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https://www.readbyqxmd.com/read/28318506/assessment-of-disease-extent-on-contrast-enhanced-mri-in-breast-cancer-detected%C3%A2-at-digital-breast-tomosynthesis-versus%C3%A2-digital-mammography-alone
#1
A V Chudgar, E F Conant, S P Weinstein, B M Keller, M Synnestvedt, P Yamartino, E S McDonald
AIM: To compare the utility of breast magnetic resonance imaging (MRI) in determining the extent of disease in patients with newly diagnosed breast cancer detected on combination digital breast tomosynthesis (DBT) versus digital screening mammography (DM). MATERIALS AND METHODS: Review of 24,563 DBT-screened patients and 10,751 DM-screened patients was performed. Two hundred and thirty-five DBT patients underwent subsequent MRI examinations; 82 to determine extent of disease after newly diagnosed breast cancer...
March 16, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28299549/elective-single-blastocyst-transfer-in-advanced-maternal-age
#2
Samer Tannus, Weon-Young Son, Michael Haim Dahan
PURPOSE: The purpose of this study was to investigate reproductive outcomes following elective single blastocyst transfer (eSBT) compared with those of double blastocyst transfer (DBT) in advanced maternal age. METHODS: This was a retrospective cohort study performed at an academic fertility center. All women aged 40 and over for whom in vitro fertilization (IVF) cycles were performed and in whom embryo culture was extended to the blastocyst stage were reviewed for possible inclusion...
March 15, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28298592/full-field-digital-mammography-and-digital-breast-tomosynthesis
#3
Marlene M Johnson
Innovation in breast imaging techniques is leading to better breast cancer detection. Concurrently, breast cancer screening recommendations are changing, and breast density is becoming a more significant factor in breast cancer screening. Digital mammography has become the preferred screening method, with more breast imaging centers including the use of digital breast tomosynthesis (DBT). The technology's role in breast imaging has not been clarified fully, and several clinical trials are addressing DBT. This article presents research findings on digital mammography and DBT and explores the future role of 3-D breast imaging...
January 2017: Radiologic Technology
https://www.readbyqxmd.com/read/28291738/design-and-validation-of-realistic-breast-models-for-use-in-multiple-alternative-forced-choice-virtual-clinical-trials
#4
Premkumar Elangovan, Alistair Mackenzie, David R Dance, Kenneth C Young, Victoria Cooke, Louise Wilkinson, Rosalind M Given-Wilson, Matthew G Wallis, Kevin Wells
A novel method has been developed for generating quasi-realistic voxel phantoms which simulate the compressed breast in mammography and digital breast tomosynthesis (DBT). The models are suitable for use in virtual clinical trials requiring realistic anatomy which use the multiple alternative forced choice (AFC) paradigm and patches from the complete breast image. The breast models are produced by extracting features of breast tissue components from DBT clinical images including skin, adipose and fibro-glandular tissue, blood vessels and Cooper's ligaments...
April 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28287917/does-reader-performance-with-digital-breast-tomosynthesis-vary-according-to-experience-with-two-dimensional-mammography
#5
Lorraine Tucker, Fiona J Gilbert, Susan M Astley, Amanda Dibden, Archana Seth, Juliet Morel, Sara Bundred, Janet Litherland, Herman Klassen, Gerald Lip, Hema Purushothaman, Hilary M Dobson, Linda McClure, Philippa Skippage, Katherine Stoner, Caroline Kissin, Ursula Beetles, Yit Yoong Lim, Emma Hurley, Jane Goligher, Rumana Rahim, Tanja J Gagliardi, Tamara Suaris, Stephen W Duffy
Purpose To assess whether individual reader performance with digital breast tomosynthesis (DBT) and two-dimensional (2D) mammography varies with number of years of experience or volume of 2D mammograms read. Materials and Methods After written informed consent was obtained, 8869 women (age range, 29-85 years; mean age, 56 years) were recruited into the TOMMY trial (A Comparison of Tomosynthesis with Digital Mammography in the UK National Health Service Breast Screening Program), an ethically approved, multicenter, multireader, retrospective reading study, between July 2011 and March 2013...
