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Anemia in pregnancy

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https://www.readbyqxmd.com/read/29928025/malaria-during-pregnancy-and-newborn-outcome-in-an-unstable-transmission-area-in-brazil-a-population-based-record-linkage-study
#1
Jamille Gregório Dombrowski, Rodrigo Medeiros de Souza, Natércia Regina Mendes Silva, André Barateiro, Sabrina Epiphanio, Lígia Antunes Gonçalves, Claudio Romero Farias Marinho
BACKGROUND: Malaria in pregnancy (MiP) is one of the major causes of mortality and morbidity in tropical regions, causing maternal anemia, intrauterine growth retardation, preterm birth, and low birth weight (LBW). The integration of the information systems on pregnancy and malaria could prove to be a useful method of improved decision making for better maternal-child health. METHODS: A population-based observational study acquired information retrospectively from all live births that occurred between 2006 and 2014 in Cruzeiro do Sul (Acre, Brazil)...
2018: PloS One
https://www.readbyqxmd.com/read/29927491/second-trimester-maternal-serum-screening-for-fetal-down-syndrome-as-a-screening-test-for-hemoglobin-bart-s-disease-a-prospective-population-based-study
#2
Chanane Wanapirak, Wirawit Piyamomgkol, Supatra Sirichotiyakul, Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Kuntharee Traisrisilp, Phudit Jatavan, Theera Tongsong
OBJECTIVE: To determine the effectiveness of second-trimester maternal serum screening (MSS) for Down syndrome as a screening test for fetal hemoglobin (Hb) Bart's disease among an unselected population. METHODS: A secondary analysis of a large prospective database (20,254 pregnancies) was conducted to compare the levels of MSS, alpha-fetoprotein (AFP), free beta-human chorionic gonadotropin (hCG) and unconjugated estriol (uE3) between pregnancies with Hb Bart's disease and unaffected pregnancies...
June 21, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29925108/febrile-neutropenia-following-parvovirus-b19-infection-and-cross-anti-kell-reaction-to-e-coli-in-pregnancy
#3
Pedro Brandão, Marília Freixo, Elisa Soares, Catarina Estevinho, Ana Sofia Portela Carvalho, Anabela Melo
Parvovirus B19 has tropism for red line blood cells, causing immune hydrops during pregnancy. A positive anti-Kell Coombs reaction usually happens during pregnancy when there is production of antibodies that target Kell antigens, but cross reactions to other antigens may occur. A 24-year-old Gypsy primigravida, 0 Rhesus positive, presented with persistent isolated hyperthermia for 2 weeks and a positive indirect Coombs test result with anti-Kell antibodies at routine tests. She had a 19-week live fetus. The blood tests revealed bicytopenia with iron deficiency anemia, leucopoenia with neutropenia, and elevated C-reactive protein...
June 20, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29917215/effects-of-micronised-dispersible-ferric-pyrophosphate-combined-with-alpha-lactalbumin-in-pregnant-women-affected-by-iron-deficiency-anemia-results-from-a-prospective-double-blind-randomized-controlled-trial
#4
A S Laganà, L Costabile, P Filati, M Noventa, A Vitagliano, R D'Anna
OBJECTIVE: This study aimed at evaluating the effects obtained by administering 30 mg of micronised dispersible ferric pyrophosphate plus 300 mg of alpha-lactalbumin (MDFP-AL) compared to 80 mg of ferrous gluconate (FG) in pregnant women affected by iron-deficiency anemia (IDA). PATIENTS AND METHODS: We considered eligible all second-trimester singleton pregnancies in women affected by IDA. We excluded any other disease, twin pregnancies, any other pharmacologic/nutraceutical treatments (besides folic acid) before/during pregnancy...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29916110/intravenous-carbetocin-versus-intravenous-oxytocin-for-preventing-atonic-postpartum-hemorrhage-after-normal-vaginal-delivery-in-high-risk-singleton-pregnancies-a-triple-blind-randomized-controlled-trial
#5
Paweena Amornpetchakul, Tripop Lertbunnaphong, Dittakarn Boriboonhiransarn, Jarunee Leetheeragul, Ratree Sirisomboon, Ratchada Jiraprasertwong
PURPOSE: To compare the effectiveness of intravenous carbetocin to that of intravenous oxytocin for prevention of atonic postpartum hemorrhage (PPH) after vaginal delivery in high-risk singleton pregnancies. METHODS: This triple-blind randomized controlled trial included singleton pregnant women who delivered at Siriraj Hospital between August 2016 and January 2017 and who were 20 years or older, had a gestational age of at least 34 weeks, had a vaginal delivery, and had at least one risk factor for atonic postpartum hemorrhage...
