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https://www.readbyqxmd.com/read/27908154/mass-detection-in-digital-breast-tomosynthesis-deep-convolutional-neural-network-with-transfer-learning-from-mammography
#1
Ravi K Samala, Heang-Ping Chan, Lubomir Hadjiiski, Mark A Helvie, Jun Wei, Kenny Cha
PURPOSE: Develop a computer-aided detection (CAD) system for masses in digital breast tomosynthesis (DBT) volume using a deep convolutional neural network (DCNN) with transfer learning from mammograms. METHODS: A data set containing 2282 digitized film and digital mammograms and 324 DBT volumes were collected with IRB approval. The mass of interest on the images was marked by an experienced breast radiologist as reference standard. The data set was partitioned into a training set (2282 mammograms with 2461 masses and 230 DBT views with 228 masses) and an independent test set (94 DBT views with 89 masses)...
December 2016: Medical Physics
https://www.readbyqxmd.com/read/27904759/a-review-of-sub-acute-subdural-hematoma-sasdh-with-our-institutional-experience-and-its-management-by-double-barrel-technique-dbt-a-novel-technique
#2
Soubhagya R Tripathy, Pankaj K Swarnakar, Sanjib Mishra, Sudhanshu S Mishra, Manmath K Dhir, Sanjay K Behera, Pratap C Nath, Somnath P Jena, Itibrata Mohanta, Deepak Das, Mani C Satapathy, Sitansu K Rout, Bikash R Behera, Deepak K Parida, Tanushree S Rath
BACKGROUND: Subacute subdural hematoma (SASDH) is an entity which is yet to capture the popular imagination among the neurosurgeons. Its management is often equated clinically to that of the chronic subdural hematoma (CSDH). However, their neurological deterioration is usually rapid, which seems to align them with acute subdural hematoma (ASDH). We proceed for their epidemiological evaluation. The advantages of a novel "double barrel technique (DbT)" over the conventional burrhole drainage are also presented...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27898274/borderline-personality-disorder-therapeutic-factors
#3
Michael H Stone
Proponents of the now half-dozen major psychotherapeutic approaches tend to claim the superiority of their different approaches-known widely by their acronyms: CBT for Cognitive Behavioral Therapy, DBT for Dialectic Behavioral Therapy, MBT for Mentalization-Based Therapy, TFP for Transference- Focused Psychotherapy, and so on. The data thus far support the utility of each method, but do not show clear-cut superiority of any one method. A large percentage of BPD patients eventually improve or even recover, but these favorable results appear to derive from a multiplicity of factors...
2016: Psychodynamic Psychiatry
https://www.readbyqxmd.com/read/27897326/exploring-the-effectiveness-of-combined-mentalization-based-group-therapy-and-dialectical-behaviour-therapy-for-inpatients-with-borderline-personality-disorder-a-pilot-study
#4
Marc-Andreas Edel, Vanessa Raaff, Giancarlo Dimaggio, Anna Buchheim, Martin Brüne
OBJECTIVES: Borderline personality disorder (BPD) is characterized by emotional instability, interpersonal dysfunction, and other features that typically develop before a background of insecure attachment and traumatic experiences. Dialectical behaviour therapy (DBT) has proven highly effective in reducing self-harm and improving emotion regulation, whereby problems concerning social cognition, which are also characteristic of BPD, may need additional approaches such as mentalization-based treatment (MBT)...
November 29, 2016: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/27896337/a-multicomponent-assembly-approach-for-the-design-of-deep-desulfurization-heterogeneous-catalysts
#5
Yanqi Xu, Weimin Xuan, Mengmeng Zhang, Haralampos N Miras, Yu-Fei Song
Deep desulfurization is a challenging task and global efforts are focused on the development of new approaches for the reduction of sulfur-containing compounds in fuel oils. In this work, we have proposed a new design strategy for the development of deep desulfurization heterogeneous catalysts. Based on the adopted design strategy, a novel composite material of polyoxometalate (POM)-based ionic liquid-grafted layered double hydroxides (LDHs) was synthesized by an exfoliation/grafting/assembly process. The structural properties of the as-prepared catalyst were characterized using FT-IR, XRD, TG, NMR, XPS, BET, SEM and HRTEM...
