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https://www.readbyqxmd.com/read/28319006/high-rates-of-severe-hypoglycemia-among-african-american-patients-with-diabetes-the-surveillance-prevention-and-management-of-diabetes-mellitus-supreme-dm-network
#1
Andrew J Karter, Kasia J Lipska, Patrick J O'Connor, Jennifer Y Liu, Howard H Moffet, Emily B Schroeder, Jean M Lawrence, Gregory A Nichols, Katherine M Newton, Ram D Pathak, Jay Desai, Beth Waitzfelder, Melissa G Butler, Abraham Thomas, John F Steiner
AIMS: Seven-year surveillance study (2005-2011) to evaluate race/ethnic differences in the trends in rates of severe hypoglycemia (SH) in a population of insured, at-risk adults with diabetes. METHODS: SH events were identified via any primary or principal diagnosis from emergency department or inpatient encounters among African American, Asian, Latino and White adult diabetes patients treated with insulin or secretagogues (Sulfonylureas or Meglitinides), receiving care from integrated healthcare delivery systems across the United States...
February 21, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28317624/cap-assisted-colonoscopy-increases-detection-of-advanced-adenomas-and-polyps
#2
Mohamed O Othman, Daniel Zhang, Sherif Elhanafi, Mohamed Eloliby, Brian Davis, Richard Guererro, Luis Alvarado, Linda Sanchez, Alok Dwivedi, Marc J Zuckerman
BACKGROUND: Cap-assisted colonoscopy (CAC) has been reported to increase the adenoma detection rate (ADR) in Asian population. However, CAC trials in non-Asian population have had conflicting results. Studies in North America have shown an improvement in ADRs with the use of CAC, but it mainly included white and African American patients. Given the lack of prospective studies of CAC in Hispanics, we conducted this randomized controlled trial. MATERIALS AND METHODS: This is a randomized controlled trial comparing CAC with standard colonoscopy (SC) in patients undergoing screening or surveillance colonoscopy...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28317286/trend-analysis-and-survival-of-primary-gallbladder-cancer-in-the-united-states-a-1973-2009-population-based-study
#3
Rubayat Rahman, Eduardo J Simoes, Chester Schmaltz, Christian S Jackson, Jamal A Ibdah
Primary gallbladder cancer is an aggressive and uncommon cancer with poor outcomes. Our study examines epidemiology, trend, and survival of gallbladder cancer in the United States from 1973 to 2009. We utilized the Surveillance Epidemiology and End Results database (SEER). Frequency and rate analyses on demographics, stage, and survival were compared among non-Hispanic whites, Hispanics, African American, and Asian/Pacific Islanders. A total of 18,124 cases were reported in SEER from 1973 to 2009 comprising 1...
March 20, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28316911/electronic-media-time-and-sedentary-behaviors-in-children-findings-from-the-built-environment-and-active-play-study-in-the-washington-dc-area
#4
Jennifer D Roberts, Lindsey Rodkey, Rashawn Ray, Brandon Knight, Brian E Saelens
An objective of the Built Environment and Active Play (BEAP) Study was to examine whether home built environment, bedroom electronic presence, parental rules and demographics predicted children's sedentary behavior (SB). In 2014, BEAP Study questionnaires were mailed to 2000 parents of children (7-12 years) within the Washington DC area. SB-Duration (hours/day) and SB-Frequency (days/week) were assessed by two questions with multiple subparts relating to SB activity type (e.g. car riding) and SB companionship (e...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28315188/social-goals-impact-adolescent-substance-use-through-influencing-adolescents-connectedness-to-their-schools
#5
Samuel N Meisel, Craig R Colder
Although developmental models of risk behavior highlight the role of school connectedness in the etiology of adolescent substance use, no studies to our knowledge have assessed longitudinal mediational models examining how adolescents form bonds to their school, and how the quality of those bonds relate to substance use. To address this gap, the current study used four waves of data, spanning ages 11-16 (grades 5-11), to examine the association between individual differences in agentic (Dominance/Power) and communal (Nurturance/Affiliation) social goals and school connectedness, and in turn, whether levels of school connectedness are associated with substance use...
