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Parathyroidectomy

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https://www.readbyqxmd.com/read/28316315/current-indications-for-surgical-treatment-of-primary-hyperparathyroidism-in-the-elderly
#1
Andrea Polistena, Roberta Lucchini, Massimo Monacelli, Roberta Triola, Stefano Avenia, Ivan Barillaro, Louis Banka Johnson, Alessandro Sanguinetti, Nicola Avenia
This study presents the results of surgery in the elderly for primary hyperparathyroidism (PHPT) from a single institution's experience. We retrospectively analyzed 898 cases of surgically treated PHPT, divided into two groups: 135 elderly patients (A) and 763 patients younger than 65 years (B). PHPT was symptomatic in 68.8 per cent patients in group A and in 81.6 per cent in group B. Unilateral temporary recurrent laryngeal nerve palsy was observed in 0.9 per cent in group A and 0.1 per cent in group B (P > 0...
March 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28315908/positive-99m-tc-mibi-and-the-subtraction-parathyroid-scan-are-related-to-intact-parathyroid-hormone-but-not-to-total-plasma-calcium-in-primary-hyperparathyroidism
#2
Sanja Dugonjić, Marija Šišić, Marija Radulović, Boris Ajdinović
OBJECTIVE: Primary hyperparathyroidism (pHPT) is characterised by increased parathyroid hormone (PTH) secretion and consequently increased plasma calcium. During the last few decades parathyroid scintigraphy (PS), is applied in almost all patients with pPHT before surgery and specifically before minimally invasive parathyroidectomy. The aim of this study was to find the best cut-off levels of total plasma calcium and intact PTH (iPTH) that correlate with positive technetium-99m-methoxy isobutyl isonitrile ((99m)Tc-MIBI) PS and with positive subtraction PS (SPS) in patients with pHPT and thus the positive diagnostic value of these PS...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28314925/evaluation-of-left-ventricular-functions-in-patients-with-primary-hyperparathyroidism-is-there-any-effect-of-parathyroidectomy
#3
Alper Kepez, Mehmet Yasar, Murat Sunbul, Cigdem Ileri, Oguzhan Deyneli, Bulent Mutlu, Osman Yesildag, Yelda Basaran
PURPOSE: Our aim was to evaluate left ventricular (LV) systolic and diastolic functions of primary hyperparathyroidism (pHPT) patients with detailed echocardiographic analysis and investigate the effect of parathyroidectomy on echocardiographic parameters. METHODS: A total of 22 eligible consecutive patients with pHPT who underwent parathyroidectomy operation were recruited to the study. Another 22 subjects with similar age, gender and frequency of cardiovascular risk factors compared to patients were used as a control group...
March 17, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28304123/incidental-parathyroidectomy-during-total-thyroidectomy-is-not-a-direct-cause-of-post-operative-hypocalcaemia
#4
Carolyn Chew, Ran Li, Michael K Ng, Steven T F Chan, Bill Fleming
BACKGROUND: Post-operative hypocalcaemia is the most common complication after total thyroidectomy, with a reported incidence of transient hypocalcaemia up to 50% and permanent hypocalcaemia 1.5-4%. The impact of incidental parathyroidectomy (IPE) on post-operative hypocalcaemia remains controversial. This study evaluated the risk factors for IPE following total thyroidectomy and compared post-operative calcium levels serially between patients with and without IPE. METHODS: A retrospective analysis of patients undergoing total thyroidectomy from January 2009 to October 2016 at Western Health was conducted...
March 17, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28296787/unintentional-parathyroidectomy-during-total-thyroidectomy-surgery-a-single-surgeon-s-experience
#5
Wei Du, Qigen Fang, Xu Zhang, Meng Cui, Ming Zhao, Weihua Lou
In this study, we investigated incidental parathyroidectomy during total thyroidectomy surgery that required central lymph node dissection and the potential risk factors. Patients requiring total thyroidectomy and tracheoesophageal groove node dissection were enrolled in the study from January 2013 to June 2015 and we obtained all medical information, including pathology reports. Furthermore, we recorded the parathyroid hormone level in all patients prior to operation and then 3 further times: 1 day, 1 week, and 3 months after surgery...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28277104/self-diagnosis-of-hyperparathyroidism-during-pregnancy-resulting-in-parathyroidectomy-and-uncomplicated-delivery
#6
Aleksandra Medza, Lukasz Obolonczyk, Anna Lewalska, Tomasz Buss, Rafal Peksa, Malgorzata Siekierska-Hellmann, Monika Berendt-Obolonczyk, Piotr Wisniewski, Krzysztof Sworczak
Primary hyperparathyroidism is a condition with hypercalcemia and elevated parathyroid hormone (PTH). Typically, treating patients with such disease does not pose a problem for doctors, unless the patient is pregnant. Firstly, pregnancy may mask signs of hypercalcemia. Secondly, treatment should be applied with special care for immature fetus. If undiagnosed and untreated, it is life-threatening for the mother and the baby. The main cause of primary hyperparathyroidism is parathyroid adenoma, which should be removed surgically in second trimester...
