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https://www.readbyqxmd.com/read/29471604/-how-to-optimally-use-currently-available-drugs-in-a-therapeutic-algorithm
#1
REVIEW
You Sun Kim
Recently, the incidence and prevalence of inflammatory bowel disease (IBD) have been increasing in worldwide, especially in Asian area. IBD is a chronic and progressive disease eventually causing bowel damage. The advance in the treatment of IBD over the past several decades has been achieved with the development of biologics. Furthermore, goals for management of IBD have been evolving from symptom-based management to mucosal healing, which can reduce the surgery rate and hospitalization. To treat the patients with IBD properly, identification of risk factors of patients should be preceded...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471190/interdecadal-changes-of-summer-aerosol-pollution-in-the-yangtze-river-basin-of-china-the-relative-influence-of-meteorological-conditions-and-the-relation-to-climate-change
#2
Jizhi Wang, Xiaoye Zhang, Duo Li, Yuanqin Yang, Junting Zhong, Yaqiang Wang, Haochi Che, Huizheng Che, Yangmei Zhang
Winter is a season of much concern for aerosol pollution in China, but less concern for pollution in the summertime. There are even less concern and larger uncertainty about interdecadal changes in summer aerosol pollution, relative influence of meteorological conditions, and their links to climate change. Here we try to reveal the relation among interdecadal changes in summer's most important circulation system affecting China (East Asian Summer Monsoon-EASM), an index of meteorological conditions (called PLAM, Parameter Linking Air Quality and Meteorological Elements, which is almost linearly related with aerosol pollution), and aerosol optical depth (AOD) in the middle and lower reaches of the Yangtze River (M-LYR) in central eastern China during summertime since the 1960's...
February 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29470472/ethnic-and-sex-related-differences-in-pain-characteristics-psychological-distress-and-pain-related-disability-in-patients-attending-a-new-zealand-teaching-hospital-pain-service
#3
Andrea Burri, David Rice, Nicola Kluger, Michal Kluger
AIM: The aim of the present observational study was to provide a description of the demographic, psychological and pain characteristics of patients attending the Waitemata Pain Services (WPS), Auckland, New Zealand. METHOD: Data were collected via a comprehensive paper-pencil questionnaire handed out to 798 consecutive new patients seen at the WPS over a four-year period. RESULTS: 32.3% attending the WPS were men and 67.7% women, with a mean age of 52...
February 23, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29470395/therapeutic-potential-of-oridonin-and-its-analogs-from-anticancer-and-antiinflammation-to-neuroprotection
#4
REVIEW
Jimin Xu, Eric A Wold, Ye Ding, Qiang Shen, Jia Zhou
Oridonin, a diterpenoid natural product commonly used in East Asian herbal medicine, is garnering increased attention in the biomedical community due to its extensive biological activities that include antitumor, anti-inflammatory, antimicrobial, hepatic fibrosis prevention, and neurological effects. Over the past decade, significant progress has been made in structure activity relationship and mechanism of action studies of oridonin for the treatment of cancer and other diseases. This review provides a brief summary on oridonin and its analogs in cancer drug discovery and antiinflammation and highlights its emerging therapeutic potential in neuroprotection applications...
February 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29470357/validation-of-the-alpha-fetoprotein-model-for-hepatocellular-carcinoma-recurrence-after-transplantation-in-an-asian-population
#5
Jinsoo Rhu, Jong Man Kim, Gyu Seong Choi, Choon Hyuck David Kwon, Jae-Won Joh
BACKGROUND: This study was designed to validate the alpha-fetoprotein model for predicting recurrence after liver transplantation in Korean hepatocellular carcinoma patients. METHODS: Patients who underwent liver transplantation for hepatocellular carcinoma at Samsung Medical Center between 2007 and 2015 were included. Recurrence, overall survival, and disease-specific survival of patients divided by both the Milan criteria and the alpha-fetoprotein model were compared using Kaplan-Meier log-rank test...
February 20, 2018: Transplantation
https://www.readbyqxmd.com/read/29470173/preemptive-nudt15-genotyping-redefining-the-management-of-patients-with-thiopurine-induced-toxicity
#6
Swarup A V Shah, Minal U Paradkar, Devendra C Desai, Tester F Ashavaid
BACKGROUND: Thiopurine methyltransferase (TPMT) gene variants have achieved limited success in predicting the outcome of thiopurine therapy, which shows wide inter-individual variations. The literature indicates a strong association between the NUDT15 gene variant and thiopurine-induced toxicity in Asian patients. The present study intends to explore the role of the NUDT15 variant (C415T) in Indian patients on thiopurine therapy. METHODS: NUDT15 and TPMT genotyping were performed using amplification-refractory mutation system-polymerase chain reaction (ARMS-PCR) and the restriction fragment length polymorphism (RFLP) technique...
