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https://www.readbyqxmd.com/read/29048574/community-crime-exposure-and-risk-for-obesity-in-preschool-children-moderation-by-the-hypothalamic-pituitary-adrenal-axis-response
#1
Maria A Gartstein, Erich Seamon, Stephanie F Thompson, Liliana J Lengua
Objective: Identification of early risk factors related to obesity is critical to preventative public health efforts. In this study, we investigated links between the Hypothalamic-Pituitary-Adrenal (HPA)-axis activity (diurnal cortisol pattern), geospatially operationalized exposure to neighborhood crime, and body mass index (BMI) for a sample of 5-year-old children. Greater community crime exposure and lower HPA-axis activity were hypothesized to contribute to higher BMI, with child HPA-axis moderating the association between crime exposure and BMI...
September 18, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29046752/an-exceedingly-rare-adrenal-collision-tumor-adrenal-adenoma-metastatic-breast-cancer-myelolipoma
#2
Dongyan Liu, Sahayini A Kumar
Adrenal collision tumors (ACTs), in which distinct tumors coexist without histological intermingling in the same adrenal gland, are rare and their actual prevalence is unknown. ACTs commonly consist of adrenal cortical adenoma, myelolipoma, or metastatic malignant tumor. We report a 58-year-old woman with a past history of breast cancer, who presented with a 1 month history of fevers, chills, and abdominal fullness. The physical examination and the laboratory data including endocrine studies were unremarkable...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29043559/nonfunctioning-adrenal-incidentaloma-affecting-central-blood-pressure-and-arterial-stiffness-parameters
#3
Tolga Akkan, Mustafa Altay, Yasemin Ünsal, Murat Dağdeviren, Esin Beyan
PURPOSE: Recently, cardiovascular risk is thought to be increased in patients with nonfunctioning adrenal incidentaloma (NFAI). There are no sufficient studies in the literature to evaluate this situation in NFAI patients without cardiovascular risk. The objective of this study is to compare peripheral and central blood pressure and arterial stiffness between patients with NFAI and healthy volunteers (of a similar age, gender and body mass index as the NFAI group) who have no traditional cardiovascular risk factors and autonomous cortisol secretion, with pulse wave analysis (PWA)...
October 17, 2017: Endocrine
https://www.readbyqxmd.com/read/29039221/how-useful-is-urinary-free-cortisol-in-the-clinic
#4
Nisa Sheriff, Ann I McCormack
Measurement of 24-h urine-free cortisol is frequently employed as a first-line screening and disease-monitoring test in Cushing's syndrome (CS). The quest for 'cortisol specificity' has seen the emergence of mass spectrometry (MS) based assays, particularly liquid chromatography/tandem mass spectrometry. In contrast to traditional immunoassays, liquid chromatography/tandem mass spectrometry 'free cortisol' measurement is less susceptible to 'interference' from cortisol precursors and metabolites. However, detection of these conjugates is important in mild CS and therefore, missed by MS if cortisol alone is measured...
October 17, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29033772/intraparenchymal-hemorrhage-due-to-brain-metastasis-of-hepatocellular-carcinoma
#5
Rafael Sartori Balbinot, Ana Laura Facco Muscope, Mateus Dal Castel, Silvana Sartori Balbinot, Raul Angelo Balbinot, Jonathan Soldera
Although extrahepatic metastases from hepatocellular carcinoma (HCC) are present in only 5-15% of cases, they are certainly factors associated with poor prognosis. The main sites include lung, lymph nodes, bones, and adrenal glands, in descending order. Metastasis in the central nervous system is extremely rare, and the incidences vary from 0.6 to 1.7%. We report a case of a 54-year-old man previously diagnosed with alcohol-induced cirrhosis of the liver and HCC. The patient was admitted presenting progressive left hemiparesis and headache which started 2 days earlier, with no history of cranioencephalic trauma...
