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https://www.readbyqxmd.com/read/29339639/mri-guided-interstitial-laser-ablation-for-intracranial-lesions-a-large-single-institution-experience-of-133-cases
#1
Ashwin A Kamath, Daniel D Friedman, Carl D Hacker, Matthew D Smyth, David D Limbrick, Albert H Kim, Ammar H Hawasli, Eric C Leuthardt
BACKGROUND: Managing difficult-to-access lesions or surgically accessible lesions in fragile patients is a central problem in neurosurgery. MRI-guided interstitial laser ablation (ILA) is a minimally invasive option that may provide a safe means of treating these challenging patients. OBJECTIVE: We aim to (1) evaluate safety, efficacy, and preliminary outcomes within a diverse and large series of ILA treatments; and (2) report technical details and operative trends that proved useful over time in the authors' experience and that may be of use to neurosurgeons who perform ILA...
January 17, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29336036/the-incidence-and-significance-of-periictal-apnea-in-epileptic-seizures
#2
Nuria Lacuey, Bilal Zonjy, Johnson P Hampson, M R Sandhya Rani, Anita Zaremba, Rup K Sainju, Brian K Gehlbach, Stephan Schuele, Daniel Friedman, Orrin Devinsky, Maromi Nei, Ronald M Harper, Luke Allen, Beate Diehl, John J Millichap, Lisa Bateman, Mark A Granner, Deidre N Dragon, George B Richerson, Samden D Lhatoo
OBJECTIVE: The aim of this study was to investigate periictal central apnea as a seizure semiological feature, its localizing value, and possible relationship with sudden unexpected death in epilepsy (SUDEP) pathomechanisms. METHODS: We prospectively studied polygraphic physiological responses, including inductance plethysmography, peripheral capillary oxygen saturation (SpO2 ), electrocardiography, and video electroencephalography (VEEG) in 473 patients in a multicenter study of SUDEP...
January 16, 2018: Epilepsia
https://www.readbyqxmd.com/read/29333520/application-of-epigenetic-data-in-human-health-risk-assessment
#3
Ila L Cote, Shaun D McCullough, Ronald N Hines, John J Vandenberg
Despite the many recent advances in the field of epigenetics, application of this knowledge in environmental health risk assessment has been limited. In this paper, we identify opportunities for application of epigenetic data to support health risk assessment. We consider current applications and present a vision for the future.
November 6, 2017: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/29327337/generalized-nonmotor-absence-seizures-what-do-absence-generalized-and-nonmotor-mean
#4
REVIEW
Iris Unterberger, Eugen Trinka, Peter W Kaplan, Gerald Walser, Gerhard Luef, Gerhard Bauer
OBJECTIVE: Clinical absences are now classified as "generalized nonmotor (absence) seizures" by the International League Against Epilepsy (ILAE). The aim of this paper is to critically review the concept of absences and to put the accompanying focal and motor symptoms into the context of the emerging pathophysiological knowledge. METHODS: For this narrative review we performed an extensive literature search on the term "absence," and analyzed the plethora of symptoms observed in clinical absences...
January 11, 2018: Epilepsia
https://www.readbyqxmd.com/read/29320479/paternal-chromosome-loss-and-metabolic-crisis-contribute-to-hybrid-inviability-in-xenopus
#5
Romain Gibeaux, Rachael Acker, Maiko Kitaoka, Georgios Georgiou, Ila van Kruijsbergen, Breanna Ford, Edward M Marcotte, Daniel K Nomura, Taejoon Kwon, Gert Jan C Veenstra, Rebecca Heald
Hybridization of eggs and sperm from closely related species can give rise to genetic diversity, or can lead to embryo inviability owing to incompatibility. Although central to evolution, the cellular and molecular mechanisms underlying post-zygotic barriers that drive reproductive isolation and speciation remain largely unknown. Species of the African clawed frog Xenopus provide an ideal system to study hybridization and genome evolution. Xenopus laevis is an allotetraploid with 36 chromosomes that arose through interspecific hybridization of diploid progenitors, whereas Xenopus tropicalis is a diploid with 20 chromosomes that diverged from a common ancestor approximately 48 million years ago...
