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"Bursac N" cardiac

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https://www.readbyqxmd.com/read/27271751/striated-muscle-function-regeneration-and-repair
#1
REVIEW
I Y Shadrin, A Khodabukus, N Bursac
As the only striated muscle tissues in the body, skeletal and cardiac muscle share numerous structural and functional characteristics, while exhibiting vastly different size and regenerative potential. Healthy skeletal muscle harbors a robust regenerative response that becomes inadequate after large muscle loss or in degenerative pathologies and aging. In contrast, the mammalian heart loses its regenerative capacity shortly after birth, leaving it susceptible to permanent damage by acute injury or chronic disease...
November 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/12480825/cardiomyocyte-cultures-with-controlled-macroscopic-anisotropy-a-model-for-functional-electrophysiological-studies-of-cardiac-muscle
#2
N Bursac, K K Parker, S Iravanian, L Tung
Structural and functional cardiac anisotropy varies with the development, location, and pathophysiology in the heart. The goal of this study was to design a cell culture model system in which the degree, change in fiber direction, and discontinuity of anisotropy can be controlled over centimeter-size length scales. Neonatal rat ventricular myocytes were cultured on fibronectin on 20-mm diameter circular cover slips. Structure-function relationships were assessed using immunostaining and optical mapping. Cell culture on microabraded cover slips yielded cell elongation and coalignment in the direction of abrasion, and uniform, macroscopically continuous, elliptical propagation with point stimulation...
December 13, 2002: Circulation Research
https://www.readbyqxmd.com/read/11669106/system-identification-of-dynamic-closed-loop-control-of-total-peripheral-resistance-by-arterial-and-cardiopulmonary-baroreceptors
#3
A N Aljuri, N Bursac, R Marini, R J Cohen
Prolonged exposure to microgravity in space flight missions (days) impairs the mechanisms responsible for defense of arterial blood pressure (ABP) and cardiac output (CO) against orthostatic stress in the post-flight period. The mechanisms responsible for the observed orthostatic intolerance are not yet completely understood. Additionally, effective counter measures to attenuate this pathophysiological response are not available. The aim of this study was to investigate the ability of our proposed system identification method to predict closed-loop dynamic changes in TPR induced by changes in mean arterial pressure (MAP) and right atrial pressure (RAP)...
August 2001: Acta Astronautica
https://www.readbyqxmd.com/read/11123231/tissue-engineering-of-functional-cardiac-muscle-molecular-structural-and-electrophysiological-studies
#4
M Papadaki, N Bursac, R Langer, J Merok, G Vunjak-Novakovic, L E Freed
The primary aim of this study was to relate molecular and structural properties of in vitro reconstructed cardiac muscle with its electrophysiological function using an in vitro model system based on neonatal rat cardiac myocytes, three-dimensional polymeric scaffolds, and bioreactors. After 1 wk of cultivation, we found that engineered cardiac muscle contained a 120- to 160-microm-thick peripheral region with cardiac myocytes that were electrically connected through gap junctions and sustained macroscopically continuous impulse propagation over a distance of 5 mm...
January 2001: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/10444466/cardiac-muscle-tissue-engineering-toward-an-in-vitro-model-for-electrophysiological-studies
#5
N Bursac, M Papadaki, R J Cohen, F J Schoen, S R Eisenberg, R Carrier, G Vunjak-Novakovic, L E Freed
The objective of this study was to establish a three-dimensional (3-D) in vitro model system of cardiac muscle for electrophysiological studies. Primary neonatal rat ventricular cells containing lower or higher fractions of cardiac myocytes were cultured on polymeric scaffolds in bioreactors to form regular or enriched cardiac muscle constructs, respectively. After 1 wk, all constructs contained a peripheral tissue-like region (50-70 micrometer thick) in which differentiated cardiac myocytes were organized in multiple layers in a 3-D configuration...
August 1999: American Journal of Physiology
https://www.readbyqxmd.com/read/10404238/cardiac-tissue-engineering-cell-seeding-cultivation-parameters-and-tissue-construct-characterization
#6
R L Carrier, M Papadaki, M Rupnick, F J Schoen, N Bursac, R Langer, L E Freed, G Vunjak-Novakovic
Cardiac tissue engineering has been motivated by the need to create functional tissue equivalents for scientific studies and cardiac tissue repair. We previously demonstrated that contractile cardiac cell-polymer constructs can be cultivated using isolated cells, 3-dimensional scaffolds, and bioreactors. In the present work, we examined the effects of (1) cell source (neonatal rat or embryonic chick), (2) initial cell seeding density, (3) cell seeding vessel, and (4) tissue culture vessel on the structure and composition of engineered cardiac muscle...
September 5, 1999: Biotechnology and Bioengineering
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