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https://www.readbyqxmd.com/read/28943165/characterization-of-invisible-breast-cancers-in-digital-mammography-and-tomosynthesis-radio-pathological-correlation
#1
P M Aguilar Angulo, C Romero Castellano, J Ruiz Martín, M P Sánchez-Camacho González-Carrato, L M Cruz Hernández
OBJECTIVE: To review the radio-pathologic features of symptomatic breast cancers not detected at digital mammography (DM) and digital breast tomosynthesis (DBT). MATERIAL AND METHODS: Retrospective analysis of 169 lesions from symptomatic patients with breast cancer that were studied with DM, DBT, ultrasound (US) and magnetic resonance (MR). We identified occult lesions (true false negatives) in DM and DBT. Clinical data, density, US and MR findings were analyzed as well as histopathological results...
September 21, 2017: Radiología
https://www.readbyqxmd.com/read/28942805/randomized-clinical-trial-of-dialectical-behavior-therapy-for-preadolescent-children-with-disruptive-mood-dysregulation-disorder-feasibility-and-outcomes
#2
Francheska Perepletchikova, Donald Nathanson, Seth R Axelrod, Caitlin Merrill, Amy Walker, Meredith Grossman, James Rebeta, Lawrence Scahill, Joan Kaufman, Barbara Flye, Elizabeth Mauer, John Walkup
OBJECTIVE: Persistent irritability and behavior outbursts in disruptive mood dysregulation disorder (DMDD) are associated with severe impairment in childhood and with negative adolescent and adult outcomes. There are no empirically established treatments for DMDD. This study examined the feasibility and preliminary efficacy of dialectical behavior therapy adapted for preadolescent children (DBT-C) with DMDD. METHOD: Children 7 to 12 years old with DMDD (N = 43) were randomly assigned 1:1 to DBT-C or treatment as usual (TAU)...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28937263/imaging-features-of-breast%C3%A2-cancers-on-digital%C3%A2-breast%C3%A2-tomosynthesis%C3%A2-according-to%C3%A2-molecular%C3%A2-subtype-association-with%C3%A2-breast%C3%A2-cancer%C3%A2-detection
#3
Su Hyun Lee, Jung Min Chang, Sung Ui Shin, A Jung Chu, Ann Yi, Nariya Cho, Woo Kyung Moon
OBJECTIVE: To evaluate imaging features of breast cancers on digital breast tomosynthesis (DBT) according to molecular subtype and to determine whether the molecular subtype affects breast cancer detection on DBT. METHODS: This was an institutional review board-approved study with a waiver of informed consent. DBT findings of 288 invasive breast cancers were reviewed according to BI-RADS lexicon. Detectability of breast cancer was quantified by the number of readers (0-3) who correctly detected the cancer in an independent blinded review...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28929809/can-breast-compression-be-reduced-in-digital-mammography-and-breast-tomosynthesis
#4
Greeshma A Agasthya, Ellen D'Orsi, Yoon-Jin Kim, Priyanka Handa, Christopher P Ho, Carl J D'Orsi, Ioannis Sechopoulos
OBJECTIVE: The objective of this study was to investigate the impact of decreasing breast compression during digital mammography and breast tomosynthesis (DBT) on perceived pain and image quality. MATERIALS AND METHODS: In this two-part study, two groups of women with prior mammograms were recruited. In part 1, subjects were positioned for craniocaudal (CC) and mediolateral oblique (MLO) views, and four levels of compression force were applied to evaluate changes in breast thickness, perceived pain, and relative tissue coverage...