January 10, 2018: Nature
https://www.readbyqxmd.com/read/29319369/the-ilae-classification-of-seizures-and-epilepsies-implications-for-the-clinic
#6
Ettore Beghi, Josemir W Sander
The classification of epileptic seizures and the epilepsies has recently been revised by the International League Against Epilepsy (ILAE) and a new classification scheme issued. Areas covered: The new classification scheme has been critically appraised in the light of the previous classifications and subsequent revisions. The purposes of the classification and its potential use have been extensively discussed. Expert Commentary: This ILAE classification scheme, the latest of a series of proposals published in the last thirty years, has made progress as it has a multi-level structure (seizure types, epilepsy types, epilepsy syndromes) allowing for differing uses and combines the previously separate seizure types and epilepsies schemes into a single instrument...
January 10, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29310076/epilepsy-in-an-elderly-population-classification-etiology-and-drug-resistance
#7
Lizbeth Hernández-Ronquillo, Scott Adams, Stephanie Ballendine, Jose F Téllez-Zenteno
PURPOSE: To characterize epilepsy in an elderly population and describe the prevalence of drug resistant epilepsy (DRE) using recently validated International League Against Epilepsy (ILAE) criteria. METHODS: Using a case-control design, 72 patients aged 60 years and older (cases) and 223 patients under age 60 (controls) were identified from the Saskatchewan Epilepsy Program database. Patients' charts were retrospectively reviewed. Bivariate and multiple logistic regression analyses were performed to identify variables that were associated with epilepsy in elderly patients...
January 3, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29281985/deep-convolutional-neural-networks-for-pan-specific-peptide-mhc-class-i-binding-prediction
#8
Youngmahn Han, Dongsup Kim
BACKGROUND: Computational scanning of peptide candidates that bind to a specific major histocompatibility complex (MHC) can speed up the peptide-based vaccine development process and therefore various methods are being actively developed. Recently, machine-learning-based methods have generated successful results by training large amounts of experimental data. However, many machine learning-based methods are generally less sensitive in recognizing locally-clustered interactions, which can synergistically stabilize peptide binding...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29273691/neuropsychological-outcome-after-subtemporal-versus-transsylvian-approach-for-selective-amygdalohippocampectomy-in-patients-with-mesial-temporal-lobe-epilepsy-a-randomised-prospective-clinical-trial
#9
Viola Lara Vogt, Daniel Delev, Alexander Grote, Johannes Schramm, Marec von Lehe, Christian Erich Elger, Juri-Alexander Witt, Christoph Helmstaedter
OBJECTIVE: To compare the effects of different surgical approaches for selective amygdalohippocampectomy in patients with pharmacoresistant mesial temporal lobe epilepsy with regard to the neuropsychological outcome and to replicate an earlier study employing a matched-pair design. METHOD: 47 patients were randomised to subtemporal versus transsylvian approaches. Memory, language, attentional and executive functions were assessed before and 1 year after surgery...
December 22, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29273324/temporal-expression-of-c-fos-and-genes-coding-for-neuropeptides-and-enzymes-of-amino-acid-and-amine-neurotransmitter-biosynthesis-in-retina-pineal-and-hypothalamus-of-a-migratory-songbird-evidence-for-circadian-rhythm-dependent-seasonal-responses
#10
Ila Mishra, Devraj Singh, Vinod Kumar
This study investigated whether, in photoperiodic songbirds, the circadian pacemaker system (CPS) connects to the seasonal photoperiodic responses, by changes at transcriptional level in the level and 24-h rhythm of its constituent neurotransmitters. We used blackheaded buntings (Emberiza melanocephala), which exhibits distinct seasonal states in captivity under appropriate photoperiods and hence served as a useful model system. Under short days, buntings remain in the photosensitive state (winter phenotype: non-migratory, non-breeding)...
December 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/29259078/astrovirus-infection-and-diarrhea-in-8-countries
#11
Maribel Paredes Olortegui, Saba Rouhani, Pablo Peñataro Yori, Mery Siguas Salas, Dixner Rengifo Trigoso, Dinesh Mondal, Ladaporn Bodhidatta, James Platts-Mills, Amidou Samie, Furqan Kabir, Aldo Lima, Sudhir Babji, Sanjaya Kumar Shrestha, Carl J Mason, Adil Kalam, Pascal Bessong, Tahmeed Ahmed, Estomih Mduma, Zulfiqar A Bhutta, Ila Lima, Rakhi Ramdass, Lawrence H Moulton, Dennis Lang, Ajila George, Anita K M Zaidi, Gagandeep Kang, Eric R Houpt, Margaret N Kosek
BACKGROUND AND OBJECTIVES: Astroviruses are important drivers of viral gastroenteritis but remain understudied in community settings and low- and middle-income countries. We present data from 8 countries with high prevalence of diarrhea and undernutrition to describe astrovirus epidemiology and assess evidence for protective immunity among children 0 to 2 years of age. METHODS: We used 25 898 surveillance stools and 7077 diarrheal stools contributed by 2082 children for enteropathogen testing, and longitudinal statistical analysis to describe incidence, risk factors, and protective immunity...
