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Physica therapy

Steve Webb
In this invited opening Plenary Lecture at the 1st European Conference on Medical Physics, I indicated some of the roles of medical physics, and specifically medical radiation therapy physics, in the development of improved cancer care for the third millennium. It is said that you are only asked to predict the future if you are seriously old and/or will not be around long enough to know if you were correct. Hopefully, however, I will be able to contribute to this field for many years to come and many of my suggestions will be enacted...
June 2008: Physica Medica: PM
Antonio Cappuccio, Filippo Castiglione, Benedetto Piccoli
Cancer immunotherapy aims at eliciting an immune system response against the tumor. However, it is often characterized by toxic side-effects. Limiting the tumor growth and, concurrently, avoiding the toxicity of a drug, is the problem of protocol design. We formulate this question as an optimization problem and derive an algorithm for its solution. Unlike the standard optimal control approach, the algorithm simulates impulse-like drug administrations. It relies on an exact computation of the gradient of the cost function with respect to any protocol by means of the variational equations, that can be solved in parallel with the system...
September 2007: Mathematical Biosciences
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