March 13, 2017: Radiology
https://www.readbyqxmd.com/read/28284945/fish-oil-prevents-rodent-anxious-states-comorbid-with-diabetes-a-putative-involvement-of-nitric-oxide-modulation
#6
Isadora Pozzetti Siba, Mariza Bortolanza, Maria Aparecida Barbato Frazão Vital, Roberto Andreatini, Joice Maria da Cunha, Elaine Aparecida Del Bel, Janaína Menezes Zanoveli
There is an urgent need to understand the pathophysiological mechanisms related to anxiety associated with diabetes, seeking more effective alternative treatments to treat it. For that, the effect of a preventive and prolonged treatment with fish oil (FO), a source of omega-3 polyunsaturated fatty acid, was tested in streptozotocin-diabetic (DBT) rats submitted to the anxiety tests. Additionally, an immunohistochemistry for neuronal NO synthase (nNOS) was performed in brain areas related to anxiety, such as lateral amygdala (AMY), hippocampus (HIP) and dorsolateral periaqueductal gray (dlPAG)...
March 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28278784/synthesis-of-silver-sulfide-modified-carbon-materials-for-adsorptive-removal-of-dibenzothiophene-in-n-hexane
#7
Mazen K Nazal, Mazen Khaled, Isam H Aljundi, Muataz Atieh, Ghassan A Oweimreen, Abdalla M Abulkibash
Carbon nanotube (CNT) and graphene oxide (GO) as common nanostructures were modified with silver sulfide (Ag2S) using chemical vapor deposition. The raw and modified materials were tested for the removal of Dibenzothiophene (DBT) from a model fuel in batch mode adsorption experiments. The maximum adsorption capacities of DBT were 52.18 and 49.65 mg g(-1), using CNT-Ag2S and GO-Ag2S, respectively. The adsorption isotherm was modeled using Freundlich, Langmuir and Temkin models using linear and non-linear regression...
February 10, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28268510/simplified-computer-aided-detection-scheme-of-microcalcification-clusters-in-digital-breast-tomosynthesis-images
#8
Ji-Wook Jeong, Seung-Hoon Chae, Eun Young Chae, Hak Hee Kim, Young Wook Choi, Sooyeul Lee
A computer-aided detection (CADe) algorithm for clustered microcalcifications (MCs) in reconstructed digital breast tomosynthesis (DBT) images is suggested. The MC-like objects were enhanced by a Hessian-based 3D calcification response function, and a signal-to-noise ratio (SNR) enhanced image was also generated to screen the MC clustering seed objects. A connected component segmentation method was used to detect the cluster seed objects, which were considered as potential clustering centers of MCs. Bounding cubes for the accepted clustering seed candidate were generated and the overlapping cubes were combined and examined...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268308/wearable-deep-body-thermometers-and-their-uses-in-continuous-monitoring-for-daily-healthcare
#9
Ming Huang, Toshiyo Tamura, Takumi Yoshimura, Tadahiro Tsuchikawa, Shigehiko Kanaya
This paper introduces noninvasive deep body thermometers suitable for continuous deep body temperature (DBT) measurement. On the basis of their features, they were used in DBT monitoring for daily healthcare. A thermometer based on the dual-heat-flux method (T_DHFM), and an aural canal thermistor (ACT), were used in two studies of daily healthcare. The medical device CoreTemp by Terumo, based on the zero-heat-flux method, was also used for a DBT reference. The first study focused on preventing heat stroke in a high-temperature and high-humidity environment, while the other focused on the temperature monitoring of patients with spinal cord injuries...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28254661/high-organic-sulfur-removal-performance-of-a-cobalt-based-metal-organic-framework
#10
Minoo Bagheri, Mohammad Yaser Masoomi, Ali Morsali
Synthesis of a new porous cobalt based metal-organic framework, [Co6(oba)6(CH3O)4(O)2]n·3DMF (TMU-11) has been carried out to introduce a new and highly efficient adsorbent of dibenzothiophene (DBT). This compound has been synthesized by solvothermal method using a nonlinear dicarboxylate ligand and characterized by single-crystal X-ray crystallography. To study the adsorption properties of the synthesized compound, TMU-11, for DBT removal, various factors, such as amount of adsorbent, contact time and temperature were examined...
