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Parathyroidectomy

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https://www.readbyqxmd.com/read/27904855/multiple-endocrine-neoplasia-type-1-with-anterior-mediastinal-parathyroid-adenoma-successful-localization-using-tc-99m-sestamibi-spect-ct
#1
Hye Lim Park, Ie Ryung Yoo, Sung Hoon Kim, Sohee Lee
The most common manifestation of multiple endocrine neoplasia type 1 (MEN1) is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland is challenging for treatment. A 51-year-old female, the eldest of 3 MEN1 sisters, had hyperparathyroidism with ectopic parathyroid adenoma in the mediastinal para-aortic region, which was detected by technetium-99m (Tc-99m) sestamibi scintigraphy and single-photon emission computed tomography/computed tomography (SPECT/CT)...
December 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27901181/evaluation-of-preoperative-ultrasonographic-and-biochemical-features-of-patients-with-aggressive-parathyroid-disease-is-there-a-reliable-predictive-marker
#2
Bekir Cakir, Sefika Burcak Polat, Mehmet Kilic, Didem Ozdemir, Cevdet Aydin, Nuran Süngü, Reyhan Ersoy
Objective: Parathyroid cancer (PC) represents < 1% of cases of PHPT. Tumors demonstrating atypical histopathologic features and don't fulfill criteria for carcinoma are classified as atypical adenomas (APA). The purpose of this study was to determine a biochemical or ultrasonographic feature that can predict aggressive disease requiring more extensive surgery and closer follow-up. Subjects and methods: Twenty eight patients operated for PHPT and diagnosed with atypical adenoma (23 patients) or carcinoma (5 patients) were enrolled in this study...
November 24, 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27900978/penile-calcific-uremic-arteriolopathy-occurring-postparathyroidectomy-in-a-hemodialysis-patient
#3
Salah Omar Bashir, Mahmoud A Aamer, Hayder A Omer, Mohamed D Morsy
Calcific uremic arteriolopathy (CUA), also known as calciphylaxis, is a rare condition most frequently seen in patients with advanced chronic kidney disease. The clinical picture is characterized by painful skin lesions and ulcerations. The underlying pathology is medial calcification and intimal proliferation with microthrombi of small arteries. CUA is commonly associated with secondary hyperparathyroidism and high serum calcium and phosphate products. This article reports an atypical case where CUA developed after parathyroidectomy and in the course of treatment of hungry bone syndrome...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27899108/geographic-variation-of-parathyroidectomy-in-patients-receiving-hemodialysis-a-retrospective-cohort-analysis
#4
James B Wetmore, Jiannong Liu, Paul J Dluzniewski, Areef Ishani, Geoffrey A Block, Allan J Collins
BACKGROUND: Secondary hyperparathyroidism (SHPT) is associated with adverse outcomes in patients receiving maintenance dialysis. Parathyroidectomy is a treatment for SHPT; whether parathyroidectomy utilization varies geographically in the US is unknown. METHODS: A retrospective cohort analysis was undertaken to identify all patients aged 18 years or older who were receiving in-center hemodialysis between 2007 and 2009, were covered by Medicare Parts A and B, and had been receiving hemodialysis for at least 1 year...
November 29, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27867880/effect-of-curative-parathyroidectomy-on-insulin-resistance
#5
Rachel Putnam, Deba Prasad Dhibar, Shweta Varshney, Arunanshu Behera, B R Mittal, Anil Bhansali, Sudhaker D Rao, Sanjay Kumar Bhadada
BACKGROUND: Primary hyperparathyroidism (PHPT) is characterized by inappropriately elevated serum parathyroid hormone (PTH) level despite elevated serum calcium. Insulin resistant is the basic pathophysiology, behind the higher prevalence of diabetes mellitus in patients with PHPT. However, the improvement in insulin resistance (IR) after curative parathyroidectomy (CPTX) has not been established yet, as the study results are conflicting. MATERIALS AND METHODS: In this prospective interventional study, ten patients with mild PHPT (Group 1) and another ten patients with moderate to severe PHPT (Group 2) were undergone CPTX...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27866715/normohormonal-primary-hyperparathyroidism-is-a-distinct%C3%A2-form-of-primary-hyperparathyroidism
#6
Megan K Applewhite, Michael G White, Jennifer Tseng, Maryam K Mohammed, Frederic Mercier, Edwin L Kaplan, Peter Angelos, Tamara Vokes, Raymon H Grogan
BACKGROUND: Normohormonal primary hyperparathyroidism presents diagnostic and intraoperative challenges, and current literature is conflicting about management. We aim to better define normohormonal primary hyperparathyroidism in order to improve the care for these patients. METHODS: In the study, 516 consecutive patients undergoing parathyroidectomy for primary hyperparathyroidism were divided into 2 groups: classic primary hyperparathyroidism (classic primary hyperparathyroidism, increased serum levels of calcium, and parathyroid hormone) and normohormonal primary hyperparathyroidism (hypercalcemia, normal serum levels of parathyroid hormone)...
