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https://www.readbyqxmd.com/read/29134116/targeting-subchondral-bone-mesenchymal-stem-cell-activities-for-intrinsic-joint-repair-in-osteoarthritis
#1
REVIEW
Dragos C Ilas, Sarah M Churchman, Dennis McGonagle, Elena Jones
Osteoarthritis (OA) is a common age-related disease with complex pathophysiology. It is characterized by wide-ranging tissue damage and ultimate biomechanical failure of the whole joint. However, signs of tissue adaptation and attempted repair responses are evident in OA-affected osteochondral tissues. Highlighted in this review article is the role of bone-resident mesenchymal stem cells (MSCs) in these bone remodeling responses, and a proposal that targeting MSC activities in OA subchondral bone could represent a novel approach for intrinsic joint regeneration in OA...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29117924/red-flags-in-epilepsy-surgery-identifying-the-patients-who-pay-a-high-cognitive-price-for-an-unsuccessful-surgical-outcome
#2
Sallie Baxendale, Pamela Thompson
Preoperative estimates of cognitive and seizure outcome must be as accurate as possible if the candidate is to make an informed decision about epilepsy surgery. Significant declines in memory function are reported in approximately 30% of temporal lobe surgery patients. The percentage varies according to the ways in which a postoperative deterioration is defined but since the majority of outcome studies do not take into account the patient's capacity to deteriorate if they are functioning at or close to the floor of a memory test prior to surgery, the published percentages may be an underrepresentation of the true extent of memory decline following epilepsy surgery...
November 5, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29107194/anti-aflatoxigenic-effect-of-organic-acids-produced-by-lactobacillus-plantarum
#3
Ana Guimarães, Ana Santiago, José A Teixeira, Armando Venâncio, Luís Abrunhosa
Lactic acid bacteria (LAB), which are commonly used in the production of fermented foods, have been gaining attention for their antifungal and antimycotoxin properties. In this work, the strain Lactobacillus plantarum UM55 was selected among other LAB for inhibiting the growth of Aspergillus flavus. Further, it is shown that cell-free supernatant (CFS) of this strain inhibits the production of aflatoxins (AFLs) by 91%. This inhibition was dependent on CFS pH, increased with increasing concentrations of CFS, and was independent of fungal growth, which was inhibited only by 32%...
January 2, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29105075/methodological-standards-for-in%C3%A2-vitro-models-of-epilepsy-and-epileptic-seizures-a-task1-wg4-report-of-the-aes-ilae-translational-task-force-of-the-ilae
#4
Joseph V Raimondo, Uwe Heinemann, Marco de Curtis, Howard P Goodkin, Chris G Dulla, Damir Janigro, Akio Ikeda, Chou-Ching K Lin, Premysl Jiruska, Aristea S Galanopoulou, Christophe Bernard
In vitro preparations are a powerful tool to explore the mechanisms and processes underlying epileptogenesis and ictogenesis. In this review, we critically review the numerous in vitro methodologies utilized in epilepsy research. We provide support for the inclusion of detailed descriptions of techniques, including often ignored parameters with unpredictable yet significant effects on study reproducibility and outcomes. In addition, we explore how recent developments in brain slice preparation relate to their use as models of epileptic activity...
November 2017: Epilepsia
https://www.readbyqxmd.com/read/29105074/common-data-elements-for-preclinical-epilepsy-research-standards-for-data-collection-and-reporting-a-task3-report-of-the-aes-ilae-translational-task-force-of-the-ilae
#5
Lauren C Harte-Hargrove, Jacqueline A French, Asla Pitkänen, Aristea S Galanopoulou, Vicky Whittemore, Helen E Scharfman
The major objective of preclinical translational epilepsy research is to advance laboratory findings toward clinical application by testing potential treatments in animal models of seizures and epilepsy. Recently there has been a focus on the failure of preclinical discoveries to translate reliably, or even to be reproduced in different laboratories. One potential cause is a lack of standardization in preclinical data collection. The resulting difficulties in comparing data across studies have led to high cost and missed opportunity, which in turn impede clinical trials and advances in medical care...
