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Adrenal mass

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https://www.readbyqxmd.com/read/28533648/increased-f-fdg-uptake-in-bilateral-gynecomastia-secondary-to-feminizing-adrenal-tumor-a-rare-case-report-and-review-of-literature
#1
Priyanka Verma, Gaurav Malhotra, Sneha Kothari, Rajlaxmi Jagtap, Ramesh V Asopa
A 21 year old male who presented with painful enlargement of both the breasts and a hyperestrogenic state, was found to harbor a heterogeneous mass arising from the right adrenal on contrast enhanced Computed Tomography abdomen. The mass was hypermetabolic with no regional, nodal or distant metastases on Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography /Computed Tomography examination. Notably, substantial tracer uptake was seen in bilateral gynecomastia. The patient underwent a right adrenalectomy with the histopathology report confirming adrenocortical carcinoma...
April 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28527122/effects-of-cigarette-smoke-exposure-during-suckling-on-food-intake-fat-mass-hormones-and-biochemical-profile-of-young-and-adult-female-rats
#2
Patricia Cristina Lisboa, Patricia Novaes Soares, Thamara Cherem Peixoto, Janaine Cavalcanti Carvalho, Camila Calvino, Vanessa Silva Tavares Rodrigues, Dayse Nascimento Bernardino, Viviane Younes-Rapozo, Alex Christian Manhães, Elaine de Oliveira, Egberto Gaspar de Moura
PURPOSE: Children from smoking mothers have a higher risk of developing obesity and associated comorbidities later in life. Different experimental models have been used to assess the mechanisms involved with this increased risk. Using a rat model of neonatal nicotine exposure via implantation of osmotic minipumps in lactating dams, we have previously shown marked sexual dimorphisms regarding metabolic and endocrine outcomes in the adult progeny. Considering that more than four thousand substances are found in tobacco smoke besides nicotine, we then studied a rat model of neonatal tobacco smoke exposure: adult male offspring had hyperphagia, obesity, hyperglycemia, hypertriglyceridemia, secondary hyperthyroidism and lower adrenal hormones...
May 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28525455/18f-fdg-pet-ct-of-malignant-angiomyolipoma-with-tumor-thrombus
#3
Andrew Griffin
Renal angiomyolipomas are the most common renal mesenchymal tumors. While classic angiomyolipomas are benign, there are a number of other subtypes. Epithelioid variants are potentially malignant and may be indistinguishable from renal cell carcinoma on imaging. We present a 52-year-old woman who underwent left nephrectomy for an aggressive-appearing malignant renal epithelioid angiomyolipoma. At 6 months postoperatively, restaging FDG PET/CT demonstrated a hypermetabolic left adrenal mass extending to the left adrenal vein, left renal vein, inferior vena cava, and right atrium (SUVmax = 12)...
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28523067/extension-of-adrenocortical-carcinoma-into-the-right-atrium
#4
Yulanka Castro-Dominguez, Fatima Samad, Hayder Hashim, Alfonso Waller
Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignant neoplasm which can produce intravascular extension into the inferior vena cava (IVC) rarely extend into the right atrium (RA). We report a case of a male patient with large ACC with extension into the IVC and RA. Computed tomography showed a large right adrenal mass with contiguous tumor thrombus extending into IVC and RA with extension to the level of tricuspid valve. Patient underwent combined cardiac and abdominal surgical intervention on cardiopulmonary bypass with removal of the mass...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28521424/reninoma-coexisting-with-adrenal-adenoma-during-pregnancy-a-case-report
#5
Mei Xue, Yan Chen, Jin Zhang, Youyan Guan, Lin Yang, Bing Wu
Reninoma is a rare form of secondary hypertension. The present study reported a case of reninoma that coexisted with an adrenal adenoma in a young female with secondary hypertension during pregnancy. The patient, a 31-year-old female exhibiting hypertension for >1 year, developed a mass in the right adrenal gland, which was detected by an ultrasound scan in the 33rd gestational week. In addition, a well-defined solid mass on the left kidney was detected by a magnetic resonance imaging scan1 month subsequent to the termination of the pregnancy...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28512133/quality-of-compounded-hydrocortisone-capsules-used-in-the-treatment-of-children
#6
Uta Neumann, Daniela Burau, Sarah Spielmann, Martin Whitaker, Richard J Ross, Charlotte Kloft, Oliver Blankenstein
Objectives: Due to the lack of paediatric licensed formulations, children are often treated with individualized pharmacy-compounded adult medication. An international web-based survey about the types of medication in children with adrenal insufficiency (AI) revealed that the majority of paediatric physicians are using pharmacy-compounded medication to treat children with AI. Observations of loss of therapy control in children with congenital adrenal hyperplasia with compounded hydrocortisone capsules and regained control after prescribing a new hydrocortisone batch led to this "real world" evaluation of pharmacy-compounded paediatric hydrocortisone capsules...
