keyword
MENU ▼
Read by QxMD icon Read
search

Hemophagocytic lymphohistiocytosis

keyword
https://www.readbyqxmd.com/read/28926358/potentially-toxic-chemotherapy-in-secondary-hemophagocytic-lymphohistiocytosis-patients-that-could-have-been-replaced-by-less-immunosuppressive-therapy
#1
(no author information available yet)
No abstract text is available yet for this article.
September 18, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28924117/successful-treatment-of-herpes-simplex-virus-hsv-1-associated-hemophagocytic-lymphohistiocytosis-hlh-with-acyclovir-a-case-report-and-literature-review
#2
Tomohiro Yabushita, Satoshi Yoshioka, Yusuke Koba, Yuichirou Ono, Nobuhiro Hiramoto, Sumie Tabata, Munehiro Itou, Norio Shimizu, Keisuke Tomii, Takayuki Ishikawa
Hemophagocytic lymphohistiocytosis (HLH) associated with herpes simplex virus (HSV)-1 infection (HSV-1-HLH) is uncommon and is potentially fatal without appropriate treatment. We herein report the case of an adult patient with HSV-1-HLH who was successfully treated with acyclovir. A 69-year-old man developed fever, pancytopenia and liver enzyme elevation after the resolution of pneumonia. These findings and the presence of hemophagocytosis in the patient's bone marrow were consistent with a diagnosis of HLH...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28914368/macrophage-activation-syndrome-in-still-s-disease-analysis-of-clinical-characteristics-and-survival-in-paediatric-and-adult-patients
#3
Piero Ruscitti, Carmela Rago, Luciana Breda, Paola Cipriani, Vasiliki Liakouli, Onorina Berardicurti, Francesco Carubbi, Caterina Di Battista, Alberto Verrotti, Roberto Giacomelli
Macrophage activation syndrome (MAS) is a reactive form of hemophagocytic lymphohistiocytosis, complicating Still's disease, both in paediatric and adult patients. In this work, we aimed to investigate clinical picture and outcome of Still's disease patients developing MAS. We performed a retrospective analysis of patients, both paediatrics and adults, affected by Still's disease attending our department. During the follow-up, each patient was investigated for MAS occurrence and possible predictors, clinical and laboratory factors, were analysed...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28912991/t-cell-histiocyte-rich-large-b-cell-lymphoma-presenting-as-hemophagocytic-lymphohistiocytosis-an-uncommon-presentation-of-a-rare-disease
#4
Uroosa Ibrahim, Gwenalyn Garcia, Amina Saqib, Shafinaz Hussein, Qun Dai
T cell histiocyte rich large B cell lymphoma (THRLBCL) is a rare subtype of non-Hodgkin's lymphoma characterized by malignant B cells with reactive T lymphocytes. The pathophysiology is thought to involve cytokine-mediated evasion of T cell immune response by malignant B cells. It usually presents at an advanced stage with extranodal involvement. An extremely unusual manifestation of the disease is hemophagocytic lymphohistiocytosis (HLH) which is a hyperinflammatory disorder. We present a case of a 43-year-old male who presented with recurrent fever and recent radiologic imaging showing splenomegaly and right inguinal lymphadenopathy...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28871523/a-personalized-diagnostic-and-treatment-approach-for-macrophage-activation-syndrome-and-secondary-hemophagocytic-lymphohistiocytosis-in-adults
#5
Bharat Kumar, Sohaib Aleem, Hana Saleh, Jennifer Petts, Zuhair K Ballas
OBJECTIVE: We assessed the clinical features and outcomes based on therapeutic options adopted during hospital stay for adult patients with macrophage activation syndrome and secondary hemophagocytic lymphohistiocytosis (MAS/sHLH). METHODS: We conducted a retrospective chart review of all adult patients (age ≥ 18 years) diagnosed with MAS/sHLH at our center between 2010 and 2015. Inclusion criteria for patients were diagnosis of MAS/sHLH during admission and patients meeting at least 5 out of 8 of Henter's criteria or at least 4 out of 6 of the criteria that were tested...
September 4, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28869447/high-concentration-of-mir-133-is-a-useful-marker-for-the-diagnosis-of-lymphoma-associated-hemophagocytic-syndrome
#6
Wuping Li, Yun Zhong, Yuerong Shuang, Hui Huang, Yan Huang, Li Yu, Xianbao Huang
BACKGROUND: Lymphoma associated hemophagocytic syndrome (LAHS) is one of the major adult secondary hemophagocytic lymphohistiocytosis (HLH). Early diagnosis and treatment contribute to improved outcome. No enlarge lymph nodes can often delay the diagnosis of underlying lymphoma. OBJECTIVE: To find out criteria distinguishing LAHS from HLH induced by benign diseases. METHODS: clinical characteristic and laboratory feature of 31 patients with HLH (10 benign disease-associated HLH and 21 LAHS) were analyzed retrospectively...
August 23, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28866302/hemophagocytic-syndrome-primary-forms-and-predisposing-conditions
#7
REVIEW
Fernando E Sepulveda, Geneviève de Saint Basile
Hemophagocytic lymphohistiocytosis (HLH, also referred to a hemophagocytic syndrome) is a life-threatening condition in which uncontrolled activation of lymphocytes and macrophages, and thus the secretion of large amounts of inflammatory cytokines, leads to a severe hyperinflammatory state. Over the last few decades, researchers have characterized primary forms of HLH caused by genetic defects that impair lymphocytes' cytotoxic machinery. Other genetic causes of HLH not related to impaired cytotoxicity have also recently been identified...