February 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28226684/simplified-computer-aided-detection-scheme-of-microcalcification-clusters-in-digital-breast-tomosynthesis-images
#11
Ji-Wook Jeong, Seung-Hoon Chae, Eun Young Chae, Hak Hee Kim, Young Wook Choi, Sooyeul Lee, Ji-Wook Jeong, Seung-Hoon Chae, Eun Young Chae, Hak Hee Kim, Young Wook Choi, Sooyeul Lee, Sooyeul Lee, Ji-Wook Jeong, Hak Hee Kim, Eun Young Chae, Young Wook Choi, Seung-Hoon Chae
A computer-aided detection (CADe) algorithm for clustered microcalcifications (MCs) in reconstructed digital breast tomosynthesis (DBT) images is suggested. The MC-like objects were enhanced by a Hessian-based 3D calcification response function, and a signal-to-noise ratio (SNR) enhanced image was also generated to screen the MC clustering seed objects. A connected component segmentation method was used to detect the cluster seed objects, which were considered as potential clustering centers of MCs. Bounding cubes for the accepted clustering seed candidate were generated and the overlapping cubes were combined and examined...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226467/wearable-deep-body-thermometers-and-their-uses-in-continuous-monitoring-for-daily-healthcare
#12
Ming Huang, Toshiyo Tamura, Takumi Yoshimura, Tadahiro Tsuchikawa, Shigehiko Kanaya, Ming Huang, Toshiyo Tamura, Takumi Yoshimura, Tadahiro Tsuchikawa, Shigehiko Kanaya, Toshiyo Tamura, Takumi Yoshimura, Ming Huang, Shigehiko Kanaya, Tadahiro Tsuchikawa
This paper introduces noninvasive deep body thermometers suitable for continuous deep body temperature (DBT) measurement. On the basis of their features, they were used in DBT monitoring for daily healthcare. A thermometer based on the dual-heat-flux method (T_DHFM), and an aural canal thermistor (ACT), were used in two studies of daily healthcare. The medical device CoreTemp by Terumo, based on the zero-heat-flux method, was also used for a DBT reference. The first study focused on preventing heat stroke in a high-temperature and high-humidity environment, while the other focused on the temperature monitoring of patients with spinal cord injuries...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221671/can-trainees-effectively-deliver-dialectical-behavior-therapy-for-individuals-with-borderline-personality-disorder-outcomes-from-a-training-clinic
#13
Shireen L Rizvi, Christopher D Hughes, Alexandra D Hittman, Pedro Vieira Oliveira
OBJECTIVE: The aim of the current study was to evaluate the effectiveness of a 6-month course of comprehensive dialectical behavior therapy (DBT) provided in a training clinic with doctoral students as therapists and assessors. METHOD: Clinical outcomes for 50 individuals with borderline personality disorder (80% female, Mage = 29.52 [SD = 9.64]) are reported. Reliable change indices and clinical significance were calculated for measures. Finally, our results were benchmarked against a "gold standard" randomized clinical trial (RCT; McMain et al...
February 21, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28221238/additional-magnetic-resonance-imaging-detected-suspicious-lesions-in-known-patients-with-breast-cancer-comparison-of-second-look-digital-tomosynthesis-and-ultrasonography
#14
Jieun Koh, Eun-Kyung Kim, Min Jung Kim, Jung Hyun Yoon, Hee Jung Moon
PURPOSE: The aim of the study was to compare the performances of second-look digital breast tomosynthesis (DBT) and ultrasonography (US) for additional magnetic resonance imaging (MRI)-detected suspicious lesions in patients referred for breast cancer. METHODS: Fifty-five patients (52.5 [9.3] years) with breast cancers newly diagnosed at a referring hospital underwent MRI and afterward DBT and US in our institution. The frequency for detecting additional MRI-detected suspicious lesions on DBT and US and performances of DBT and US were compared...
February 18, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28221096/clinical-performance-of-synthesized-two-dimensional-mammography-combined-with-tomosynthesis-in-a-large-screening-population
#15
Mireille P Aujero, Sara C Gavenonis, Ron Benjamin, Zugui Zhang, Jacqueline S Holt
Purpose To compare the clinical performance of synthesized two-dimensional (s2D) mammography combined with digital breast tomosynthesis (DBT) with that of full-field digital mammography (FFDM) alone and FFDM combined with DBT in a large community-based screening population by analyzing recall rate, positive predictive value, and cancer detection rate. Materials and Methods This was a retrospective study approved by the institutional review board and was HIPAA compliant with waiver of informed consent. A total of 78 810 screening mammograms from October 11, 2011, to June 30, 2016, were retrospectively collected...
