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S Moretto, A Saita, C M Scoffone, M Talso, B K Somani, O Traxer, O Angerri, T Knoll, E Liatsikos, T R W Herrmann, Ø Ulvik, A Skolarikos, C M Cracco, E X Keller, M Paciotti, A Piccolini, A Uleri, T Tailly, L Carmignani, A Pietropaolo, M Corrales, G Lughezzani, M Lazzeri, V Fasulo, V De Coninck, P Arena, U Nagele, S Ferretti, P Kronenberg, D Perez-Fentes, P J Osther, I K Goumas, P Acquati, L Ajayi, P Diana, P Casale, N M Buffi
PURPOSE: We aimed to accurately determine ureteral stricture (US) rates following urolithiasis treatments and their related risk factors. METHODS: We conducted a systematic review and meta-analysis following the PRISMA guidelines using databases from inception to November 2023. Studies were deemed eligible for analysis if they included ≥ 18 years old patients with urinary lithiasis (Patients) who were subjected to endoscopic treatment (Intervention) with ureteroscopy (URS), percutaneous nephrolithotomy (PCNL), or shock wave lithotripsy (SWL) (Comparator) to assess the incidence of US (Outcome) in prospective and retrospective studies (Study design)...
April 13, 2024: World Journal of Urology
#2
JOURNAL ARTICLE
G Stocker, S Lorenzen, T Ettrich, A-L Herz, F Longo, A Kiani, M Venerito, J Trojan, R Mahlberg, N Moosmann, B Chibaudel, S Kubicka, R Greil, S Daum, M Geissler, J Larcher-Senn, G Keller, F Lordick, G M Haag
PURPOSE: Platinum-fluoropyrimidine combinations are standard of care for treatment of metastatic esophagogastric adenocarcinoma. The optimal duration of first-line chemotherapy is unknown, however, and maintenance strategies have not yet been established. DESIGN: MATEO is an international randomized phase II trial exploring efficacy and safety of S-1 maintenance therapy in human epidermal growth factor receptor 2 (HER2)-negative advanced esophagogastric adenocarcinoma...
June 2, 2023: ESMO Open
#3
JOURNAL ARTICLE
S Y Bögli, D Utebay, N Smits, L P Westphal, L Hirsbrunner, S Unseld, E Keller, G Brandi
BACKGROUND: Sex-related differences in patients with aneurysmal subarachnoid hemorrhage (aSAH) exist. More females than males are affected. Aneurysm location is associated to sex. The relationship between sex and outcome, however, is unclear. Possible differences in management might influence the occurrence of primary and secondary brain injury and thus outcome. The study compares demographics, intensity of treatment, complications, and outcome among females and males with aSAH. METHODS: All consecutive patients with aSAH admitted to the neurocritical care unit, University Hospital Zurich over a 5-year period were eligible in this retrospective study...
August 19, 2022: Acta Neurochirurgica
#4
JOURNAL ARTICLE
Amy C Keller, Ji H Chun, L A Knaub, M M Henckel, S E Hull, R L Scalzo, G B Pott, L A Walker, J E B Reusch
OBJECTIVE: Cardiovascular disease is of paramount importance, yet there are few relevant rat models to investigate its pathology and explore potential therapeutics. Housing at thermoneutral temperature (30 °C) is being employed to humanize metabolic derangements in rodents. We hypothesized that housing rats in thermoneutral conditions would potentiate a high-fat diet, resulting in diabetes and dysmetabolism, and deleteriously impact vascular function, in comparison to traditional room temperature housing (22 °C)...
July 26, 2022: Journal of Hypertension
#5
JOURNAL ARTICLE
N J Coorey, L Kensitt, J Davies, E Keller, M Sheel, K Chani, S Barry, R Boyd, J Denholm, K Watts, G Fox, C Lowbridge, R Perera, J Waring, B Marais, K Viney
BACKGROUND: Australia has a low incidence of TB and has committed to eliminating the disease. Identification of risk factors associated with TB is critical to achieving this goal. METHODS: We undertook a prospective cohort study involving persons receiving TB treatment in four Australian jurisdictions. Risk factors and their association with delayed treatment completion (treatment delayed by at least 1 month) were analysed using univariate analyses and multivariate logistic regression. RESULTS: Baseline surveys were completed for 402 persons with TB...
