclear protein that interacts with the transcription factor MORF4-related gene on chromosome 15 (MRG15)...
April 15, 2010: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/19803731/surges-of-electroencephalogram-activity-at-the-time-of-death-a-case-series
#14
Lakhmir S Chawla, Seth Akst, Christopher Junker, Barbara Jacobs, Michael G Seneff
Abstract Level of consciousness at the end of life in critically ill patients is poorly characterized. We report a case series of seven patients who were neurologically intact before the decision to withdraw care due to extensive systemic critical illness. As part of our end-of-life care protocol, bispectral index (BIS) monitor (Aspect Medical Systems, Newton, MA) or SEDline (Hospira, Lake Forest, IL) monitoring devices are placed on each patient to ensure adequate comfort. Both monitoring systems use an integer-based system (BIS or PSI, respectively) to reflect the level of consciousness/effect of anesthesia...
December 2009: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/19650763/biochemical-consequences-of-sedlin-mutations-that-cause-spondyloepiphyseal-dysplasia-tarda
#15
Mei Y Choi, Caleb C Y Chan, Danny Chan, Keith D K Luk, Kathryn S E Cheah, Julian A Tanner
SEDT (spondyloepiphyseal dysplasia tarda) is a late-onset X-linked recessive skeletal dysplasia caused by mutations in the gene SEDL coding for sedlin. In the present paper, we investigated four missense mutations observed in SEDT and compare biochemical and cellular characteristics relative to the wild-type protein to address the mechanism of disease and to gain insight into the function of the sedlin protein. In situ hybridization and immunohistochemical experiments in mouse growth plates revealed sedlin to be predominantly expressed in proliferating and hypertrophic chondrocytes...
October 15, 2009: Biochemical Journal
https://www.readbyqxmd.com/read/19220810/identification-of-the-novel-trapp-associated-protein-tca17
#16
Ben Montpetit, Elizabeth Conibear
Vesicle tethers are long coiled-coil proteins or multisubunit complexes that provide specificity to the membrane fusion process by linking cargo-containing vesicles to target membranes. Transport protein particle (TRAPP) is a well-characterized multisubunit tethering complex that acts as a GTP exchange factor and is present in two cellular forms: a 7 subunit TRAPP I complex required for ER-to-Golgi transport, and a 10 subunit TRAPP II complex that mediates post-Golgi trafficking. In this work, we have identified Tca17, which is encoded by the non-essential ORF YEL048c, as a novel binding partner of the TRAPP complex...
June 2009: Traffic
https://www.readbyqxmd.com/read/16634419/patient-state-index
#17
REVIEW
David Drover, H R Ortega
The patient state index (PSI) is a clinically validated measure of the effect of anaesthesia and sedation. The PSI is calculated via a proprietary algorithm by a high-resolution 4-channel electroencephalograph (EEG) monitor after advanced artifact rejection. The PSI has been designed specifically for intra-operative and intensive care use to monitor patient sedation and drug effect. The algorithm relies on EEG power, frequency and phase information from anterior-posterior relationships of the brain as well as coherence between bilateral brain regions...
March 2006: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/16120574/-effect-of-a-novel-splicing-mutation-ivs2-2a-c-of-sedl-gene-on-rna-processing
#18
Qiang Luo, Chao Gao, Huai-Li Wang, Jian-Hua Zhou, Tie-Zheng Gao
X-linked spondyloepiphyseal dysplasia tarda (SEDL) is a rare osteochondrodysplasia caused by the mutation of SEDL gene, which mainly involves vertebral bodies and hips. To explore the effect of the novel splicing mutation (IVS2 -2A-->C) of SEDL gene on mRNA processing in a large Chinese family with X-linked spondyloepiphyseal dysplasia tarda and to elucidate the molecular base of SEDL, total RNA was isolated from EDTA blood samples of patients and controls. RT-PCR was performed on total RNA. cDNA was analyzed by bi-directionally direct sequencing of PCR products and Polyacrylamide gel electrophoresis (PAGE)...
July 2005: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/15221797/x-linked-spondyloepiphyseal-dysplasia-tarda-novel-and-recurrent-mutations-in-13-european-families
#19
Jörg Fiedler, Martine Le Merrer, Geert Mortier, Solange Heuertz, Laurence Faivre, Rolf E Brenner
X-linked spondyloepiphyseal dysplasia tarda is a skeletal dysplasia mainly affecting the vertebrae and epiphyses and commonly associated with the early development of degenerative joint disease. Radiographically the disorder is characterized by a typical hump-shaped deformity of the vertebral bodies. SEDT is caused by mutations in SEDL located on Xp22.12-p22.31. To further elucidate the spectrum of underlying variations we performed a screening of all 6 exons of SEDL within 13 European SEDT families and identified 6 new (c...
July 2004: Human Mutation
https://www.readbyqxmd.com/read/15016825/the-structure-of-the-mapk-scaffold-mp1-bound-to-its-partner-p14-a-complex-with-a-critical-role-in-endosomal-map-kinase-signaling
#20
Vladimir V Lunin, Christine Munger, John Wagner, Zheng Ye, Miroslaw Cygler, Michael Sacher
Scaffold proteins of the mitogen-activated protein kinase (MAPK) pathway have been proposed to form an active signaling module and enhance the specificity of the transduced signal. Here, we report a 2-A resolution structure of the MAPK scaffold protein MP1 in a complex with its partner protein, p14, that localizes the complex to late endosomes. The structures of these two proteins are remarkably similar, with a five-stranded beta-sheet flanked on either side by a total of three helices. The proteins form a heterodimer in solution and interact mainly through the edge beta-strand in each protein to generate a 10-stranded beta-sheet core...
May 28, 2004: Journal of Biological Chemistry
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