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https://www.readbyqxmd.com/read/28322853/the-role-of-histopathologic-subtype-in-the-setting-of-hippocampal-sclerosis-associated-mesial-temporal-lobe-epilepsy
#1
Jordan M Gales, Lara Jehi, Amy Nowacki, Richard A Prayson
Hippocampal sclerosis (HS) and focal cortical dysplasia (FCD) are among the most common neuropathological findings in those undergoing surgery for refractory mesial temporal lobe epilepsy (MTLE). Existing data regarding differences among the most recent International League Against Epilepsy (ILAE) HS subtypes remains limited. This study sought to characterize the roles of HS subtype and coexistent FCD. Epilepsy surgery pathologic specimens in 307 cases of temporal lobe epilepsy with HS were reviewed (mean age ± SD, 37 ± 15 years, 56% women)...
March 17, 2017: Human Pathology
https://www.readbyqxmd.com/read/28299938/synthesis-of-substituted-benzo-b-thiophenes-via-sequential-one-pot-copper-catalyzed-intermolecular-c-s-bond-formation-and-palladium-catalyzed-intramolecular-arene-alkene-coupling-of-bis-het-aryl-alkyl-1-3-monothiodiketones-and-o-bromoiodoarenes
#2
Somaraju Yugandar, Saidulu Konda, Hiriyakkanavar Ila
A new, convergent, one-pot synthesis of 2,3-substituted benzo[b]thiophenes from readily available 1,3-bis(het)aryl-1,3-monothiodiketones and o-bromoiodoarenes involving a sequential copper-catalyzed intermolecular C-S coupling followed by palladium-catalyzed intramolecular arene-alkene coupling of in situ generated β-(o-bromoaryl)thiovinylketones has been described. Synthesis of a few thieno- and furano-fused 2-(het)aroylethylidenethiochromenes via intramolcular direct C-H (het)arylation of β-(o-bromoaryl)thioenones carrying 2-thienyl/furyl groups under different palladium-catalyzed conditions has also been reported...
March 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/28295708/seasonal-alterations-in-the-daily-rhythms-in-hypothalamic-expression-of-genes-involved-in-the-photoperiodic-transduction-and-neurosteroid-dependent-processes-in-migratory-blackheaded-buntings
#3
Ila Mishra, Devraj Singh, Vinod Kumar
This study investigated seasonal alterations in the daily rhythms of hypothalamic expression of genes involved in the photoperiodic regulation of annual cycles in birds. We measured 4-hourly mRNA expression of genes involved in the photoperiodic transduction (OPN5, EYA3, CGA, TSHβ, DIO2, DIO3) and neurosteroid-dependent processes (AR, CYP19, ERα, ERβ) in the hypothalamus of migratory blackheaded buntings photoinduced with photosensitive, photostimulated (early and late stimulated) and photorefractory seasonal states...
March 14, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28294303/a-disease-disorder-illness-or-condition-how-to-label-epilepsy
#4
A J Noble, A Robinson, A G Marson
The International League Against Epilepsy (ILAE) is an important source of guidance for health professionals when it comes to epilepsy. Their latest recommendation that epilepsy should no longer be called a "disorder," but a "disease" has though caused controversy. The ILAE contends the change will improve epilepsy's image. Some clinicians and other organizations fear the change may not though be accepted by patients as in common parlance "disease" can be associated with "contagiousness"/"infection." To allow practicing clinicians to make informed judgements about what language they use, we completed the first study to assess the preferences of those with epilepsy and significant others and explore if any of their characteristics were associated with preference...
March 14, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28276064/instruction-manual-for-the-ilae-2017-operational-classification-of-seizure-types
#5
Robert S Fisher, J Helen Cross, Carol D'Souza, Jacqueline A French, Sheryl R Haut, Norimichi Higurashi, Edouard Hirsch, Floor E Jansen, Lieven Lagae, Solomon L Moshé, Jukka Peltola, Eliane Roulet Perez, Ingrid E Scheffer, Andreas Schulze-Bonhage, Ernest Somerville, Michael Sperling, Elza Márcia Yacubian, Sameer M Zuberi
This companion paper to the introduction of the International League Against Epilepsy (ILAE) 2017 classification of seizure types provides guidance on how to employ the classification. Illustration of the classification is enacted by tables, a glossary of relevant terms, mapping of old to new terms, suggested abbreviations, and examples. Basic and extended versions of the classification are available, depending on the desired degree of detail. Key signs and symptoms of seizures (semiology) are used as a basis for categories of seizures that are focal or generalized from onset or with unknown onset...