May 1, 2022: International Journal of Tuberculosis and Lung Disease
#6
JOURNAL ARTICLE
Keller G Sheppard, Jacob I Stowell
Public perceptions of police legitimacy and effectiveness have been challenged by recent high-profile use of fatal force incidents by the police. Prior scholarship suggests that that controversial incidents involving police use of force can engender distrust of the police. Further, the neighborhood effects literature has demonstrated the importance of community context for police-community relationships and differential responses to controversial incidents by neighborhoods. The current study assesses how communities of varying racial compositions and levels of economic disadvantage respond to police fatal force incidents by assessing neighborhood crime reporting behaviors...
September 15, 2021: Journal of Interpersonal Violence
#7
JOURNAL ARTICLE
G Narula, M Haeberlin, J Balsiger, C Strässle, L L Imbach, E Keller
OBJECTIVE: The burst suppression pattern in clinical electroencephalographic (EEG) recordings is an important diagnostic tool because of its association with comas of various etiologies, as with hypoxia, drug related intoxication or deep anesthesia. The detection of bursts and the calculation of burst/suppression ratio are often used to monitor the level of anesthesia during treatment of status epilepticus. However, manual counting of bursts is a laborious process open to inter-rater variation and motivates a need for automatic detection...
October 2021: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
#8
JOURNAL ARTICLE
O F Gardner, S C Juneja, H Whetstone, Y Nartiss, J T Sieker, C Veillette, G M Keller, A M Craft
In an effort to develop an effective source of clinically relevant cells and tissues for cartilage repair a directed differentiation method was used to generate articular chondrocytes and cartilage tissues from human embryonic stem cells (hESCs). It has previously been demonstrated that chondrocytes derived from hESCs retain a stable cartilage-forming phenotype following subcutaneous implantation in mice. In this report, the potential of hESC-derived articular-like cartilage to repair osteochondral defects created in the rat trochlea was evaluated...
November 5, 2019: European Cells & Materials
#9
JOURNAL ARTICLE
J K Thomas, G J Fadul, G P Keller, M F Chaudhury
The success of the Screwworm Eradication Program is due to continuous mass rearing and dispersal of large numbers of competitive sterile flies in the field. Spray-dried powders of whole bovine blood, chicken egg, and milk substitute constituted the nutritional components of the traditional artificial larval diet used for mass rearing New World Screwworm (NWS), Cochliomyia hominivorax (Coquerel), Diptera: Calliphoridae. However, due to shifting availability and increasing costs of diet ingredients, it is necessary to investigate alternative products for the diet...
May 1, 2018: Journal of Insect Science
#10
JOURNAL ARTICLE
L Bauer, A Hapfelmeier, S Blank, M Reiche, J Slotta-Huspenina, M Jesinghaus, A Novotny, T Schmidt, B Grosser, M Kohlruss, W Weichert, K Ott, G Keller
Background: Perioperative chemotherapy is an established treatment of advanced gastric cancer patients. Treatment selection is based on clinical staging (cT). We aimed to establish and validate a prognostic score including clinical and molecular factors, to optimize treatment decisions for these patients. Patients and methods: We analyzed 626 carcinomas of the stomach and of the gastro-esophageal junction from two academic centers including primarily resected and pre-/perioperatively treated patients...
January 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#11
JOURNAL ARTICLE
Keller G Guimarães, Rossimiriam P de Freitas, Ana L T G Ruiz, Giovanna F Fiorito, João E de Carvalho, Elaine F F da Cunha, Teodorico C Ramalho, Rosemeire B Alves
A series of novel isocoumarin derivatives were synthesized using Castro-Stephens cross-coupling. Moreover, novel 3,4-dihydroisocoumarin derivatives were obtained by catalytic hydrogenation of the corresponding isocoumarin precursors. The antiproliferative activity of all compounds was evaluated in vitro in different tumor cells. Furthermore, docking calculations were performed for the kallikrein 5 (KLK5) active site to predict the possible mechanism of action of this series of compounds. Theoretical findings indicate that the 3,4-dihydroisocoumarin derivative 10a forms hydrogen bonds with Ser190 and Gln192 residues of KLK5...