November 2017: Epilepsia
https://www.readbyqxmd.com/read/29105073/methodological-standards-and-interpretation-of-video-electroencephalography-in-adult-control-rodents-a%C3%A2-task1-wg1-report-of-the-aes-ilae-translational-task%C3%A2-force-of-the-ilae
#6
Shilpa D Kadam, Raimondo D'Ambrosio, Venceslas Duveau, Corinne Roucard, Norberto Garcia-Cairasco, Akio Ikeda, Marco de Curtis, Aristea S Galanopoulou, Kevin M Kelly
In vivo electrophysiological recordings are widely used in neuroscience research, and video-electroencephalography (vEEG) has become a mainstay of preclinical neuroscience research, including studies of epilepsy and cognition. Studies utilizing vEEG typically involve comparison of measurements obtained from different experimental groups, or from the same experimental group at different times, in which one set of measurements serves as "control" and the others as "test" of the variables of interest. Thus, controls provide mainly a reference measurement for the experimental test...
November 2017: Epilepsia
https://www.readbyqxmd.com/read/29105072/harmonization-in-preclinical-epilepsy-research-a-joint-aes-ilae-translational-initiative
#7
Aristea S Galanopoulou, Jacqueline A French, Terence O'Brien, Michele Simonato
Among the priority next steps outlined during the first translational epilepsy research workshop in London, United Kingdom (2012), jointly organized by the American Epilepsy Society (AES) and the International League Against Epilepsy (ILAE), are the harmonization of research practices used in preclinical studies and the development of infrastructure that facilitates multicenter preclinical studies. The AES/ILAE Translational Task Force of the ILAE has been pursuing initiatives that advance these goals. In this supplement, we present the first reports of the working groups of the Task Force that aim to improve practices of performing rodent video-electroencephalography (vEEG) studies in experimental controls, generate systematic reviews of preclinical research data, and develop preclinical common data elements (CDEs) for epilepsy research in animals...
November 2017: Epilepsia
https://www.readbyqxmd.com/read/29105071/identification-and-characterization-of-outcome-measures-reported-in-animal-models-of-epilepsy-protocol-for-a-systematic-review-of-the-literature-a-task2-report-of-the-aes-ilae-translational-task-force-of-the-ilae
#8
Michele Simonato, Sloka Iyengar, Amy Brooks-Kayal, Stephen Collins, Antoine Depaulis, David W Howells, Frances Jensen, Jing Liao, Malcolm R Macleod, Manisha Patel, Heidrun Potschka, Matthew Walker, Vicky Whittemore, Emily S Sena
Current antiseizure therapy is ineffective in approximately one third of people with epilepsy and is often associated with substantial side effects. In addition, most current therapeutic paradigms offer treatment, but not cure, and no therapies are able to modify the underlying disease, that is, can prevent or halt the process of epileptogenesis or alleviate the cognitive and psychiatric comorbidities. Preclinical research in the field of epilepsy has been extensive, but unfortunately, not all the animal models being used have been validated for their predictive value...
November 2017: Epilepsia
https://www.readbyqxmd.com/read/29105070/standards-for-data-acquisition-and-software-based-analysis-of-in%C3%A2-vivo-electroencephalography-recordings-from-animals-a-task1-wg5-report-of-the-aes-ilae-translational-task-force-of-the-ilae
#9
Jason T Moyer, Vadym Gnatkovsky, Tomonori Ono, Jakub Otáhal, Joost Wagenaar, William C Stacey, Jeffrey Noebels, Akio Ikeda, Kevin Staley, Marco de Curtis, Brian Litt, Aristea S Galanopoulou
Electroencephalography (EEG)-the direct recording of the electrical activity of populations of neurons-is a tremendously important tool for diagnosing, treating, and researching epilepsy. Although standard procedures for recording and analyzing human EEG exist and are broadly accepted, there are no such standards for research in animal models of seizures and epilepsy-recording montages, acquisition systems, and processing algorithms may differ substantially among investigators and laboratories. The lack of standard procedures for acquiring and analyzing EEG from animal models of epilepsy hinders the interpretation of experimental results and reduces the ability of the scientific community to efficiently translate new experimental findings into clinical practice...
November 2017: Epilepsia
https://www.readbyqxmd.com/read/29105069/methodological-standards-and-functional-correlates-of-depth-in%C3%A2-vivo-electrophysiological-recordings-in-control-rodents-a-task1-wg3-report-of-the-aes-ilae-translational-task-force-of-the-ilae
#10
Amanda E Hernan, Catherine A Schevon, Gregory A Worrell, Aristea S Galanopoulou, Philippe Kahane, Marco de Curtis, Akio Ikeda, Pascale Quilichini, Adam Williamson, Norberto Garcia-Cairasco, Rod C Scott, Igor Timofeev
This paper is a result of work of the AES/ILAE Translational Task Force of the International League Against Epilepsy. The aim is to provide acceptable standards and interpretation of results of electrophysiological depth recordings in vivo in control rodents.
