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Ana M Tobiasz, Jose R Duncan, Zoran Bursac, Ryan D Sullivan, Danielle L Tate, Alex M Dopico, Anna N Bukiya, Giancarlo Mari
Prenatal alcohol exposure often results in an array of fetal developmental abnormalities termed fetal alcohol spectrum disorders (FASDs). Despite the high prevalence of FASDs, the pathophysiology of fetal damage by alcohol remains poorly understood. One of the major obstacles in studying fetal development in response to alcohol exposure is the inability to standardize the amount, pattern of alcohol consumption, and peak blood alcohol levels in pregnant mothers. In the present study, we used Doppler ultrasonography to assess fetal growth and cardiovascular parameters in response to alcohol exposure in pregnant baboons...
January 1, 2017: Reproductive Sciences
Michael A Preston, Katherine Glover-Collins, Levi Ross, Austin Porter, Zoran Bursac, Delores Woods, Jacqueline Burton, Karen Crowell, Jonathan Laryea, Ronda S Henry-Tillman
To test the efficacy of a community-based intervention, Empowering Communities for Life (EC4L), designed to increase colorectal cancer (CRC) screening through fecal occult blood test (FOBT) in rural underserved communities in a randomized controlled trial. Participants were randomized into 3 groups (2 interventions and 1 control). Interventions were delivered by community lay health workers or by academic health professionals. The main outcome of interest was return rate of FOBT screening kit within 60 days...
August 12, 2017: American Journal of Surgery
Mounica Yanamandala, Wuqiang Zhu, Daniel J Garry, Timothy J Kamp, Joshua M Hare, Ho-Wook Jun, Young-Sup Yoon, Nenad Bursac, Sumanth D Prabhu, Gerald W Dorn, Roberto Bolli, Richard N Kitsis, Jianyi Zhang
Transplantations of various stem cells or their progeny have repeatedly improved cardiac performance in animal models of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent. Some of the recognized challenges are poor engraftment of implanted cells and, in the case of human cardiomyocytes, functional immaturity and lack of electrical integration, leading to limited contribution to the heart's contractile activity and increased arrhythmogenic risks. Advances in tissue and genetic engineering techniques are expected to improve the survival and integration of transplanted cells, and to support structural, functional, and bioenergetic recovery of the recipient hearts...
August 8, 2017: Journal of the American College of Cardiology
I Y Shadrin, A Khodabukus, N Bursac
As the only striated muscle tissues in the body, skeletal and cardiac muscle share numerous structural and functional characteristics, while exhibiting vastly different size and regenerative potential. Healthy skeletal muscle harbors a robust regenerative response that becomes inadequate after large muscle loss or in degenerative pathologies and aging. In contrast, the mammalian heart loses its regenerative capacity shortly after birth, leaving it susceptible to permanent damage by acute injury or chronic disease...
November 2016: Cellular and Molecular Life Sciences: CMLS
Rebecca A Krukowski, Zoran Bursac, Melissa A Little, Robert C Klesges
INTRODUCTION: There is wide variability in the amount of weight gained when quitting smoking, but little is known about key predictors of weight gain. We examined the impact of body mass index (BMI) category and sociodemographic variables on post-cessation weight gain. MATERIALS AND METHODS: We utilized National Health and Nutrition Examination Survey data from five consecutive cycles of data collection from 2003-2004 to 2011-2012 to estimate post-cessation weight gain by BMI category among recent quitters (n = 654)...
2016: PloS One
Karen J Derefinko, Robert C Klesges, Zoran Bursac, Melissa A Little, Ann Hryshko-Mullen, Gerald W Talcott
The negative impact of alcohol is a significant concern to the US military given the costs associated with alcohol-related offenses. Despite considerable research in active duty personnel, relatively little is known about the current extent of alcohol use among incoming recruits. We examined the history of alcohol use and harmful patterns of alcohol consumption among recruits entering the United States Air Force (USAF; N=50,549) over the span of 4 years (2010-2014). Across all years, drinking rates reflected national average trends for those aged 18-24 (NIDA, 2014)...
July 2016: Addictive Behaviors
Corey J Hayes, Teresa J Hudson, Martha M Phillips, Zoran Bursac, James S Williams, Mark A Austin, Mark J Edlund, Bradley C Martin
PURPOSE: Our aim is to determine if propoxyphene withdrawal from the US market was associated with opioid continuation, continued chronic opioid use, and secondary propoxyphene-related adverse events (emergency department visits, opioid-related events, and acetaminophen toxicity). METHODS: Medical service use and pharmacy data from 19/11/08 to 19/11/11 were collected from the national Veterans Healthcare Administration healthcare databases. A quasi-experimental pre-post retrospective cohort design utilizing a historical comparison group provided the study framework...
