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Cerebral palsy toxin

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https://www.readbyqxmd.com/read/27916232/neuroinflammation-in-intrauterine-growth-restriction
#1
REVIEW
Julie A Wixey, Kirat K Chand, Paul B Colditz, S Tracey Bjorkman
Disruption to the maternal environment during pregnancy from events such as hypoxia, stress, toxins, inflammation, and reduced placental blood flow can affect fetal development. Intrauterine growth restriction (IUGR) is commonly caused by chronic placental insufficiency, interrupting supply of oxygen and nutrients to the fetus resulting in abnormal fetal growth. IUGR is a major cause of perinatal morbidity and mortality, occurring in approximately 5-10% of pregnancies. The fetal brain is particularly vulnerable in IUGR and there is an increased risk of long-term neurological disorders including cerebral palsy, epilepsy, learning difficulties, behavioural difficulties and psychiatric diagnoses...
November 25, 2016: Placenta
https://www.readbyqxmd.com/read/27882910/does-nintendo-wii-balance-board-improve-standing-balance-a-randomised-controlled-trial-in-children-with-cerebral-palsy
#2
Valeska Gatica-Rojas, Guillermo Méndez-Rebolledo, Eduardo Guzman-Muñoz, Alex Soto-Poblete, Ricardo Cartes-Velásquez, Edith Elgueta-Cancino, Eduardo Cofré Lizama
BACKGROUND: Evidence on the effect of systemic exercise programs to improve the standing balance with the Nintendo Wii system is very limited and its post- treatment effectiveness is unknown in cerebral palsy (CP) patients. AIM: Primary aim was to compare the effect of Nintendo Wii balance board (Wii- therapy) and standard physiotherapy (SPT), on the performance of standing balance in children and adolescents with CP. Secondary aim was to determine the post-treatment effectiveness of Wii-therapy and SPT...
November 24, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27861211/what-s-new-in-the-management-of-foot-deformities-in-children-with-cerebral-palsy
#3
John A Heydemann, Oussama Abousamra, Jeanne M Franzone, Brian E Kaufman, Julieanne P Sees
BACKGROUND: Foot deformities have been frequently reported in cerebral palsy (CP), and numerous diagnostic modalities and treatment options have recently been developed to achieve a better level of management for children with CP. METHODS: A thorough search of the English literature, published between January 2013 and March 2016, was performed. A summary of the new findings that had not previously described was reported. The review included recent advances regarding clinical and gait evaluation, orthotic management, botulinum toxin A treatment, and surgical correction...
November 17, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27744462/effects-of-botulinum-toxin-serotype-a-on-sleep-problems-in-children-with-cerebral-palsy-and-on-mothers-sleep-quality-and-depression
#4
Vildan Binay Safer, Sibel Ozbudak Demir, Esma Ozkan, Fulya Demircioglu Guneri
OBJECTIVE: To evaluate botulinum toxin serotype A (BoNT-A) effects on sleep problems in children with cerebral palsy (CP) and on mothers` sleep quality and depression at multiple time points. METHODS: This is a single center, cross sectional, and observational study was conducted to assess children with CP who were admitted. We recruited children with CP who were admitted to Ministry of Health Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey between September 2012 and April 2014 for the BoNT-A injection for lower limb spasticity...
October 2016: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/27677011/correction-of-hip-internal-rotation-in-walking-cerebral-palsy-adolescent-using-a-soft-tissue-procedure-an-alternative-to-femoral-rotation-osteotomy
#5
Bruno Dohin, Elie Haddad, Hassan Al Khoury Salem, Mohamed Merhez Kilani
OBJECTIVE: Hip internal rotation (HIR) during gait is one of the main functional disorders related to cerebral palsy (CP) in children. Most of the procedures proposed rotational osteotomy of the femur (FRO), (and/or tibia). However, multilevel surgery (SEMLS) including bone procedure, implicates more difficult and longer rehabilitation. When bone deformity is moderate, the authors hypothesized that FRO could be avoided. They developed a soft tissues procedure to improve HIR. The aim of the study was assessment of the procedure...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676961/physiological-anatomy-of-botulinum-toxin-effect-on-the-spastic-muscle-of-children-with-cerebral-palsy
#6
Claire Mietton, Laurent Schaeffer, Nathalie Streichenberger, Vincent Cunin, Berrouz Kassai, Isabelle Poirot
OBJECTIVE: Botulinum toxin is one of the treatments available to treat spasticity in patients with cerebral palsy (CP) from 2 years of age. The long-term action of the toxin on the neuromuscular junction (NMJ) and muscle structure is still unknown. We formulated the hypothesis that repeated injections of botulinum toxin could modify muscle structure. The main aim of our 3-year monocentric descriptive study is to evaluate the long-term effect of repeated injections of botulinum toxin on the muscle and the neuromuscular junction in patients with CP...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676935/perceived-effectiveness-tolerance-of-cares-in-children-and-adults-with-cerebral-palsy