April 2017: Radiology
https://www.readbyqxmd.com/read/28214227/automated-breast-density-computation-in-digital-mammography-and-digital-breast-tomosynthesis-influence-on-mean-glandular-dose-and-birads-density-categorization
#16
Maria Castillo-García, Margarita Chevalier, Julia Garayoa, Alejandro Rodriguez-Ruiz, Diego García-Pinto, Julio Valverde
RATIONALE AND OBJECTIVES: The study aimed to compare the breast density estimates from two algorithms on full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) and to analyze the clinical implications. MATERIALS AND METHODS: We selected 561 FFDM and DBT examinations from patients without breast pathologies. Two versions of a commercial software (Quantra 2D and Quantra 3D) calculated the volumetric breast density automatically in FFDM and DBT, respectively...
February 14, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28211806/digital-breast-tomosynthesis-plus-mammography-magnetic-resonance-imaging-plus-mammography-and-mammography-alone-a-comparison-of-diagnostic-performance-in-symptomatic-women
#17
Wei Tang, Fei-Xiang Hu, Hui Zhu, Qi-Feng Wang, Ya-Jia Gu, Wei-Jun Peng
PURPOSE: To compare the diagnostic efficiency of digital breast tomosynthesis (DBT) plus digital mammography (DM) and magnetic resonance imaging (MRI) plus DM in symptomatic women. MATERIALS AND METHODS: The protocol used in our study was accepted by the ethics committee at our hospital, and informed consent was obtained from all patients. Between June and December 2014, 197 patients with 238 histologically proven lesions all underwent DM, DBT and MRI. Two radiologists were responsible for interpreting all images according to the Breast Imaging Reporting and Data System (BI-RADS)...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28205250/crystal-structure-of-dibenzothiophene-sulfone-monooxygenase-bdsa-from-bacillus-subtilis-wu-s2b
#18
Masahiko Okai, Woo Cheol Lee, Li-Jun Guan, Takashi Ohshiro, Yoshikazu Izumi, Masaru Tanokura
The dibenzothiophene (DBT) sulfone monooxygenase BdsA from Bacillus subtilis WU-S2B catalyzes the conversion of DBT sulfone to 2'-hydroxybiphenyl 2-sulfinate (HBPS). We report the crystal structures of BdsA at a resolution of 2.80 Å. BdsA exists as a homotetramer with a dimer-of-dimers configuration in the crystal, and the interaction between E288 and R296 in BdsA is important for tetramer formation. A structural comparison with homologous proteins shows that the orientation and location of the α9-α12 helices in BdsA are closer to those of the closed form than those of the open form in the EDTA monooxygenase EmoA...
February 16, 2017: Proteins
https://www.readbyqxmd.com/read/28202601/cell-scientist-to-watch-arun-shukla
#19
(no author information available yet)
Arun Shukla received his master's degree in Biotechnology from the Jawaharlal Nehru University in New Delhi, and joined the lab of Nobel laureate Hartmut Michel at the Max Planck Institute of Biophysics in Frankfurt, Germany, for his PhD. He then moved to the United States for his postdoctoral work with Robert Lefkowitz at Duke University (Durham, NC) in a very close collaboration with Brian Kobilka (Stanford University, CA). Arun became an Assistant Professor in the Department of Medicine at Duke University in 2011, before returning to India in April 2014 as an Assistant Professor at the Indian Institute of Technology (IIT) in Kanpur as a Wellcome Trust DBT India Alliance Intermediate Fellow...
February 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28197878/two-homozygous-mutations-in-the-exon-5-of-bckdhb-gene-that-may-cause-the-classic-form-of-maple-syrup-urine-disease
#20
Ling Su, Zhikun Lu, Fatao Li, Yongxian Shao, Huiying Sheng, Yanna Cai, Li Liu
Maple syrup urine disease (MSUD) is a rare autosomal recessive genetic disorder caused by defects in the catabolism of the branched-chain amino acids (BCAAs). Classic form of MSUD (CMSUD) is caused by mutations in BCKDHA, BCKDHB, DBT genes mostly. In this study, we analyzed the clinical and genetic characteristics of two patients with CMSUD. Two homozygous mutations, c.517G > T (p.Asp173Tyr) and c.503G > A (p.Arg168His), both in the exon 5 of BCKDHB were detected respectively. The novel mutation p...
February 15, 2017: Metabolic Brain Disease
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