November 2015: Pharmacoepidemiology and Drug Safety
J V Tranquillo, N Bursac
Attempts to terminate monomorphic tachycardia by rapid pacing occasionally lead to acceleration of the tachycardia rate followed by fibrillation. Previous experimental studies have shown that rapid pacing can convert a single-wave functional reentry into a stable multi-wave reentry with accelerated rate, but only when the single spiral rate is significantly lower than the rate the tissue can sustain. In addition the acceleration was facilitated by broad and deep conduction velocity restitution. This study explores the mechanisms that modulate the potential for and degree of acceleration...
August 2006: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
D C Kanellis, S Bursac, P N Tsichlis, S Volarevic, A G Eliopoulos
Tumor Progression Locus 2 (TPL2) is widely recognized as a cytoplasmic mitogen-activated protein 3 kinase with a prominent role in the regulation of inflammatory and oncogenic signal transduction. Herein we report that TPL2 may also operate in the nucleus as a physical and functional partner of nucleophosmin (NPM/B23), a major nucleolar phosphoprotein with diverse cellular activities linked to malignancy. We demonstrate that TPL2 mediates the phosphorylation of a fraction of NPM at threonine 199, an event required for its proteasomal degradation and maintenance of steady-state NPM levels...
May 7, 2015: Oncogene
Mark Juhas, George C Engelmayr, Andrew N Fontanella, Gregory M Palmer, Nenad Bursac
Tissue-engineered skeletal muscle can serve as a physiological model of natural muscle and a potential therapeutic vehicle for rapid repair of severe muscle loss and injury. Here, we describe a platform for engineering and testing highly functional biomimetic muscle tissues with a resident satellite cell niche and capacity for robust myogenesis and self-regeneration in vitro. Using a mouse dorsal window implantation model and transduction with fluorescent intracellular calcium indicator, GCaMP3, we nondestructively monitored, in real time, vascular integration and the functional state of engineered muscle in vivo...
April 15, 2014: Proceedings of the National Academy of Sciences of the United States of America
Biljana N Bursać, Ana D Vasiljević, Nataša M Nestorović, Nataša A Veličković, Danijela D Vojnović Milutinović, Gordana M Matić, Ana D Djordjevic
Fructose overconsumption has been involved in the genesis and progression of the metabolic syndrome. Hypothalamus and adipose tissue, major organs for control of food intake and energy metabolism, play crucial roles in metabolic homeostasis. We hypothesized that glucocorticoid signaling mediates the effects of a fructose-enriched diet on visceral adiposity by acting on neuropeptide Y (NPY) in the hypothalamus and altering adipogenic transcription factors in the visceral adipose tissue. We analyzed the effects of 9-week consumption of 60% fructose solution on dyslipidemia, insulin and leptin sensitivity, and adipose tissue histology in male Wistar rats...
April 2014: Journal of Nutritional Biochemistry
Robert D Kirkton, Nima Badie, Nenad Bursac
BACKGROUND: Electrophysiological mismatch between host cardiomyocytes and donor cells can directly affect the electrical safety of cardiac cell therapies; however, the ability to study host-donor interactions at the microscopic scale in situ is severely limited. We systematically explored how action potential (AP) differences between cardiomyocytes and other excitable cells modulate vulnerability to conduction failure in vitro. METHODS AND RESULTS: AP propagation was optically mapped at 75 μm resolution in micropatterned strands (n=152) in which host neonatal rat ventricular myocytes (AP duration=153...
December 2013: Circulation. Arrhythmia and Electrophysiology
Marsha L Eigenbrodt, Gregory W Evans, Kathryn M Rose, Zoran Bursac, Richard E Tracy, Jawahar L Mehta, David J Couper
BACKGROUND: External common carotid artery (CCA) diameter and intima-media thickness (IMT) are independently associated with incident stroke and other cardiovascular events. Arterial geometry such as large IMT and large diameter may reflect vulnerable plaques and so impact stroke risk. Finally, arterial changes that exist bilaterally may increase stroke risk. METHOD: We studied middle-aged men and women (n=7276) from a prospective observational study who had right (R) and left (L) CCA IMT and external diameters measured via B-mode ultrasound (1987-89) in order to categorize CCA geometry...
June 15, 2013: Cardiovascular Ultrasound
Katarina Bojanić, Danijel Bursać, Jasenka Zmijanac, Zeljko Duić, Federica Scavonetto, Toby N Weingarten, Juraj Sprung
PURPOSE: Isolated cor triatriatum sinistrum (CTS) is a heart malformation in which a perforated fibromuscular membrane divides the left atrium into two chambers. When communication between these chambers is restricted, a patient may have signs and symptoms of mitral stenosis. The later stages of pregnancy are associated with tachycardia and increases in intravascular volume. We describe how this altered physiology may affect pregnant women with asymptomatic CTS. We also review the literature relating to pregnancy in patients with CTS...