June 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29907852/predictors-of-anemia-and-iron-status-at-birth-in-neonates-born-to-women-carrying-multiple-fetuses
#6
Yuan Ru, Eva K Pressman, Ronnie Guillet, Philip J Katzman, Stephen J Bacak, Kimberly O O'Brien
BACKGROUND: Iron (Fe) status of neonates born to women carrying multiple fetuses might be compromised as a consequence of the high prevalence of maternal Fe deficiency and anemia coupled with an increased risk of preterm birth. This study aimed to characterize and identify determinants of anemia in this neonatal population. METHODS: Umbilical cord blood obtained from 183 neonates was utilized to assess hemoglobin (Hb), ferritin (SF), soluble transferrin receptor (sTfR), hepcidin, serum Fe, erythropoietin, folate, vitamin B-12, C-reactive protein, and interleukin-6...
June 15, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29905543/importance-of-isolated-gestational-hypothyroxinemia-in-the-development-of-obstetric-and-somatic-pathologies
#7
N Morchiladze, B Tkeshelashvili, T Gagua, D Gagua
The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period. Aim of the study was to define the importance of isolated hypothyroxinemia in the development of obstetric and somatic pathologies in outpatient population of pregnant females. The study of prospective design was performed at the base of "David Gagua Clinic" Ltd...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29903176/-follow-up-study-on-diet-folic-acid-and-iron-status-in-358-cases-of-uighur-pregnant-women-from-xinjiang-kashi
#8
Tuerxunjiang Maimaitiming, Xiaojun Wang, Camila Tuerxunjiang, Yanqiong Yang, Dilihuomaer Wuerkaixi, Jinfen Pu, Li Wang, Liuqianzi Yan
OBJECTIVE: To understand the dietary intake situation of Uighur pregnant women, investigate folic acid level and its influencing factors, to provide evidence for health education of maternal nutrition and implementation of proper nutrition, balanceddiet guidance. METHODS: 358 cases of Uighur trimester pregnant women for the study, took the method of 3 d 24 h dietary recall to survey their dietary and collect blood samples. The Hb was detected by the cyanide methemoglobinmethod...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902780/contribution-of-fetal-brain-mri-in-management-of-severe-fetal-anemia
#9
L Ghesquière, V Houfflin-Debarge, P Verpillat, T Fourquet, S Joriot, C Coulon, P Vaast, C Garabedian
INTRODUCTION: Intrauterine transfusion (IUT) has changed fetal anemia prognosis. However, long-term neurodevelopmental outcome is altered in 5% of children. Our objective was to study the contribution of fetal MRI to diagnosis brain lesions in case of fetal anemia. MATERIAL AND METHODS: Retrospective monocentric descriptive study from 2005 to 2016, including all patients followed for fetal anemia requiring IUT. The indications for MRI were: hydrops fetalis and / or hemoglobin <5 g / dL and / or more than 3 IUTs and / or acute severe anemia and / or ultrasound abnormality...
June 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29902448/postponing-early-intrauterine-transfusion-with-intravenous-immunoglobulin-treatment-the-petit-study-on-severe-hemolytic-disease-of-the-fetus-and-newborn
#10
Carolien Zwiers, Johanna G van der Bom, Inge L van Kamp, Nan Van Geloven, Enrico Lopriore, John Smoleniec, Roland Devlieger, Pauline E Sim, Marie Anne Ledingham, Eleonor Tiblad, Kenneth J Moise, Karl-Philip Gloning, Mark D Kilby, Timothy G Overton, Ditte S Jørgensen, Katrine V Schou, Bettina Paek, Martin Walker, Emma Parry, Dick Oepkes, Masja de Haas
BACKGROUND: Intrauterine transfusion for severe alloimmunization in pregnancy performed before 20 weeks' gestation is associated with a higher fetal death rate. Intravenous immunoglobulins may prevent hemolysis and could therefore be a non-invasive alternative for early transfusions. OBJECTIVE(S): We evaluated whether maternal treatment with intravenous immunoglobulins defers the development of severe fetal anemia and its consequences in a retrospective cohort to which 12 fetal therapy centers contributed...