May 16, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28511867/social-housing-and-social-isolation-impact-on-stress-indices-and-energy-balance-in-male-and-female-syrian-hamsters-mesocricetus-auratus
#7
Amy P Ross, Alisa Norvelle, Dennis C Choi, James C Walton, H Elliott Albers, Kim L Huhman
Although Syrian hamsters are thought to be naturally solitary, recent evidence from our laboratory demonstrates that hamsters may actually prefer social contact. Hamsters increase their preference for a location associated with an agonistic encounter regardless of whether they have "won" or "lost". It has also been reported that social housing as well as exposure to intermittent social defeat or to a brief footshock stressor increase food intake and body mass in hamsters. By contrast, it has also been suggested that housing hamsters in social isolation causes anxiety-induced anorexia and reductions in body mass selectively in females...
May 13, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28511479/extramedullary-haematopoiesis-presenting-as-an-adrenal-mass
#8
Subramanian Kannan, Prashant Kulkarni, Akhila Lakshmikantha, Karthik Gadabanahalli
No abstract text is available yet for this article.
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509906/therapeutic-efficacy-of-atypical-antipsychotic-drugs-by-targeting-multiple-stress-related-metabolic-pathways
#9
H L Cai, P Jiang, Q Y Tan, R L Dang, M M Tang, Y Xue, Y Deng, B K Zhang, P F Fang, P Xu, D X Xiang, H D Li, J K Yao
Schizophrenia (SZ) is considered to be a multifactorial brain disorder with defects involving many biochemical pathways. Patients with SZ show variable responses to current pharmacological treatments of SZ because of the heterogeneity of this disorder. Stress has a significant role in the pathophysiological pathways and therapeutic responses of SZ. Atypical antipsychotic drugs (AAPDs) can modulate the stress response of the hypothalamic-pituitary-adrenal (HPA) axis and exert therapeutic effects on stress by targeting the prefrontal cortex (PFC) and hippocampus...
May 16, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28507832/disseminated-nocardia-farcinica-pneumonia-with-left-adrenal-gland-abscess
#10
Christopher Jackson, Brennan McCullar, Kiran Joglekar, Ankur Seth, Hiren Pokharna
Adrenal masses pose a diagnostic challenge. The differential diagnosis includes functional adrenal tumors, incidentally found adrenal masses, metastases from an unknown primary cancer, and abscesses. Infrequently, adrenal gland abscesses have been reported in disseminated nocardiosis affecting immunocompetent and immunocompromised patients. We report a case of disseminated Nocardia farcinica pneumonia with an adrenal gland abscess in an immunocompetent patient with no identified risk factors for nocardiosis...
April 12, 2017: Curēus
https://www.readbyqxmd.com/read/28506406/adrenal-ganglioneuroma-the-padua-endocrine-surgery-unit-experience
#11
Maurizio Iacobone, Francesca Torresan, Marilisa Citton, Donatella Schiavone, Giovanni Viel, Gennaro Favia
BACKGROUND: Adrenal ganglioneuroma (AGN) is a rare tumor that originates from the gangliar cells of the sympathetic nervous system. It represents less than 5% of all adrenal masses. AGN occurs as a large mass, with benign behavior and no relevant symptoms and hormonal secretion, but it is often misdiagnosed because the preoperative radiological diagnosis is generally challenging. The aim of the present paper is to report the experience of a tertiary referral academic center regarding the management of AGN and review the relevant literature...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28503265/the-effects-of-caffeine-on-the-long-bones-and-testes-in-immature-and-young-adult-rats
#12
Yoojin Kwak, Hyeonhae Choi, Jaesook Roh
This study was to evaluate the age-dependent effects of caffeine exposure on the long bones and reproductive organs using male rats. A total of 15 immature male rats and 15 young adult male rats were allocated randomly to three groups: a control group and two groups fed caffeine with 120 and 180 mg/kg/day for 4 weeks. Exposure to caffeine at either dose significantly reduced body weight gain; a proportional reduction in muscle and fat mass in immature animals, whereas a selective reduction in fat mass with relatively preserved muscle mass in young adult animals...
April 2017: Toxicological Research
https://www.readbyqxmd.com/read/28503116/melatonin-pharmacology-functions-and-therapeutic-benefits
#13
REVIEW
Sylvie Tordjman, Sylvie Chokron, Richard Delorme, Annaëlle Charrier, Eric Bellissant, Nemat Jaafari, Claire Fougerou
BACKGROUND: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of biological functions through circadian rhythms (24-hour cycles) in relation to periodic environmental changes and therefore adaptation of the individual to his/her internal and external environment. Measures of melatonin are considered the best peripheral indices of human circadian timing based on an internal 24-hour clock...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28502504/high-density-lipoproteins-and-adrenal-steroidogenesis-a-population-based-study
#14
Edward Buitenwerf, Michiel N Kerstens, Thera P Links, Ido P Kema, Robin P F Dullaart
BACKGROUND: Cholesterol trafficked within plasma lipoproteins, in particular high-density lipoproteins (HDL), may represent an important source of cholesterol that is required for adrenal steroidogenesis. Based on a urinary gas chromatography method, compromised adrenal function has been suggested in men but not in women with (genetically determined) low plasma HDL-cholesterol (HDL-C). OBJECTIVE: The objective of the article was to examine the extent to which glucocorticoid production relates to HDL-C in a population-based cohort...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28497381/deep-benign-fibrous-histiocytoma-of-the-anterior-mediastinum-mimicking-malignancy
#15
Angelica Puopolo, William Newmarch, Brian Casserly
The following report describes the case of a 43-year-old male smoker that was referred to the rapid access lung clinic with haemoptysis, chest pain, and axillary lymphadenopathy-a clinical picture that raised concern for a possible underlying malignancy. Preliminary investigations revealed elevated D-dimers, low-volume haemoptysis, and a normal chest X-ray, which lowered the index of suspicion. However, computed tomography (CT) pulmonary angiogram identified a right hilar mass, several parenchymal cysts, and a large mediastinal mass...
