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https://www.readbyqxmd.com/read/28924113/the-evaluation-of-interstitial-abnormalities-in-group-b-of-the-2011-global-initiative-for-chronic-obstructive-lung-disease-gold-classification-of-chronic-obstructive-pulmonary-disease-copd
#1
Masahiro Ohgiya, Hirotoshi Matsui, Atsuhisa Tamura, Takafumi Kato, Shinobu Akagawa, Ken Ohta
Objective In 2011, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification categorized chronic obstructive pulmonary disease (COPD) patients into 4 groups. A report demonstrated that the mortality in Group B was higher than that in Group C. Ischemic heart disease and cancer were suggested to be the cause. The aim of the present study was to test the hypothesis that interstitial lung abnormalities (ILAs) are more prevalent in Group B than Group C and that they may be responsible for the higher mortality in Group B...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28916681/circannual-testis-and-moult-cycles-persist-under-photoperiods-that-disrupt-circadian-activity-and-clock-gene-cycles-in-spotted-munia
#2
Neha Agarwal, Ila Mishra, Ruchi Komal, Sangeeta Rani, Vinod Kumar
We investigated if circannual rhythms underlying annual testis maturation and moult cycles were independent of the duration and frequency of light period and the circadian clock control in non-photoperiodic spotted munia. Birds were subjected to an aberrant light-dark (LD) cycle (3.5L:3.5D; T7, T=period length of LD cycle) and continuous light (LL, 24L:0D), with controls on 12L:12D (T24, 24 h LD cycle). Initial experiment measured the activity pattern and 24 h mRNA oscillations of circadian clock genes (bmal1, clock, per2, cry1, cry2) in the hypothalamus, putative site of the seasonal timing...
September 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28906319/enteroaggregative-e-coli-subclinical-infection-and-co-infections-and-impaired-child-growth-in-the-mal-ed-cohort-study
#3
Aldo A M Lima, Alberto M Soares, José Q S Filho, Alexandre Havt, Ila F N Lima, Noélia L Lima, Cláudia B Abreu, Francisco S Junior, Rosa M S Mota, William K-Y Pan, Christopher Troeger, Pedro H Q S Medeiros, Herlice N Vera, Mara M G Prata, Ben McCormick, Monica McGrath, Elizabeth Rogawski, Eric Houpt, James Platts-Mills, Jean Gratz, Amidou Samie, Pascal Bessong, Sudhir Babji, Gangadeep Kang, Qureshi Shahida, Sadia Shakoor, Zulfiqar Bhutta, Rashidul Haque, Tahmeed Ahmed, Estomih Mduma, Erling Svensen, Margaret Kosek, Pablo Penataro Yori, Ladaporn Bodhidatta, Shrestha Jasmin, Carl Mason, Dennis Lang, Michael Gottlieb, Richard L Guerrant
OBJECTIVE: We evaluated the impact of subclinical enteroaggregative Escherichia coli (EAEC) infection alone and in combination with other pathogens in the first six months of life on child growth. METHODS: Non-diarrheal samples from 1,684 children across eight Multisite Birth Cohort Study, Malnutrition and Enteric Diseases (MAL-ED) sites in Asia, Africa, and Latin America were tested monthly; over 90% of children were followed-up twice weekly for the first six months of life...
September 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28898555/complementary-and-alternative-medicine-in-u-s-adults-with-diabetes-reasons-for-use-and-perceived-benefits
#4
Taeho Greg Rhee, Sarah M Westberg, Ila M Harris
OBJECTIVES: While complementary and alternative medicine (CAM) is increasingly used, little is known about reasons for CAM use (treatment, wellness or both) and self-reported perceived benefits among U.S. adults with diabetes at the national level. We estimated prevalence rates of overall and specific types of CAM by reason for use, and examined perceived benefits of using CAM by reason for use among U.S. adults with diabetes. METHODS: We used cross-sectional data from the 2012 National Health Interview Survey, which represents non-institutionalized adults with diabetes (n = 3,386 unweighted)...
