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https://www.readbyqxmd.com/read/29666081/mantle-cell-lymphoma-presenting-as-bilateral-adrenal-huge-masses
#1
Abtin Doroudinia, Mehrdad Bakhshayesh Karam, Mostafa Ranjbar, Arash Nikmanesh, Payam Mehrian
We present a middle-aged woman complaining of weakness, lethargy and weight loss for 6 months. Positron emission tomography (PET)/CT scan revealed huge bilateral adrenal masses with intense 18F-fluorodeoxyglucose avidity. Biopsy and immunohistochemical staining were compatible with mantle cell lymphoma (MCL). The patient received six cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) followed by four cycles of intrathechal methotrexate chemotherapy. Bone marrow aspiration biopsy was performed for initial staging and also before bone marrow transplantation...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29665739/pax8-positive-b-cell-lymphoma-in-adrenal-gland-masquerading-as-metastatic-renal-cell-carcinoma
#2
Rugvedita Parakh, Lin Cheng, Maria Tretiakova
Extranodal lymphomas involve adrenal glands as a mass lesion in 3% to 5% of cases as identified by imaging studies. Definitive diagnosis of the neoplasm is provided by morphological and immunophenotypical evaluation on limited tissue obtained by fine needle aspiration or core biopsy. We report a diagnostically challenging case that presented as masses involving adrenal gland and lung in the setting of a concurrent primary renal cell carcinoma. PAX8, a frequently used marker for renal cell carcinoma, was immunoreactive in the neoplastic cells of the adrenal mass, and thus highly suggestive for metastatic renal cell carcinoma...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29660998/annals-express-the-challenge-of-improving-the-diagnostic-yield-from-metanephrine-testing-in-suspected-phaeochromocytoma-and-paraganglioma
#3
Intan Nureslyna Samsudin, Michael M Page, Kirsten Hoad, Paul Chubb, Melissa Gillett, Paul Glendenning, Samuel Vasikaran
BACKGROUND: Plasma free metanephrines (PFM) or urinary fractionated metanephrines (UFM) are the preferred biochemical tests for the diagnosis of phaeochromocytoma and paraganglioma (PPGL). Borderline increased results should be followed up to either exclude or confirm diagnosis. METHODS: We extracted all PFM and UFM results reported by our laboratory over a 6-month period from the laboratory information system. We categorised patients with borderline increased results according to whether follow-up testing had been performed as suggested in the initial laboratory report...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29660928/adrenal-schwannoma-ct-mr-manifestations-and-pathological-correlation
#4
Wei Tang, Xiang-Rong Yu, Liang-Ping Zhou, Hong-Bo Gao, Qi-Feng Wang, Wei-Jun Peng
OBJECTIVES: This study aimed to describe the computed tomography (CT), magnetic resonance imaging (MRI) imaging features of adrenal schwannoma and to correlate imaging findings with histopathologic findings. METHODS: The findings from multiphase CT or MRI examinations of seventeen patients with histopathologically confirmed adrenal schwannoma were reviewed. The imaging criteria included shape, size, margin, attenuation, signal intensity, secondary degeneration, and internal mass enhancement pattern...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29659392/pedunculated-hepatocellular-carcinoma-mimicking-right-adrenal-tumor-on-fdg-pet-ct
#5
Aisheng Dong, Xinping Zhong, Yang Wang
Pedunculated hepatocellular carcinoma is an unusual form of hepatocellular carcinoma protruding from the liver with or without a pedicle. We present a case of pedunculated hepatocellular carcinoma misdiagnosed as right adrenal tumor on MRI and FDG PET/CT. Intraoperative exploration revealed the mass was attached to the liver, but the right adrenal gland was intact. Laparoscopic biopsy revealed poorly differentiated hepatocellular carcinoma. This case indicates it may be difficult to diagnose pedunculated hepatocellular carcinoma because it is hard to define its origin on imaging...
