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"Keller G"

Keller G Guimarães, Rossimiriam P de Freitas, Ana L T G Ruiz, Giovanna F Fiorito, João E de Carvalho, Elaine F F da Cunha, Teodorico C Ramalho, Rosemeire B Alves
A series of novel isocoumarin derivatives were synthesized using Castro-Stephens cross-coupling. Moreover, novel 3,4-dihydroisocoumarin derivatives were obtained by catalytic hydrogenation of the corresponding isocoumarin precursors. The antiproliferative activity of all compounds was evaluated in vitro in different tumor cells. Furthermore, docking calculations were performed for the kallikrein 5 (KLK5) active site to predict the possible mechanism of action of this series of compounds. Theoretical findings indicate that the 3,4-dihydroisocoumarin derivative 10a forms hydrogen bonds with Ser190 and Gln192 residues of KLK5...
March 23, 2016: European Journal of Medicinal Chemistry
D Gallagher, A Bramall, A Paquin, A Voronova, S Burns, P Neilsen, G Keller, D Kaplan, F Miller
No abstract text is available yet for this article.
December 2015: International Journal of Developmental Neuroscience
B Oliveri, S R Mastaglia, G M Brito, M Seijo, G A Keller, J Somoza, R A Diez, G Di Girolamo
BACKGROUND/OBJECTIVES: The superiority of cholecalciferol (D3) over ergocalciferol (D2) in sustaining serum 25-hydroxy vitamin D (25OHD) levels is controversial. To compare D2 with D3 we performed a single-blind, placebo-controlled randomized trial spanning 11 weeks. SUBJECTS/METHODS: Healthy volunteers (n=33, aged 33.4±6 years) were divided into three groups (n=11, each): D2, D3 and placebo. Treatment started with a loading dose (100,000 IU) followed by 4800 IU/day (d) between d7 and d20 and follow-up until d77...
June 2015: European Journal of Clinical Nutrition
K Malinowsky, U Nitsche, K-P Janssen, F G Bader, C Späth, E Drecoll, G Keller, H Höfler, J Slotta-Huspenina, K-F Becker
BACKGROUND: Patients with UICC/AJCC stage II colon cancer have a high 5-year overall survival rate after surgery. Nevertheless, a significant subgroup of patients develops tumour recurrence. Currently, there are no clinically established biomarkers available to identify this patient group. We applied reverse-phase protein arrays (RPPA) for phosphatidylinositide-3-kinase pathway activation mapping to stratify patients according to their risk of tumour recurrence after surgery. METHODS: Full-length proteins were extracted from formalin-fixed, paraffin-embedded tissue samples of 118 patients who underwent curative resection...
April 15, 2014: British Journal of Cancer
J S Greenwood, G A Keller, M J Chrispeels
We have examined the properties and subcellular localization of phytohemagglutinin (PHA), the major lectin of the common bean (Phaseolus vulgaris.), in the axis cells of nearly mature and imbibed mature seeds. On a protein basis the axis contained about 15% as much PHA as the cotyledons. Localization of PHA was done with an indirect immunolabeling method (rabbit antibodies against PHA, followed by colloidal gold particles coated with goat antibodies against rabbit immunoglobulins) on ultra-thin cryosections which were embedded in plastic on the grids after the immunolabeling procedure...
December 1984: Planta
C Sautter, G Keller, B Hock
Glyoxysomal citrate synthase (gCS) was purified from crude extracts of watermelon (Citrullus vulgaris Schrad.) cotyledons, yielding a homogenous protein with a subunit MW of 48 kDa. The enzyme was selectively inhibited by 5,5'-dithiobis-(2-nitrobenzoic acid), allowing quantification in the presence of the mitochondrial isoenzyme (mCS). Differences were also observed with respect to inhibition by ATP (k i=2.6 mmol · l(-1) for gCS, k i=0.33 mmol · l(-1) for mCS). The antibodies prepared against gCS did not cross-react with mCS...
March 1988: Planta
V Tolva, G B Bertoni, P G Bianchi, G C Keller, R Casana
Carotid artery stenting (CAS) is a validated option in the treatment of selected extracranial carotid artery stenosis. Carotid artery dissection during CAS is a rare but potentially devastating complication. We report a case of acute dissection and thrombosis of the left internal carotid artery during filter tip wire engaging maneuvers, complicated by intraoperative complete blindness of the left eye. Immediate conversion to carotid endarterectomy was performed under general anesthesia with electroencephalographic monitoring...
August 2013: Vascular
M F Amato, D C Lerman, G Keller, G Digirolamo, I M I Bignone
No abstract text is available yet for this article.