September 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28929783/use-of-single-view-digital-breast-tomosynthesis-dbt-and-ultrasound-vs-additional-views-and-ultrasound-for-the-assessment-of-screen-detected-abnormalities-german-multi-reader-study
#5
Sylvia H Heywang-Köbrunner, Astrid Hacker, Alexander Jänsch, Ronald Kates, Sabina Wulz-Horber
Background Data on the value of digital breast tomosynthesis (DBT) for further assessment of screen-detected lesions are still limited. Purpose To compare screening mammography, single-view DBT and ultrasound-information (TS) vs. screening mammography, additional views and ultrasound-information (AV) for assessment of screen-detected abnormalities. Material and Methods The use of wide-angle DBT for screen-detected, soft-tissue abnormalities requiring additional views was investigated: 241 cases (206 benign and 35 malignant lesions), verified by histology or two-year follow-up, were read by ten readers as TS and as AV sets, yielding 2410 diagnoses for each set...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28914430/position-paper-recommendations-for-a-digital-mammography-quality-assurance-program%C3%A2-v4-0
#6
J C P Heggie, P Barnes, L Cartwright, J Diffey, J Tse, J Herley, I D McLean, F J Thomson, R K Grewal, L T Collins
In 2001 the ACPSEM published a position paper on quality assurance in screen film mammography which was subsequently adopted as a basis for the quality assurance programs of both the Royal Australian and New Zealand College of Radiologists (RANZCR) and of BreastScreen Australia. Since then the clinical implementation of digital mammography has been realised and it has become evident that existing screen-film protocols were not appropriate to assure the required image quality needed for reliable diagnosis or to address the new dose implications resulting from digital technology...
September 15, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/28901614/investigating-simulation-based-metrics-for-characterizing-linear-iterative-reconstruction-in-digital-breast-tomosynthesis
#7
Sean D Rose, Adrian A Sanchez, Emil Y Sidky, Xiaochuan Pan
PURPOSE: Simulation-based image quality metrics are adapted and investigated for characterizing the parameter dependences of linear iterative image reconstruction for DBT. METHODS: Three metrics based on a 2D DBT simulation are investigated: (1) a root-mean-square-error (RMSE) between the test phantom and reconstructed image, (2) a gradient RMSE where the comparison is made after taking a spatial gradient of both image and phantom, and (3) a region-of-interest (ROI) Hotelling observer (HO) for signal-known-exactly/background-known-exactly (SKE/BKE) and signal-known-exactly/background-known-statistically (SKE/BKS) detection tasks...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28898193/molecular-breast-imaging-in-breast-cancer-screening-and-problem-solving
#8
Robin B Shermis, Roberta E Redfern, Jessica Burns, Haris Kudrolli
In the United States, legislative actions in over 28 states require radiologists to notify women who undergo breast screening mammography of their breast density. This has led to increased public interest in supplemental screening, but radiologists have not come to a consensus on a supplemental screening modality. In choosing between the most common options, whole-breast ultrasonography (US) and magnetic resonance (MR) imaging, one must weigh the benefits and drawbacks of each modality, as increased cancer detection may be accompanied by increased examination costs and biopsy rates...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28893379/comparison-of-outcomes-of-st-elevation-myocardial-infarction-treated-by-percutaneous-coronary-intervention-during-off-hours-versus-on-hours
#9
REVIEW
Tariq H Enezate, Jad Omran, Ashraf S Al-Dadah, Martin Alpert, Ehtisham Mahmud, Mitul Patel, Herbert D Aronow, Deepak L Bhatt
Previous studies have reported worse outcomes and longer door-to-balloon times (DBTs) in patients presenting with ST-elevation myocardial infarction (STEMI) after normal working hours, during weekends, and on holidays (off-hours) compared with normal business hours (on-hours). Recent studies, however, have reported similar outcomes regardless of presentation time. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were queried from January 1990 through December 2016. Only studies comparing STEMI outcomes during off-hours versus on-hours with percutaneous coronary intervention were included...
August 4, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28881266/lesion-localization-using-the-scroll-bar-on-tomosynthesis-why-doesn-t-it-always-work
#10
REVIEW
Sarah M Friedewald, Victoria A Young, Dipti Gupta
The scroll bar on digital breast tomosynthesis (DBT) is an important tool that facilitates localization of lesions on the orthogonal view. While this works well most of the time, occasionally the location of the lesion as directed by the scroll bar is seemingly inaccurate. There are five important reasons why the scroll bar indicator may suggest a contradictory lesion location. Understanding specific scenarios when this may occur will aid the reader in reconciling these differences.