November 17, 2016: Surgery
https://www.readbyqxmd.com/read/27865597/expert-consensus-of-general-surgery-residents-proficiency-with-common-endocrine-operations
#7
Roy Phitayakorn, Rachel R Kelz, Emil Petrusa, Rebecca S Sippel, Cord Sturgeon, Kepal N Patel, Nancy D Perrier
BACKGROUND: Proficiency with common endocrine operations is expected of graduating, general surgery residents. However, no expert consensus guidelines exist about these expectations. METHODS: Members of the American Association of Endocrine Surgeons were surveyed about their opinions on resident proficiency with common endocrine operations. RESULTS: Overall response rate was 38%. A total of 92% of the respondents operate with residents. On average, they believed that the steps of a total thyroidectomy for benign disease and a well-localized parathyroidectomy could be performed by a postgraduate year 4 surgery resident...
November 16, 2016: Surgery
https://www.readbyqxmd.com/read/27865592/parathyroidectomy-for-primary-hyperparathyroidism-improves-sleep-quality-a-prospective-study
#8
Justin La, Tracy S Wang, Abdulrahman Y Hammad, Laura Burgardt, Kara Doffek, Azadeh A Carr, Joseph L Shaker, Ty B Carroll, Douglas B Evans, Tina W F Yen
BACKGROUND: This prospective survey study assessed changes in sleep quality in patients with primary hyperparathyroidism after parathyroidectomy. METHODS: Patients undergoing parathyroidectomy for primary hyperparathyroidism (n = 110) or thyroidectomy for benign euthyroid disease (control group; n = 45) were recruited between June 2013 and June 2015 and completed the Pittsburgh Sleep Quality Index preoperatively and at 1- and 6 months postoperatively. "Poor" sleep quality was defined as a score >5; a clinically important and relevant improvement was a ≥3-point decrease...
November 16, 2016: Surgery
https://www.readbyqxmd.com/read/27864717/intraoperative-localization-of-the-parathyroid-glands-with-indocyanine-green-and-firefly-r-technology-during-baba-robotic-thyroidectomy
#9
Hyeong Won Yu, Joon Woo Chung, Jin Wook Yi, Ra-Yeong Song, Joon-Hyop Lee, Hyungju Kwon, Su-Jin Kim, Young Jun Chai, June Young Choi, Kyu Eun Lee
BACKGROUND: It is unclear whether near-infrared (NIR) light-induced indocyanine green (ICG) fluorescence can effectively identify, and thus permit the preservation of, parathyroid glands in bilateral axillo-breast approach (BABA) robotic thyroidectomy. This case-control study with a prospectively recruited consecutive series and a retrospectively selected control group assessed the usefulness of ICG with Firefly(R) technology to identify the parathyroid glands intraoperatively during BABA robotic thyroidectomy...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27863787/characterizing-the-operative-findings-and-utility-of-intraoperative-parathyroid-hormone-iopth-monitoring-in-patients-with-normal-baseline-iopth-and-normohormonal-primary-hyperparathyroidism
#10
Gina Trinh, Salem I Noureldine, Jonathon O Russell, Nishant Agrawal, Michael Lopez, Jason D Prescott, Martha A Zeiger, Ralph P Tufano
BACKGROUND: During parathyroidectomy with intraoperative parathyroid hormone monitoring, the successful removal of a hypersecreting gland(s) resulting in normocalcemia is indicated by a >50% decrease in intraoperative parathyroid hormone level, typically into the normal range. Some patients, however, will have baseline parathyroid hormone levels within the normal range. We sought to determine the utility of intraoperative parathyroid hormone testing in these patients. METHODS: We retrospectively studied all patients who underwent parathyroidectomy for primary hyperparathyroidism at our institution over a 10-year period...