March 8, 2017: Epilepsia
https://www.readbyqxmd.com/read/28276062/ilae-classification-of-the-epilepsies-position-paper-of-the-ilae-commission-for-classification-and-terminology
#6
Ingrid E Scheffer, Samuel Berkovic, Giuseppe Capovilla, Mary B Connolly, Jacqueline French, Laura Guilhoto, Edouard Hirsch, Satish Jain, Gary W Mathern, Solomon L Moshé, Douglas R Nordli, Emilio Perucca, Torbjörn Tomson, Samuel Wiebe, Yue-Hua Zhang, Sameer M Zuberi
The International League Against Epilepsy (ILAE) Classification of the Epilepsies has been updated to reflect our gain in understanding of the epilepsies and their underlying mechanisms following the major scientific advances that have taken place since the last ratified classification in 1989. As a critical tool for the practicing clinician, epilepsy classification must be relevant and dynamic to changes in thinking, yet robust and translatable to all areas of the globe. Its primary purpose is for diagnosis of patients, but it is also critical for epilepsy research, development of antiepileptic therapies, and communication around the world...
March 8, 2017: Epilepsia
https://www.readbyqxmd.com/read/28276060/operational-classification-of-seizure-types-by-the-international-league-against-epilepsy-position-paper-of-the-ilae-commission-for-classification-and-terminology
#7
Robert S Fisher, J Helen Cross, Jacqueline A French, Norimichi Higurashi, Edouard Hirsch, Floor E Jansen, Lieven Lagae, Solomon L Moshé, Jukka Peltola, Eliane Roulet Perez, Ingrid E Scheffer, Sameer M Zuberi
The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure types, and to adopt more transparent names. Because current knowledge is insufficient to form a scientifically based classification, the 2017 Classification is operational (practical) and based on the 1981 Classification, extended in 2010...
March 8, 2017: Epilepsia
https://www.readbyqxmd.com/read/28274064/prosthetic-rehabilitation-of-completely-blind-subject-with-bilateral-customised-ocular-prosthesis-a-case-report
#8
Chetan Pathak, Salil Pawah, Gurpreet Singh, Ila Yadav, Shrey Kundra
The special sensory organs play significant role in our daily lives. Until one of them is totally or partially lost, its real value is not fully appreciated. The most tragic, yet common loss of sensory organ is that of an eye. Restoration of unilateral ocular defects is very challenging for a maxillofacial prosthodontist and requires great skill to mimic bilateral eye. Restoration of bilateral defects using customized eye prosthesis presents even more difficult task for clinician especially in communication with patient, impression procedures, and patient education regarding insertion, removal and maintenance of prosthesis...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28247928/advancing-alternatives-analysis-the-role-of-predictive-toxicology-in-selecting-safer-chemical-products-and-processes
#9
Timothy Malloy, Virginia Zaunbrecher, Elizabeth Beryt, Richard Judson, Raymond Tice, Patrick Allard, Ann Blake, Ila Cote, Hilary Godwin, Lauren Heine, Patrick Kerzic, Jakub Kostal, Gary Marchant, Jennifer McPartland, Kelly Moran, Andre Nel, Oladele Oguseitan, Mark Rossi, Kristina Thayer, Joel Tickner, Margaret Whittaker, Ken Zarker
Alternatives analysis (AA) is a method used in regulation and product design to identify, assess, and evaluate the safety and viability of potential substitutes for hazardous chemicals. It requires toxicological data for the existing chemical and potential alternatives. Predictive toxicology uses in silico and in vitro approaches, computational models, and other tools to expedite toxicological data generation in more cost-effective manner than traditional approaches. This article briefly reviews the challenges associated with using predictive toxicology in regulatory AA, then presents four recommendations for its advancement...