July 29, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28871810/mammography-positioning-standards-in-the-digital-era-is-the-status-quo-acceptable
#11
Ashley I Huppe, Kelly L Overman, Jason B Gatewood, Jacqueline D Hill, Louise C Miller, Marc F Inciardi
OBJECTIVE: The objective of our study was to evaluate positioning of full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) compared with film-screen (FS) mammography positioning standards. MATERIALS AND METHODS: A retrospective study was conducted of consecutive patients who underwent screening FFDM in 2010-2012 and DBT in 2012-2013 at an academic institution. Examinations were performed by five experienced technologists who underwent updated standardized positioning training...
September 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28870962/value-of-additional-digital-breast-tomosynthesis-for-preoperative-staging-of-breast-cancer-in-dense-breasts
#12
Julia Krammer, Kathrin Stepniewski, Clemens G Kaiser, Joachim Brade, Philipp Riffel, Stefan O Schoenberg, Klaus Wasser
AIM: This retrospective study was initiated to determine the diagnostic value of additional preoperative breast tomosynthesis (DBT) for breast cancer staging in dense breasts. PATIENTS AND METHODS: Sixty-six patients (69 breasts) with findings of American College of Radiology category 3 or 4 with Breast Imaging Reporting and Data System 5, 6 or 0 were included. All patients underwent digital mammography and additional DBT. RESULTS: A total of 40/69 (58%) cancers were detected on both mammography and DBT, 23 (33...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28861164/danggui-buxue-tang-suppresses-high-glucose-induced-proliferation-and-extracellular-matrix-accumulation-of-mesangial-cells-via-inhibiting-lncrna-pvt1
#13
Rui Zhang, Jinbo Li, Tao Huang, Xiuge Wang
BACKGROUND: Danggui Buxue Tang (DBT), a traditional Chinese medicine decoction, has been proven to have satisfactory effects on treating diabetic nephropathy (DN). In this study, we explored the potential underlying mechanism of DBT in DN treatment. METHODS: The DBT-containning serum was prepared by intragastric administration with DBT for rats. The levels of fibronectin (FN), laminin (LN) and collagen IV (COL IV) and TGF-β1 protein secreted in cell culture medium were determined by ELISA assay...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28852418/danggui-buxue-tang-a-simple-chinese-formula-containing-astragali-radix-and-angelicae-sinensis-radix-stimulates-the-expressions-of-neurotrophic-factors-in-cultured-sh-sy5y-cells
#14
Amy G W Gong, Huai Y Wang, Tina T X Dong, Karl W K Tsim, Y Z Zheng
BACKGROUND: Danggui Buxue Tang (DBT), a phytoestrogen-enriched Chinese herbal formula, serves as dietary supplement in stimulating the "Blood" functions of menopausal women. In traditional Chinese medicine (TCM) theory, "Blood" has a strong relationship with brain activities. Previous studies supported that some ingredients of DBT possessed neuronal beneficial functions. Therefore, the neurotrophic function and the mechanistic action of DBT were systematically evaluated in cultured human neuroblastoma SH-SY5Y cells...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28841194/psfm-dbt-identifying-dna-binding-proteins-by-combing-position-specific-frequency-matrix-and-distance-bigram-transformation
#15
Jun Zhang, Bin Liu
DNA-binding proteins play crucial roles in various biological processes, such as DNA replication and repair, transcriptional regulation and many other biological activities associated with DNA. Experimental recognition techniques for DNA-binding proteins identification are both time consuming and expensive. Effective methods for identifying these proteins only based on protein sequences are highly required. The key for sequence-based methods is to effectively represent protein sequences. It has been reported by various previous studies that evolutionary information is crucial for DNA-binding protein identification...