June 11, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29901736/prenatal-and-postnatal-supplementation-with-lipid-based-nutrient-supplements-reduces-anemia-and-iron-deficiency-in-18-month-old-bangladeshi-children-a-cluster-randomized-effectiveness-trial
#11
Susana L Matias, Malay K Mridha, Rebecca T Young, Md Showkat A Khan, Zakia Siddiqui, Md Barkat Ullah, Stephen A Vosti, Kathryn G Dewey
Background: Anemia, iron deficiency (ID), and iron deficiency anemia (IDA) among young children are public health concerns in developing countries. Objective: We evaluated the effects of small-quantity lipid-based nutrient supplements (LNSs) and micronutrient powder (MNP) on anemia, ID, and IDA in 18-mo-old Bangladeshi children. Methods: We enrolled 4011 pregnant women in a cluster-randomized effectiveness trial with 4 arms-1) LNS-LNS: LNSs (including 20 mg Fe) for women daily during pregnancy and 6 mo postpartum and LNSs (including 9 mg Fe) for children daily from 6 to 24 mo of age (LNS-C); 2) IFA-LNS: iron (60 mg) and folic acid (IFA) for women daily during pregnancy and every other day for 3 mo postpartum and LNS-C for children; 3) IFA-MNP: IFA for women, and MNP (including 10 mg Fe) for children daily from 6 to 24 mo; and 4) IFA-Control: IFA for women and no child supplement...
June 13, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29888000/association-of-colecalciferol-ferritin-and-anemia-among-pregnant-women-result-from-cohort-study-on-vitamin-d-status-and-its-impact-during-pregnancy-and-childhood-in-indonesia
#12
Raden Tina Dewi Judistiani, Lani Gumilang, Sefita Aryuti Nirmala, Setyorini Irianti, Deni Wirhana, Irman Permana, Liza Sofjan, Hesty Duhita, Lies Ani Tambunan, Jeffry Iman Gurnadi, Umar Seno, Reni Ghrahani, Agnes Rengga Indrati, Yunia Sribudiani, Tetty Yuniati, Budi Setiabudiawan
Studies had shown that iron-cycling was disturbed by inflammatory process through the role of hepcidin. Pregnancy is characterized by shifts of interleukin. Our objective was to determine if 25(OH) vitamin D (colecalciferol) status was associated with ferritin, anemia, and its changes during pregnancy. Method. A cohort study was done in 4 cities in West Java, Indonesia, beginning in July 2016. Subjects were followed up until third trimester. Examinations included were maternal ferritin, colecalciferol, and haemoglobin level...
2018: Anemia
https://www.readbyqxmd.com/read/29884138/the-complex-treatment-including-rituximab-in-the-management-of-catastrophic-antiphospholid-syndrome-with-renal-involvement
#13
Aleksandra Rymarz, Stanisław Niemczyk
BACKGROUND: Catastrophic antiphospholipid syndrome (CAPS) is a rare, life-threatening form of antiphospholipid syndrome (APS) involving many organs and leading to their insufficiency. The pathogenesis of CAPS is associated with the presence of antiphospholipid antibodies (aPL). Typical therapy includes anticoagulation, glucocorticoids, therapeutic plasma exchanges and/or intravenous immunoglobulin. Despite this aggressive treatment, the mortality rate of 37% is still high. Novel therapeutic agents are required...
June 8, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29871663/two-potentially-lethal-conditions-of-probable-immune-origin-occurring-in-a-pregnant-woman-a-case-report
#14
H M Senanayake, M Patabendige
BACKGROUND: Thrombotic thrombocytopenic purpura and peripartum cardiomyopathy are potentially lethal complications of pregnancy. We describe a case in which both of these developed in the same patient. The etiologies of both conditions remain uncertain, but they share immune hyperreactivity as a possible cause. CASE PRESENTATION: A 33-year-old Lankan primigravida gave birth at 38 weeks of gestation by cesarean section when she presented with right-sided abdominal pain and a provisional diagnosis of appendicitis...
June 6, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29848951/trends-in-deaths-from-rheumatic-heart-disease-in-the-eastern-mediterranean-region-burden-and-challenges
#15
Azza M A M Abul-Fadl, Maha M Mourad, Alaa Ghamrawy, Ayah Ebada Sarhan
Rheumatic heart disease (RHD) is a preventable disease that is prevalent in developing regions of the world. Its eradication from most of the developed world indicates that this disease can be controlled and eliminated. Aim: To conduct an in-depth analysis of the trends and challenges of controlling RHD in the Eastern Mediterranean region (EMR). Methodology: Global data from the World Health Organization (WHO) data banks were retrieved for total deaths and age standardized death rate per 100,000 (ASDR) by age group, sex, and year (from 2000 to 2015)...