March 1, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28247517/hematology-oncology-pharmacy-association-entry-level-competencies-task-force-response-statement-to-the-2016-american-college-of-clinical-pharmacy-accp-pharmacotherapy-didactic-curriculum-toolkit
#10
Ginah Nightingale, Ila M Saunders, Jill M Comeau, Karen Fancher, Tim Miller, Cindy O'Bryant, Jason Yeh
As more disease states have an increasing number of therapeutic options, pharmacy schools are continuously challenged to provide pharmacy students with a comprehensive education in a finite amount of time. It is particularly challenging to determine which diseases and associated therapeutic options should be included in the curriculum. The 2016 ACCP Pharmacotherapy Didactic Curriculum Toolkit seeks to provide clarity and guidance to schools and colleges of pharmacy to assist with curricular development.(1) Oncologic disorders are a vital part of the pharmacy curricula and are taught in the majority of colleges of pharmacy in the United States in the didactic and experiential setting...
March 1, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28246042/discovery-of-substituted-oxadiazoles-as-a-novel-scaffold-for-dna-gyrase-inhibitors
#11
Žiga Jakopin, Janez Ilaš, Michaela Barančoková, Matjaž Brvar, Päivi Tammela, Marija Sollner Dolenc, Tihomir Tomašič, Danijel Kikelj
DNA gyrase and topoisomerase IV are type IIa topoisomerases that are essential bacterial enzymes required to oversee the topological state of DNA during transcription and replication processes. Their ATPase domains, GyrB and ParE, respectively, are recognized as viable targets for small molecule inhibitors, however, no synthetic or natural product GyrB/ParE inhibitors have so far reached the clinic for use as novel antibacterial agents, except for novobiocin which was withdrawn from the market. In the present study, a series of substituted oxadiazoles have been designed and synthesized as potential DNA gyrase inhibitors...
April 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28230705/determinant-variables-enteric-pathogen-burden-gut-function-and-immune-related-inflammatory-biomarkers-associated-with-childhood-malnutrition-a-prospective-case-control-study-in-northeastern-brazil
#12
Aldo Am Lima, Álvaro M Leite, Alessandra Di Moura, Noélia L Lima, Alberto M Soares, Cláudia B Abreu, José Quirino Filho, Rosa Ms Mota, Ila Fn Lima, Alexandre Havt, Pedro Hqs Medeiros, Mara Mg Prata, Marjorie M Guedes, Paloma A Cavalcante, Herlice N Veras, Ana Ks Santos, Sean R Moore, Relana C Pinkerton, Eric R Houpt, Richard L Guerrant
Malnutrition results in serious consequences for growth and cognitive development in children. We studied select child and maternal biological factors, socio-economic factors, enteric pathogenic burden, and gut function biomarkers in 402 children 6-24 months of age in North-eastern Brazil. In this prospective case-control study, not being fed colostrum (odds ratio [OR] = 3.29, 95% confidence interval [CI] 1.73-6.26), maternal age ≥18 years (OR = 1.88, 95% CI 1.10-3.22), and no electrical fan (OR = 2.46, 95% CI 1...
February 22, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28230254/resistance-to-valproic-acid-as-predictor-of-treatment-resistance-in-genetic-generalized-epilepsies
#13
Joanna Gesche, Marina Khanevski, Carl Solberg, Christoph Patrick Beier
This study aimed at defining clinical predictors of drug resistance in adults with genetic generalized epilepsy (GGE) who were treated with a broad spectrum of antiepileptic drugs. Of a cohort of 137 unselected adult GGE patients with long-term follow up, clinical and demographic data, putative prognostic factors (e.g., psychiatric comorbidities, electroencephalography [EEG]), treatment response, and data indicative of social status were collected. Fifty-eight patients had seizures within the past year. Thirty-three patients met the definition of "drug-resistant epilepsy" according to the International League Against Epilepsy (ILAE) definition...
February 23, 2017: Epilepsia
https://www.readbyqxmd.com/read/28202823/-participation-of-people-with-epilepsy-in-sports
#14
Sadatoshi Tsuji
People with epilepsy (PWE) have been discouraged from participating in exercise and sports because of the fear of inducing seizures or increasing seizure frequency, risks associated with such activities, stigma, and overprotection. Recently, there has been a shift in the medical recommendations toward encouraging, rather than restricting, participation. Cases of exercise-induced seizures are rare. Physical activity can exert beneficial actions, such as a reduction in seizure susceptibility and the number of seizures, improvement in quality of life (QOL), and better social integration...