#7
Laetitia Houx, Hélène Saudreau, Philippe Galien, Christelle Pons, Marion Roquet, Ronan Garlantezec, Sylvain Brochard
OBJECTIVE: A better understanding of the perception of the rehabilitative and medical care's by persons with cerebral palsy (CP) and their families may help in providing better adherence to these cares. The main objective of this study was to assess overall satisfaction, self-perception of effectiveness and tolerance of the rehabilitative and medical cares in individuals with CP. MATERIAL AND METHODS: This was a cross-sectional questionnaire-based study. A total of 950 questionnaires were sent to French Britain children and adults with CP...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676869/pediatric-stroke-rehabilitation-a-review-of-techniques-facilitating-motor-recovery
#8
Eleni Papathanasiou, Mathilde Chevignard, Carole Vuillerot, Anne Tiberghien, Ingrid Godard
OBJECTIVE: Paediatric stroke is a relatively rare medical condition, but it often leads to long lasting motor and cognitive impairments. Rehabilitation of motor impairments has been widely studied, with most studies performed in children with cerebral palsy (CP). However, CP covers a variety of medical conditions, including brain lesions due to paediatric stroke occurring early in life, but not stroke occurring later on during childhood. The specificity of rehabilitation after paediatric stroke remains understudied...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27631386/a-randomized-controlled-trial-on-effectiveness-of-intermittent-serial-casting-on-spastic-equinus-foot-in-children-with-cerebral-palsy-after-botulinum-toxin-a-treatment
#9
Nigar Dursun, Tugba Gokbel, Melike Akarsu, Erbil Dursun
OBJECTIVE: Physical therapy (PT) and botulinum toxin-A (BTX-A) injections are widely used in the treatment of spastic equinus foot due to cerebral palsy. The aim of this study was to show effects of intermittent serial casting (SC) in addition to standard treatment on spasticity, passive range of motion (PROM), and gait. DESIGN: Fifty-one ambulatory patients, treated by BTX-A to plantar flexor muscles, were randomly assigned to casting or control groups in a 2:1 ratio...
September 14, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27606053/perinatal-neuroprotection-update
#10
REVIEW
Angie C Jelin, Kirsten Salmeen, Dawn Gano, Irina Burd, Mari-Paule Thiet
Antepartum, intrapartum, and neonatal events can result in a spectrum of long-term neurological sequelae, including cerebral palsy, cognitive delay, schizophrenia, and autism spectrum disorders [1]. Advances in obstetrical and neonatal care have led to survival at earlier gestational ages and consequently increasing numbers of periviable infants who are at significant risk for long-term neurological deficits. Therefore, efforts to decrease and prevent cerebral insults attempt not only to decrease preterm delivery but also to improve neurological outcomes in infants delivered preterm...
2016: F1000Research
https://www.readbyqxmd.com/read/27594069/a-major-improvement-in-social-participation-of-two-children-with-cerebral-palsy-by-a-single-botulinum-toxin-injection
#11
Elif Yalcin, Sehim Kutlay, Olcay Ilgu, Mufit Akyuz
No abstract text is available yet for this article.
November 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27581857/edwards-p-sakzewski-l-copeland-l-et-al-safety-of-botulinum-toxin-type-a-for-children-with-nonambulatory-cerebral-palsy-pediatrics-136-5-895-904
#12
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27570991/cost-minimization-analysis-in-the-treatment-of-spasticity-in-children-with-cerebral-palsy-with-botulinum-toxin-type-a-an-observational-longitudinal-retrospective-study
#13
Gloria Tapias, Mar García-Romero, Carlos Crespo, Maribel Cuesta, Carles Forné, Samuel Ignacio Pascual-Pascual
OBJECTIVE: Cost-minimization analysis of onabotulinumtoxinA and abobotulinumtoxinA, taking into account the real dose administered to children with spasticity associated with dynamic equinus foot deformity due to cerebral palsy. METHOD: A single centre, observational, longitudinal, and retrospective study which included spastic paediatric patients aged 2-to-18-years and treated with onabotulinumtoxinA or abobotulinumtoxinA from December 1995 to October 2012, in the Paediatric Neurology Unit of a first-level Spanish hospital...
September 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27497402/botulinum-toxin-injections-for-chronic-sialorrhoea-in-children-are-effective-regardless-of-the-degree-of-neurological-dysfunction-a-single-tertiary-institution-experience
#14
Murali Mahadevan, Maayan Gruber, Darin Bilish, Kathryn Edwards, David Davies-Payne, Graeme van der Meer
OBJECTIVE: To determine the effectiveness of submandibular salivary gland Botulinum Toxin Type-A (BTX-A) injection in the treatment of drooling in children with varying degrees of neurological dysfunction. METHODS: A retrospective review of pre- and post-procedure drooling frequency and severity scores of patients receiving BTX-A between January 2008 and January 2013. Stratification to different subgroups of neurological impairment was performed according to Gross Motor Function Classification System (GMFCS) score...
