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Thrombosis, Polycystic ovary syndrome

Syed Douhath Yousuf, Fouzia Rashid, Tahira Mattoo, Chander Shekhar, Syed Mudassar, M Afzal Zargar, Mohd Ashraf Ganie
STUDY OBJECTIVES: Polycystic ovary syndrome(PCOS), the commonest endocrinopathy of women, is a state of chronic low grade inflammation and is closely linked to type 2 diabetes mellitus and cardiovascular disease.Oral contraceptive pills(OCP's), is the usual first choice of treatment in women with PCOS.Because OCP use has been linked to the risk of venous thrombosis and there is limited data on impact of OCP use on inflammatory state of PCOS women our objective is to compare the levels of intercellular adhesion molecule-1(ICAM-1),tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1(MCP-1) between drug naive and OCP treated PCOS women...
July 2, 2016: Journal of Pediatric and Adolescent Gynecology
(no author information available yet)
Aromatase inhibitors have been used for the treatment of breast cancer, ovulation induction, endometriosis, and other estrogen-modulated conditions. For women with breast cancer, bone mineral density screening is recommended with long-term aromatase inhibitor use because of risk of osteoporosis due to estrogen deficiency. Based on long-term adverse effects and complication safety data, when compared with tamoxifen, aromatase inhibitors are associated with a reduced incidence of thrombosis, endometrial cancer, and vaginal bleeding...
June 2016: Obstetrics and Gynecology
(no author information available yet)
Aromatase inhibitors have been used for the treatment of breast cancer, ovulation induction, endometriosis, and other estrogen-modulated conditions. For women with breast cancer, bone mineral density screening is recommended with long-term aromatase inhibitor use because of risk of osteoporosis due to estrogen deficiency. Based on long-term adverse effects and complication safety data, when compared with tamoxifen, aromatase inhibitors are associated with a reduced incidence of thrombosis, endometrial cancer, and vaginal bleeding...
June 2016: Obstetrics and Gynecology
Michael S Broder, Eunice Chang, Dasha Cherepanov, Maureen P Neary, William H Ludlam
OBJECTIVE: Cushing disease (CD) causes a wide variety of nonspecific symptoms, which may result in delayed diagnosis. It may be possible to uncover unusual combinations of otherwise common symptoms using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Our aim was to identify and evaluate dyads of clinical symptoms or conditions associated with CD. METHODS: We conducted a matched case-control study using a commercial healthcare insurance claims database designed to compare the relative risk (RR) of individual conditions and dyad combinations of conditions among patients with CD versus matched non-CD controls...
May 2016: Endocrine Practice
Y J Lee, J E Jeong, J K Joo, K S Lee
Idiopathic intracranial hypertension (IIH) is a rare neurologic disorder. It is also known as pseudotumor cerebri. The incidence of IIH is one to two per 100,000 population annually. The higher incidence is in obese women from 15 to 44 years. The main symptoms are headache and visual loss. It mostly affects women of childbearing age who are overweight or obese. There are many theories of pathogenesis of IIH, but precise pathogenesis is unknown. One of the causes of IIH is intracranial venous sinus thrombosis...
2015: Clinical and Experimental Obstetrics & Gynecology
Samantha F Moore, Christopher M Williams, Edward Brown, Thomas A Blair, Matthew T Harper, Richard J Coward, Alastair W Poole, Ingeborg Hers
AIMS: Patients with conditions that are associated with insulin resistance such as obesity, type 2 diabetes mellitus, and polycystic ovary syndrome have an increased risk of thrombosis and a concurrent hyperactive platelet phenotype. Our aim was to determine whether insulin resistance of megakaryocytes/platelets promotes platelet hyperactivation. METHODS AND RESULTS: We generated a conditional mouse model where the insulin receptor (IR) was specifically knocked out in megakaryocytes/platelets and performed ex vivo platelet activation studies in wild-type (WT) and IR-deficient platelets by measuring aggregation, integrin αIIbβ3 activation, and dense and α-granule secretion...
July 1, 2015: Cardiovascular Research
Bulent O Yildiz
Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic disorder. Patients with PCOS present with clinical signs of androgen excess (ie, hirsutism and acne), menstrual irregularities, and infertility. Combined oral contraceptive (OC) pills are the first-line medical therapy for the long-term management of PCOS. Containing a combination of estrogen and progestin, OCs restore regular menses, improve androgen excess, and provide effective contraception and protection from endometrial cancer. The benefits of hormonal contraception outweigh the risks in the vast majority of women with PCOS...