March 6, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28258382/-is-autotransplantation-with-parathyroidectomy-for-secondary-hyperparathyroidism-outdated
#7
H Dralle
No abstract text is available yet for this article.
March 3, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28220742/calcific-uraemic-arteriolopathy-calciphylaxis-in-patients-on-renal-replacement-therapy
#8
S Sebastian, H F Jordaan, J W Schneider, M R Moosa, M R Davids
BACKGROUND: Calcific uraemic arteriolopathy (calciphylaxis) is an unusual and potentially fatal condition characterised by small-vessel calcification and ischaemic skin necrosis. It mainly affects patients with end-stage renal disease (ESRD) on haemodialysis, but may rarely occur in the absence of ESRD in conditions such as primary hyperparathyroidism, malignancy, alcoholic liver disease and connective tissue disease. METHODS: We reviewed the records of all patients diagnosed with calciphylaxis while on renal replacement therapy at Tygerberg Hospital, Cape Town, South Africa, between 1990 and 2014, to describe its presentation, course and final outcome...
January 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28213926/association-of-hypercalcemia-before-treatment-with-hypocalcemia-after-treatment-in-dogs-with-primary-hyperparathyroidism
#9
J D Dear, P H Kass, A M Della Maggiore, E C Feldman
BACKGROUND: Development of hypocalcemia after treatment of hyperparathyroidism results in increased costs and risk of poorer outcomes. Previous studies have shown conflicting data about predictors of hypocalcemia after these procedures. HYPOTHESIS/OBJECTIVES: The objective of this study was to investigate whether ionized calcium (iCa) concentrations before treatment are predictive of hypocalcemia or its clinical signs after surgical removal or heat ablation in dogs with primary hyperparathyroidism...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28199935/surgical-management-of-a-giant-parathyroid-adenoma-through-minimal-invasive-parathyroidectomy-a-case-report
#10
Georgios Sahsamanis, Konstantinos Gkouzis, Stavros Samaras, Dionysios Pinialidis, Georgios Dimitrakopoulos
INTRODUCTION: Primary hyperparathyroidism is a common endocrine disorder mostly associated to parathyroid adenomas. Although those tend to be small in size, rare cases of giant parathyroid adenomas may be present. CASE PRESENTATION: A 42year old female was admitted in our department due to weakness and vague abdominal pain for the past 8 months. Preoperative laboratory exams indicated primary hyperparathyroidism as a cause to her symptomatology, with elevated values of parathormone and normal values of serum calcium...
January 31, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28192245/feasibility-and-safety-of-minimally-invasive-radioguided-parathyroidectomy-using-very-low-intraoperative-dose-of-tc-99m-mibi
#11
Mostafa Mehrabibahar, Zohreh Mousavi, Ramin Sadeghi, Parvin Layegh, Masoumeh Nouri, Mehdi Asadi
BACKGROUND: Surgical resection of the abnormal parathyroid glands is the only curative treatment for primary hyperparathyroidism (PHPT). Radioguided parathyroidectomy with technetium-99m (TC-99m) sestamibi has been successfully used in patients with PHPT. This study was designed to evaluate the results of a series of patients with PHPT who underwent minimally invasive radioguided parathyroidectomy (MIRP) using very low dose (1 mCi) of TC-99m sestamibi (MIBI) without application of intraoperative parathyroid hormone (PTH) assay or frozen section analysis...
February 10, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28170301/influence-of-parathyroidectomy-on-bone-calcium-concentration-evaluation-with-spectral-ct-in-patients-with-secondary-hyperparathyroidism-undergoing-hemodialysis-a-prospective-feasibility-study
#12
Qiang Ma, Zhenghan Yang, Xue Han, Fen Liu, Dechun Su, Haidong Xing
Purpose To use spectral computed tomography (CT) to evaluate the influence of parathyroidectomy (PTX) on calcium concentration in trabecular bone and cortical bone in patients undergoing hemodialysis with secondary hyperparathyroidism. Materials and Methods This study was performed with institutional review board approval. Written consent was obtained from each patient. Thirty-eight men (mean age ± standard deviation, 55.69 years ± 8.05; range, 42-72 years) undergoing maintenance hemodialysis who underwent PTX and 40 patients (mean age, 56...
February 7, 2017: Radiology
https://www.readbyqxmd.com/read/28166819/validation-of-selective-use-of-intraoperative-pth-monitoring-in-parathyroidectomy
#13
Alexandra Thielmann, Paul Kerr
BACKGROUND: The objective of this study was to validate our approach of treating primary hyperparathyroidism using sestamibi scan directed parathyroidectomy, without routine use of intraoperative parathyroid hormone measurements (ioPTH). METHODS: We prospectively established a protocol limiting the use of ioPTH to patients with negative or equivocal sestamibi scans, and those who had risk factors for multi-gland disease. We then performed a retrospective review to determine our disease control rate...
