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https://www.readbyqxmd.com/read/29052905/metabolic-changes-in-patients-with-prostate-cancer-during-androgen-deprivation-therapy
#1
REVIEW
Koji Mitsuzuka, Yoichi Arai
Androgen deprivation therapy continues to be widely used for the treatment of prostate cancer despite the appearance of new-generation androgen-receptor targeting drugs after 2000. Androgen deprivation therapy can alleviate symptoms in patients with metastatic prostate cancer and might have a survival benefit in some patients, but it causes undesirable changes in lipid, glucose, muscle or bone metabolism. These metabolic changes could lead to new onset or worsening of diseases, such as obesity, metabolic syndrome, diabetes mellitus, cardiovascular disease, sarcopenia or fracture...
October 20, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29052135/hepatitis-c-virus-associated-cancers
#2
Zhigang Yi, Zhenghong Yuan
Most hepatitis C virus (HCV) infection results in persistent infection. Significant portion of chronic HCV-infected patients develop hepatocellular carcinoma (HCC). Chronic hepatitis C is also associated with extrahepatic manifestations, including cryoglobulinemia, lymphoma, insulin resistance, type 2 diabetes, and neurological disorders. The molecular mechanisms of how HCV infection causes liver cancer are largely unknown. HCV replication or viral proteins may perturb cellular hemostasis and induce the generation of reactive oxygen species (ROS); viral components or viral replication products act as agonist to trigger innate immune response and cause chronic inflammation...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29051018/access-to-employee-wellness-programs-and-use-of-preventive-care-services-among-u-s-adults
#3
Oluwaseyi O Isehunwa, Erik L Carlton, Yang Wang, Yu Jiang, Satish Kedia, Cyril F Chang, Daniel Fijabi, Soumitra S Bhuyan
INTRODUCTION: There is little research at the national level on access to employee wellness programs and the use of preventive care services. This study examined the use of seven preventive care services among U.S working adults with access to employee wellness programs. METHODS: The study population comprised 17,699 working adults aged ≥18 years, obtained from the 2015 National Health Interview Survey. Multivariate logistic regression models examined the relationship between access to employee wellness programs and use of seven preventive care services: influenza vaccination, blood pressure check, diabetes check, cholesterol check, Pap smear test, mammogram, and colon cancer screening...
October 16, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29050282/effective-antitumor-peptide-vaccines-can-induce-severe-autoimmune-pathology
#4
Hussein Sultan, Jimena Trillo-Tinoco, Paulo Rodriguez, Esteban Celis
Immunotherapy has shown a tremendous success in treating cancer. Unfortunately, this success is frequently associated with severe autoimmune pathology. In this study, we used the transgenic RIP-gp mouse model to assess the antitumor therapeutic benefit of peptide vaccination while evaluating the possible associated autoimmune pathology. We report that palmitoylated gp33-41 peptide and poly-IC adjuvant vaccine (BiVax) generated ∼ 5-10 % of antigen specific T cell responses in wild type and supposedly immune tolerant RIP-gp mice...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050004/study-on-clinical-factors-involved-in-helicobacter-pylori-uninfected-undifferentiated-type-early-gastric-cancer
#5
Yusuke Horiuchi, Junko Fujisaki, Naoki Ishizuka, Masami Omae, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
BACKGROUND: The factors associated with the pathogenesis of Helicobacter pylori-uninfected undifferentiated-type early gastric cancer (HPUGC) remain unclear. This study compared patient characteristics, including medical history and alcohol/tobacco use, of HPUGC patients with characteristics of patients with H. pylori-positive undifferentiated-type early gastric cancer (HPPGC) to clarify and gain understanding on those differences that could play a role in the pathogenesis. METHODS: This retrospective study included 282 patients who were treated endoscopically from March 2005 to March 2014...
October 19, 2017: Digestion
https://www.readbyqxmd.com/read/29049820/association-of-history-of-gestational-diabetes-with-long-term-cardiovascular-disease-risk-in-a-large-prospective-cohort-of-us-women
#6
Deirdre K Tobias, Jennifer J Stuart, Shanshan Li, Jorge Chavarro, Eric B Rimm, Janet Rich-Edwards, Frank B Hu, JoAnn E Manson, Cuilin Zhang
Importance: Previous studies identify gestational diabetes (GD) as a risk factor for intermediate markers of cardiovascular disease (CVD) risk; however, few are prospective, evaluate hard CVD end points, or account for shared risk factors including body weight and lifestyle. Objective: To prospectively evaluate history of GD in relation to incident CVD risk. Design, Setting, and Participants: The Nurses' Health Study II (NHS II) is an observational cohort study of US female nurses established in 1989, with ongoing follow-up...