April 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29648902/diagnostic-evaluation-in-steroid-induced-myopathy-case-report-suggesting-clinical-utility-of-quantitative-muscle-ultrasonography
#6
Marco Alessandro Minetto, Cristina Caresio, Valentina D'Angelo, Fabio Lanfranco, Lucia Ghizzoni, Silvestro Roatta, Emanuela Arvat, Santosh Kesari
PURPOSE: We present a patient with adrenal Cushing's syndrome causing steroid myopathy. The purpose of the case report is to illustrate the clinical usefulness of quantitative muscle ultrasonography for the assessment of glucocorticoid-induced changes in muscle mass (MM) and structure. METHODS: Assessments of physical performance, muscle strength, MM (i.e., total body skeletal MM, appendicular skeletal MM, and thickness of lower limb muscles), and muscle structure (i...
April 12, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29644036/pulmonary-paraganglioma-in-a-10-year-old-a-case-report-and-review-of-the-literature
#7
Tracy R Geoffrion, Linde DeKeyzer, Gopi Shah, Suja J Nair, Timothy J Pirolli, Kemp Kernstine
Paraganglioma is a rare extra-adrenal tumor of the paraganglia often found in association with sympathetic and parasympathetic nerves. The case presented is of a 10-year-old boy with hemoptysis who was found to have an obstructive bronchial mass. He underwent surgical resection and biopsy confirmed primary pulmonary paraganglioma. He was subsequently found to have an associated genetic syndrome. This is the first case report describing a primary pulmonary paraganglioma in a child.
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29643654/role-of-endoscopic-ultrasound-guided-fine-needle-aspiration-in-adrenal-lesions-analysis-of-32-patients
#8
Rakesh K Gupta, Kaushik Majumdar, Ravindra K Saran, Siddharth Srivastava, Puja Sakhuja, Vineeta V Batra
Objective: Endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) is a precise and safe technique that provides both radiological and pathological diagnosis with a better diagnostic yield and minimal adverse events. EUS-FNAC led to the remarkable increase in the detection rate of incidentaloma found during radiologic staging or follow-up in various malignancy or unrelated conditions. Aims: We did this preliminary study with an aim to evaluate the role of EUS-FNA in diagnosing and classifying adrenal lesions, clinical impact, and compare the outcome with the previously published literature...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29642753/determination-of-olaquindox-carbadox-and-cyadox-in-animal-feeds-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry
#9
Xiaohuan Miao, Lijun Xu, Haipu Li, Zhaoguang Yang
Olaquindox, carbadox, and cyadox are chemically synthesized antibacterial and growth promoting agents for animals. At high doses they may exert mutagenicity and hepatic and adrenal toxicities in animals. Regrettably, these substances are frequently abused or misused when added into animal feeds. Thus, developing a sensitive and reliable method for simultaneous determination of olaquindox, carbadox, and cyadox in different kinds of animal feeds is crucially important for food safety monitoring. In this paper we optimized instrumental conditions, various extraction solutions, different kinds of solid phase extraction cartridges, and effects of pH on the loading solvents of the Oasis HLB cartridge...
April 12, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29616089/pedigree-analysis-diagnosis-and-treatment-in-von-hippel-lindau-syndrome-a-report-of-three-cases
#10
Yuanliang Wang, Guobiao Liang, Jing Tian, Xin Wang, Anjian Chen, Tiancai Liang, Yang Du, Hao Li, Jiang Du, Lang Yu, Zongping Chen
The objective of the present study was to systematically investigate the clinical features, diagnosis and therapeutic treatment of Von Hippel-Lindau (VHL) syndrome in order to improve understanding of this disease. A total of 3 cases of VHL syndrome treated at the Affiliated Hospital of Zunyi Medical College (Zunyi, China) between September 2014 and October 2015 were retrospectively analyzed. The associated literature was reviewed, and the diagnostic and therapeutic features were discussed. Case 1 was diagnosed as VHL syndrome accompanied by a renal tumor on the right side, and radical tumor resection in the right kidney was performed...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29608696/serum-cortisol-levels-via-radioimmunoassay-vs-liquid-chromatography-mass-spectrophotometry-in-healthy-control-subjects-and-patients-with-adrenal-incidentalomas
#11
Martha K P Huayllas, Brian C Netzel, Ravinder J Singh, Claudio E Kater
Background: Adrenal incidentalomas (AIs) are present in 4% of adults. As many as 30% may secrete cortisol autonomously in the absence of specific signs of overt hypercortisolism, in a phenomenon called subclinical hypercortisolism (SH). Diagnosis of SH is established by serum cortisol resistance to dexamethasone suppression. Methods: We compared serum cortisol concentrations, as determined by radioimmunoassay (RIA) and liquid chromatography/tandem mass spectronomy (LC/MS-MS), in 73 patients with AI group (52 with unilateral AI) and 34 control subjects in 3 scenarios: basal; after 1-mg dexamethasone suppression; and after 0...