February 22, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29469948/sensory-acceptability-of-iron-fortified-red-lentil-lens-culinaris-medik-dal
#7
Rajib Podder, Shaan M Khan, Bunyamin Tar'an, Robert T Tyler, Carol J Henry, Chowdhury Jalal, Phyllis J Shand, Albert Vandenberg
Panelists in Saskatoon, Canada (n = 45) and Dhaka, Bangladesh (n = 98) participated in sensory evaluations of the sensory properties of both cooked and uncooked dehulled red lentil dal fortified with FeSO4 ·7H2 O, NaFeEDTA or FeSO4 ·H2 O at fortificant Fe concentrations of 800, 1,600 (both cooked and uncooked), or 2,800 ppm. Appearance, odor, and overall acceptability of cooked and uncooked samples were rated using a 9-point hedonic scale (1 = dislike extremely to 9 = like extremely). Taste and texture were rated for the cooked samples prepared as typical south Asian lentil meals...
February 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29469728/generalized-eruptive-syringomas
#8
Amy Huang, Gina Taylor, Tracey N Liebman
Eruptive syringoma is a rare variant of syringoma, benign neoplasms of the eccrine sweat ducts that appear on the face, neck, chest, and axillae of predominately Asian and African American women before or during puberty [1, 2]. Lesions appear as small skin-colored or slightly pigmented, flat-topped papules [2]. The condition can be cosmetically disfiguring and difficult to treat, especially in dark-skinned patients. The investigators report a 52-year old Guyanese woman who presented with widespread, chronic, non-pruritic and nontender, skin-colored papules that arose approximately 20 years earlier...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469595/combined-treatment-for-skin-laxity-of-the-aging-face-with-monopolar-radiofrequency-and-intense-focused-ultrasound-in-korean-subjects
#9
Hyuck Hoon Kwon, Won-Yong Lee, Sun Chul Choi, Jae Yoon Jung, Youin Bae, Gyeong-Hun Park
BACKGROUND: Although various minimal invasive approaches are available for aging skin laxity, they alone may not lead to notably satisfactory results. OBJECTIVE: To evaluate the effectiveness and safety of combination regimen with monopolar radiofrequency (MRF) and intense-focused ultrasound (IFUS) in facial lifting and tightening. METHODS: Twenty-two Korean participants with aging face received a sequential single session of MRF and IFUS treatment...
February 22, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29469591/associations-of-health-insurance-coverage-mental-health-problems-and-drug-use-with-mental-health-service-use-in-us-adults-an-analysis-of-2013-national-survey-on-drug-use-and-health
#10
Nianyang Wang, Xin Xie
OBJECTIVE: To estimate the prevalence of mental health service use among US adults, examine the associations of mental health service use with health insurance coverage, mental health problems and drug use, and detect health disparities. METHODS: This was a cross-sectional study with 5,434 adults receiving mental health service out of 37,424 adult respondents from the 2013 National Survey on Drug Use and Health. Weighted univariate and multiple logistic regression analyses were used to estimate the associations of potential factors with mental health service use...
February 22, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29469356/-genetic-variation-of-thelazia-callipaeda-among-isolates-collected-from-patients-in-zunyi-city-guizhou-province
#11
Zheng Ming-Hui, Ye Chang-Lin, Jiang Nan, Luo Bo, Shen Yu-Juan, He Li-Fang, Liu Hui
OBJECTIVE: To identify the genetic variation and possible sources of Thelazia callipaeda isolates collected from patients in Zunyi City, Guizhou Province. METHODS: Seven cases of T. callipaeda infection in Zunyi City, 2016 were verified, and DNA (s) were extracted from the T. callipaeda 's body collected from the thelaziasis patients. A mitochondrial COX1 fragment was amplified and sequenced. The sequence alignment and phylogenetical analysis were performed to compare the genetic variation of the gene sequence with the homologous sequences downloaded from Genebank...
September 27, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29469190/prognostic-significance-of-platelet-to-lymphocyte-ratio-in-patients-with-ovarian-cancer-a-meta-analysis
#12
Tian Chuan, Song Wei, Tian Xia, Sun Yong
BACKGROUND: The platelet-to-lymphocyte ratio (PLR) has been found to predict clinical outcomes in borderline ovarian tumors and the other genital neoplasms. However, its prognostic value in patients with ovarian cancer remains controversial. The aim of this study was to assess its prognostic value in ovarian cancer. METHODS: We searched MEDLINE, EMBASE and the Cochrane databases to identify studies evaluating the prognostic significance of pretreatment PLR in ovarian cancer...
February 22, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29469040/long-term-follow-up-and-quantitative-hepatitis-b-surface-antigen-monitoring-in-north-american-chronic-hbv-carriers
#13
Conar R O'Neil, Stephen E Congly, M Sarah Rose, Samuel S Lee, Meredith A Borman, Carmen L Charlton, Carla Osiowy, Mark G Swain, Kelly W Burak, Carla S Coffin
INTRODUCTION: Quantitative hepatitis B surface antigen (qHBsAg) combined with HBV DNA may be useful for predicting chronic hepatitis B (CHB) activity and nucleoside analogue (NA) response. MATERIAL AND METHODS: In this retrospective cohort study we evaluated qHBsAg levels according to CHB disease phase and among patients on treatment. Random effect logistic regression analysis was used to analyze qHBsAg change with time in the NA-treated cohort. RESULTS: 545 CHB carriers [56% M, median age 48 y (IQR 38-59), 73% Asian] had qHBsAg testing...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29468857/the-5th-biennial-meeting-of-the-asian-society-of-gynecologic-oncology-november-30th-to-december-2nd-2017
#14
Eiichiro Tominaga, Yusuke Kobayashi, Daisuke Aoki
No abstract text is available yet for this article.