October 16, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29049401/risk-factors-for-intrahepatic-and-extrahepatic-cholangiocarcinoma-in-the-united-states-a-population-based-study-in-seer-medicare
#7
Jessica L Petrick, Baiyu Yang, Sean F Altekruse, Alison L Van Dyke, Jill Koshiol, Barry I Graubard, Katherine A McGlynn
OBJECTIVES: Intrahepatic (ICC) and extrahepatic (ECC) cholangiocarcinomas are rare tumors that arise from the epithelial cells of the bile ducts, and the etiology of both cancer types is poorly understood. Thus, we utilized the Surveillance, Epidemiology, and End Results (SEER)-Medicare resource to examine risk factors and novel preexisting medical conditions that may be associated with these cancer types. METHODS: Between 2000 and 2011, 2,092 ICC and 2,981 ECC cases and 323,615 controls were identified using the SEER-Medicare database...
2017: PloS One
https://www.readbyqxmd.com/read/29049319/clinical-outcome-and-prognostic-factors-associated-with-invasive-pulmonary-aspergillosis-an-11-year-follow-up-report-from-taiwan
#8
Kuo-Shao Sun, Ching-Fang Tsai, Solomon Chih-Cheng Chen, Wan-Chun Huang
BACKGROUND: Invasive pulmonary aspergillosis (IPA) has high mortality rate but prognostic factors are not well established. The aim of our study was to evaluate the trend in in-hospital mortality over a period of 11 years and identify factors affecting the clinical outcomes of patients with IPA. METHOD: We conducted a nationwide inpatient population study using data from the Taiwan National Health Insurance Research Database. A total of 407 IPA patients from 2002 to 2012 were included in the study...
2017: PloS One
https://www.readbyqxmd.com/read/29049175/retrospective-analysis-for-the-false-positive-diagnosis-of-pet-ct-scan-in-lung-cancer-patients
#9
Mingxia Feng, Xuemei Yang, Qiang Ma, Yong He
Early diagnosis is pivotal for prognosis of lung cancer patients. Positron emission tomography/computed tomography (PET-CT) is a useful method for human cancer diagnosis. In this study, we aimed to explore the false positive diagnosis of PET-CT in lung cancerIn total, 754 patients diagnosed with lung cancer via PET-CT were retrospectively collected in this study. Histopathological detection served as gold standard. The diagnostic accuracy of PET-CT was defined as the proportion of lung cancer cases confirmed by pathological diagnosis in the study subjects, and the percentages of misdiagnosed cases represented the false positive diagnosis of PET-CT...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049093/association-of-metformin-use-and-survival-outcome-in-women-with-cervical-cancer
#10
Tsuyoshi Takiuchi, Hiroko Machida, Marianne S Hom, Sayedamin Mostofizadeh, Marina Frimer, Laurie L Brunette, Koji Matsuo
OBJECTIVE: Although preclinical studies suggest possible antitumor effects of metformin against cervical cancer, there is currently a lack of clinical data examining the association of metformin use and survival in women with cervical cancer. The aim of this study was to examine survival of women with cervical cancer who were receiving metformin. METHODS: This is a retrospective study examining consecutive cases of stages I to IV cervical cancer between 2000 and 2014...
September 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29049018/prevalence-of-single-and-multiple-leading-causes-of-death-by-race-ethnicity-among-us-adults-aged-60-to-79-years
#11
James Davis, Janell Penha, Omar Mbowe, Deborah A Taira
INTRODUCTION: Diabetes, cancer, cardiovascular disease (CVD) (coronary artery disease, heart attack, and angina pectoris), and chronic lung disease (emphysema, chronic bronchitis, and chronic obstructive pulmonary disease) are major causes of death in the United States. The objective of this study was to assess racial/ethnic differences in the prevalence of these conditions as cause of death among people aged 60 to 79 years with one or more of these conditions. METHODS: We used data on the prevalence of major chronic conditions from the National Health Interview Survey on 56,290 adults aged 60 to 79 years who reported having any of the chronic conditions assessed in the National Health Interview Survey for 2006 through 2014...