March 23, 2016: European Journal of Medicinal Chemistry
#12
JOURNAL ARTICLE
D Gallagher, A Bramall, A Paquin, A Voronova, S Burns, P Neilsen, G Keller, D Kaplan, F Miller
No abstract text is available yet for this article.
December 2015: International Journal of Developmental Neuroscience
#13
RANDOMIZED CONTROLLED TRIAL
B Oliveri, S R Mastaglia, G M Brito, M Seijo, G A Keller, J Somoza, R A Diez, G Di Girolamo
BACKGROUND/OBJECTIVES: The superiority of cholecalciferol (D3) over ergocalciferol (D2) in sustaining serum 25-hydroxy vitamin D (25OHD) levels is controversial. To compare D2 with D3 we performed a single-blind, placebo-controlled randomized trial spanning 11 weeks. SUBJECTS/METHODS: Healthy volunteers (n=33, aged 33.4±6 years) were divided into three groups (n=11, each): D2, D3 and placebo. Treatment started with a loading dose (100,000 IU) followed by 4800 IU/day (d) between d7 and d20 and follow-up until d77...
June 2015: European Journal of Clinical Nutrition
#14
JOURNAL ARTICLE
K Malinowsky, U Nitsche, K-P Janssen, F G Bader, C Späth, E Drecoll, G Keller, H Höfler, J Slotta-Huspenina, K-F Becker
BACKGROUND: Patients with UICC/AJCC stage II colon cancer have a high 5-year overall survival rate after surgery. Nevertheless, a significant subgroup of patients develops tumour recurrence. Currently, there are no clinically established biomarkers available to identify this patient group. We applied reverse-phase protein arrays (RPPA) for phosphatidylinositide-3-kinase pathway activation mapping to stratify patients according to their risk of tumour recurrence after surgery. METHODS: Full-length proteins were extracted from formalin-fixed, paraffin-embedded tissue samples of 118 patients who underwent curative resection...
April 15, 2014: British Journal of Cancer
#15
JOURNAL ARTICLE
J S Greenwood, G A Keller, M J Chrispeels
We have examined the properties and subcellular localization of phytohemagglutinin (PHA), the major lectin of the common bean (Phaseolus vulgaris.), in the axis cells of nearly mature and imbibed mature seeds. On a protein basis the axis contained about 15% as much PHA as the cotyledons. Localization of PHA was done with an indirect immunolabeling method (rabbit antibodies against PHA, followed by colloidal gold particles coated with goat antibodies against rabbit immunoglobulins) on ultra-thin cryosections which were embedded in plastic on the grids after the immunolabeling procedure...
December 1984: Planta
#16
JOURNAL ARTICLE
C Sautter, G Keller, B Hock
Glyoxysomal citrate synthase (gCS) was purified from crude extracts of watermelon (Citrullus vulgaris Schrad.) cotyledons, yielding a homogenous protein with a subunit MW of 48 kDa. The enzyme was selectively inhibited by 5,5'-dithiobis-(2-nitrobenzoic acid), allowing quantification in the presence of the mitochondrial isoenzyme (mCS). Differences were also observed with respect to inhibition by ATP (k i=2.6 mmol · l(-1) for gCS, k i=0.33 mmol · l(-1) for mCS). The antibodies prepared against gCS did not cross-react with mCS...
March 1988: Planta
#17
JOURNAL ARTICLE
V Tolva, G B Bertoni, P G Bianchi, G C Keller, R Casana
Carotid artery stenting (CAS) is a validated option in the treatment of selected extracranial carotid artery stenosis. Carotid artery dissection during CAS is a rare but potentially devastating complication. We report a case of acute dissection and thrombosis of the left internal carotid artery during filter tip wire engaging maneuvers, complicated by intraoperative complete blindness of the left eye. Immediate conversion to carotid endarterectomy was performed under general anesthesia with electroencephalographic monitoring...