October 2007: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
J A Blake, M Dolan, H Drabkin, D P Hill, Ni Li, D Sitnikov, S Bridges, S Burgess, T Buza, F McCarthy, D Peddinti, L Pillai, S Carbon, H Dietze, A Ireland, S E Lewis, C J Mungall, P Gaudet, R L Chrisholm, P Fey, W A Kibbe, S Basu, D A Siegele, B K McIntosh, D P Renfro, A E Zweifel, J C Hu, N H Brown, S Tweedie, Y Alam-Faruque, R Apweiler, A Auchinchloss, K Axelsen, B Bely, M -C Blatter, C Bonilla, L Bouguerleret, E Boutet, L Breuza, A Bridge, W M Chan, G Chavali, E Coudert, E Dimmer, A Estreicher, L Famiglietti, M Feuermann, A Gos, N Gruaz-Gumowski, R Hieta, C Hinz, C Hulo, R Huntley, J James, F Jungo, G Keller, K Laiho, D Legge, P Lemercier, D Lieberherr, M Magrane, M J Martin, P Masson, P Mutowo-Muellenet, C O'Donovan, I Pedruzzi, K Pichler, D Poggioli, P Porras Millán, S Poux, C Rivoire, B Roechert, T Sawford, M Schneider, A Stutz, S Sundaram, M Tognolli, I Xenarios, R Foulgar, J Lomax, P Roncaglia, V K Khodiyar, R C Lovering, P J Talmud, M Chibucos, M Gwinn Giglio, H -Y Chang, S Hunter, C McAnulla, A Mitchell, A Sangrador, R Stephan, M A Harris, S G Oliver, K Rutherford, V Wood, J Bahler, A Lock, P J Kersey, D M McDowall, D M Staines, M Dwinell, M Shimoyama, S Laulederkind, T Hayman, S -J Wang, V Petri, T Lowry, P D'Eustachio, L Matthews, R Balakrishnan, G Binkley, J M Cherry, M C Costanzo, S S Dwight, S R Engel, D G Fisk, B C Hitz, E L Hong, K Karra, S R Miyasato, R S Nash, J Park, M S Skrzypek, S Weng, E D Wong, T Z Berardini, E Huala, H Mi, P D Thomas, J Chan, R Kishore, P Sternberg, K Van Auken, D Howe, M Westerfield
The Gene Ontology (GO) Consortium (GOC, is a community-based bioinformatics resource that classifies gene product function through the use of structured, controlled vocabularies. Over the past year, the GOC has implemented several processes to increase the quantity, quality and specificity of GO annotations. First, the number of manual, literature-based annotations has grown at an increasing rate. Second, as a result of a new 'phylogenetic annotation' process, manually reviewed, homology-based annotations are becoming available for a broad range of species...
January 2013: Nucleic Acids Research
G Yuan, I Regel, F Lian, T Friedrich, I Hitkova, R D Hofheinz, P Ströbel, R Langer, G Keller, C Röcken, W Zimmermann, R M Schmid, M P A Ebert, E Burgermeister
Resistance to chemotherapy is a major obstacle for curative treatment of human gastric cancer (GC). However, the underlying molecular mechanisms are largely unknown. Wingless-type MMTV integration site family members (WNTs) are secreted glycoproteins involved in embryogenesis and, on inappropriate expression in the adult, in cancer. Here, we show expression of WNT6 in GC patient specimens, human GC cell lines and in a mouse model of GC. In human GC cells, WNT6 expression was enhanced by caveolin-1 (Cav1), a scaffold protein of plasma membrane caveolae...
January 17, 2013: Oncogene
S J Micallef, X Li, J V Schiesser, C E Hirst, Q C Yu, S M Lim, M C Nostro, D A Elliott, F Sarangi, L C Harrison, G Keller, A G Elefanty, E G Stanley
AIMS/HYPOTHESIS: We aimed to generate human embryonic stem cell (hESC) reporter lines that would facilitate the characterisation of insulin-producing (INS⁺) cells derived in vitro. METHODS: Homologous recombination was used to insert sequences encoding green fluorescent protein (GFP) into the INS locus, to create reporter cell lines enabling the prospective isolation of viable INS⁺ cells. RESULTS: Differentiation of INS(GFP/w) hESCs using published protocols demonstrated that all GFP⁺ cells co-produced insulin, confirming the fidelity of the reporter gene...
March 2012: Diabetologia
C L Basford, K J Prentice, A B Hardy, F Sarangi, S J Micallef, X Li, Q Guo, A G Elefanty, E G Stanley, G Keller, E M Allister, M C Nostro, M B Wheeler
AIMS/HYPOTHESIS: Using a novel directed differentiation protocol, we recently generated up to 25% insulin-producing cells from human embryonic stem cells (hESCs) (insulin(+) cells). At this juncture, it was important to functionally and molecularly characterise these hESC-derived insulin(+) cells and identify key differences and similarities between them and primary beta cells. METHODS: We used a new reporter hESC line with green fluorescent protein (GFP) cDNA targeted to the INS locus by homologous recombination (INS (GFP/w)) and an untargeted hESC line (HES2)...