September 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29033674/appearance-of-adrenal-myelolipomas-on-2-deoxy-2-18-f-fluoro-d-glucose-positron-emission-tomography-computed-tomography
#6
Steven P Rowe, Mehrbod S Javadi, Lilja B Solnes, Elliot K Fishman
With the widespread use of 2-deoxy-2-((18)F) fluoro-D-glucose positron emission tomography-computed tomography (FDG PET/CT) in oncologic imaging, it has become increasingly important for physicians who interpret FDG PET/CT scans to confidently recognize the spectrum of incidentally encountered benign and malignant findings. The adrenal glands represent an interesting nexus of multiple rare and common benign intrinsic tumors as well as metastases from a variety of primary malignancies. Given the breadth of adrenal gland pathology, careful description of the FDG PET/CT appearance of these pathologies is of value to help reduce misinterpretation...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29026518/castleman-s-disease-a-rare-presentation-in-a-retroperitoneal-accessory-spleen-treated-with-a-minimally-invasive-robotic-approach
#7
Fabio Sbrana, Dimin Zhou, Ina Zamfirova, Nathaniel Leonardi
Unicentric Castleman's disease (UCD) is a rare disorder of unknown etiology characterized by localized lymphoid tissue proliferation and interfollicular hypervascularity. A 33-year-old Caucasian female presented with vague abdominal discomfort and pain with pressure. Ultrasound and computed tomography detected a large peripancreatic mass. Robotic-assisted resection of the mass along with en bloc dissection of the encased left adrenal gland was done. Frozen section examination confirmed UCD hyaline vascular variant in a retroperitoneal accessory spleen...
October 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29026405/lateral-retroperitoneoscopic-adrenalectomy-for-complicated-adrenal-tumor-larger-than-5-centimeters
#8
Wei Chen, Wei Lin, Deng-Jun Han, Yong Liang
BACKGROUND: The role of lateral retroperitoneoscopic adrenalectomy (LRA) for complicated tumor with large diameter remains controversial, this study aimed to evaluate the effectiveness of this procedure on the management of tumor larger than 5cm in diameter. METHODS: A retrospective comparison was conducted of 67 patients with large complicated adrenal tumor (>5cm). 41 patients received LRA, and 26 received open adrenalectomy (OA) in our hospital between January 2011 and June 2015...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29025828/diurnal-cortisol-and-mental-well-being-in-middle-and-older-age-evidence-from-four-cohort-studies
#9
Mai Stafford, Yoav Ben-Shlomo, Cyrus Cooper, Catharine Gale, Michael P Gardner, Marie-Claude Geoffroy, Chris Power, Diana Kuh, Rachel Cooper
OBJECTIVES: We conducted an individual participant meta-analysis to test the hypothesis that cortisol patterns indicative of dysregulated hypothalamic-pituitary-adrenal axis functioning would be prospectively associated with poorer well-being at follow-up. SETTING: Four large UK-based cohort studies. PARTICIPANTS: Those providing valid salivary or serum cortisol samples (n=7515 for morning cortisol; n=1612 for cortisol awakening response) at baseline (age 44-82) and well-being data on the Warwick Edinburgh Mental Wellbeing Scale at follow-up (0-8 years) were included...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29021924/large-unilateral-adrenal-mass-with-surrounding-brown-fat-a-case-report
#10
Gabriel O Ologun, Zinal M Patel, Navpreet K Rana, Andrew Trecartin, Alice Shen, Douglas Trostle, David Bertsch
Pheochromocytomas are rare tumors derived from chromaffin cells located in the adrenal and extra adrenal tissues. Pheochromocytomas are diagnosed biochemically and localized using different imaging modalities. The definitive management is surgical resection. Brown adipose tissues are normally present during fetal development, with regression over time. Brown adipose tissues are thermogenic and usually located in the neck, mediastinum, and retroperitoneum. Here, we report a case of a unilateral pheochromocytoma surrounded by brown fat...