August 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28840599/butyltin-compounds-alter-secretion-of-interleukin-6-from-human-immune-cells
#16
Shyretha Brown, Wendy Wilburn, Tyesha Martin, Margaret Whalen
Butyltins (BTs), tributyltin (TBT) and dibutyltin (DBT) are organotin compounds that have been used in a variety of industrial applications; as a result, these compounds have been found in human blood. Interleukin (IL)-6 is a proinflammatory mediator that is produced by T lymphocytes and monocytes. It is responsible for immune response regulation as well as tissue repair and cellular growth. Both BTs decrease the ability of human natural killer cells to destroy tumor cells and alter the secretion of proinflammatory cytokines tumor necrosis factor alpha, interferon gamma and IL-1 beta (β) from human lymphocytes ex vivo...
August 24, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28838603/effect-of-shorter-door-to-balloon-times-over-20-years-on-outcomes-of-patients-with-anterior-st-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#17
Amgad Mentias, Mohammad Q Raza, Amr F Barakat, Dalia Youssef, Russell Raymond, Venu Menon, Conrad Simpfendorfer, Irving Franco, Stephen Ellis, E Murat Tuzcu, Samir R Kapadia
Cardiovascular disease remains the most common cause of mortality. We studied the change in outcomes for anterior ST-elevation myocardial infarction (STEMI) between 1995 and 2014. Over the past 20 years, 1,658 patients presenting to our center with anterior STEMI underwent primary percutaneous coronary intervention within 12 hours of presentation. We divided these into 4 quartiles, 1995 to 1999 (n = 312), 2000 to 2004 (n = 408), 2005 to 2009 (n = 428), and 2010 to 2014 (n = 510). Across the 4 quartiles, mean age decreased (64...
July 24, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28834445/biologic-profiles-of-invasive-breast-cancers-detected-only-with-digital-breast-tomosynthesis
#18
Jin You Kim, Hyun Jung Kang, Jong Ki Shin, Nam Kyung Lee, You Seon Song, Kyung Jin Nam, Ki Seok Choo
OBJECTIVE: The purpose of this study was to analyze the clinicopathologic and immunohistochemical features of invasive breast cancers detected only with digital breast tomosynthesis (DBT), compared with those of cancers detected with both DBT and full-field digital mammography (FFDM). MATERIALS AND METHODS: The medical records of 261 women (108 without and 153 with symptoms) with invasive breast cancers who underwent FFDM and DBT between April 2015 and June 2016 were retrospectively reviewed...
August 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28834441/pathologic-outcomes-of-architectural-distortion-on-digital-2d-versus-tomosynthesis-mammography
#19
Manisha Bahl, Leslie R Lamb, Constance D Lehman
OBJECTIVE: The purpose of this study is to compare the risk of malignancy associated with architectural distortion detected on 2D digital mammography (DM) versus digital breast tomosynthesis (DBT). MATERIALS AND METHODS: We performed a retrospective review of architectural distortion cases recommended for biopsy from September 2007 to February 2011, the period before DBT integration (hereafter known as the DM group), and from January 2013 to June 2016, the period after DBT integration (hereafter known as the DBT group)...
August 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28832336/improving-image-quality-for-digital-breast-tomosynthesis-an-automated-detection-and-diffusion-based-method-for-metal-artifact-reduction
#20
Yao Lu, Heang-Ping Chan, Jun Wei, Lubomir M Hadjiiski, Ravi K Samala
In digital breast tomosynthesis (DBT), the high-attenuation metallic clips marking a previous biopsy site in the breast cause errors in the estimation of attenuation along the ray paths intersecting the markers during reconstruction, which result in interplane and inplane artifacts obscuring the visibility of subtle lesions. We proposed a new metal artifact reduction (MAR) method to improve image quality. Our method uses automatic detection and segmentation to generate a marker location map for each projection (PV)...
September 15, 2017: Physics in Medicine and Biology
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