August 2013: Vascular
#18
M F Amato, D C Lerman, G Keller, G Digirolamo, I M I Bignone
No abstract text is available yet for this article.
October 2007: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
#19
JOURNAL ARTICLE
J A Blake, M Dolan, H Drabkin, D P Hill, Ni Li, D Sitnikov, S Bridges, S Burgess, T Buza, F McCarthy, D Peddinti, L Pillai, S Carbon, H Dietze, A Ireland, S E Lewis, C J Mungall, P Gaudet, R L Chrisholm, P Fey, W A Kibbe, S Basu, D A Siegele, B K McIntosh, D P Renfro, A E Zweifel, J C Hu, N H Brown, S Tweedie, Y Alam-Faruque, R Apweiler, A Auchinchloss, K Axelsen, B Bely, M -C Blatter, C Bonilla, L Bouguerleret, E Boutet, L Breuza, A Bridge, W M Chan, G Chavali, E Coudert, E Dimmer, A Estreicher, L Famiglietti, M Feuermann, A Gos, N Gruaz-Gumowski, R Hieta, C Hinz, C Hulo, R Huntley, J James, F Jungo, G Keller, K Laiho, D Legge, P Lemercier, D Lieberherr, M Magrane, M J Martin, P Masson, P Mutowo-Muellenet, C O'Donovan, I Pedruzzi, K Pichler, D Poggioli, P Porras Millán, S Poux, C Rivoire, B Roechert, T Sawford, M Schneider, A Stutz, S Sundaram, M Tognolli, I Xenarios, R Foulgar, J Lomax, P Roncaglia, V K Khodiyar, R C Lovering, P J Talmud, M Chibucos, M Gwinn Giglio, H -Y Chang, S Hunter, C McAnulla, A Mitchell, A Sangrador, R Stephan, M A Harris, S G Oliver, K Rutherford, V Wood, J Bahler, A Lock, P J Kersey, D M McDowall, D M Staines, M Dwinell, M Shimoyama, S Laulederkind, T Hayman, S -J Wang, V Petri, T Lowry, P D'Eustachio, L Matthews, R Balakrishnan, G Binkley, J M Cherry, M C Costanzo, S S Dwight, S R Engel, D G Fisk, B C Hitz, E L Hong, K Karra, S R Miyasato, R S Nash, J Park, M S Skrzypek, S Weng, E D Wong, T Z Berardini, E Huala, H Mi, P D Thomas, J Chan, R Kishore, P Sternberg, K Van Auken, D Howe, M Westerfield
The Gene Ontology (GO) Consortium (GOC, https://www.geneontology.org) is a community-based bioinformatics resource that classifies gene product function through the use of structured, controlled vocabularies. Over the past year, the GOC has implemented several processes to increase the quantity, quality and specificity of GO annotations. First, the number of manual, literature-based annotations has grown at an increasing rate. Second, as a result of a new 'phylogenetic annotation' process, manually reviewed, homology-based annotations are becoming available for a broad range of species...
January 2013: Nucleic Acids Research
#20
JOURNAL ARTICLE
G Yuan, I Regel, F Lian, T Friedrich, I Hitkova, R D Hofheinz, P Ströbel, R Langer, G Keller, C Röcken, W Zimmermann, R M Schmid, M P A Ebert, E Burgermeister
Resistance to chemotherapy is a major obstacle for curative treatment of human gastric cancer (GC). However, the underlying molecular mechanisms are largely unknown. Wingless-type MMTV integration site family members (WNTs) are secreted glycoproteins involved in embryogenesis and, on inappropriate expression in the adult, in cancer. Here, we show expression of WNT6 in GC patient specimens, human GC cell lines and in a mouse model of GC. In human GC cells, WNT6 expression was enhanced by caveolin-1 (Cav1), a scaffold protein of plasma membrane caveolae...
January 17, 2013: Oncogene
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