August 9, 2017: Curēus
https://www.readbyqxmd.com/read/29019745/imaging-of-nonmalignant-adrenal-lesions-in-children
#11
Kiran M Sargar, Geetika Khanna, Rebecca Hulett Bowling
The adrenal glands in children can be affected by a variety of benign lesions. The diagnosis of adrenal lesions can be challenging, but assessment of morphologic changes in correlation with the clinical presentation can lead to an accurate diagnosis. These lesions can be classified by their cause: congenital (eg, discoid adrenal gland, horseshoe adrenal gland, and epithelial cysts), vascular and/or traumatic (eg, adrenal hemorrhage), infectious (eg, granulomatous diseases), enzyme deficiency disorders (eg, congenital adrenal hyperplasia [CAH] and Wolman disease), benign neoplasms (eg, pheochromocytomas, ganglioneuromas, adrenal adenomas, and myelolipomas), and adrenal mass mimics (eg, extralobar sequestration and extramedullary hematopoiesis)...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29018153/prednisolone-has-the-same-cardiovascular-risk-profile-as-hydrocortisone-in-glucocorticoid-replacement
#12
David J F Smith, Hemanth Prabhudev, Sirazum Choudhury, Karim Meeran
INTRODUCTION: Patients who need glucocorticoid replacement in both primary and secondary adrenal insufficiency have the choice of either once daily prednisolone or thrice daily hydrocortisone. A recent European study found no difference between prednisolone and hydrocortisone users in several markers including glucose, weight, body mass index (BMI), systolic and diastolic blood pressure and waist circumference, although an increase in cholesterol and low density lipoprotein (LDL) was suggested in a subgroup of these patients...
October 10, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29017384/leukocyte-cell-derived-chemotaxin-2-amyloidosis-alect2-in-a-patient-with-lung-adenocarcinoma-an-autopsy-report-and-literature-review
#13
Hamza Tariq, Francis E Sharkey
Amyloidosis caused by deposition of leukocyte cell-derived chemotaxin-2 amyloidosis (ALECT2) is the most recently described form of systemic amyloidosis and has quickly emerged as a common and possibly underdiagnosed cause of slowly declining renal function, particularly in patients of Hispanic ancestry. We describe the autopsy findings in a 70-year-old Hispanic woman who died of metastatic lung adenocarcinoma and was incidentally found to have extensive amyloid deposition in the kidneys, liver, spleen, adrenal glands, small intestine, gallbladder, lungs, bilateral ovaries, and uterus...
October 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29017055/microenvironment-driven-shift-of-cohesion-detachment-balance-within-tumors-induces-a-switch-toward-metastasis-in-neuroblastoma
#14
Céline Delloye-Bourgeois, Lorette Bertin, Karine Thoinet, Loraine Jarrosson, Karine Kindbeiter, Thomas Buffet, Servane Tauszig-Delamasure, Muriel Bozon, Aurélien Marabelle, Valérie Combaret, Christophe Bergeron, Edmund Derrington, Valérie Castellani
Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells. Disseminated forms have high frequency of multiple tumoral foci whose etiology remains unknown; NB embryonic origin limits investigations in patients and current models. We developed an avian embryonic model driving human NB tumorigenesis in tissues homologous to patients. We found that aggressive NBs display a metastatic mode, secondary dissemination via peripheral nerves and aorta. Through tumor transcriptional profiling, we found that NB dissemination is induced by the shutdown of a pro-cohesion autocrine signal, SEMA3C, which constrains the tumoral mass...
October 9, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29016342/case-report-histoplasmosis-in-himachal-pradesh-india-an-emerging-endemic-focus
#15
Vikram K Mahajan, Rashmi Kaul Raina, Suman Singh, Rattan Sagar Rashpa, Anuradha Sood, Pushpinder S Chauhan, Karaninder S Mehta, Ritu Rawat, Vikas Sharma
We describe four cases of histoplasmosis indigenous to Himachal Pradesh (India) that will be of considerable public health interest. A 48-year-old human immunodeficiency virus (HIV)-negative man with cervical and mediastinal lymphadenopathy, hepatosplenomegaly, adrenal mass, and bone marrow involvement was treated as disseminated tuberculosis without benefit. Progressive disseminated histoplasmosis was diagnosed from the fungus in smears from adrenal mass. Another 37-year-old HIV-positive man was on treatment of suspected pulmonary tuberculosis...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28990974/iodine-and-fat-quantification-for-differentiation-of-adrenal-gland-adenomas-from-metastases-using-third-generation-dual-source-dual-energy-computed-tomography
#16
Simon S Martin, Sebastian Weidinger, Rouben Czwikla, Benjamin Kaltenbach, Moritz H Albrecht, Lukas Lenga, Thomas J Vogl, Julian L Wichmann
OBJECTIVES: The aim of this study was to investigate the value of third-generation dual-source dual-energy computed tomography (DECT) iodine and fat quantification in differentiating adrenal gland adenomas from metastases. MATERIALS AND METHODS: Sixty-two patients (38 men and 24 women; mean age, 69.1 years) underwent clinically indicated DECT of the abdomen on a third-generation dual-source scanner. Examinations were retrospectively included due to detected adrenal masses...