February 6, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28161839/osteoprotegerin-and-uremic-osteoporosis-in-chronic-hemodialysis-patients
#14
Diana Moldovan, Crina Rusu, Alina Potra, Ioan Moldovan, Ioan Mihai Patiu, Mirela Gherman-Caprioara, Ina Maria Kacso
INTRODUCTION: Osteoprotegerin (OPG) is a powerful inhibitor of osteoclast activity, and it plays an important role in bone metabolism. In hemodialysis (HD) patients, the relationship between OPG and bone mineral density (BMD) is important, but remains unclear yet. The study objective was to assess the OPG role related to uremic osteoporosis in HD patients. METHODS: This cross-sectional study has been realized on a cohort of 63 chronic HD patients. INCLUSION CRITERIA: elderly prevalent HD patients with an age over 55 years old...
February 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28160140/optimizing-outpatient-pain-management-after-thyroid-and-parathyroid-surgery-a-two-institution-experience
#15
Irene Lou, Todd B Chennell, Sarah C Schaefer, Herbert Chen, Rebecca S Sippel, Courtney Balentine, David F Schneider, Jacob Moalem
BACKGROUND: Thyroidectomy and parathyroidectomy are the most commonly performed endocrine operations, and are increasingly being completed on a same-day basis; however, few data exist regarding the outpatient postoperative pain requirement of these patients. We aimed to describe the outpatient narcotic medication needs for patients undergoing thyroid and parathyroid surgery, and to identify predictors of higher requirement. METHOD: We examined patients undergoing thyroid and parathyroid surgery at two large academic institutions from 1 January-30 May 2014...
February 3, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28155099/inadvertent-parathyroidectomy-during-thyroid-surgery
#16
D M McGoldrick, M Majeed, A A Achakzai, H P Redmond
INTRODUCTION: Inadvertent parathyroidectomy is a recognised complication of thyroid surgery. We aimed to investigate the incidence of and risk factors for inadvertent parathyroidectomy during thyroid surgery, in our patient cohort. METHODS: A retrospective review of the records of all patients undergoing thyroid surgery in our institution between January 2012 and December 2014 was performed. Medical records, laboratory investigations and histopathology reports were evaluated...
February 2, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28145779/scan-directed-mini-incision-focused-parathyroidectomy-how-accurate-is-accurate-enough
#17
I M Shapey, S Jabbar, Z Khan, J E Nicholson, R J Watson
INTRODUCTION Mini-incision focused parathyroidectomy (MI-FP) is advocated as an alternative to bilateral neck exploration (BNE), owing to its reduced morbidity. The site and side of the affected gland is identified preoperatively using a combination of ultrasound and sestamibi scans. However, the acceptable degree of inter-scan concordance required to prompt MI-FP without compromising accuracy is undetermined. METHODS Accuracy of preoperative imaging was determined both individually and in combination for all parathyroidectomies (2007-2014)...
February 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28138716/-accidental-esophageal-resection-in-subtotal-parathyroidectomy
#18
H Dralle, K Kols, C Dotzenrath, W T Knoefel
No abstract text is available yet for this article.
February 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28133267/-multiple-endocrine-neoplasia-type-1-men1-presenting-with-hypoglycemic-attacks-a-case-report
#19
Yusuke Okubo, Takeshi Tono, Maki Fukamizu, Yasuhito Kawasaki, Koji Shinozaki, Takaaki Ishii, Tomohiro Katayama, Yumiko Yamauchi, Hideaki Fukamizu, Takashi Tominaga, Shuho Senba, Seiji Yasuda, Minoru Otsuru
A woman in her 60s visited our hospital because of frequent hypoglycemia and episodes of unconsciousness over the last 6 years. A 4 cm tumor was detected on the pancreatic tail using abdominal computed tomography and ultrasonography. An insulinoma was strongly suspected from the results of the fasting test and glucagon load test, and a distal pancreatectomy with splenectomy was performed. Pathological examination indicated an insulinoma and neuroendocrine tumor(NET)G2 based on the WHO 2010 classification. The patient's blood sugar and insulin levels returned to normal, and hypoglycemic attacks disappeared postoperatively...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131138/primary-hyperparathyroidism-effects-on-bone-health
#20
REVIEW
Kyle A Zanocco, Michael W Yeh
Primary hyperparathyroidism (PHPT) is the most common cause of chronic hypercalcemia. With the advent of routine calcium screening, the classic presentation of renal and osseous symptoms has been largely replaced with mild, asymptomatic disease. In hypercalcemia caused by PHPT, serum parathyroid hormone levels are either high, or inappropriately normal. A single-gland adenoma is responsible for 80% of PHPT cases. Less frequent causes include 4-gland hyperplasia and parathyroid carcinoma. Diminished bone mineral density and nephrolithiasis are the major current clinical sequelae...
March 2017: Endocrinology and Metabolism Clinics of North America
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