November 29, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27888024/performance-of-photon-counting-breast-computed-tomography-digital-mammography-and-digital-breast-tomosynthesis-in-evaluating-breast-specimens
#6
Ann-Christin Rößler, Willi Kalender, Daniel Kolditz, Christian Steiding, Veikko Ruth, Caroline Preuss, Sandra Christina Peter, Barbara Brehm, Matthias Hammon, Rüdiger Schulz-Wendtland, Evelyn Wenkel
RATIONALE AND OBJECTIVES: This study compared a novel photon-counting breast computed tomography (pcBCT) system with digital mammography (DM) and digital breast tomosynthesis (DBT) systems. For this reason, surgical specimens were examined with all three techniques and rated by three observers. MATERIALS AND METHODS: A total of 30 surgical specimens were investigated with DM, DBT, and pcBCT; the associated images were shown to three experienced radiologists. Findings (22 microcalcifications and 23 mass lesions) were recorded and compared to the results of the pathological examination...
November 22, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27882604/the-dog-bone-technique-a-novel-easy-and-safe-catheter-maneuver-for-aortic-arch-and-coarctation-stenting
#7
Marinos Kantzis, Anja Lehner, Kai Thorsten Laser, Anca Racolta, Radka Vcasna, Marcus Fischer, Deniz Kececioglu, Nikolaus A Haas
BACKGROUND: Various techniques are described to facilitate stable stent implantation in aortic arch stenosis or coarctation. We describe an alternative technique, which due to its unique appearance during stent implantation, we have named "Dog Bone Technique" (DBT). TECHNIQUE: The stent/balloon assembly is placed across the stenosis, the long sheath is retrieved to uncover the distal 20-50% of the stent. The balloon is inflated with the pressure inflator just to expand slightly the stent...
November 24, 2016: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/27879317/correlated-evolution-between-ck1%C3%AE-and-the-serine-rich-motif-contributes-to-regulating-the-mammalian-circadian-clock
#8
Lijuan Xing, Yang An, Guangsen Shi, Jie Yan, Pancheng Xie, Zhipeng Qu, Zhihui Zhang, Zhiwei Liu, Dejing Pan, Ying Xu
Understanding the mechanism underlying the physiological divergence of species is a long-standing issue in evolutionary biology. The circadian clock is a highly conserved system existing in almost all organisms that regulates a wide range of physiological and behavioral events to adapt to the day-night cycle. Here, the interactions between hCK1δ/ϵ/DBT (Drosophila ortholog of CK1δ/ϵ) and serine rich (SR) motifs from hPER2 (ortholog of Drosophila per) were reconstructed in a Drosophila circadian system. The results indicated that in Drosophila, the SR mutant form hPER2S662G does not recapitulate the mouse or human mutant phenotype...
November 22, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27879022/catalytic-janus-nanosheets-based-emulsion-for-ultra-deep-desulfurization
#9
Lixin Xia, Hairan Zhang, Zhichao Wei, Yi Jiang, Ling Zhang, Jie Zhao, Junhui Zhang, Li Dong, Erni Li, Laurent Ruhlmann, Qian Zhang
Catalytic Janus nanosheets were synthesized using an anion-exchange reaction between heteropolyacids (HPAs) and the modified ionic liquids (ILs) moieties of Janus nanosheets. Their morphologies and surface properties were characterized using SEM, EDS, FTIR and XPS spectra. Because of their inherent Janus structure, the nanosheets exhibited good amphipathic character with ILs and oil to form a stable ILs-in-oil emulsion. Therefore, such Janus nanosheets can be utilized both as emulsifiers and catalysts to perform emulsive desulfurization...