March 28, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29606280/cardiovascular-mortality-in-patients-with-subclinical-cushing
#12
Valentina Morelli, Maura Arosio, Iacopo Chiodini
Patients with adrenal incidentaloma (AI) and subclinical hypercortisolism (SH) show a high prevalence of cardiovascular risk factors and an increased prevalence and incidence of cardiovascular events. Furthermore, some recent data suggest that in these patients, the cardiovascular mortality is also increased. Unfortunately, to date, the diagnosis of SH is still a matter of debate, and, therefore, it is still not possible to address the treatment of choice (i.e. surgical or conservative approach) in many AI patients...
March 29, 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29601891/dehydroepiandrosterone-supplementation-is-not-beneficial-in-the-late-postmenopausal-period-in-diet-induced-obese-rats
#13
Caio Jordão Teixeira, Luciene Maria Ribeiro, Katherine Veras, Layanne Cabral da Cunha Araujo, Rui Curi, Carla Roberta de Oliveira Carvalho
AIMS: Dehydroepiandrosterone (DHEA) is an adrenal steroid hormone that is a precursor of sexual hormones. It is reduced during aging and is strongly associated with insulin resistance and obesity. There is evidence for beneficial effects of this steroid, in both human and animal models, during perimenopause. However, the impact of DHEA treatment during late postmenopause on glucose metabolism is not clearly documented. We tested the hypothesis that DHEA supplementation could improve insulin sensitivity in an ovariectomized obese rat model (OVX) that was fed a high-fat diet for 11 weeks...
March 27, 2018: Life Sciences
https://www.readbyqxmd.com/read/29600100/unusual-cardiac-paraganglioma-mimicking-an-atypical-carcinoid-tumor-of-the-lung
#14
Dean Spencer, Mark Evans, Beverly Wang, J Lawrence Delrosario, Timmy Cheng, Jeffrey Milliken
We present a case of unusual cardiac paraganglioma (PG) initially misdiagnosed as atypical carcinoid tumor of the lung and discuss key clinical and pathologic characteristics that guide surgical management of these rare chromaffin cell tumors. A 64-year-old female with persistent cough and back pain was found to have a 4 cm × 3 cm mass abutting multiple cardiopulmonary structures. A biopsy was performed at an outside institution and pathology reported "atypical neuroendocrine carcinoma, consistent with carcinoid"...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29594468/extensive-spinal-extradural-ganglioneuroma-of-the-lumbar-spine-mimicking-lymphoma
#15
REVIEW
Seung Hun Kang, Sang Min Lee, Doo Hoe Ha, Hye Jin Lee
BACKGROUND: Ganglioneuromas are rare, benign, well-differentiated tumors arising from neural crest cells that commonly occur in the posterior mediastinum, retroperitoneum, cervical spine, and adrenal gland. We report an unusual case of an extensive spinal extradural ganglioneuroma, circumferentially and longitudinally affecting the extradural space of the lumbar spine and continuously invading bilateral psoas muscles. CASE DESCRIPTION: A 32-year-old man presented with a 1-week history of abdominal pain and diarrhea...