September 12, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28893869/the-muc5b-promoter-polymorphism-is-associated-with-specific-interstitial-lung-abnormality-subtypes
#5
Rachel K Putman, Gunnar Gudmundsson, Tetsuro Araki, Mizuki Nishino, Sigurdur Sigurdsson, Elías F Gudmundsson, Gudny Eiríksdottír, Thor Aspelund, James C Ross, Raúl San José Estépar, Ezra R Miller, Yoshitake Yamada, Masahiro Yanagawa, Noriyuki Tomiyama, Lenore J Launer, Tamara B Harris, Souheil El-Chemaly, Benjamin A Raby, Michael H Cho, Ivan O Rosas, George R Washko, David A Schwartz, Edwin K Silverman, Vilmundur Gudnason, Hiroto Hatabu, Gary M Hunninghake
The MUC5B promoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population; whether these findings are replicated and influenced by the ILA subtype is not known. We evaluated the associations between the MUC5B genotype and ILA in cohorts with extensive imaging characterisation.We performed ILA phenotyping and MUC5B promoter genotyping in 5308 and 9292 participants from the AGES-Reykjavik and COPDGene cohorts, respectively.We found that ILA was present in 7% of participants from the AGES-Reykjavik, 8% of non-Hispanic white participants from COPDGene and 7% of African-American participants from COPDGene...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28885172/status-and-prospects-of-next-generation-sequencing-technologies-in-crop-plants
#6
T R Sharma, B N Devanna, Kanti Kiran, Pankaj K Singh, Kirti Arora, Priyanka Jain, Ila M Tiwari, Himanshu Dubey, Banita Saklani, Mandeep Kumari, Jyoti Singh, Rajdeep Jaswal, Ritu Kapoor, Deepak V Pawar, Shruti Sinha, Deepak Singh Bisht, A U Solanke, T K Mondal
The history of DNA sequencing dates back to 1970s. During this period the two first generation nucleotide sequencing techniques were developed. Subsequently the Sanger's dideoxy method of sequencing gained popularity over Maxam and Gilbert's chemical method of sequencing. However, in the last decade, we have observed revolutionary changes in DNA sequencing technologies leading to the emergence of next-generation sequencing (NGS) techniques. NGS technologies have enhanced the throughput and speed of sequencing combined with bringing down the overall cost of the process over a time...
September 8, 2017: Current Issues in Molecular Biology
https://www.readbyqxmd.com/read/28879851/fundamental-bound-on-the-persistence-and-capacity-of-short-term-memory-stored-as-graded-persistent-activity
#7
Onur Ozan Koyluoglu, Yoni Pertzov, Sanjay Manohar, Masud Husain, Ila R Fiete
It is widely believed that persistent neural activity underlies short-term memory. Yet, as we show, temporal degradation in such networks behaves differently from human short-term memory performance. We build a more general framework where the memory is viewed as a problem of passing information through noisy channels that represent analog persistent activity networks. Rather than directly storing information, such memory networks might hold information encoded to achieve robustness against noise. We derive a fundamental lower-bound on memory recall precision, which declines with storage duration and number of stored items...