March 2015: Journal of Clinical Endocrinology and Metabolism
Dorte Glintborg, Katrine Hass Rubin, Mads Nybo, Bo Abrahamsen, Marianne Andersen
OBJECTIVE: The prevalence of type 2 diabetes is increased in polycystic ovary syndrome (PCOS), but the prevalence of other diseases is not clarified. We aimed to investigate morbidity and medicine prescriptions in PCOS. DESIGN: A National Register-based study. METHODS: Patients with PCOS (PCOS Denmark and an embedded cohort; PCOS Odense University Hospital (OUH)) and one control population. Premenopausal women with PCOS underwent clinical and biochemical examination (PCOS OUH, n=1217)...
May 2015: European Journal of Endocrinology
Øjvind Lidegaard
INTRODUCTION: This paper reviews the risk of thrombosis with use of different types of hormonal contraception in women of different ages. AREAS COVERED: Combined hormonal contraceptives with desogestrel, gestodene, drospirenone or cyproterone acetate (high-risk products) confer a sixfold increased risk of venous thromboembolism as compared with nonusers, and about twice the risk as compared with users of products with norethisterone, levonorgestrel or norgestimate (low-risk products)...
October 2014: Expert Opinion on Drug Safety
Frank W Booth, Christian K Roberts, Matthew J Laye
Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause of most chronic diseases. The initial third of the article considers: activity and prevention definitions; historical evidence showing physical inactivity is detrimental to health and normal organ functional capacities; cause versus treatment; physical activity and inactivity mechanisms differ; gene-environment interaction (including aerobic training adaptations, personalized medicine, and co-twin physical activity); and specificity of adaptations to type of training...
April 2012: Comprehensive Physiology
Nina Rogenhofer, Laura Engels, Nadja Bogdanova, Frank Tüttelmann, Christian J Thaler, Arseni Markoff
OBJECTIVE: The aim of this study was to analyze the contribution of the M2 haplotype of ANXA5 gene, previously identified as a risk factor for RPL and thrombophilia related pregnancy complications, to repeated miscarriage observed in PCOS patients. PATIENTS/METHODS: 100 PCOS patients, 500 fertile women and 533 random population controls were genotyped for M2/ANXA5. RESULTS: M2 haplotype carriers faced a 3.4 fold elevated RPL risk (odds ratio 5...
August 2013: Metabolism: Clinical and Experimental
Simon-Vermot, Keller
Obesity increases the risk of metabolic complications such as diabetes, dyslipidaemia, systemic hypertension and cardiovascular disease. These are mainly responsible for the increased mortality of obese people. Other metabolic consequences of obesity are: gallstones, steatosis of the liver and the polycystic ovary syndrome. Beside the body mass index the distribution of body fat is important. Centralized obesity, as measured by the waist-to-hip circumference ratio (WHR), is associated with increased mortality and morbidity...
August 1, 2000: Therapeutische Umschau. Revue Thérapeutique
María Insenser, Rafael Montes-Nieto, Mora Murri, Héctor F Escobar-Morreale
Polycystic ovary syndrome (PCOS) is considered a complex multifactorial disorder resulting from the interaction of genetic, environmental, and lifestyle influences. Nontargeted proteomics and metabolomics have been used in the past years with the aim of identifying molecules potentially involved in the pathophysiology of this frequent disorder. The biomolecules identified so far participate in many metabolic pathways, including energy metabolism (glucose and lipid metabolism), protein metabolic processes and protein folding, cytoskeleton structure, immune response, inflammation and iron metabolism, fibrinolysis and thrombosis, oxidative stress and intracellular calcium metabolism...
May 6, 2013: Molecular and Cellular Endocrinology
Frank González, John P Kirwan, Neal S Rote, Judi Minium
Women with polycystic ovary syndrome (PCOS) have chronic low-grade inflammation that can increase the risk of atherothrombosis. We performed a cross-sectional study to examine the effect of glucose ingestion on markers of atherothrombotic inflammation in mononuclear cells (MNC) of 16 women with PCOS (8 lean, 8 obese) and 16 weight-matched controls. Activator protein-1 (AP-1) activation and the protein content of early growth response-1 (EGR-1), matrix matalloproteinases-2 (MMP2), and tissue factor (TF) were quantified from MNC obtained from blood drawn fasting and 2 h after glucose ingestion...