March 29, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29589383/bone-health-in-adrenal-disorders
#16
REVIEW
Beom Jun Kim, Seung Hun Lee, Jung Min Koh
Secondary osteoporosis resulting from specific clinical disorders may be potentially reversible, and thus continuous efforts to find and adequately treat the secondary causes of skeletal fragility are critical to ameliorate fracture risk and to avoid unnecessary treatment with anti-osteoporotic drugs. Among the hyperfunctional adrenal masses, Cushing's syndrome, pheochromocytoma, and primary aldosteronism are receiving particularly great attention due to their high morbidity and mortality mainly by increasing cardiovascular risk...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29588244/intracranial-epidural-metastases-of-adrenal-pheochromocytoma-a-rare-entity
#17
Lillian B Boettcher, Hussam Abou-Al-Shaar, Vijay M Ravindra, Jeffrey Horn, Cheryl Ann Palmer, Sarah T Menacho
Pheochromocytomas are uncommon neuroendocrine tumors of the adrenal medulla. Malignant behavior is seen in approximately 10% of these lesions, evidenced by distant metastasis to sites without chromaffin tissue. The authors report a rare case of intracranial epidural metastases of an adrenal pheochromocytoma in a 24-year-old man. The patient originally presented at the age of 10 years with adrenal pheochromocytoma and subsequently developed extensive metastatic bone and lung disease. He was monitored in the intervening years until recent imaging demonstrated an enlarging right parietal mass...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29587644/a-novel-germline-armc5-mutation-in-a-patient-with-bilateral-macronodular-adrenal-hyperplasia-a-case-report
#18
Qiuli Liu, Dali Tong, Jing Xu, Xingxia Yang, Yuting Yi, Dianzheng Zhang, Luofu Wang, Jun Zhang, Yao Zhang, Yaoming Li, Lianpeng Chang, Rongrong Chen, Yanfang Guan, Xin Yi, Jun Jiang
BACKGROUND: Bilateral macronodular adrenal hyperplasia (BMAH) is a rare cause of Cushing's syndrome (CS). BMAH is predominantly believed to be caused by two mutations, a germline and somatic one, respectively, as described in the two-hit hypothesis. In many familial cases of BMAH, mutations in armadillo repeat containing 5 (ARMC5), a putative tumor suppressor gene, are thought to induce the disorder. The objective of this study was to report a case in which the patient presented with BMAH induced by a novel heterozygous germline ARMC5 mutation (c...
March 27, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29581611/obesity-does-not-affect-peri-and-postoperative-outcomes-of-transabdominal-laparoscopic-adrenalectomy
#19
Takahiro Inaishi, Toyone Kikumori, Dai Takeuchi, Hiromasa Ishihara, Noriyuki Miyajima, Masahiro Shibata, Yuko Takano, Kenichi Nakanishi, Sumiyo Noda, Yasuhiro Kodera
Laparoscopic adrenalectomy is the gold standard procedure for most adrenal tumors. Obesity is considered as a risk factor for surgical complications. This study aimed to evaluate whether obesity affects peri- and postoperative outcomes of transabdominal laparoscopic adrenalectomy using body mass index (BMI). This retrospective study included 98 patients who underwent transabdominal laparoscopic adrenalectomy between January 2011 and December 2016. We divided the patients into 2 groups: non-obese group (BMI < 25 kg/m2) and obese group (BMI ≥ 25 kg/m2)...
February 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29578440/-phytocorrection-of-immunological-and-biochemical-changes-in-the-combined-impact-of-coal-dust-and-high-dose-of-radiation
#20
L Chulenbayeva, O Ilderbayev, Zh Taldykbayev, G Ilderbayeva, A Argynbekova
The objective of this researsh is to study the effects of Eminium Regelii phytopreparation (ERP) on immune status and free radical oxidation in the tissues of the adrenal glands and immunocompetent organs after combined exposure to 6 Gy dose of gamma irradiation and coal dust (remote period). The study was realized on 30 white laboratory male rats of the Wistar line, weighing 240±20g, that were divided into equal 3 groups: I group - intact, ІІ group - were exposured to combined effects of coal dust and gamma irradiation, III group - were exposured to combined effects and in parallel taking phytopreparation Eminium Regel...
February 2018: Georgian Medical News
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