November 23, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27872860/danggui-buxue-tang-attenuates-tubulointerstitial-fibrosis-via-suppressing-nlrp3-inflammasome-in-a-rat-model-of-unilateral-ureteral-obstruction
#10
Linna Wang, Jiwei Ma, Cunxia Guo, Changyong Chen, Zhong Yin, Xueguang Zhang, Xiangmei Chen
Inflammation significantly contributes to the progression of chronic kidney disease (CKD). This study aimed to characterize Danggui Buxue Tang (DBT) renoprotection and relationship with NOD-like receptors family pyrin domain-containing 3 (NLRP3) inflammasome expression in rats with unilateral ureteral obstruction (UUO). Sprague-Dawley rats were subjected to UUO and randomly assigned to untreated UUO, enalapril-treated (10 mg/kg/day), and DBT-treated (9 g/kg/day) groups. Sham-operated rats served as controls, with 8 rats in each group...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27864040/study-of-circadian-rhythmicity-of-physiological-response-and-skin-temperature-of-sheep-during-summer-and-winter-in-semi-arid-tropical-environment
#11
Kalyan De, Davendra Kumar, Vijay Kumar Saxena, Syed Mohammed Khursheed Naqvi
The present study aimed to evaluate the circadian rhythmicity of some physiological variables, including rectal temperature (RT), respiration rate (RR), heart rate (HR) and skin temperature (ST) in sheep during the summer and winter in semi-arid tropical environment. Eight Malpura rams of 3-4year of age with an average body weight of 37.1±1.99kg were selected for the study. All the animals were fed individually for a maintenance requirement on a body weight basis. The RT, RR, HR and ST values were measured in each animal at 3hour intervals for 24 consecutive hours...
November 15, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27861206/comparison-of-the-detection-rate-of-simulated-microcalcifications-in-full-field-digital-mammography-digital-breast-tomosynthesis-and-synthetically-reconstructed-2-dimensional-images-performed-with-2-different-digital-x-ray-mammography-systems
#12
Sabine Peters, Martin Hellmich, Alexander Stork, Jörn Kemper, Olga Grinstein, Michael Püsken, Leandra Stahlhut, Sonja Kinner, David Maintz, Kathrin Barbara Krug
OBJECTIVE: The aim of this study was to compare the microcalcification detectability in an anthropomorphic phantom model regarding number, size, and shape in full-field digital mammography (FFDM), synthetically reconstructed 2-dimensional (Synthetic-2D) images, and digital breast tomosynthesis (DBT) performed with 2 different x-ray mammography systems. MATERIALS AND METHODS: Simulated microcalcifications of different numbers (0 to >39), sizes (diameter, 100-800 μm), and shapes (round vs heterogeneous) were scattered by random distribution on 50 film phantoms each divided in 4 quadrants...
November 17, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/27858962/a-randomized-trial-of-brief-dialectical-behaviour-therapy-skills-training-in-suicidal-patients-suffering-from-borderline-disorder
#13
Shelley F McMain, Tim Guimond, Ryan Barnhart, Liat Habinski, David L Streiner
OBJECTIVE: Evidence-based therapies for borderline personality disorder (BPD) are lengthy and scarce. Data on brief interventions are limited, and their role in the treatment of BPD is unclear. Our aim was therefore to evaluate the clinical effectiveness of brief dialectical behaviour therapy (DBT) skills training as an adjunctive intervention for high suicide risk in patients with BPD. METHOD: Eighty-four out-patients were randomized to 20 weeks of DBT skills (n = 42) or a waitlist (WL; n = 42)...
November 13, 2016: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27856300/hemin-utilizing-g-quadruplex-dnazymes-are-strongly-active-in-organic-co-solvents
#14
Thomas D Canale, Dipankar Sen
The widespread use of organic solvents in industrial processes has focused in recent years on the utility of "green" solvents - those with less harmful environmental, health, and safety properties - such as methanol and formamide. However, protein enzymes, regarded as green catalysts, are often incompatible with organic solvents. Herein, we have explored the oxidative properties of a Fe(III)-heme, or hemin, utilizing catalytic DNA (heme·DNAzyme) in different green solvent-water mixtures. We find that the peroxidase and peroxygenase activities of the heme·DNAzyme are strongly enhanced in 20-30% v/v methanol or formamide, relative to water alone...