March 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29468518/cultural-factors-influencing-osteoarthritis-care-in-asian-communities-a-review-of-the-evidence
#15
REVIEW
Thrmiga Sathiyamoorthy, Shabana Amanda Ali, Marita Kloseck
With the prevalence of osteoarthritis (OA) increasing internationally, there is a need to study the impact of this disease on culturally diverse populations. Individuals of Asian descent make up more than 60% of the world population, yet comprehensive information on the cultural factors that impact OA care is not available. Scoping review methodology using directed content analysis was employed to identify and analyze existing research on OA care for Asians. A categorization matrix was developed using the six care areas from the OA clinical practice guidelines along with an additional three non-clinical areas (cross-cultural adaptation of clinical tools; psychological well-being; family systems and informal care) identified in an initial scan resulting in a total of nine OA care areas to guide initial coding...
February 21, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29468338/vitamin-d-receptor-foki-taqi-and-apai-polymorphisms-and-susceptibility-to-systemic-lupus-erythematosus-an-updated-meta-analysis
#16
Sang-Cheol Bae, Young Ho Lee
This study aimed to explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to systemic lupus erythematosus (SLE). Meta-analyses were conducted to determine the associations between the VDR FokI, TaqI, and ApaI polymorphisms and SLE in all subjects and each ethnic group. A total of 12 studies were considered in the meta-analysis, which involved 1974 patients and 2506 controls. Meta-analysis of the VDR FokI polymorphism showed no association between SLE and the FokI F allele in all study subjects (OR = 1...
February 21, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29468327/-video-assisted-thoracic-surgery-a-global-development
#17
REVIEW
G Leschber
More than 200 years ago the first attempts at thoracoscopy were made but only after its introduction 25 years ago has video-assisted thoracoscopic surgery (VATS) experienced rapid progress. Due to worldwide cooperation and international networking tremendous progress of the technique was made by thoracic surgeons on all continents developing the technique into a less invasive operating procedure on the thorax. For patients this meant improvement in the quality of life and ultimately better survival rates following lung cancer surgery...
February 21, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29468063/effects-of-metformin-on-survival-outcomes-of-pancreatic-cancer-patients-with-diabetes-a-meta-analysis
#18
Wenxiu Xin, Luo Fang, Qilu Fang, Xiaowei Zheng, Ping Huang
Pancreatic cancer risk is reduced by metformin treatment in patients with diabetes. However, the effect of metformin on pancreatic cancer overall survival is unclear. The aim of the present study was to determine the association between metformin and clinical outcomes of pancreatic cancer patients with diabetes. An electronic and manual search was conducted using PubMed, Web of Science, Medline-Ovid and Cochrane Library databases between the beginning and March 31, 2017. A total of 8 studies consisting of 4,293 patients with pancreatic cancer with diabetes were included, comprising 2,033 patients who had received metformin and 2,260 patients who had not...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29468046/rapid-identification-of-the-asian-gypsy-moth-and-its-related-species-based-on-mitochondrial-dna
#19
Ying Wu, Qiuyang Du, Haiwen Qin, Juan Shi, Zhiyi Wu, Weidong Shao
The gypsy moth- Lymantria dispar (Linnaeus)-is a worldwide forest defoliator and is of two types: the European gypsy moth and the Asian gypsy moth. Because of multiple invasions of the Asian gypsy moth, the North American Plant Protection Organization officially approved Regional Standards for Phytosanitary Measures No. 33. Accordingly, special quarantine measures have been implemented for 30 special focused ports in the epidemic areas of the Asian gypsy moth, including China, which has imposed great inconvenience on export trade...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29467956/vitamin-d-receptor-taq-i-polymorphism-and-the-risk-of-prostate-cancer-a-meta-analysis
#20
Shaosan Kang, Yansheng Zhao, Lei Wang, Jian Liu, Xi Chen, Xiaofeng Liu, Zhijie Shi, Weixing Gao, Fenghong Cao
Numerous previous studies reported the association of Vitamin D receptor gene Taq I polymorphism with prostate cancer risk, however these results were controversial. In order to provide a relatively comprehensive description of this relationship, we conducted this meta-analysis by searching PubMed, Embase, and China National Knowledge Infrastructure. Finally, 36 studies with 8,423 cases and 8,887 controls were included. Taq I polymorphism was found to marginally increase the prostate cancer risk in recessive genetic model (tt/Tt vs...
January 23, 2018: Oncotarget
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