September 7, 2017: ELife
https://www.readbyqxmd.com/read/28878285/interleukin-33-promotes-inflammation-induced-lymphangiogenesis-via-st2-traf6-mediated-akt-enos-no-signalling-pathway
#8
Longhui Han, Minglian Zhang, Xu Liang, Xin Jia, Jinchen Jia, Miying Zhao, Yiming Fan
The interplay between inflammation and lymphangiogenesis is mediated by various cytokines. However, most of these molecules and their associated mechanism are yet to be defined. Here, we explored the role of IL-33 in modulating inflammation-induced lymphangiogenesis (ILA) and its underlying mechanisms using an ILA mouse model and a lymphatic endothelial cell (LEC) line. Our results show that IL-33 promoted the proliferation, migration and tube formation of LECs and ILA in vivo. The pro-lymphangiogenic activity of IL-33 was abolished by ST2 blockage...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28855434/isolated-late-activation-detected-by-magnetocardiography-predicts-future-lethal-ventricular-arrhythmic-events-in-patients-with-arrhythmogenic-right-ventricular-cardiomyopathy
#9
Yoshitaka Kimura, Hiroshi Takaki, Yuko Y Inoue, Yasutaka Oguchi, Tomomi Nagayama, Takahiro Nakashima, Shoji Kawakami, Satoshi Nagase, Takashi Noda, Takeshi Aiba, Wataru Shimizu, Shiro Kamakura, Masaru Sugimachi, Satoshi Yasuda, Hiroaki Shimokawa, Kengo Kusano
BACKGROUND: Risk stratification of ventricular arrhythmias is vital to the optimal management in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). We hypothesized that 64-channel magnetocardiography (MCG) would be useful to detect isolated late activation (ILA) by overcoming the limitations of conventional noninvasive predictors of ventricular tachyarrhythmias, including epsilon waves, late potential (LP), and right ventricular ejection fraction (RVEF), in ARVC patients...
August 30, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28850830/comparison-of-clinical-features-and-surgical-outcome-in-focal-cortical-dysplasia-type-1-and-type-2
#10
Cihan Isler, Baris Kucukyuruk, Cigdem Ozkara, Aysegul Gunduz, Merih Is, Taner Tanriverdi, Nil Comunoglu, Buge Oz, Mustafa Uzan
INTRODUCTION: Recent ILAE classification defined focal cortical dysplasia (FCD) patients with accompanying epileptic lesions as a separate group. We investigated data of patients with sole FCD lesions regarding long-term seizure outcome and different characteristics of FCD type 1 and type 2 patients. METHODS: Eighty children and adult patients underwent surgery for FCD were included to the analysis of factors differentiating FCD type 1 and type 2 groups and their effect on long-term outcome...
October 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28843774/putting-the-new-ilae-classification-of-focal-cortical-dysplasia-into-practice-in-western-china
#11
Cheng Huang, Heng Zhang, Xiao-Sa Chi, Ni Chen, Jing Gong, Qiao Zhou, Ingmar Blümcke, Dong Zhou, Jin-Mei Li
PURPOSE: To re-examine drug-resistant epilepsy cases using the revised 2011 ILAE classification of focal cortical dysplasia (FCD). METHODS: Patients with drug-resistant epilepsy who have undergone epilepsy surgery in West China Hospital between July 2012 and Jun 2014 were included. Clinical histories, pathological diagnoses, and surgical outcomes were reviewed. A questionnaire was developed to investigate the clinical practice of the new classification. A short-term training program on FCD was carried out to improve pathological diagnosis accuracy...
July 24, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28833053/a-distinct-clinicopathological-variant-of-focal-cortical-dysplasia-iiid-characterized-by-loss-of-layer-4-in-the-occipital-lobe-in-12-children-with-remote-hypoxic-ischemic-injury
#12
Dan-Dan Wang, Yue-Shan Piao, Ingmar Blumcke, Roland Coras, Wen-Jing Zhou, Qiu-Ping Gui, Cui-Cui Liu, Jing-Xia Hu, Li-Zhen Cao, Guo-Jun Zhang, De-Hong Lu
OBJECTIVE: In 2011, the International League Against Epilepsy (ILAE) proposed a consensus classification system of focal cortical dysplasia (FCD) to distinguish clinicopathological subtypes, for example, "isolated" FCD type Ia-c and IIa-b, versus "associated" FCD type IIIa-d. The histopathological differentiation of FCD type I and III variants remains, however, a challenging issue in everyday practice. We present a unique histopathological pattern in patients with difficult-to-diagnose FCD, which highlights this dilemma, but also helps to refine the current ILAE classification scheme of FCD...