November 15, 2016: Surgery
https://www.readbyqxmd.com/read/27863779/how-long-should-we-follow-patients-after-apparently-curative-parathyroidectomy
#11
Irene Lou, Courtney Balentine, Samuel Clarkson, David F Schneider, Rebecca S Sippel, Herbert Chen
BACKGROUND: Little is known about the long-term recurrence risk for primary hyperparathyroidism after immediately "curative" parathyroidectomy. This study aimed to evaluate the risk of recurrent hyperparathyroidism in the 10 years after operation. METHOD: We retrospectively identified patients with sporadic primary hyperparathyroidism undergoing initial parathyroidectomy between November 1, 2000 and June 30, 2005. Recurrence was defined as serum calcium >10...
November 15, 2016: Surgery
https://www.readbyqxmd.com/read/27863777/concentration-of-serum-calcium-is-not-correlated-with-symptoms-or-severity-of-primary-hyperparathyroidism-an-examination-of-20-081-consecutive-adults
#12
Deva Boone, Douglas Politz, Jose Lopez, Jamie Mitchell, Kevin Parrack, James Norman
BACKGROUND: Guidelines for operative treatment of primary hyperparathyroidism include calcium levels >1 mg/dL above normal. We sought to determine whether greater calcium concentrations were associated with increased symptoms or disease severity. METHODS: A retrospective review of a prospectively maintained database of adults undergoing parathyroidectomy for primary hyperparathyroidism, grouped according to greatest preoperative calcium level: those patients with calcium concentrations between 10...
November 15, 2016: Surgery
https://www.readbyqxmd.com/read/27863776/parathyroidectomy-prior-to-kidney-transplant-decreases-graft-failure
#13
Glenda G Callender, Jennifer Malinowski, Mahsa Javid, Yawei Zhang, Huang Huang, Courtney E Quinn, Tobias Carling, Ricarda Tomlin, J Douglas Smith, Sanjay Kulkarni
BACKGROUND: Uncorrected uremic hyperparathyroidism is associated with delayed graft function after kidney transplantation. The current guidelines of the Kidney Disease Improving Global Outcomes recommend maintaining parathyroid hormone ≤9x normal in patients pre-kidney transplantation. This study explores the effect of increased levels of serum parathyroid hormone and preoperative parathyroidectomy on outcomes after kidney transplantation. METHODS: A retrospective review was performed of adult patients who underwent kidney transplantation between January 1, 2005, and December 31, 2014, at a single institution...
November 15, 2016: Surgery
https://www.readbyqxmd.com/read/27863650/perioperative-considerations-and-complications-in-pediatric-parathyroidectomy
#14
Curtis Hanba, Michael Bobian, Peter F Svider, Anthony Sheyn, Bianca Siegel, Ho-Sheng Lin, S Naweed Raza
OBJECTIVES/HYPOTHESIS: To evaluate perioperative considerations and post-operative complications associated with parathyroidectomy in the pediatric population. METHODS: The Kids' Inpatient Database 21 (KID) was searched for patients who underwent parathyroidectomy in 2009 and 2012. Patient demographics, hospital stay, associated charges, and post-operative adverse sequelae were evaluated in all patients and included patient comorbidity and additional procedure requirement analysis...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27851636/2002-serotonin-syndrome-following-intraoperative-methylene-blue-administration-during-parathyroidectomy
#15
Afshan Hussain, Gregory Huang, Elisha Chance
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847113/differences-in-single-gland-and-multigland-disease-are-seen-in-low-biochemical-profile-primary-hyperparathyroidism
#16
James Y Lim, Max C Herman, Lev Bubis, Irene Epelboym, John D Allendorf, John A Chabot, James A Lee, Jennifer H Kuo
BACKGROUND: Primary hyperparathyroidism is characterized by increased levels of serum calcium and parathyroid hormone. Recently, 2 additional mild biochemical profiles have emerged, normocalcemic and normohormonal primary hyperparathyroidism. We reviewed our surgical experience of mild biochemical profile patients and compared them with classic primary hyperparathyroidism patients. METHODS: This is a single institution, retrospective cohort review of all patients who underwent parathyroidectomy for primary hyperparathyroidism from 2006-2012...