March 17, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28302596/estimating-accuracy-at-exercise-intensities-a-comparative-study-of-self-monitoring-heart-rate-and-physical-activity-wearable-devices
#6
Erin E Dooley, Natalie M Golaszewski, John B Bartholomew
BACKGROUND: Physical activity tracking wearable devices have emerged as an increasingly popular method for consumers to assess their daily activity and calories expended. However, whether these wearable devices are valid at different levels of exercise intensity is unknown. OBJECTIVE: The objective of this study was to examine heart rate (HR) and energy expenditure (EE) validity of 3 popular wrist-worn activity monitors at different exercise intensities. METHODS: A total of 62 participants (females: 58%, 36/62; nonwhite: 47% [13/62 Hispanic, 8/62 Asian, 7/62 black/ African American, 1/62 other]) wore the Apple Watch, Fitbit Charge HR, and Garmin Forerunner 225...
March 16, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28300324/risk-of-stress-fracture-varies-by-race-ethnic-origin-in-a-cohort-study-of-1-3-million-u-s-army-soldiers
#7
Lakmini Bulathsinhala, Julie M Hughes, Craig J McKinnon, Joseph R Kardouni, Katelyn I Guerriere, Kristin L Popp, Ronald W Matheny, Mary L Bouxsein
Stress fractures (SF) are common and costly injuries in military personnel. Risk for SF has been shown to vary with race/ethnicity. Previous studies report increased SF risk in White and Hispanic Soldiers compared to Black soldiers. However, these studies did not account for the large ethnic diversity in the U.S. Military. PURPOSE: We aimed to identify differences in SF risk among racial/ethnic groups within the U.S. Army. METHODS: A retrospective cohort study was conducted using data from the Total Army Injury and Health Outcomes Database from 2001 until 2011...
March 16, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28300201/identification-of-a-novel-locus-associated-with-skin-colour-in-african-admixed-populations
#8
Natalia Hernandez-Pacheco, Carlos Flores, Santos Alonso, Celeste Eng, Angel C Y Mak, Scott Hunstman, Donglei Hu, Marquitta J White, Sam S Oh, Kelley Meade, Harold J Farber, Pedro C Avila, Denise Serebrisky, Shannon M Thyne, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Saunak Sen, Rajesh Kumar, Michael Lenoir, Jose R Rodriguez-Santana, Esteban G Burchard, Maria Pino-Yanes
Skin pigmentation is a complex trait that varies largely among populations. Most genome-wide association studies of this trait have been performed in Europeans and Asians. We aimed to uncover genes influencing skin colour in African-admixed individuals. We performed a genome-wide association study of melanin levels in 285 Hispanic/Latino individuals from Puerto Rico, analyzing 14 million genetic variants. A total of 82 variants with p-value ≤1 × 10(-5) were followed up in 373 African Americans. Fourteen single nucleotide polymorphisms were replicated, of which nine were associated with skin colour at genome-wide significance in a meta-analysis across the two studies...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299888/the-relationship-of-race-oncotype-dx-and-ki67-in-a-population-highly-screened-for-breast-cancer
#9
Amber A Guth, Jennifer Chun Kim, Shira Schwartz, Jennifer Montes, Rebecca Akiko Snyder, Deborah Axelrod, Freya Schnabel
Oncotype DX recurrence score (ODX) can predict risk of invasive breast cancer recurrence and benefit of chemotherapy. Literature is limited on the relationship of ODX and race in women with hormone receptor positive and node negative/positive disease. Our study examines the relationship between race and clinical characteristics within a population of highly screened women with newly diagnosed breast cancer. The institutional Breast Cancer Database was queried for patients with newly diagnosed breast cancer between January2010 and March2015...
March 2017: Breast Journal
https://www.readbyqxmd.com/read/28299887/fibroepithelial-lesions-in-the-breast-of-adolescent-females-a-clinicopathological-study-of-54-cases
#10
Dara S Ross, Dilip D Giri, Muzaffar M Akram, Jeffrey P Catalano, Cristina Olcese, Kimberly J Van Zee, Edi Brogi
Fibroepithelial lesions (FELs) are the most frequent breast tumors in adolescent females. The pubertal hormonal surge could impact the growth and microscopic appearance of FELs in this age group. In this study, we evaluate the morphology and clinical behavior of FELs in adolescents. We searched the 1992-2012 pathology data base for FELs in females 18 years old or younger (F ≤18 years). Seven FELs from 1975 to 1983 were also included. Three pathologists reviewed all available material. Patient (pt) characteristics and follow-up information were obtained from electronic medical records...