August 23, 2017: Epilepsia
https://www.readbyqxmd.com/read/28828001/structure-activity-relationships-and-molecular-docking-studies-of-chromene-and-chromene-based-azo-chromophores-a-novel-series-of-potent-antimicrobial-and-anticancer-agents
#13
Tarek H Afifi, Rawda M Okasha, Hany E A Ahmed, Janez Ilaš, Tarek Saleh, Alaa S Abd-El-Aziz
The design of novel materials with significant biological properties is a main target in drug design research. Chromene compounds represent an interesting medicinal scaffold in drug replacement systems. This report illustrates a successful synthesis and characterization of two novel series of chromene compounds using multi-component reactions. The synthesis of the first example of azo chromophores containing chromene moieties has also been established using the same methodology. The antimicrobial activity of the new molecules has been tested against seven human pathogens including two Gm+ve, two Gm-ve bacteria, and four fungi, and the results of the inhibition zones with minimum inhibitory concentrations were reported as compared to reference drugs...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28822872/different-mossy-fiber-sprouting-patterns-in-ilae-hippocampal-sclerosis-types
#14
Barbara Schmeiser, Jinmei Li, Armin Brandt, Josef Zentner, Soroush Doostkam, Thomas M Freiman
OBJECTIVE: Hippocampal sclerosis (HS) is the most prevalent pathology in temporal lobe epilepsy (TLE) characterized by segmental neuronal cell loss in the cornu ammonis (CA) 1-4. In addition, migration of granule cells and reorganization of their axons is observed, known as granule cell dispersion (GCD) and mossy fiber sprouting (MFS). The loss of mossy fibers` (MF) target cells in CA4 and CA3 was considered to be causative for MFS. The ILAE HS (International League Against Epilepsy) classification identifies three subtypes with different cell loss patterns in CA1-4...
August 8, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28805769/-psychiatry-of-the-future-an-overview-of-foreign-scientists-opinions-of-the-position-of-psychiatry-in-the-modern-world
#15
E D Belousova, N N Zavadenko, A A Kholin, A A Sharkov
This review presents the recently published revised classifications of epilepsies and seizure types developed by the International League Against Epilepsy (ILAE). The Classification of Epilepsies includes several diagnostic levels (steps): 1) from seizure type to epilepsy type (generalized/focal/combined generalized and focal/unknown), 2) diagnosis of epilepsy syndrome 3) etiology (genetic/ structural/ infectious/ metabolic/ immune/unknown). A clinician can use any level of the classification. Operational classification of seizure types is replaced by the previous classification that was grounded on the anatomical basis...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28802123/clathrodin-hymenidin-and-oroidin-and-their-synthetic-analogues-as-inhibitors-of-the-voltage-gated-potassium-channels
#16
Nace Zidar, Aleš Žula, Tihomir Tomašič, Marc Rogers, Robert W Kirby, Jan Tytgat, Steve Peigneur, Danijel Kikelj, Janez Ilaš, Lucija Peterlin Mašič
We have prepared three alkaloids from the Agelas sponges, clathrodin, hymenidin and oroidin, and a series of their synthetic analogues, and evaluated their inhibitory effect against six isoforms of the Kv1 subfamily of voltage-gated potassium channels, Kv1.1-Kv1.6, expressed in Chinese Hamster ovary (CHO) cells using automated patch clamp electrophysiology assay. The most potent inhibitor was the (E)-N-(3-(2-amino-1H-imidazol-4-yl)allyl)-4,5-dichloro-1H-pyrrole-2-carboxamide (6g) with IC50 values between 1...