February 2012: Diabetologia
G A Keller, P Czerniuk, R Bertuola, F de Mena, M V Simoni, A R Assefi, Guillermo Di Girolamo
OBJECTIVE: To evaluate the relative bioavailability of a new formulation containing 5 mg mosapride and 10 mg rabeprazole (T) and compare it with the branded formulations of both drugs co-administered in separate tablets (R) to meet the regulatory requirements of bioequivalence in Argentina. METHODS: A randomized-sequence, open-label, two-period crossover study was conducted on 24 healthy Caucasian volunteers in a fasting state. A single oral dose of either T or R formulations was followed by a 7-day washout period...
November 2011: Current Medical Research and Opinion
G Gregory Keller, Edmund Dziuk, Jerold S Bell
The Orthopedic Foundation for Animals (OFA) maintains an on-line health pedigree database for inherited disorders of animals. With the American Kennel Club Canine Health Foundation, the OFA maintains the Canine Health Information Center (CHIC) for parent breed clubs to identify breed-specific required health tests. Analysis of the results of OFA evaluations in the hip and elbow registries show that selection based on phenotype improves conformation. Disorders with complex inheritance respond best to selection based on depth (ancestors) and breadth (siblings) of pedigree health test results...
August 2011: Veterinary Journal
C Saroul, G Keller, M Benaissa, J J Lehot
The objectives are to present the different minimally invasive cardiac surgery techniques to repair the mitral valve, TAVI and MitraClip, as well as the implications for the anaesthetist. Evaluate retrospectively the anaesthesist methods, change in monitoring and how the patients are selected. The mitral valve repair by minithoracotomy and video-surgery requires selective left intubation and monitoring by TEE. The TAVI methods seem to be working best under local anaesthesia and sedation for haemodynamic and neurologic monitoring...
May 2011: Annales Françaises D'anesthèsie et de Rèanimation
F-P Desgranges, O Desebbe, A Ghazouani, K Gilbert, G Keller, P Chiari, J Robin, O Bastien, J-J Lehot, M Cannesson
BACKGROUND: Plethysmographic variability index (PVI) is an accurate predictor of fluid responsiveness in mechanically ventilated patients. However, the site of measurement of the plethysmographic waveform impacts its morphology and its respiratory variation. The goal of this study was to investigate the ability of PVI to predict fluid responsiveness at three sites of measurement (the forehead, ear, and finger) in mechanically ventilated patients under general anaesthesia. METHODS: We studied 28 subjects after induction of general anaesthesia...
September 2011: British Journal of Anaesthesia
No abstract text is available yet for this article.
December 1945: Bulletin
J-J Lehot, C Heuclin, J Neidecker, R Cartier, P Ffrench, M E Reverdy, D Revel, M Billard, C Lupo, B Gonnard, G Keller, G Aulagner, O Bastien
OBJECTIVES: To evaluate whether intensivists would accept to optimize their orderings of biological samplings, x-rays and target drugs and to assess the consequence on patient's outcome. STUDY DESIGN: Monocentric evaluation of medical economic procedure. METHODS: Meetings of consultants, registrars and residents started on Dec 21, 2006 with two to three sessions a year in order to evaluate the process of medical ordering. The physicians and pharmacists gave the results of orderings at each meeting...
October 2010: Annales Françaises D'anesthèsie et de Rèanimation
G N Keller, R N Berzofsky, R Burt, J Stefka, A Traynor, C Link, A LeFever
BACKGROUND: With the advancement of genetics and hematopoiesis resulting in therapeutic applications, a growing focus has developed on the quality assessment of biological products generated for various cellular therapies. Endotoxin is a critical measure for the presence of Gram-negative bacteria, known to cause endotoxemia. Cellular products are currently regulated as medical devices. Each location engaged in clinical protocols is responsible for establishing a quality assurance program...
1999: Cytotherapy
P Gaudet, L Lane, P Fey, A Bridge, S Poux, A Auchincloss, K Axelsen, S Braconi Quintaje, E Boutet, P Brown, E Coudert, R S Datta, W C de Lima, T de Oliveira Lima, S Duvaud, N Farriol-Mathis, S Ferro Rojas, M Feuermann, A Gateau, U Hinz, C Hulo, J James, S Jimenez, F Jungo, G Keller, P Lemercier, D Lieberherr, M Moinat, A Nikolskaya, I Pedruzzi, C Rivoire, B Roechert, M Schneider, E Stanley, M Tognolli, K Sjölander, L Bougueleret, R L Chisholm, A Bairoch
UniProtKB/Swiss-Prot, a curated protein database, and dictyBase, the Model Organism Database for Dictyostelium discoideum, have established a collaboration to improve data sharing. One of the major steps in this effort was the 'Dicty annotation marathon', a week-long exercise with 30 annotators aimed at achieving a major increase in the number of D. discoideum proteins represented in UniProtKB/Swiss-Prot. The marathon led to the annotation of over 1000 D. discoideum proteins in UniProtKB/Swiss-Prot. Concomitantly, there were a large number of updates in dictyBase concerning gene symbols, protein names and gene models...
2009: Database: the Journal of Biological Databases and Curation
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