October 19, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29047326/integrating-chws-as-part-of-the-team-leading-diabetes-group-visits-a-randomized-controlled-feasibility-study
#12
Elizabeth M Vaughan, Craig A Johnston, Victor J Cardenas, Jennette P Moreno, John P Foreyt
Purpose The purpose of the study was to evaluate the feasibility of integrating Community Health Workers (CHWs) as part of the team leading diabetes group visits. Methods This was a randomized controlled study that integrated CHWs as part of the team leading diabetes group visits for low-income Hispanic adults (n = 50). Group visits met for 3 hours each month for a 6-month duration. Main measures included baseline and 6-month clinical outcomes (ie, A1C, lipids), concordance with 8 standard of care guidelines (ie, screens for cervical, breast, and colon cancer) from the US Preventive Task Force and American Diabetes Association, and participant acceptability...
October 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/29046789/a-retrospective-study-of-late-adverse-events-in-proton-beam-therapy-for-prostate-cancer
#13
Hirokazu Makishima, Hitoshi Ishikawa, Keiichi Tanaka, Yutaro Mori, Masashi Mizumoto, Kayoko Ohnishi, Teruhito Aihara, Nobuyoshi Fukumitsu, Toshiyuki Okumura, Hideyuki Sakurai
The efficacy and safety of proton beam therapy (PBT) were retrospectively evaluated in 111 consecutive patients with prostate cancer who underwent definitive PBT between 2008 and 2012. Following exclusion of 18 patients due to treatment suspension, loss to follow-up, and histology, the analysis included 93 patients with a median age of 68 years (range, 49-81 years). A total of 7, 32 and 54 prostate cancer patients were classified as low-, intermediate- and high-risk, respectively, as follows: High-risk, T≥3a or prostate-specific antigen (PSA) ≥20 ng/ml or Gleason Score ≥8; low-risk, T ≤2b and PSA≤10 ng/ml and Gleason Score=6; intermediate-risk, all other combinations...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29046248/clinical-characteristics-and-treatment-outcomes-of-vancomycin-resistant-enterococcus-faecium-bacteremia
#14
Jung-Jr Ye, Shian-Sen Shie, Chun-Wen Cheng, Jeng-How Yang, Po-Yen Huang, Ting-Shu Wu, Ming-Hsun Lee, Ching-Tai Huang
BACKGROUND: Vancomycin-resistant Enterococcus faecium (VRE-fm) bacteremia causes significant mortality in hospitalized patients. We sought to investigate clinical characteristics, treatment outcomes, and microbiological eradication associated with VRE-fm bacteremia. METHODS: A retrospective cohort study was conducted and included 210 adult patients admitted between January 1, 2011 and December 31, 2015. RESULTS: The mean Pitt bacteremia score was 4...
October 5, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29045908/long-term-exposure-to-residential-railway-and-road-traffic-noise-and-risk-for-diabetes-in-a-danish-cohort
#15
Nina Roswall, Ole Raaschou-Nielsen, Steen Solvang Jensen, Anne Tjønneland, Mette Sørensen
BACKGROUND: Road traffic noise exposure has been found associated with diabetes incidence. Evidence for an association between railway noise exposure is less clear, as large studies with detailed railway noise modelling are lacking. PURPOSE: To investigate the association between residential railway noise and diabetes incidence, and to repeat previous analyses on road traffic noise and diabetes with longer follow-up time. METHODS: Among 50,534 middle-aged Danes enrolled into the Diet, Cancer and Health cohort from 1993 to 97, we identified 5062 cases of incident diabetes during a median follow-up of 15...