February 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28195252/pathological-assessment-of-epilepsy-surgery-brain-tissue
#15
G Marucci, M Giulioni
Surgical resection represents a successful strategy to achieve seizure control in patients with drug resistant epilepsy. In the last years increasing importance has been recognized to pathological substrate for epilepsy classifications and for predicting seizure and neuropsychological outcome after surgery. The current histopathological classifications of epilepsy-associated abnormalities certainly represent an amazing effort to overcome the limits of the previous classifications and constitute a formidable tool in the management of patients after epilepsy surgery...
June 2016: Pathologica
https://www.readbyqxmd.com/read/28142100/epilepsy-and-treatment-gap-in-urban-and-rural-areas-of-the-southern-kazakhstan-in-adults
#16
Alla Guekht, Nazira Zharkinbekova, Alexander Shpak, W Allen Hauser
PURPOSE: There are no data in the English literature about the epidemiology of epilepsy in the large countries in the Asian region of the former Soviet Union. This paper presents the results of epidemiological studies of active epilepsy in the population 14years of age and older in the Province of South Kazakhstan. METHODS: The study population consisted of 306.44 thousand persons: 139.42 in the urban Enbekshinskiy district of the city of Shymkent and 167.02 in the rural Sairam district...
February 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28139515/clinical-analysis-of-partial-epilepsy-with-auras
#17
Yang Liu, Xiao-Ming Guo, Xun Wu, Ping Li, Wei-Wei Wang
BACKGROUND: An aura is usually considered to be the initial clinical sign of a seizure. The types of abnormal neuron activities (i.e., localized and generalized firing) play an important role in the diagnosis of epilepsy. The goal of this study was to investigate the types of auras and its correlation with the localization and treatment of epilepsy. METHODS: The 426 epileptic patients with auras from a single center were reviewed with reference to International League Against Epilepsy (ILAE, 1981) classification; the clinical manifestations and incidence of auras were analyzed in this retrospective study, as well as the results of electroencephalogram (EEG), brain magnetic resonance imaging (MRI) and the treatment methods...
February 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28097245/consideration-of-proper-operative-route-for-interlaminar-approach-for-percutaneous-endoscopic-lumbar-discectomy
#18
Juichi Tonosu, Yasushi Oshima, Ryutaro Shiboi, Akihiko Hayashi, Yuichi Takano, Hirohiko Inanami, Hisashi Koga
BACKGROUND: Percutaneous endoscopic lumbar discectomy (PELD) is one of the less invasive treatments of lumbar disc herniation (LDH), and has three different operative approaches. This study focused on the interlaminar approach (ILA) and investigated the appropriate operative route for this approach. METHODS: ILA was performed in 41 patients with LDH. The width of the interlaminar space, LDH size, and positional relation between LDH and the corresponding nerve root were radiologically evaluated...
December 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28096411/hepatitis-e-virus-orf3-is-a-functional-ion-channel-required-for-release-of-infectious-particles
#19
Qiang Ding, Brigitte Heller, Juan M V Capuccino, Bokai Song, Ila Nimgaonkar, Gabriela Hrebikova, Jorge E Contreras, Alexander Ploss
Hepatitis E virus (HEV) is the leading cause of enterically transmitted viral hepatitis globally. Of HEV's three ORFs, the function of ORF3 has remained elusive. Here, we demonstrate that via homophilic interactions ORF3 forms multimeric complexes associated with intracellular endoplasmic reticulum (ER)-derived membranes. HEV ORF3 shares several structural features with class I viroporins, and the function of HEV ORF3 can be maintained by replacing it with the well-characterized viroporin influenza A virus (IAV) matrix-2 protein...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28093803/novel-ecg-synchronized-pulsatile-ecls-system-with-various-heart-rates-and-cardiac-arrhythmias-an-in-vitro-study
#20
Shigang Wang, Shannon B Spencer, Allen R Kunselman, Akif Ündar
The objective of this study is to evaluate electrocardiography (ECG)-synchronized pulsatile flow under varying heart rates and different atrial and ventricular arrhythmias in a simulated extracorporeal life support (ECLS) system. The ECLS circuit consisted of an i-cor diagonal pump and console, an iLA membrane ventilator, and an 18 Fr arterial cannula. The circuit was primed with lactated Ringer's solution and packed red blood cells (hematocrit 35%). An ECG simulator was used to trigger pulsatile flow and to generate selected cardiac rhythms...
January 2017: Artificial Organs
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