November 2017: Epilepsia
https://www.readbyqxmd.com/read/29103440/effects-of-low-level-laser-irradiation-on-the-rate-of-orthodontic-tooth-movement-and-associated-pain-with-self-ligating-brackets
#11
Irfan Qamruddin, Mohammad Khursheed Alam, Verda Mahroof, Mubassar Fida, Mohd Fadhli Khamis, Adam Husein
INTRODUCTION: The aim of this study was to evaluate the effect of low-level laser irradiation applied at 3-week intervals on orthodontic tooth movement and pain associated with orthodontic tooth movement using self-ligating brackets. METHODS: Twenty-two patients (11 male, 11 female; mean age, 19.8 ± 3.1 years) with Angle Class II Division 1 malocclusion were recruited for this split-mouth clinical trial; they required extraction of maxillary first premolars bilaterally...
November 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29089238/-clinical-and-pathological-definition-of-temporal-medium-epilepsy-subtypes-with-hypocampic-sclerosis
#12
Gonzalo Olivares-Granados, Rosa María Ríos-Pelegrina, Jesús Ruiz-Giménez, Alberto Galdón-Castillo, Teresa Escobar-Delgado, Raimundo García Del Moral
BACKGROUND AND OBJECTIVE: Mesial temporal lobe epilepsy with hippocampal sclerosis is the most common cause of refractory epilepsy, and the most common indication for surgery. Although effective, surgery fails in up to 40% of patients. The objective of our study was to establish a correlation between the different histological subtypes of mesial temporal lobe epilepsy with hippocampal sclerosis and the prognosis, seizures control, side effects and anticonvulsivant drug withdrawal in patients with refractory epilepsy...
October 28, 2017: Neurocirugía
https://www.readbyqxmd.com/read/29065907/regulatory-remodeling-in-the-allo-tetraploid-frog-xenopus-laevis
#13
Dei M Elurbe, Sarita S Paranjpe, Georgios Georgiou, Ila van Kruijsbergen, Ozren Bogdanovic, Romain Gibeaux, Rebecca Heald, Ryan Lister, Martijn A Huynen, Simon J van Heeringen, Gert Jan C Veenstra
BACKGROUND: Genome duplication has played a pivotal role in the evolution of many eukaryotic lineages, including the vertebrates. A relatively recent vertebrate genome duplication is that in Xenopus laevis, which resulted from the hybridization of two closely related species about 17 million years ago. However, little is known about the consequences of this duplication at the level of the genome, the epigenome, and gene expression. RESULTS: The X. laevis genome consists of two subgenomes, referred to as L (long chromosomes) and S (short chromosomes), that originated from distinct diploid progenitors...
October 24, 2017: Genome Biology
https://www.readbyqxmd.com/read/29063584/structural-brain-abnormalities-in-genetic-generalized-epilepsies-a-systematic-review-and-meta-analysis
#14
REVIEW
Shauni Nuyts, Wendyl D'Souza, Stephen C Bowden, Simon J Vogrin
According to the International League Against Epilepsy (ILAE) definition, no structural abnormalities are present on a standard brain magnetic resonance image in genetic generalized epilepsy (GGE) patients. However, recent studies raise contradictory evidence with increasing use of quantitative magnetic resonance imaging techniques. Following PRISMA guidelines, a systematic, quantitative review was conducted using 28 peer-reviewed, case-control studies published after 1989. Furthermore, a meta-analysis with a random-effect model revealed differences in structural brain abnormalities between GGE patients and controls...
October 24, 2017: Epilepsia
https://www.readbyqxmd.com/read/29059623/optimization-of-membrane-unit-location-in-a-full-scale-membrane-bioreactor-using-computational-fluid-dynamics
#15
Qing Wu, Xiaoxu Yan, Kang Xiao, Jing Guan, Tianyu Li, Peng Liang, Xia Huang
The location of membrane units in the membrane tank is a key factor in the construction of a full-scale membrane bioreactor (MBR), as it would greatly affect the hydrodynamics in the tank, which could in turn affect the membrane fouling rate while running. Yet, in most cases, these units were empirically installed in tanks, no theory guides were currently available for the design of a proper location. In this study, the hydrodynamics in the membrane tank of a full-scale MBR was simulated using computational fluid dynamics (CFD)...