May 30, 2018: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/29848380/compliance-to-iron-and-folic-acid-supplementation-in-pregnancy-northwest-ethiopia
#16
Tesfaye Molla Birhanu, Mequanent Kassa Birarra, Fantahun Ayenew Mekonnen
OBJECTIVE: Strict compliance to iron and folic acid supplementation is vital for prevention of anemia in pregnancy. However, data are scarce in Ethiopia. So, we conducted this study to assess the level of compliance to iron and folic acid supplementation during pregnancy and its associated factors. RESULTS: Of 418 women, over half, 231 (55.3%), adhered to the recommended iron and folic acid supplementation. Women who started antenatal care (ANC) follow up early [AOR; 95% CI 2...
May 30, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29843553/efficacy-of-ferrous-bis-glycinate-versus-ferrous-glycine-sulphate-in-the-treatment-of-iron-deficiency-anemia-with-pregnancy-a-randomized-double-blind-clinical-trial
#17
Ahmed Abbas, Safaa A Abdelbadee, Ahmed Alanwar, Sayed Mostafa
OBJECTIVE: The current study aims to compare the efficacy and tolerability of oral ferrous bis-glycinate versus ferrous glycine sulphate in the treatment of iron deficiency anemia (IDA) with pregnancy. METHODS: A randomized double-blind clinical trial ( NCT02590224 ) conducted at a tertiary University Hospital in the period between 1 January 2016 and 31 July 2017 included pregnant women at 14-18 weeks of gestation with mild to moderate IDA. Patients were randomized into two groups: (Group I) received oral ferrous bis-glycinate tablets once daily for eight consecutive weeks and (Group II) received oral ferrous glycine sulphate capsules in the same dose and duration...
May 29, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29796364/pregnancy-related-hemophagocytic-lymphohistiocytosis-associated-with-herpes-simplex-virus-2-infection-a-diagnostic-dilemma
#18
M Farhan Nasser, Shorabh Sharma, Elizabeth Albers, Sapna Sharma, Anurag Duggal
Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory disorder characterized by the uncontrolled proliferation of lymphocytes and histiocytes with hemophagocytic activity in the bone marrow. To our knowledge, there have been a few reported cases of pregnancy-related HLH. This case highlights the importance of considering HLH in a pregnant woman along with other diagnoses, such as HELLP (which stands for hemolysis, elevated liver enzyme levels, and low platelet levels) syndrome and hemolytic anemias...
March 20, 2018: Curēus
https://www.readbyqxmd.com/read/29787560/neutrophils-to-lymphocytes-ratio-and-platelets-to-lymphocytes-ratio-in-pregnancy-a-population-study
#19
Anat Hershko Klement, Efrat Hadi, Aula Asali, Tal Shavit, Amir Wiser, Einat Haikin, Yael Barkan, Tal Biron-Shental, Alona Zer, Yifat Gadot
BACKGROUND: Neutrophils to lymphocytes ratio (NLR) and platelets to lymphocytes ratio (PLR) are both inflammatory ratios that can be easily calculated from a simple blood count. They are frequently reported and tested as prognostic factors in several medical disciplines. Pregnancy involves special reference values for laboratory assays. OBJECTIVE: The aim of this study was to define pregnancy-related reference values for NLR and PLR according to trimester, background morbidity and according to the patient's age...
2018: PloS One
https://www.readbyqxmd.com/read/29770322/sociodemographic-and-medical-risk-factors-associated-with-antepartum-depression
#20
Giridhara R Babu, G V S Murthy, Neeru Singh, Anita Nath, Mohanbabu Rathnaiah, Nolita Saldanha, R Deepa, Sanjay Kinra
Background: The increasing recognition of antenatal depression is an emerging area of concern in developing countries. We conducted a study to estimate the prevalence of antenatal mental distress and its relation with sociodemographic factors, obstetric factors, and physiological wellbeing in pregnant women attending public health facilities in Bengaluru, South India. Methods: Nested within a cohort study, we assessed the mental status in 823 pregnant women in two public referral hospitals...
2018: Frontiers in Public Health
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