December 19, 2017: Pediatrics
https://www.readbyqxmd.com/read/29246506/age-related-changes-of-skeletal-muscle-mass-and-strength-among-italian-and-taiwanese-older-people-results-from-the-milan-expo-2015-survey-and-the-i-lan-longitudinal-aging-study
#12
Emanuele Marzetti, An-Chun Hwang, Matteo Tosato, Li-Ning Peng, Riccardo Calvani, Anna Picca, Liang-Kung Chen, Francesco Landi
BACKGROUND: Muscle mass and strength ineluctably decline with advancing age. Yet, the impact of ethnicity on the pattern of changes and their magnitude is unclear. The aims of the present study were to analyze age- and gender-specific changes in measures of muscle mass and strength among community-living persons and to identify differences between Caucasian and Asian participants. METHODS: The Italian survey ("Longevity Check-up"), conducted during Milan EXPO 2015, consisted of a population assessment aimed at evaluating the prevalence of specific health metrics in persons outside of a conventional research setting (n=1924), with a special focus on muscle mass and strength...
December 12, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29239018/design-synthesis-and-biological-evaluation-of-1-ethyl-3-thiazol-2-yl-urea-derivatives-as-escherichia-coli-dna-gyrase-inhibitors
#13
Tihomir Tomašič, Michaela Barančoková, Nace Zidar, Janez Ilaš, Päivi Tammela, Danijel Kikelj
Discovery of novel DNA gyrase B inhibitors remains an attractive field in the search for new antibacterial drugs to overcome the known bacterial resistance mechanisms. In the present study, we designed and synthesized novel ethylurea derivatives of 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine, 2-(2-aminothiazol-4-yl)acetic acid, and benzo[1,2-d]thiazole-2,6-diamine and evaluated their Escherichia coli DNA gyrase inhibition. The most potent DNA gyrase inhibitors in the prepared library of compounds were benzo[1,2-d]thiazoles 32-34, 36, and 37 with IC50 values in the low micromolar range...
December 14, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29218288/giant-anterior-neck-lipoma-with-bleeding-pressure-ulcer-in-an-elderly-man-a-rare-entity
#14
Gaurav Jain, Ila Tyagi, Leela Pant, Namrata Nargotra
Giant lipomas are benign soft tissue tumors found rarely in the neck and are still rarer in the anterior part of the neck. A 70-year-old male patient was presented with a huge swelling measuring 35 cm in maximum dimension, in the front of the neck, reaching up till the umbilicus. The swelling was painless, slow growing and acquired the huge size in approximately 20 years. Ultrasound and CT scan findings were suggestive of a soft tissue lesion. Fine needle aspiration cytology yielded mature adipose tissue fragments...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29217611/air-pollution-and-subclinical-interstitial-lung-disease-the-multi-ethnic-study-of-atherosclerosis-mesa-air-lung-study
#15
Coralynn Sack, Sverre Vedal, Lianne Sheppard, Ganesh Raghu, R Graham Barr, Anna Podolanczuk, Brent Doney, Eric A Hoffman, Amanda Gassett, Karen Hinckley-Stukovsky, Kayleen Williams, Steve Kawut, David J Lederer, Joel D Kaufman
We studied whether ambient air pollution is associated with interstitial lung abnormalities (ILAs) and high attenuation areas (HAAs), which are qualitative and quantitative measurements of subclinical interstitial lung disease (ILD) on computed tomography (CT).We performed analyses of community-based dwellers enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) study. We used cohort-specific spatio-temporal models to estimate ambient pollution (fine particulate matter (PM2.5), nitrogen oxides (NOx), nitrogen dioxide (NO2) and ozone (O3)) at each home...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29217418/molecular-characterization-of-virulence-and-antimicrobial-resistance-profile-of-shigella-species-isolated-from-children-with-moderate-to-severe-diarrhea-in-northeastern-brazil
#16
Pedro Henrique Quintela Soares Medeiros, Aldo Ângelo Moreira Lima, Marjorie Moreira Guedes, Alexandre Havt, Mariana Duarte Bona, Luís Carlos Rey, Alberto Melo Soares, Richard Littleton Guerrant, Bernhard H Weigl, Ila Fernanda Nunes Lima