March 2017: Breast Journal
https://www.readbyqxmd.com/read/28296344/genome-wide-analysis-identifies-an-african-specific-variant-in-sema4d-associated-with-body-mass-index
#11
Guanjie Chen, Ayo P Doumatey, Jie Zhou, Lin Lei, Amy R Bentley, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng, Albert Amoah, Clement Adebamowo, Joseph Acheampong, Thomas Johnson, Johnnie Oli, Daniel Shriner, Adebowale A Adeyemo, Charles N Rotimi
OBJECTIVE: The prevalence of obesity varies between ethnic groups. No genome-wide association study (GWAS) for body mass index (BMI) has been conducted in continental Africans. METHODS: We performed a GWAS for BMI in 1,570 West Africans (WA). Replication was conducted in independent samples of WA (n = 1,411) and African Americans (AA) (n = 9,020). RESULTS: We identified a novel genome-wide significant African-specific locus for BMI (SEMA4D, rs80068415; minor allele frequency = 0...
March 13, 2017: Obesity
https://www.readbyqxmd.com/read/28295514/intragenic-copy-number-variation-in-the-filaggrin-gene-in-ethiopian-patients-with-atopic-dermatitis
#12
Kerstin Fernandez, Samina Asad, Fulya Taylan, Carl-Fredrik Wahlgren, Kassahun D Bilcha, Magnus Nordenskjöld, Mårten C G Winge, Maria Bradley
Genetic variants in filaggrin (FLG) involving truncating mutations or intragenic copy number variation are strongly associated with the risk of developing atopic dermatitis (AD) in European and Asian populations. Few loss-of-function mutations have been identified in Africans, although an association between FLG copy number variation and AD severity in a small African American cohort has been proposed. We studied the association between FLG copy number and AD in 132 Ethiopians and found no association between AD severity and FLG copy number, suggesting that other, still unidentified genetic factors are of more importance in predisposing Ethiopians to AD...
March 10, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28295283/novel-colon-cancer-susceptibility-variants-identified-from-a-genome-wide-association-study-in-african-americans
#13
Hansong Wang, Stephanie L Schmit, Christopher A Haiman, Temitope O Keku, Ikuko Kato, Julie R Palmer, David van den Berg, Lynne R Wilkens, Terrilea Burnett, David V Conti, Fredrick R Schumacher, Lisa B Signorello, William J Blot, Krista A Zanetti, Curtis Harris, Mala Pande, Sonja I Berndt, Polly A Newcomb, Dee W West, Robert Haile, Daniel O Stram, Jane C Figueiredo, Loïc Le Marchand
Genome-wide association studies (GWAS) in ethnic/racial minority populations can help to fine-map previously identified risk regions or discover new risk loci because of the genetic diversity in these populations. We conducted a GWAS of colorectal cancer (CRC) in 6,597 African Americans (1,894 cases and 4,703 controls) (Stage 1) and followed up the most promising markers in a replication set of 2,041 participants of African descent (891 cases and 1,150 controls) (Stage 2). We identified a novel variant, rs56848936 in the gene SYMPK at 19q13...
March 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28295138/frequency-and-risk-factors-for-live-discharge-from-hospice
#14
David Russell, Eli L Diamond, Bonnie Lauder, Ritchell R Dignam, Dawn W Dowding, Timothy R Peng, Holly G Prigerson, Kathryn H Bowles
OBJECTIVES: To report frequencies and associated risk factors for 4 distinct causes of live discharge from hospice. DESIGN: Retrospective cohort study using electronic medical records of hospice patients who received care from a large urban not-for-profit hospice agency in New York City during a 3-year period between 2013 and 2015 (n = 9,190). RESULTS: Roughly one in five hospice patients were discharged alive (21%; n = 1911). Acute hospitalization was the most frequent reason for live discharge (42% of all live discharges; n = 802)...
March 13, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28294452/phylogenetic-relationships-and-divergence-dates-of-softshell-turtles-testudines-trionychidae-inferred-from-complete-mitochondrial-genomes
#15
Haifeng Li, Juanjuan Liu, Lei Xiong, Huanhuan Zhang, Huaxing Zhou, Huazong Yin, Wanxing Jing, Jun Li, Qiong Shi, Yuqin Wang, Jianjun Liu, Liuwang Nie
The softshell turtles (Trionychidae) are one of the most widely distributed reptile groups in the world, and fossils have been found on all continents except Antarctica. The phylogenetic relationships among members of this group have been previously studied; however, there are disagreements regarding its taxonomy, its phylogeography and divergence times are still poorly understood as well. Here we present a comprehensive mitogenomic study of softshell turtles. We sequenced the complete mitochondrial genomes of 10 softshell turtles, in addition to the GenBank sequence of Dogania subplana, Lissemys punctata, Trionyx triunguis, which cover all extant genera within Trionychidae except for Cyclanorbis and Cycloderma...
March 15, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28294365/prevalence-of-prenatal-alcohol-exposure-in-the-state-of-texas-as-assessed-by-phosphatidylethanol-in-newborn-dried-blood-spot-specimens
#16
Ludmila N Bakhireva, Janet Sharkis, Shikhar Shrestha, Tristan J Miranda-Sohrabji, Sonnie Williams, Rajesh C Miranda
BACKGROUND: While 2-5% of school-aged children in the U.S. are estimated to be affected by Fetal Alcohol Spectrum Disorders (FASD), the prevalence of prenatal alcohol exposure (PAE) might be substantially under-reported. Our objective was to systematically estimate the prevalence of PAE in Texas by measuring a direct ethanol metabolite, phosphatidylethanol (PEth), in 1,000 infant residual dried blood spots (irDBS) in the Texas Newborn Screening Repository. METHODS: All Public Health Regions were represented proportional to their 2014 birth rate (~0...
March 13, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28293491/disparities-in-utilization-of-jaw-surgery-for-treatment-of-sleep-apnea-a-nationwide-analysis
#17
Ravi K Garg, Ying Shan, Jeffrey A Havlena, Ahmed M Afifi
BACKGROUND: Maxillomandibular advancement has been shown to be one of the most effective operations for management of severe obstructive sleep apnea, yet pharyngeal surgery is more commonly performed. The goal of this study was to identify socioeconomic factors associated with this phenomenon. METHODS: Patients aged 14 or older with a primary hospital diagnosis of sleep apnea were identified using the National Inpatient Sample from 2005 to 2012. ICD9 codes were used to determine whether a pharyngeal or jaw procedure was performed...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28291093/racial-and-ethnic-variation-in-pediatric-cardiac-extracorporeal-life-support-survival
#18
Titus Chan, Jane Di Gennaro, Reid W D Farris, Monique Radman, David Michael McMullan
OBJECTIVES: Previous studies have suggested an association between nonwhite race and poor outcomes in small subsets of cardiac surgery patients who require extracorporeal life support. This study aims to examine the association of race/ethnicity with mortality in pediatric patients who receive extracorporeal life support for cardiac support. DESIGN: Retrospective analysis of registry data. SETTING: Prospectively collected multi-institutional registry data...
April 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28282529/evidence-of-socio-economic-stress-and-female-foeticide-in-racial-disparities-in-the-gender-ratio-at-birth-in-the-united-states-1995-2014
#19
Victor Grech
BACKGROUND: Males are born in excess of females, expressed as M/T (male/total births), which is expected to approximate 0.515. Racial M/T disparities have been long known. This study was carried out in order to identify such disparities in different races in the United States. DESIGN: Monthly male and female live births by race for the entire US were obtained from the website of the Centers for Disease Control and Prevention for 1995-2014 for the four racial groups: American Indian or Alaska Native, Asian or Pacific Islander, Black or African American and White...
March 1, 2017: Early Human Development
https://www.readbyqxmd.com/read/28278601/age-4-predictors-of-oppositional-defiant-disorder-in-early-grammar-school
#20
John V Lavigne, Fred B Bryant, Joyce Hopkins, Karen R Gouze
Our ability to predict which children will exhibit oppositional defiant disorder (ODD) at the time of entry into grammar school at age 6 lags behind our understanding of the risk factors for ODD. This study examined how well a set of multidomain risk factors for ODD assessed in 4-year-old children predicted age 6 ODD diagnostic status. Participants were a diverse sample of 796 4-year-old children (391 boys).The sample was 54% White, non-Hispanic; 16.8% African American, 20.4% Hispanic; 2.4% Asian; and 4.4% Other or mixed race...
February 26, 2017: Journal of Clinical Child and Adolescent Psychology
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