November 12, 2016: Surgery
https://www.readbyqxmd.com/read/27844209/the-impact-of-parathyroidectomy-on-serum-adamts1-adamts4-levels-insulin-resistance-and-subclinical-cardiovascular-disease-in-primary-hyperparathyroidism
#17
Melia Karakose, Mustafa Caliskan, Muyesser Sayki Arslan, Taner Demirci, Suleyman Karakose, Erman Cakal
PURPOSE: Primary hyperparathyroidism has been associated with increased incidence of morbidity and mortality of the cardiovascular system. The etiopathogenetic mechanisms underlying this association are still not completely clear. Accumulating evidence suggested that a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS) has a role in the development of inflammation and atherosclerosis. In this study, we aimed to determine whether there is a change in serum levels of ADAMTS1, ADAMTS4, carotid intima-media thickness, and cardiovascular risk score after the surgery and also whether there is a relationship between ADAMTS levels and cardiovascular risk score in hypercalcemic primary hyperparathyroidism patients...
November 14, 2016: Endocrine
https://www.readbyqxmd.com/read/27842919/operative-intervention-for-primary-hyperparathyroidism-offers-greater-bone-recovery-in-patients-with-sporadic-disease-than-in-those-with-multiple-endocrine-neoplasia-type-1-related-hyperparathyroidism
#18
Angelica M Silva, Danica Vodopivec, Ioannis Christakis, Genevieve Lyons, Qiu Wei, Steven G Waguespack, Steven M Petak, Elizabeth Grubbs, Jeffrey E Lee, Nancy Perrier
BACKGROUND: We investigated whether the outcome of bone disease of primary hyperparathyroidism differs in multiple endocrine neoplasia type 1-associated disease and sporadic hyperparathyroidism at 1-year postoperatively. METHODS: Multiple endocrine neoplasia type 1/hyperparathyroidism and sporadic hyperparathyroidism patients who underwent parathyroidectomy from 1990 to 2013 and dual-energy x-ray absorptiometry at baseline and 1-year postoperatively were included...
November 11, 2016: Surgery
https://www.readbyqxmd.com/read/27842909/influence-of-a-negative-sestamibi-scan-on-the-decision-for-parathyroid-operation-by-the-endocrinologist-and-surgeon
#19
Susana Wu, Stephanie H Hwang, Philip I Haigh
BACKGROUND: It has been observed that negative sestamibi scans may impact practice patterns in patients with primary hyperparathyroidism. However, there are no published data on the issue. The objective was to elucidate the influence of negative sestamibi scans on referrals by endocrinologists for parathyroidectomy and surgeon decision-making. METHODS: All patients with primary hyperparathyroidism were identified within a region-wide health care system over a 2-year period...
November 11, 2016: Surgery
https://www.readbyqxmd.com/read/27837463/parathyroidectomy-for-primary-hyperparathyroidism-in-the-elderly-experience-of-a-single-endocrine-surgery-center
#20
Pietro Giorgio Calò, Fabio Medas, Giulia Loi, Giuseppe Pisano, Salvatore Sorrenti, Enrico Erdas, Angelo Nicolosi
BACKGROUND: Primary hyperparathyroidism is a common endocrine disease, and its incidence increases with age. AIMS: Our aim was to retrospectively evaluate the impact of age on patient outcomes following parathyroidectomy for primary hyperparathyroidism. METHODS: Two-hundred fifty-six consecutive patients undergoing parathyroidectomy with preoperative diagnosis of primary hyperparathyroidism were divided into three groups according to patient age: group A, ≤64 years; group B, 65-74 years; and group C, ≥75 years...
November 11, 2016: Aging Clinical and Experimental Research
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