October 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29058320/the-transfer-of-crel-contextual-control-same-opposite-less-than-more-than-through-equivalence-relations
#16
William F Perez, Roberta Kovac, Yara C Nico, Daniel M Caro, Adriana P Fidalgo, Ila Linares, João Henrique de Almeida, Júlio C de Rose
According to Relational Frame Theory (RFT) Crel denotes a contextual stimulus that controls a particular type of relational response (sameness, opposition, comparative, temporal, hierarchical etc.) in a given situation. Previous studies suggest that contextual functions may be indirectly acquired via transfer of function. The present study investigated the transfer of Crel contextual control through equivalence relations. Experiment 1 evaluated the transfer of Crel contextual functions for relational responses based on sameness and opposition...
October 23, 2017: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/29057851/type-and-etiology-of-pediatric-epilepsy-in-jordan-a-multi-center-study
#17
Abdelkarim A Al-Qudah, Abla Albsoul-Younes, Amira T Masri, Samah K AbuRahmah, Ibrahim A Alabadi, Omar A Nafi, Lubna F Gharaibeh, Amer A Murtaja, Lina H Al-Sakran, Haya A Arabiat, Abdallah A Al-Shorman
OBJECTIVE: To study types and etiologies of epilepsy in Jordanian pediatric epileptic patients maintained on antiepileptic drugs using customized classification scheme of International League Against Epilepsy (ILAE) (2010) report. METHODS: This is a cross-sectional, multi-centre study on pediatric epileptic patients on antiepileptic drugs, who were managed in the pediatric neurology clinics at 6 teaching public hospitals in Jordan. RESULTS: Out of the 663 patients included in the study, (90...
October 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29050067/-neuropathologic-findings-in-intractable-epilepsy-a-clinicopathologic-analysis-of-822-cases
#18
Z J Duan, K Yao, J Zhou, L Li, F Zhai, C Q Liu, Z Ma, Y Bian, G M Luan, X L Qi
Objective: To investigate the clinicopathologic characteristics of intractable epilepsy. Methods: Based on the classification criteria proposed by the International League Against Epilepsy (ILAE), a retrospective analysis of the pathological characteristics was done in 822 patients who underwent epilepsy surgery in Sanbo Brain Hospital, Capital Medical University, from June 2008 to December 2012. Results: The mean age of epilepsy onset was 9.9 years, mean duration of epilepsy was 11.9 years. Complex partial seizures were the main presenting features...
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29047494/on-the-validity-of-the-integral-localized-approximation-for-bessel-beams-and-associated-radiation-pressure-forces
#19
Leonardo A Ambrosio, Jiajie Wang, Gérard Gouesbet
In this paper we investigate the integral version of the localized approximation (ILA)-a powerful technique for evaluating the beam shape coefficients in the framework of the generalized Lorenz-Mie theory-as applied to ideal scalar Bessel beams (BBs). Originally conceived for arbitrary shaped beams with a propagating factor exp(±ikz), it has recently been shown that care must be taken when applying the ILA for the case of ideal scalar BBs, since they carry a propagating factor exp(±ikz cos α), with α being the axicon angle, which cannot be smoothly accommodated into its mathematical formalism...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29043847/smoking-related-interstitial-fibrosis-evidence-of-radiologic-regression-with-advancing-age-and-smoking-cessation
#20
Aurélie Fabre, Ann Treacy, Lisa P Lavelle, Maciek Narski, Nazia Faheem, David Healy, Jonathan D Dodd, Michael P Keane, James J Egan, Gilles Jebrak, Hervé Mal, Marcus W Butler
More data are needed regarding the radiology, co-morbidities and natural history of smoking-related interstitial fibrosis (SRIF), a common pathological finding, mainly described heretofore in association with lung cancer, where respiratory bronchiolitis (RB) usually co-exists. We prospectively acquired high resolution CT scan data (edge-enhancing lung reconstructions) to detect any radiologic interstitial lung abnormality (ILA) in individuals who ultimately underwent surgical lobectomy for lung cancer (n = 20), for radiologic/pathologic correlation...
October 18, 2017: COPD
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