Alireza A Shamshirsaz, Samadh F Ravangard, Garry Turner, Adam Borgida, Mary Beth Janicki, Winston A Campbell, Carolyn Zelop, Amirhoushang A Shamshirsaz, Melissa Spiel, Anne Marie Prabulos, Deborah Feldman, John Rodis, Charles J Ingardia, Padmalatha Gurram, Kisti Fuller, Yu M Fang, Peter Benn, James F X Egan
OBJECTIVES: The purpose of this study was to evaluate the efficacy of the genetic sonogram in Down syndrome screening for women who have received the stepwise sequential test. METHODS: This retrospective cohort study included women with singleton pregnancies who underwent stepwise sequential (first-trimester combined and second-trimester serum) screening and then had a genetic sonogram between March 2005 and January 2010. Stepwise sequential Down syndrome risks were multiplied by either a positive or negative likelihood ratio based on the second-trimester sonographic findings to determine the final Down syndrome risk...
September 2013: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine