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https://www.readbyqxmd.com/read/28737649/race-age-and-geography-impact-hepatitis-c-genotype-distribution-in-the-united-states
#1
Stuart C Gordon, Sheri Trudeau, Jia Li, Yueren Zhou, Loralee B Rupp, Scott D Holmberg, Anne C Moorman, Philip R Spradling, Eyasu Teshale, Joseph A Boscarino, Yihe G Daida, Mark A Schmidt, Mei Lu
GOALS: To determine the impact of geography and patient characteristics on hepatitis C virus (HCV) genotype and subtype distribution in a large sample of patients under routine clinical care BACKGROUND:: HCV genotype impacts disease course and response to treatment. Although several studies have reported genotype distribution within specific US populations, there are no comprehensive descriptions in large, geographically diverse cohorts. STUDY: Using data from the Chronic Hepatitis Cohort Study, we present the distribution of HCV genotypes (GT) and subtypes (ST) among a racially diverse cohort of over 8000 HCV-infected patients from four large US health systems...
July 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28730704/the-athena-hpv-study-underrepresents-other-high-risk-hpv-genotypes-when-compared-with-a-diverse-new-york-city-population
#2
G Ramos Rivera, S N Khader, S Lajara, K Schlesinger, D Y Goldstein, R C Naeem, M J Suhrland, A S Fox
OBJECTIVE: Persistent infection with oncogenic high risk HPV (hrHPV) types causes virtually all cases of cervical cancer. HPV 16 and 18 have been targeted for individual genotyping and vaccination because of their presence in 71% of invasive cervical cancers worldwide. Montefiore Medical Center, Bronx, New York serves a population known for ethnic and racial diversity. Given this diversity it is possible that HPV genotypes not individually detected by current testing are causing significant disease...
July 21, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28728635/gene-by-environment-interactions-on-alcohol-use-among-asian-american-college-freshmen
#3
Jeremy W Luk, Tiebing Liang, Tamara L Wall
OBJECTIVE: Among northeast Asians, the variant aldehyde dehydrogenase allele, ALDH2*2 (rs671, A/G, minor/major), has been inversely associated with alcohol dependence. The strength of the associations between ALDH2*2 and drinking behaviors depends on the developmental stage, the phenotype studied, and other moderating variables. This study examined ALDH2 gene status as a moderator of the associations between parental drinking, peer drinking, and acculturation with alcohol use among 222 Chinese American and Korean American college freshmen...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28728634/prospective-effects-of-parenting-on-substance-use-and-problems-across-asian-pacific-islander-and-european-american-youth-tests-of-moderated-mediation
#4
Jeremy W Luk, Kevin M King, Carolyn A McCarty, Elizabeth McCauley, Ann Vander Stoep
OBJECTIVE: Parental warmth and knowledge are protective factors against substance use, whereas parental psychological control is a risk factor. However, the interpretation of parenting and its effects on developmental outcomes may vary cross-culturally. This study examined direct and indirect effects of three parenting dimensions on substance use across Asian/Pacific Islander (API) and European Americans. METHOD: A community sample of 97 API and 255 European Americans were followed from Grades 6 to 12...
July 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28723761/efficacy-of-the-prophylactic-use-of-octreotide-for-the-prevention-of-complications-after-pancreatic-resection-an-updated-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
Chunli Wang, Xin Zhao, Shengyi You
BACKGROUND: The use of octreotide prophylaxis in the prevention of complications after pancreatic resection remains controversial. The aim of this systematic review and meta-analysis was to evaluate the efficacy of octreotide prophylactic treatment to prevent complications after pancreatic resection. METHODS: Five databases (PubMed, Medline, SinoMed, Embase, and Cochrane Library) were searched for eligible studies from 1980 to November 2016 with the limitation of human subjects and randomized controlled trials (RCTs)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722672/ethnic-heterogeneity-and-prostate-cancer-mortality-in-hispanic-latino-men-a-population-based-study
#6
Felix M Chinea, Vivek N Patel, Deukwoo Kwon, Narottam Lamichhane, Chris Lopez, Sanoj Punnen, Erin N Kobetz, Matthew C Abramowitz, Alan Pollack
BACKGROUND: Few studies focus on prostate cancer (PCa) outcomes in Hispanic/Latino men. Our study explores whether Hispanic/Latino subgroups demonstrate significantly different prostate cancer-specific mortality (PCSM) relative to Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) men. METHODS: We extracted a population-based cohort of men diagnosed with local-regional PCa from 2000-2013 (n= 486,865). PCSM was measured in racial/ethnic groups: NHW (n=352,886), NHB (n= 70,983), Hispanic/Latino (n= 40,462), and Asian American/Pacific Islander (n= 22,534)...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28720073/heterogeneity-in-national-u-s-mortality-trends-within-heart-disease-subgroups-2000-2015
#7
Stephen Sidney, Charles P Quesenberry, Marc G Jaffe, Michael Sorel, Alan S Go, Jamal S Rana
BACKGROUND: The long-term downward national U.S. trend in heart disease-related mortality slowed substantially during 2011-2014 before turning upward in 2015. Examining mortality trends in the major subgroups of heart disease may provide insight into potentially more targeted and effective prevention and treatment approaches to promote favorable trajectories. We examined national trends between 2000 and 2015 in mortality attributed to major heart disease subgroups including ischemic heart disease, heart failure, and all other types of heart disease...
July 18, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28718431/racial-differences-in-cancer-susceptibility-and-survival-more-than-the-color-of-the-skin
#8
REVIEW
Berna C Özdemir, Gian-Paolo Dotto
Epidemiological studies point to race as a determining factor in cancer susceptibility. In US registries recording cancer incidence and survival by race (distinguishing 'black versus white'), individuals of African ancestry have a globally increased risk of malignancies compared with Caucasians and Asian Americans. Differences in socioeconomic status and health-care access play a key role. However, the lesser disease susceptibility of Hispanic populations with comparable lifestyles and socioeconomic status as African Americans (Hispanic paradox) points to the concomitant importance of genetic determinants...
March 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28717922/healthy-living-behaviors-among-chinese-american-preschool-aged-children-results-of-a-parent-survey
#9
Virginia Rall Chomitz, Alison Brown, Victoria Lee, Aviva Must, Kenneth Kwan Ho Chui
Associations between diet, physical activity, parenting, and acculturation among Chinese-American children are understudied. Parents/caregivers of children attending child-care programs in Boston Chinatown completed a self-administered survey on demographics, child's diet, physical activities, anthropometrics, and parenting practices. Associations were evaluated in multivariable regression analysis, stratified by survey language preference, a proxy for acculturation. Responding Asian families = 132; 86...
July 17, 2017: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/28715553/validation-of-the-children-s-hospital-of-philadelphia-retinopathy-of-prematurity-chop-rop-model
#10
Gil Binenbaum, Gui-Shuang Ying, Lauren A Tomlinson
Importance: The Children's Hospital of Philadelphia Retinopathy of Prematurity (CHOP ROP) model uses birth weight (BW), gestational age at birth (GA), and weight gain rate to predict the risk of severe retinopathy of prematurity (ROP). In a model development study, it predicted all infants requiring treatment, while greatly reducing the number of examinations compared with current screening guidelines. Objective: To validate the CHOP ROP model in a multicenter cohort that is large enough to obtain a precise estimate of the model's sensitivity for treatment-requiring ROP...
July 13, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28714709/asian-americans-respond-less-favorably-to-excitement-vs-calm-focused-physicians-compared-to-european-americans
#11
Tamara Sims, Birgit Koopmann-Holm, Henry R Young, Da Jiang, Helene Fung, Jeanne L Tsai
OBJECTIVES: Despite being considered a "model minority," Asian Americans report worse health care encounters than do European Americans. This may be due to affective mismatches between Asian American patients and their European American physicians. We predicted that because Asian Americans value excitement (vs. calm) less than European Americans, they will respond less favorably to excitement-focused (vs. calm) physicians. METHOD: In Study 1, 198 European American, Chinese American, and Hong Kong Chinese community adults read a medical scenario and indicated their preference for an excitement-focused versus calm-focused physician...
July 17, 2017: Cultural Diversity & Ethnic Minority Psychology
https://www.readbyqxmd.com/read/28714599/the-utility-of-empirically-assigning-ancestry-groups-in-cross-population-genetic-studies-of-addiction
#12
Roseann E Peterson, Alexis C Edwards, Silviu-Alin Bacanu, Danielle M Dick, Kenneth S Kendler, Bradley T Webb
BACKGROUND AND OBJECTIVES: Given moderate heritability and significant heterogeneity among addiction phenotypes, successful genome-wide association studies (GWAS) are expected to need very large samples. As sample sizes grow, so can genetic diversity leading to challenges in analyzing these data. Methods for empirically assigning individuals to genetically informed ancestry groups are needed. METHODS: We describe a strategy for empirically assigning ancestry groups in ethnically diverse GWAS data including extensions of principal component analysis (PCA) and population matching through minimum Mahalanobis distance...
July 17, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28714442/content-validity-of-a-screening-instrument-for-breast-cancer-early-detection-among-asian-american-women-the-cultural-health-and-screening-mammography-belief-scale
#13
Meng Zhao, Patricia L Conard
BACKGROUND AND PURPOSE: Asian American women have the lowest mammography screening rate in the United States. There is no standardized instrument available to measure their cultural beliefs regarding screening mammography. The purpose of this study is to evaluate the content validity of the Cultural Health and Screening Mammography Belief Scale (CHSMBS) developed for this population. Procedures for Instrument Development: The content validity was examined using content validity index (CVI)...
December 1, 2016: Journal of Nursing Measurement
https://www.readbyqxmd.com/read/28711797/symptom-severity-and-disability-in-psychiatric-disorders-the-u-s-collaborative-psychiatric-epidemiology-survey
#14
R García-Velázquez, M Jokela, T H Rosenström
BACKGROUND: While most psychiatric diagnoses are based on simple counts of symptoms, some symptoms may be sign of a more severe mental syndrome than others. This calls for validated estimates of the relative severity specific symptoms imply within a disorder. We focused on four diagnostic disorders: Manic Episode (ME), Major Depressive Episode (MDE), Post-traumatic Stress Disorder (PTSD) and Generalized Anxiety Disorder (GAD). Symptom-specific severity parameters were estimated, and validated by examining their association with levels of self-reported disability in daily activities over and above the number of symptoms...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28709582/the-incidence-of-transfusion-and-associated-risk-factors-in-pelvic-reconstructive-surgery
#15
Lopa K Pandya, Courtney Lynch, Andrew F Hundley, Silpa Nekkanti, Catherine O Hudson
BACKGROUND: Almost 400,000 female pelvic reconstructive operations were performed in 2010 for urinary incontinence and pelvic organ prolapse in the United States, and it is likely that this will continue to increase each year. There is a lack of population-based data evaluating the risk of blood transfusion after urogynecologic procedures. OBJECTIVES: To assess the incidence of blood transfusion related to pelvic reconstructive surgery in a large national surgical quality database and to identify transfusion-associated risk factors...
July 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28704695/emergence-of-the-asian-genotype-of-denv-1-in-south-india
#16
D Cecilia, J A Patil, M B Kakade, A Walimbe, K Alagarasu, B Anukumar, A Abraham
A large outbreak of dengue occurred in Tamil Nadu, South India in 2012 with 12,000 cases and CFR of 0.5%. Molecular characterization of virus present in the sera of dengue patients was undertaken to determine if there were changes in the virus population. All four serotypes were circulating but DENV-1 was dominant, present in 52% of the serotyped samples. Furthermore, the genotype of only DENV-1 had changed; the Asian genotype had displaced the American/African. Phylogenetic analysis revealed that the Asian genotype was introduced from Singapore and shared 99% similarity with viruses, associated with large outbreaks in Singapore and Sri Lanka...
July 10, 2017: Virology
https://www.readbyqxmd.com/read/28704570/signs-of-eclampsia-during-singleton-deliveries-and-early-neonatal-mortality-in-low-and-middle-income-countries-from-three-who-regions
#17
Saverio Bellizzi, Howard L Sobel, Mohamed M Ali
OBJECTIVE: To determine the prevalence of eclampsia symptoms and to explore associations between eclampsia and early neonatal mortality. METHODS: The present secondary analysis included Demographic and Health Surveys data from 2005 to 2012; details of signs related to severe obstetric adverse events of singleton deliveries during interviewees' most recent delivery in the preceding 5 years were included. Data and delivery history were merged for pooled analyses. Convulsions-used as an indicator for having experienced eclampsia-and early neonatal mortality rates were compared, and a generalized random effect model, adjusted for heterogeneity between and within countries, was used to investigate the impact of presumed eclampsia on early neonatal mortality...
July 13, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28701306/geographic-variations-in-cardiovascular-disease-mortality-among-asian-american-subgroups-2003-2011
#18
Jia Pu, Katherine G Hastings, Derek Boothroyd, Powell O Jose, Sukyung Chung, Janki B Shah, Mark R Cullen, Latha P Palaniappan, David H Rehkopf
BACKGROUND: There are well-documented geographical differences in cardiovascular disease (CVD) mortality for non-Hispanic whites. However, it remains unknown whether similar geographical variation in CVD mortality exists for Asian American subgroups. This study aims to examine geographical differences in CVD mortality among Asian American subgroups living in the United States and whether they are consistent with geographical differences observed among non-Hispanic whites. METHODS AND RESULTS: Using US death records from 2003 to 2011 (n=3 897 040 CVD deaths), age-adjusted CVD mortality rates per 100 000 population and age-adjusted mortality rate ratios were calculated for the 6 largest Asian American subgroups (Asian Indian, Chinese, Filipino, Japanese, Korean, and Vietnamese) and compared with non-Hispanic whites...
July 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28700747/the-association-between-ethnicity-and-vaginal-microbiota-composition-in-amsterdam-the-netherlands
#19
Hanneke Borgdorff, Charlotte van der Veer, Robin van Houdt, Catharina J Alberts, Henry J de Vries, Sylvia M Bruisten, Marieke B Snijder, Maria Prins, Suzanne E Geerlings, Maarten F Schim van der Loeff, Janneke H H M van de Wijgert
OBJECTIVE: To evaluate whether ethnicity is independently associated with vaginal microbiota (VMB) composition in women living in Amsterdam, the Netherlands, as has been shown for American women. METHODS: Women (18-34 years, non-pregnant, N = 610) representing the six largest ethnic groups (Dutch, African Surinamese, South-Asian Surinamese, Turkish, Moroccan, and Ghanaian) were sampled from the population-based HELIUS study. Sampling was performed irrespective of health status or healthcare seeking behavior...
2017: PloS One
https://www.readbyqxmd.com/read/28689925/a-geographical-workforce-analysis-of-hand-therapy-services-in-relation-to-us-population-characteristics
#20
Caroline W Stegink-Jansen, Prisca M Collins, Ronald W Lindsey, James L Wilson
INTRODUCTION: A paucity of work force planning literature exists for hand therapy services. PURPOSE: This descriptive study aimed to map the geographical distribution of US Certified Hand Therapists (CHT) and describe characteristics of US populations living in respective CHT workplace areas. METHODS: A de-identified Zip Code list of all active CHTs through April 2016 from the Hand Therapy Certification Commission, included 5572 CHTs with US Census Zip Code Tabulation Areas (ZCTA)...
July 6, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
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