June 2013: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Biljana N Bursać, Ana D Djordjevic, Ana D Vasiljević, Danijela D Vojnović Milutinović, Nataša A Veličković, Nataša M Nestorović, Gordana M Matić
The rise in consumption of refined sugars high in fructose appears to be an important factor for the development of obesity and metabolic syndrome. Fructose has been shown to be involved in genesis and progression of the syndrome through deregulation of metabolic pathways in adipose tissue. There is evidence that enhanced glucocorticoid regeneration within adipose tissue, mediated by the enzyme 11beta-hydroxysteroid dehydrogenase Type 1 (11βHSD1), may contribute to adiposity and metabolic disease. 11βHSD1 reductase activity is dependent on NADPH, a cofactor generated by hexose-6-phosphate dehydrogenase (H6PDH)...
June 2013: Journal of Nutritional Biochemistry
Paul Greene, Paulette Mehta, Karen Hye-cheon Kim Yeary, Zoran Bursac, Jianjun Zhang, Geoff Goldsmith, Ronda Henry-Tillman
INTRODUCTION: Colorectal cancer is a common disease, and incidence and death rates are higher in medically underserved populations. The colorectal cancer death rate in Arkansas exceeds the national rate. The objective of this study was to examine population characteristics relevant to the design and implementation of a state-sponsored colorectal cancer screening program that is responsive to medically underserved populations. METHODS: Trained interviewers in 2006 conducted a random-digit-dialed telephone survey comprising items selected from the Health Information National Trends Survey to characterize demographic factors, health care variables, and colorectal screening history in a sample (n = 2,021) representative of the Arkansas population...
2012: Preventing Chronic Disease
Barbara Muller-Borer, Gwyn Esch, Rob Aldina, Woohyun Woon, Raymond Fox, Nenad Bursac, Sylvia Hiller, Nobuyuo Maeda, Neal Shepherd, Jian Ping Jin, Mary Hutson, Page Anderson, Margaret L Kirby, Nadia N Malouf
The phenotype of somatic cells has recently been found to be reversible. Direct reprogramming of one cell type into another has been achieved with transduction and over expression of exogenous defined transcription factors emphasizing their role in specifying cell fate. To discover early and novel endogenous transcription factors that may have a role in adult-derived stem cell acquisition of a cardiomyocyte phenotype, mesenchymal stem cells from human and mouse bone marrow and rat liver were co-cultured with neonatal cardiomyocytes as an in vitro cardiogenic microenvironment...
2012: PloS One
Luke C McSpadden, Hung Nguyen, Nenad Bursac
BACKGROUND: Cardiac cell therapies can yield electric coupling of unexcitable donor cells to host cardiomyocytes with functional consequences that remain unexplored. METHODS AND RESULTS: We micropatterned cell pairs consisting of a neonatal rat ventricular myocyte (NRVM) coupled to an engineered human embryonic kidney 293 (HEK293) cell expressing either connexin-43 (Cx43 HEK) or inward rectifier potassium channel 2.1 (Kir2.1) and Cx43 (Kir2.1+Cx43 HEK). The NRVM-HEK contact length was fixed yielding a coupling strength of 68...
August 1, 2012: Circulation. Arrhythmia and Electrophysiology
Delia Smith West, Zoran Bursac, Carol E Cornell, Holly C Felix, Jennifer K Fausett, Rebecca A Krukowski, Shelly Lensing, Sharhonda J Love, T Elaine Prewitt, Cornelia Beck
BACKGROUND: Older adults have high obesity rates and respond well to evidence-based weight-loss programs, such as the Diabetes Prevention Program (DPP) Lifestyle intervention. The goal of this study was to determine whether a translation of the DPP Lifestyle program delivered by lay health educators and conducted in senior centers is effective in promoting weight loss among older adults. DESIGN: An RCT with older adults nested within senior centers. Senior centers identified lay health educators to receive training and deliver the intervention program at the senior center...
October 2011: American Journal of Preventive Medicine
Petr Rada, Pavel Doležal, Petr L Jedelský, Dejan Bursac, Andrew J Perry, Miroslava Šedinová, Kateřina Smíšková, Marian Novotný, Neritza Campo Beltrán, Ivan Hrdý, Trevor Lithgow, Jan Tachezy
Trichomonas vaginalis is a parasitic protist of the Excavata group. It contains an anaerobic form of mitochondria called hydrogenosomes, which produce hydrogen and ATP; the majority of mitochondrial pathways and the organellar genome were lost during the mitochondrion-to-hydrogenosome transition. Consequently, all hydrogenosomal proteins are encoded in the nucleus and imported into the organelles. However, little is known about the membrane machineries required for biogenesis of the organelle and metabolite exchange...
2011: PloS One
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