August 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28790353/host-delivered-rnai-an-efficient-approach-to-increase-rice-resistance-to-sheath-blight-pathogen-rhizoctonia-solani
#17
Ila Mukul Tiwari, Arun Jesuraj, Richa Kamboj, B N Devanna, Jose R Botella, T R Sharma
Rhizoctonia solani, the causal agent of rice sheath blight disease, causes significant losses worldwide as there are no cultivars providing absolute resistance to this fungal pathogen. We have used Host Delivered RNA Interference (HD-RNAi) technology to target two PATHOGENICITY MAP KINASE 1 (PMK1) homologues, RPMK1-1 and RPMK1-2, from R. solani using a hybrid RNAi construct. PMK1 homologues in other fungal pathogens are essential for the formation of appressorium, the fungal infection structures required for penetration of the plant cuticle, as well as invasive growth once inside the plant tissues and overall viability of the pathogen within the plant...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28780245/prevalence-and-virulence-gene-profiling-of-enteroaggregative-escherichia-coli-in-malnourished-and-nourished-brazilian-children
#18
Alexandre Havt, Ila Fn Lima, Pedro Hqs Medeiros, Marco Af Clementino, Ana Ks Santos, Marília Smg Amaral, Herlice N Veras, Mara Mg Prata, Noélia L Lima, Alessandra Di Moura, Álvaro M Leite, Alberto M Soares, José Q Filho, Eric R Houpt, James P Nataro, Richard L Guerrant, Aldo Am Lima
The impact of enteroaggregative E. coli (EAEC) infection on childhood malnutrition and inflammation has been suggested, regardless of diarrhea. We investigated whether EAEC and its virulence-related genes (VRGs) are associated with malnutrition in a case-control study. Children aged 6-24 months from Brazil were enrolled as malnourished if weight-for-age Z-score (WAZ) ≤ -2 and nourished if WAZ > -1. Stools were cultured and examined for E. coli. DNA was extracted from fecal isolates and tested for EAEC by polymerase chain reaction (PCR)...
July 4, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28753039/occupational-exposures-and-subclinical-interstitial-lung-disease-the-multi-ethnic-study-of-atherosclerosis-mesa-air-lung-study
#19
Coralynn S Sack, Brent C Doney, Anna J Podolanczuk, Laura G Hooper, Noah S Seixas, Eric A Hoffman, Steven M Kawut, Sverre Vedal, Ganesh Raghu, R Graham Barr, David J Lederer, Joel D Kaufman
RATIONALE: The impact of a broad range of occupational exposures on subclinical interstitial lung disease (ILD) has not been studied. OBJECTIVE: To determine whether occupational exposures to vapors, gas, dust and fumes (VGDF) are associated with high attenuation areas (HAA) and interstitial lung abnormalities (ILA), which are quantitative and qualitative CT-based measurements of subclinical ILD, respectively. METHODS: We performed analyses of participants enrolled in MESA, a population-based cohort age 45-84 at recruitment...
July 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28742106/epidemiology-of-enteroaggregative-escherichia-coli-infections-and-associated-outcomes-in-the-mal-ed-birth-cohort
#20
MULTICENTER STUDY
Elizabeth T Rogawski, Richard L Guerrant, Alexandre Havt, Ila F N Lima, Pedro H Q S Medeiros, Jessica C Seidman, Benjamin J J McCormick, Sudhir Babji, Dinesh Hariraju, Ladaporn Bodhidatta, Jasmin Shrestha, Japhat Anania, Athanasia Maro, Amidou Samie, Pablo Peñataro Yori, Shahida Qureshi, Mustafa Mahfuz, Pascal O Bessong, Margaret N Kosek, Tahmeed Ahmed, Zulfiqar A Bhutta, Dennis R Lang, Michael Gottlieb, Eric R Houpt, Aldo A M Lima
BACKGROUND: Enteroaggregative E. coli (EAEC) have been associated with mildly inflammatory diarrhea in outbreaks and in travelers and have been increasingly recognized as enteric pathogens in young children with and without overt diarrhea. We examined the risk factors for EAEC infections and their associations with environmental enteropathy biomarkers and growth outcomes over the first two years of life in eight low-resource settings of the MAL-ED study. METHODS: EAEC infections were detected by PCR gene probes for aatA and aaiC virulence traits in 27,094 non-diarrheal surveillance stools and 7,692 diarrheal stools from 2,092 children in the MAL-ED birth cohort...
July 2017: PLoS Neglected Tropical Diseases
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