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Thrombosis,Polycystic ovary syndrome

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https://www.readbyqxmd.com/read/27381237/does-oral-contraceptive-pill-increase-plasma-intercellular-adhesion-molecule-1-monocyte-chemoattractant-protein-1-and-tumor-necrosis-factor-%C3%AE-levels-in-women-with-polycystic-ovary-syndrome-pcos-a-pilot-study
#1
Syed Douhath Yousuf, Fouzia Rashid, Tahira Mattoo, Chander Shekhar, Syed Mudassar, M Afzal Zargar, Mohd Ashraf Ganie
STUDY OBJECTIVES: Polycystic ovary syndrome(PCOS), the commonest endocrinopathy of women, is a state of chronic low grade inflammation and is closely linked to type 2 diabetes mellitus and cardiovascular disease.Oral contraceptive pills(OCP's), is the usual first choice of treatment in women with PCOS.Because OCP use has been linked to the risk of venous thrombosis and there is limited data on impact of OCP use on inflammatory state of PCOS women our objective is to compare the levels of intercellular adhesion molecule-1(ICAM-1),tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1(MCP-1) between drug naive and OCP treated PCOS women...
July 2, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27214191/committee-opinion-no-663-aromatase-inhibitors-in-gynecologic-practice
#2
(no author information available yet)
Aromatase inhibitors have been used for the treatment of breast cancer, ovulation induction, endometriosis, and other estrogen-modulated conditions. For women with breast cancer, bone mineral density screening is recommended with long-term aromatase inhibitor use because of risk of osteoporosis due to estrogen deficiency. Based on long-term adverse effects and complication safety data, when compared with tamoxifen, aromatase inhibitors are associated with a reduced incidence of thrombosis, endometrial cancer, and vaginal bleeding...
June 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27214185/committee-opinion-no-663-summary-aromatase-inhibitors-in-gynecologic-practice
#3
(no author information available yet)
Aromatase inhibitors have been used for the treatment of breast cancer, ovulation induction, endometriosis, and other estrogen-modulated conditions. For women with breast cancer, bone mineral density screening is recommended with long-term aromatase inhibitor use because of risk of osteoporosis due to estrogen deficiency. Based on long-term adverse effects and complication safety data, when compared with tamoxifen, aromatase inhibitors are associated with a reduced incidence of thrombosis, endometrial cancer, and vaginal bleeding...
June 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26789346/identification-of-potential-markers-for-cushing-disease
#4
Michael S Broder, Eunice Chang, Dasha Cherepanov, Maureen P Neary, William H Ludlam
OBJECTIVE: Cushing disease (CD) causes a wide variety of nonspecific symptoms, which may result in delayed diagnosis. It may be possible to uncover unusual combinations of otherwise common symptoms using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Our aim was to identify and evaluate dyads of clinical symptoms or conditions associated with CD. METHODS: We conducted a matched case-control study using a commercial healthcare insurance claims database designed to compare the relative risk (RR) of individual conditions and dyad combinations of conditions among patients with CD versus matched non-CD controls...
May 2016: Endocrine Practice
https://www.readbyqxmd.com/read/26411233/a-case-of-idiopathic-intracranial-hypertension-associated-with-pcos
#5
Y J Lee, J E Jeong, J K Joo, K S Lee
Idiopathic intracranial hypertension (IIH) is a rare neurologic disorder. It is also known as pseudotumor cerebri. The incidence of IIH is one to two per 100,000 population annually. The higher incidence is in obese women from 15 to 44 years. The main symptoms are headache and visual loss. It mostly affects women of childbearing age who are overweight or obese. There are many theories of pathogenesis of IIH, but precise pathogenesis is unknown. One of the causes of IIH is intracranial venous sinus thrombosis...
2015: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/25902782/loss-of-the-insulin-receptor-in-murine-megakaryocytes-platelets-causes-thrombocytosis-and-alterations-in-igf-signalling
#6
Samantha F Moore, Christopher M Williams, Edward Brown, Thomas A Blair, Matthew T Harper, Richard J Coward, Alastair W Poole, Ingeborg Hers
AIMS: Patients with conditions that are associated with insulin resistance such as obesity, type 2 diabetes mellitus, and polycystic ovary syndrome have an increased risk of thrombosis and a concurrent hyperactive platelet phenotype. Our aim was to determine whether insulin resistance of megakaryocytes/platelets promotes platelet hyperactivation. METHODS AND RESULTS: We generated a conditional mouse model where the insulin receptor (IR) was specifically knocked out in megakaryocytes/platelets and performed ex vivo platelet activation studies in wild-type (WT) and IR-deficient platelets by measuring aggregation, integrin αIIbβ3 activation, and dense and α-granule secretion...
July 1, 2015: Cardiovascular Research
https://www.readbyqxmd.com/read/25701301/approach-to-the-patient-contraception-in-women-with-polycystic-ovary-syndrome
#7
Bulent O Yildiz
Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder. Patients with PCOS present with clinical signs of androgen excess (ie, hirsutism and acne), menstrual irregularities, and infertility. Combined oral contraceptive (OC) pills are the first-line medical therapy for the long-term management of PCOS. Containing a combination of estrogen and progestin, OCs restore regular menses, improve androgen excess, and provide effective contraception and protection from endometrial cancer. The benefits of hormonal contraception outweigh the risks in the vast majority of women with PCOS...
March 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25656495/morbidity-and-medicine-prescriptions-in-a-nationwide-danish-population-of-patients-diagnosed-with-polycystic-ovary-syndrome
#8
Dorte Glintborg, Katrine Hass Rubin, Mads Nybo, Bo Abrahamsen, Marianne Andersen
OBJECTIVE: The prevalence of type 2 diabetes is increased in polycystic ovary syndrome (PCOS), but the prevalence of other diseases is not clarified. We aimed to investigate morbidity and medicine prescriptions in PCOS. DESIGN: A National Register-based study. METHODS: Patients with PCOS (PCOS Denmark and an embedded cohort; PCOS Odense University Hospital (OUH)) and one control population. Premenopausal women with PCOS underwent clinical and biochemical examination (PCOS OUH, n=1217)...
May 2015: European Journal of Endocrinology
https://www.readbyqxmd.com/read/25227335/hormonal-contraception-thrombosis-and-age
#9
REVIEW
Øjvind Lidegaard
INTRODUCTION: This paper reviews the risk of thrombosis with use of different types of hormonal contraception in women of different ages. AREAS COVERED: Combined hormonal contraceptives with desogestrel, gestodene, drospirenone or cyproterone acetate (high-risk products) confer a sixfold increased risk of venous thromboembolism as compared with nonusers, and about twice the risk as compared with users of products with norethisterone, levonorgestrel or norgestimate (low-risk products)...
October 2014: Expert Opinion on Drug Safety
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