Molecular characterization of virulence and antimicrobial resistance profiles were determined for Shigella species isolated from children with diarrhea in Fortaleza, Brazil. Fecal specimens were collected along with socioeconomic and clinical data from children with moderate to severe diarrhea requiring emergency care. Shigella spp. were isolated by standard microbiological techniques, and we developed 4 multiplex polymerase chain reaction assays to detect 16 virulence-related genes (VRGs). Antimicrobial susceptibility tests were performed using disk diffusion assays...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29211169/artisanal-fisherwomen-shellfish-gatherers-analyzing-the-impact-of-upper-limb-functioning-and-disability-on-health-related-quality-of-life
#17
Juliana Dos Santos Müller, Ila Rocha Falcão, Maria Carolina Barreto Moreira Couto, Wendel da Silva Viana, Ivone Batista Alves, Denise Nunes Viola, Courtney Georgette Woods, Rita de Cássia Franco Rêgo
The aim is to analyze upper limb functioning and disability, and its association with health-related quality of life among artisanal fisherwomen from Bahia, Brazil. Cross-sectional epidemiological study was conducted with a sample of 209 fisherwomen. Structured questionnaires were used for socio-demographic and comorbidity information, as well as the instruments Disabilities of the Arm, Shoulder and Hand (DASH) and Short-Form Healthy Survey (SF-36) respectively, to evaluate the upper limbs and health-related quality of life...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29207938/characterization-of-collaborative-practice-agreements-held-by-hematopoietic-stem-cell-transplant-pharmacists
#18
Amy Bryk, Susannah Koontz, JoAl Mayor, Jeffrey Betcher, Rebecca Tombleson, Ryan Bookout, Ila M Saunders
Background Current workforce shortages within the hematopoietic stem cell transplant field necessitate capitalizing on the role of oncology-trained pharmacists. Working within an agreed-upon protocol, pharmacists are able to expand patient care delivery through optimal medication therapy management. Methods An electronic survey was developed by the Advocacy & Policy Working Committee of the American Society for Blood and Marrow Transplantation Pharmacy Special Interest Group and distributed to pharmacists involved in the care of hematopoietic stem cell transplant patients...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29206345/synthesis-and-evaluation-of-n-phenylpyrrolamides-as-dna-gyrase-b-inhibitors
#19
Martina Durcik, Päivi Tammela, Michaela Barančoková, Tihomir Tomašič, Janez Ilaš, Danijel Kikelj, Nace Zidar
ATP-competitive inhibitors of DNA gyrase and topoisomerase IV (topo IV) are among the most interesting classes of antibacterial drugs that do not have any representative in the antibacterial pipeline. We have developed thirty-two new N-phenylpyrrolamides and evaluated them against DNA gyrase and topoisomerase IV from Escherichia coli and Staphylococcus aureus. Antibacterial activities were studied against Gram-positive and Gram-negative bacterial strains. The most potent compound displayed an IC50 of 47 nM against E...
December 5, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29203588/spatially-resolved-and-quantitative-analysis-of-vista-pd-1h-as-a-novel-immunotherapy-target-in-human-non-small-cell-lung-cancer
#20
Franz Villarroel-Espindola, Xiaoqing Yu, Ila Datar, Nikita Mani, Miguel F Sanmamed, Vamsidhar Velcheti, Konstantinos N Syrigos, Maria I Toki, Hongyu Zhao, Lieping Chen, Roy S Herbst, Kurt A Schalper
PURPOSE: Determine the localized expression pattern and clinical significance of VISTA/PD-1H in human NSCLC. EXPERIMENTAL DESIGN: Using multiplex quantitative immunofluorescence (QIF), we performed localized measurements of VISTA, PD-1 and PD-L1 protein in 758 stage I-IV NSCLCs from 3 independent cohorts represented in tissue microarray format. The targets were selectively measured in cytokeratin+ tumor epithelial cells, CD3+ T-cells, CD4+ T-helper cells, CD8+ cytotoxic T-cells, CD20+ B-lymphocytes and CD68+ tumor-associated macrophages...
December 4, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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