May 11, 2017: Lung
https://www.readbyqxmd.com/read/28491156/primary-lung-carcinoid-metastatic-to-the-breast
#16
Marianna Zagurovskaya, Karen Tran-Harding, Richard Gibbs
Lung carcinoid tumors account for approximately 2% of lung cancers, with 10% of the tumors represented by the atypical type. While atypical carcinoids are metastatic to intrathoracic lymph nodes in approximately half of the cases on the initial presentation, distant metastases are seen in only 20% of the patients and are found most frequently in bones, liver, adrenal glands, and brain. We present a case of an unusual metastatic disease to the breast in 51-year-old female who developed a new breast mass 2 years after left lower lobectomy due to atypical carcinoid tumor...
June 2017: Radiology case reports
https://www.readbyqxmd.com/read/28481069/-laparoscopic-adrenalectomy-advantages-of-the-minimally-invasive-approach
#17
P Rodríguez Iglesias, J Gómez-Chacón Villalba, L Rodríguez Caraballo, P Ortolá Fortes, J Cortés Sáez, A Marco Macián, J J Vila Carbó
AIM: To describe our experience as a tertiary center on the use of laparoscopic adrenal surgery in children. MATERIAL AND METHODS: A descriptive, retrospective study of patients with pathologic adrenal masses undergoing laparoscopic adrenal surgery, between 2012 and 2015. Epidemiological variables, surgical technique, complications and follow-up were studied. RESULTS: Nine patients were studied with a median age of 62 months (5-184). In 3 patients (33...
October 10, 2016: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/28480655/effects-of-adrenal-androgen-levels-on-bone-age-advancement-in-prepubertal-children-using-the-ewha-birth-and-growth-cohort-study
#18
Jung Hyun Kwon, Hye Ah Lee, Young Ju Kim, Hwayoung Lee, Eun Ae Park, Su Jin Cho, Hye Sun Gwak, Eunhee Ha, Hyesook Park, Hae Soon Kim
Bone age (BA) advancement in prepubertal children may be associated with earlier onset of puberty and obesity. This study aimed to define the effects of adrenal androgen levels on the advancement of BA in prepubertal children, independent of obesity. During July and August 2011, we examined BA in 200 prepubertal children aged 7-9 years who were part of the Ewha Birth & Growth Cohort Study. BA was assessed by the Greulich-Pyle method. An index of BA advancement was calculated as the ratio of BA to chronological age (CA) (BA/CA), and this ratio was classified into 3 tertiles...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28479316/reference-intervals-for-plasma-concentrations-of-adrenal-steroids-measured-by-lc-ms-ms-impact-of-gender-age-oral-contraceptives-body-mass-index-and-blood-pressure-status
#19
Graeme Eisenhofer, Mirko Peitzsch, Denise Kaden, Katharina Langton, Christina Pamporaki, Jimmy Masjkur, George Tsatsaronis, Anastasios Mangelis, Tracy A Williams, Martin Reincke, Jacques W M Lenders, Stefan R Bornstein
BACKGROUND: Mass spectrometric-based measurements of the steroid metabolome have been introduced to diagnose disorders featuring abnormal steroidogenesis. Defined reference intervals are important for interpreting such data. METHODS: Liquid chromatography-tandem mass spectrometry was used to establish reference intervals for 16 steroids (pregnenolone, progesterone, 11-deoxycorticosterone, corticosterone, aldosterone, 18-oxocortisol, 18-hydroxycortisol, 17-hydroxyprogesterone, 21-deoxycortisol, 11-deoxycortisol, cortisol, cortisone, dehydroepiandrosterone, dehydroepiandrosterone-sulfate, androstenedione, testosterone) measured in plasma from 525 volunteers with (n=227) and without (n=298) hypertension, including 68 women on oral contraceptives...
May 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28479067/enhanced-metabolite-annotation-via-dynamic-retention-time-prediction-steroidogenesis-alterations-as-a-case-study
#20
Giuseppe Marco Randazzo, David Tonoli, Petra Strajhar, Ioannis Xenarios, Alex Odermatt, Julien Boccard, Serge Rudaz
The development of metabolomics based on ultra-high pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) now allows hundreds to thousands of metabolites to be simultaneously monitored in biological matrices. In that context, bioinformatics and multivariate data analysis (MVA) play a crucial role in the detection of relevant alteration patterns. However, sound biological interpretations must necessarily be supported by metabolite identifications to be definitive or at least have a high degree of confidence...
April 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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