October 15, 2017: Environmental Research
https://www.readbyqxmd.com/read/29045725/stemmapper-a-curated-gene-expression-database-for-stem-cell-lineage-analysis
#16
José P Pinto, Rui S R Machado, Ramiro Magno, Daniel V Oliveira, Susana Machado, Raquel P Andrade, José Bragança, Isabel Duarte, Matthias E Futschik
Transcriptomic data have become a fundamental resource for stem cell (SC) biologists as well as for a wider research audience studying SC-related processes such as aging, embryonic development and prevalent diseases including cancer, diabetes and neurodegenerative diseases. Access and analysis of the growing amount of freely available transcriptomics datasets for SCs, however, are not trivial tasks. Here, we present StemMapper, a manually curated gene expression database and comprehensive resource for SC research, built on integrated data for different lineages of human and mouse SCs...
October 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29045658/exendin-4-a-glucagon-like-peptide-1-receptor-agonist-attenuates-breast-cancer-growth-by-inhibiting-nf-%C3%AE%C2%BAb-activation
#17
Chikayo Iwaya, Takashi Nomiyama, Shiho Komatsu, Takako Kawanami, Yoko Tsutsumi, Yuriko Hamaguchi, Tsuyoshi Horikawa, Yasuteru Yoshinaga, Shinichi Yamashita, Tomoko Tanaka, Yuichi Terawaki, Makito Tanabe, Kazuki Nabeshima, Akinori Iwasaki, Toshihiko Yanase
Incretin therapies have received significant attention because of their tissue-protective effects, which extend beyond those associated with glycemic control. Cancer is a primary cause of death in patients with diabetes mellitus. We previously reported anti-prostate cancer effects of the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist exendin-4 (Ex-4). Breast cancer is one of the most common cancers in female patients with type 2 diabetes mellitus and obesity. Thus, we examined whether GLP-1 action could attenuate breast cancer...
October 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/29045263/diagnosis-of-axillary-web-syndrome-in-patients-after-breast-cancer-surgery-epidemiology-risk-factors-and-clinical-aspects-a-prospective-study
#18
Patricia V G Figueira, Cinira A S Haddad, Samantha K L de Almeida Rizzi, Gil Facina, Afonso C P Nazario
OBJECTIVES: Axillary web syndrome (AWS) is a complication after breast cancer surgery associated with the axillary approach. We defined a diagnosis tool as well as evaluated cord frequency, characteristics, and risk factors. METHODS: A prospective cohort study of 173 women followed-up at Breast Diseases Division of Universidade Federal de São Paulo between July 2014 and September 2015 was established as an evaluation protocol to diagnose AWS. Sociodemographic status, anthropometric values, range of motion, comorbidities, pain, cord frequency, and characteristics (localization, number, palpable, and/or visible) among other data were collected at different time points before and after surgery...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29044635/development-and-application-of-a-real-time-polymerase-chain-reaction-assay-for-detection-of-a-novel-gut-bacteriophage-crassphage
#19
Yuying Liang, Xin Jin, Yuan Huang, Shuiping Chen
BACKGROUND: crAssphage is a novel and by far the most abundant bacteriophage in human gut. This bacteriophage might modulate gut microbiota balance so as to be involved in some diseases like obesity, diabetes, metabolic disorders, hypertension, and cancer. Therefore, a rapid and reliable detection and quantification method for crAssphage is essential for studying its molecular epidemiology and pathogenicity in human diseases. MATERIALS AND METHODS: The primers-probes set for the quantitative real-time PCR assay was designed based on the DNA polymerase gene (ORF00018) of crAssphage...
October 16, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29042458/exenatide-modulates-tumor-endothelial-cell-interactions-in-human-ovarian-cancer-cells
#20
Agnieszka Kosowska, Enrique Gallego-Colon, Wojciech Garczorz, Agnieszka Klych-Ratuszny, Mohammad Reza F Aghdam, Michal Wozniak, Andrzej Witek, Agnieszka Wroblewska-Czech, Anna Cygal, Jerzy Wojnar, Tomasz Francuz
Diabetes and cancer are prevalent diseases whose incidence is increasing globally. Diabetic women have a moderate risk increase of ovarian cancer which have associated worse prognosis, reduced survival and shorter relapse-free survival. Incretin drugs such as Exenatide, a synthetic analogue of Exendin-4, and Liraglutide are used as therapy for the type 2 diabetes (T2D). We studied the effects of GLP-1 and Exendin-4 on migration, apoptosis and metalloproteinase production in two human ovarian cancer cells (SKOV-3 and CAOV-3)...
October 17, 2017: Endocrine Connections
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