February 15, 2013: American Journal of Physiology. Endocrinology and Metabolism
Frank González, John P Kirwan, Neal S Rote, Judi Minium
Women with polycystic ovary syndrome (PCOS) have coagulation disturbances and inflammation, which increases the risk of atherothrombosis. We evaluated the status of circulating tissue factor (TF), the receptor for coagulation factor VII involved in atherothrombosis, in women with PCOS and weight-matched controls. Two-way analysis of variance models were fit to evaluate the effect of PCOS status and weight class on TF and other parameters. The TF levels were significantly higher in lean women with PCOS compared to lean controls...
January 2013: Clinical and Applied Thrombosis/hemostasis
Pratap Kumar, Sameer Farouk Sait, Alok Sharma, Mukesh Kumar
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication of assisted reproduction technology. The syndrome is characterized by cystic enlargement of the ovaries and a fluid shift from the intravascular to the third space due to increased capillary permeability and ovarian neoangiogenesis. Its occurrence is dependent on the administration of human chorionic gonadotrophin (hCG). β-hCG and its analogs, estrogen, estradiol, prolactin, histamine and prostaglandins have all been implicated in OHSS but now it is increasingly better understood that the vasoactivesubstances such as interleukins, tumor necrosis factor-α, endothelin-1, and vascular endothelial growth factor (VEGF) secreted by the ovaries have been implicated in increasing vascular permeability...
May 2011: Journal of Human Reproductive Sciences
Carlos Quesnel García-Benítez, Ricardo Nicolás Avilés-Cabrera
Ovarian hyperstimulation syndrome is an iatrogenic complication of controlled ovarian hyperstimulation. Its features are excessive growth of the ovaries and leakage of fluid from the intravascular space with ascites, hypovolemia and electrolyte imbalance, inducing a state of hypercoagulability, which can cause arterial or venous thrombosis. Thromboembolic events are the less common complications but they are the most serious. We communicate the case of a 30 years old woman with history of primary infertility; she was in treatment with controlled ovarian hyperstimulation...
March 2011: Ginecología y Obstetricia de México
Douglas E Vaughan
The plasminogen activator (i.e., fibrinolytic) system is one of the key endogenous defense mechanisms against intravascular thrombosis. Thrombolytic agents represent the only direct way of augmenting fibrinolytic activity in humans, and have proven to be of value in the treatment of acute myocardial infarction and stroke. Although these agents are efficacious in the acute setting, they are not a viable option for long-term use. Net fibrinolytic activity is plasma is largely determined by the balance between tissue-type plasminogen activator (t-PA) and its natural, fast-acting inhibitor, plasminogen activator inhibitor-1 (PAI-1)...
2011: Transactions of the American Clinical and Climatological Association
Yunus Nazli, Necmettin Colak, Omer N Aksoy, Omer Cakir
Thyroid vein thrombosis is a rare variety of venous thrombosis. The use of oral contraceptives and heterozygous methylenetetrahydrofolate reductase (MTHFR) gene mutation could have synergistic effects on the onset of venous thromboembolism. We report a 28-year-old woman with thyroid vein thrombosis. The thrombosis was possibly provoked by a combination of heterozygous MTHFR gene mutation and the use of a combined oral contraceptive (COC) containing cyproterone acetate/ethinylestradiol (CPA/EE) for polycystic ovary syndrome (PCOS)...
June 2011: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Winifred Mak, Anuja Dokras
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with multiple comorbidities such as diabetes, dyslipidemia, hypertension, and metabolic syndrome, all of which predispose women with PCOS to early atherosclerosis. Women with PCOS also have a higher prevalence of subclinical atherosclerosis, as reflected in dysregulation of endothelial function, increased carotid intimal-medial thickness, and presence of coronary artery calcification. Preliminary data indicate that serum biomarkers of cardiovascular disease such as high-sensitivity C-reactive protein, homocysteine, and adiponectin are abnormal in women with PCOS...
October 2009: Seminars in Thrombosis and Hemostasis
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