September 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27374483/quantifying-passive-muscle-stiffness-in-children-with-and-without-cerebral-palsy-using-ultrasound-shear-wave-elastography
#15
Joline E Brandenburg, Sarah F Eby, Pengfei Song, Shirley Kingsley-Berg, William Bamlet, Gary C Sieck, Kai-Nan An
AIM: The aim of this study was to compare passive muscle stiffness in children with cerebral palsy (CP) and children with typical development using a novel ultrasound technique: ultrasound shear wave elastography (SWE). METHOD: We conducted a prospective study of 13 children with CP (six females and seven males, median age 5y 1mo [interquartile range 4y 4mo-7y 8mo]) and 13 children with typical development (six females and seven males, median age 5y 3mo [interquartile range 4y 4mo-9y 4mo])...
December 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27301473/clinical-motion-analyses-over-eight-consecutive-years-in-a-child-with-crouch-gait-a-case-report
#16
Erin E Butler, Katherine M Steele, Leslie Torburn, James G Gamble, Jessica Rose
BACKGROUND: This case report provides a unique look at the progression of crouch gait in a child with cerebral palsy over an 8-year time period, through annual physical examinations, three-dimensional gait analyses, and evaluation of postural balance. Our patient received regular botulinum toxin-A injections, casting, and physical therapy but no surgical interventions. CASE PRESENTATION: A white American boy with spastic diplegic cerebral palsy was evaluated annually by clinical motion analyses, including physical examination, joint kinematics, electromyography, energy expenditure, and standing postural balance tests, from 6 to 13 years of age...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27281791/sialorrhea-in-children-with-cerebral-palsy
#17
Bruno Leonardo Scofano Dias, Alexandre Ribeiro Fernandes, Heber de Souza Maia Filho
OBJECTIVE: To review the literature on sialorrhea in children with cerebral palsy. SOURCE OF DATA: Non-systematic review using the keywords "sialorrhea" and "child" carried out in the PubMed(®), LILACS(®), and SciELO(®) databases during July 2015. A total of 458 articles were obtained, of which 158 were analyzed as they were associated with sialorrhea in children; 70 had content related to sialorrhea in cerebral palsy or the assessment and treatment of sialorrhea in other neurological disorders, which were also assessed...
June 6, 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27274487/hip-dislocation-in-cerebral-palsy-evolution-of-the-contralateral-side-after-reconstructive-surgery
#18
João Caetano Munhoz Abdo, Edilson Forlin
OBJECTIVE: To evaluate the progression of the contralateral hip after unilateral reconstruction of hip dislocation in patients classified as GMFCS IV-V; and to identify potential prognostic factors for their evolution. METHODS: This was a retrospective study on 17 patients with spastic cerebral palsy, who were classified on the GMFCS scale (Gross Motor Functional Classification System) as degrees IV and V, and who underwent unilateral reconstruction surgery to treat hip dislocation (adductor release, femoral varus osteotomy and acetabuloplasty)...
May 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/27240493/managing-children-with-sialorrhoea-drooling-experience-from-the-first-301-children-in-our-saliva-control-clinic
#19
Jenny Montgomery, Sarah McCusker, Kerry Lang, Susan Grosse, Alastair Mace, Ruby Lumley, Haytham Kubba
OBJECTIVES: Sialorrhoea (drooling) is defined as the involuntary escape of saliva from the mouth. It is considered normal in young children but may cause social problems in older children. Sialorrhoea is frequently seen in children with cerebral palsy, with rates between 10% and 58% and in other neurodevelopmental diseases. Management of these children can be challenging and often requires an individual and stepwise approach. This is a large case series of children managed at the saliva control clinic in Glasgow, Scotland...
June 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27221328/-submandibular-gland-resection-for-the-management-of-sialorrhea-in-paediatric-patients-with-cerebral-palsy-and-unresponsive-to-type-a-botullinum-toxin-pilot-study
#20
Mario Sabas Hernández-Palestina, Juan Carlos Cisneros-Lesser, María Elena Arellano-Saldaña, Said Estibeyesbo Plascencia-Nieto
BACKGROUND: Sialorrhoea has a prevalence of between 10% and 58% in patients with cerebral palsy. Amongst the invasive treatments, botulinum toxin-A injections in submandibular and parotid glands and various surgical techniques are worth mentioning. There are no studies in Mexico on the usefulness of surgery to manage sialorrhoea. OBJECTIVE: To evaluate the usefulness of submandibular gland resection in improving sialorrhoea in patients with cerebral palsy and with a poor response to botulinum toxin...
May 21, 2016: Cirugia y Cirujanos
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