November 14, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27853437/the-use-of-virtual-reality-to-facilitate-mindfulness-skills-training-in-dialectical-behavioral-therapy-for-borderline-personality-disorder-a-case-study
#15
Maria V Nararro-Haro, Hunter G Hoffman, Azucena Garcia-Palacios, Mariana Sampaio, Wadee Alhalabi, Karyn Hall, Marsha Linehan
Borderline personality disorder (BPD) is a severe mental disorder characterized by a dysfunctional pattern of affective instability, impulsivity, and disturbed interpersonal relationships. Dialectical Behavior Therapy (DBT®) is the most effective treatment for Borderline Personality Disorder, but demand for DBT® far exceeds existing clinical resources. Most patients with BPD never receive DBT®. Incorporating computer technology into the DBT® could help increase dissemination. Immersive Virtual Reality technology (VR) is becoming widely available to mainstream consumers...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27852348/an-adaptive-randomized-trial-of-dialectical-behavior-therapy-and-cognitive-behavior-therapy-for-binge-eating
#16
E Y Chen, J Cacioppo, K Fettich, R Gallop, M S McCloskey, T Olino, T A Zeffiro
BACKGROUND: Early weak treatment response is one of the few trans-diagnostic, treatment-agnostic predictors of poor outcome following a full treatment course. We sought to improve the outcome of clients with weak initial response to guided self-help cognitive behavior therapy (GSH). METHOD: One hundred and nine women with binge-eating disorder (BED) or bulimia nervosa (BN) (DSM-IV-TR) received 4 weeks of GSH. Based on their response, they were grouped into: (1) early strong responders who continued GSH (cGSH), and early weak responders randomized to (2) dialectical behavior therapy (DBT), or (3) individual and additional group cognitive behavior therapy (CBT+)...
November 17, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27842661/diagnostic-performance-of-digital-breast-tomosynthesis-with-a-wide-scan-angle-compared-to-full-field-digital-mammography-for-the-detection-and-characterization-of-microcalcifications
#17
Paola Clauser, Georg Nagl, Thomas H Helbich, Katja Pinker-Domenig, Michael Weber, Panagiotis Kapetas, Maria Bernathova, Pascal A T Baltzer
OBJECTIVES: To assess the diagnostic performance of digital breast tomosynthesis (DBT), with a wide scan-angle, compared to full-field digital mammography (FFDM), for the detection and characterization of microcalcifications. METHODS: IRB approval was obtained for this retrospective study. We selected 150 FFDM and DBT (50 benign and 50 malignant histologically verified microcalcifications, 50 cases classified as BI-RADS 1). Four radiologists evaluated, in separate sessions and blinded to patients' history and histology, the presence of microcalcifications...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27837442/non-calcified-ductal-carcinoma-in-situ-of-the-breast-comparison-of-diagnostic-accuracy-of-digital-breast-tomosynthesis-digital-mammography-and-ultrasonography
#18
Xiaohui Su, Qing Lin, Chunxiao Cui, Wenjian Xu, Zhimin Wei, Jie Fei, Lili Li
BACKGROUND: To retrospectively compare the diagnostic accuracy of digital breast tomosynthesis (DBT), digital mammography (DM), and ultrasonography (US) in non-calcified ductal carcinoma in situ (DCIS, include DCIS with micro-invasion). PATIENTS AND METHODS: Ninety-eight patients with non-calcified DCIS (include DCIS with micro-invasion) were enrolled in our study. Breast carcinoma in situ was confirmed by surgical pathologic evaluation. Our Institutional Review Board granted approval and the participating women provided written informed consent...
November 11, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/27836476/total-tin-and-organotin-speciation-in-historic-layers-of-antifouling-paint-on-leisure-boat-hulls
#19
Maria Lagerström, Jakob Strand, Britta Eklund, Erik Ytreberg
Despite their ban on small vessels in 1989 in the EU, organotin compounds (OTCs) are still being released into the environment due to their presence in historic paint layers on leisure boats. 23 paint samples scraped from recreational boats from three countries around the Baltic Sea were analyzed for total tin (Sn) and OTCs. Two antifouling paint products were also subjected to the same analyses. A new method for the detection of Sn in paint flake samples was developed and found to yield more accurate results compared to four different acid digestion methods...
November 8, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27832960/novel-indole-based-compounds-that-differentiate-alkylindole-sensitive-receptors-from-cannabinoid-receptors-and-microtubules-characterization-of-their-activity-on-glioma-cell-migration
#20
Susan Fung, Cong Xu, Ernest Hamel, James B Wager-Miller, Grace Woodruff, Aaron Miller, Christina Sanford, Ken Mackie, Nephi Stella
Indole-based compounds, such as the alkyl-indole (AI) compound WIN55212-2, activate the cannabinoid receptors, CB1 and CB2, two well-characterized G protein-coupled receptors (GPCR). Reports indicate that several indole-based cannabinoid agonists, including WIN55212-2, lack selectivity and interact with at least two additional targets: AI-sensitive GPCRs and microtubules. Studying how indole-based compounds modulate the activity of these 4 targets has been difficult as selective chemical tools were not available...
November 7, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
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