October 3, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28984256/neonatal-endocrine-labomas-pitfalls-and-challenges-in-reporting-neonatal-hormonal-reports
#17
Sachin Chittawar, Deep Dutta, Deepak Khandelwal, Rajiv Singla
This review highlights pitfalls and challenges in interpreting neonatal hormone reports. Pre-analytical errors contribute to nearly 50% of all errors. Modern chemiluminescence assay are more accurate, have lower risk of Hook's effect, but continue to have problems of assay interference. Liquid chromatography mass spectroscopy is gold standard for most hormone assays. Neonatal hypoglycemia diagnostic cut-offs are lower than adults. Random growth hormone testing is of value in diagnosing growth hormone deficiency in neonates...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28982623/robotic-radical-left-nephrectomy-with-inferior-vena-cava-level-iii-thrombectomy
#18
Ryan J Nelson, Matthew J Maurice, Jihad H Kaouk
INTRODUCTION AND OBJECTIVE: We present our robotic approach and technique to manage a large left renal tumor with inferior vena cava (IVC) Level III thrombus. The superior mesenteric artery crossing the left renal vein requires robotic docking from the left, for dissection of the left kidney followed by repositioning and re-docking the robot from the right side for dissection of the right renal vein, distal and proximal IVC, and the remaining left renal vein insertion into the IVC. METHODS: We present a 53-year-old man with a 10...
September 2017: Urology
https://www.readbyqxmd.com/read/28982516/robotic-assisted-thoracoscopic-transdiaphragmatic-adrenalectomy-ratta-for-metastatic-renal-cell-carcinoma
#19
Christopher M Russell, Simpa S Salami, Amir H Lebastchi, Kiran H Lagisetty, Rohit Mehra, Khaled S Hafez, Rishindra M Reddy, Alon Z Weizer
OBJECTIVE: Robotic-assisted thoracoscopic transdiaphragmatic adrenalectomy (RATTA) represents a novel surgical approach for the management of adrenal pathology in patients with a history of extensive transperitoneal or retroperitoneal procedures. METHODS: Here we report the first described case of RATTA in a 56-year-old woman with metastatic renal cell carcinoma to the left adrenal gland and right lung. With the assistance of cardiothoracic surgery, this patient underwent robotic-assisted thoracoscopic pulmonary wedge resection and RATTA...
July 2017: Urology
https://www.readbyqxmd.com/read/28981384/the-effects-of-a-korean-ginseng-ginst15-on-hypo-pituitary-adrenal-and-oxidative-activity-induced-by-intense-work-stress
#20
Shawn D Flanagan, William H DuPont, Lydia K Caldwell, Vincent H Hardesty, Emily C Barnhart, Matthew K Beeler, Emily M Post, Jeff S Volek, William J Kraemer
The effect of GINST15, an enzyme fermented ginseng supplement, on hormonal and inflammatory responses to physical stress in humans is unknown. The purpose of this investigation was to examine the constitutive and stress-induced effects of GINST15 supplement on hypo-pituitary-adrenal (HPA) and antioxidant activity in addition to muscle damage. Ten women (age: 38.7 ± 7.8 years; height: 163.81 ± 4.4 cm; body mass 76.0 ± 11.6 kg) and nine men (age: 41.2. ± 9.7 years; height: 177.4 ± 5...
October 5, 2017: Journal of Medicinal Food
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