August 31, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28864373/significance-of-hyperferritinemia-in-hospitalized-adults
#8
Meredith Schaffner, Lori Rosenstein, Zuhair Ballas, Manish Suneja
BACKGROUND: Although high ferritin levels are associated with iron overload, it is known that ferritin is also an acute-phase reactant that may be elevated in conditions associated with acute and chronic inflammation. In addition, an elevated ferritin level is a criterion for the diagnosis of hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS). Therefore, the significance of elevated serum ferritin is often unclear. As HLH/MAS is a medical emergency, prompt diagnosis is important to guide appropriate treatment...
August 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28863861/neuromyelitis-optica-atypical-hemophagocytic-lymphohistiocytosis-and-heterozygous-perforin-a91v-mutation
#9
Boaz Palterer, Francesca Brugnolo, Elena Sieni, Alessandro Barilaro, Paola Parronchi
Neuromyelitis optica is an autoimmune demyelinating inflammatory disease characterized by optic neuritis and myelitis with anti-aquaporin 4 antibodies. Hemophagocytic lymphohistiocytosis is a severe systemic inflammatory syndrome that can present in a genetic primary form or secondarily to infective, neoplastic or autoimmune diseases. Our case discusses the first reported case of atypical late-onset hemophagocytic lymphohistiocytosis in a patient with neuromyelitis optica, with multiple triggering factors and carrying the common A91V hypomorphic perforin mutation, that blurs the distinction between primary and secondary forms...
October 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28860338/hif1a-is-a-critical-downstream-mediator-for-hemophagocytic-lymphohistiocytosis
#10
Rui Huang, Yoshihiro Hayashi, Xiaomei Yan, Jiachen Bu, Jieyu Wang, Yue Zhang, Yile Zhou, Yuting Tang, Lingyun Wu, Zefeng Xu, Xin Liu, Qianfei Wang, Jianfeng Zhou, Zhijian Xiao, James P Bridges, Rebecca A Marsh, Kejian Zhang, Michael B Jordan, Yuhua Li, Gang Huang
Hemophagocytic lymphohistiocytosis is a life-threatening syndrome characterized by overwhelming immune activation. A steroid and chemotherapy-based regimen remains as the first-line of therapy but it has substantial morbidity. Thus, novel, less toxic therapy for hemophagocytic lymphohistiocytosis is urgently needed. Although differences exist between familial hemophagocytic lymphohistiocytosis and secondary hemophagocytic lymphohistiocytosis, they have many common features. Using bioinformatic analysis with familial hemophagocytic lymphohistiocytosis and systemic juvenile idiopathic arthritis, which is associated with secondary hemophagocytic lymphohistiocytosis, we identified a common hypoxia-inducible factor 1A (HIF1A) signature...
August 31, 2017: Haematologica
https://www.readbyqxmd.com/read/28859036/hemophagocytic-lymphohistiocytosis-a-dangerous-intruder-in-pediatric-acute-lymphoblastic-leukemia
#11
Isabel Martínez-Romera, Marta Villa, Pilar Areal, Esther Rodrigo, Blanca Herrero, Blanca López-Ibor
Hemophagocytic lymphohistiocytosis (HLH) is a condition caused by a pathologic immune activation, which is responsible for its signs and symptoms. It may also appear as a secondary process caused by malignancy. Developing HLH during treatment for acute lymphoblastic leukemia (ALL) is extremely uncommon, but underdiagnosis may be fatal. Two patients with ALL on chemotherapy maintenance treatment who developed HLH triggered by infection are presented here. We emphasize the importance of being aware of this condition when a patient with ALL in complete remission presents with unexplained hepatomegaly, cytopenia, and fever...
August 30, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28856025/efficacy-of-prompt-initiation-of-antiretroviral-therapy-in-the-treatment-of-hemophagocytic-lymphohistiocytosis-triggered-by-uncontrolled-human-immunodeficiency-virus
#12
Bryan P Fitzgerald, Amy L Wojciechowski, Rajinder P S Bajwa
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, rapidly progressive hematologic disorder involving uncontrolled immune system activation. HLH has been associated with viral infections, including human immunodeficiency virus (HIV) infections. We report a case of a critically ill 30-year-old female who was hospitalized with HIV-associated HLH, with a CD4 count of 4 cells/mL and HIV viral load of 1,842,730 copies/mL. After ruling out other potential infectious causes of HLH, antiretroviral therapy (ART) was initiated with darunavir, ritonavir, tenofovir, and emtricitabine...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28854959/hemophagocytic-lymphohistiocytosis-presenting-in-a-pediatric-patient-with-near-total-colonic-and-small-bowel-aganglionosis-a-case-report
#13
Brittany Badal, Michael J Wilsey, Sara Karjoo
BACKGROUND: Total colonic and small bowel aganglionosis is a rare condition typically requiring intestinal transplant for long-term survival. There have not been any previously reported cases of near total intestinal aganglionosis complicated by concerns for hemophagocytic lymphohistiocytosis and need for both multivisceral organ transplant and hematopoietic stem cell transplant. CASE PRESENTATION: Our patient is a 35-month-old Egyptian boy who presented with bilious emesis and failure to pass meconium shortly after birth...
August 31, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28844807/-hemophagocytic-lymphohistiocytosis-associated-with-plasmodium-falciparum
#14
M O M Harioly Nirina, T M Raheritiana, M O J Harioly Nirina, A S Rasolonjatovo, A O Rakoto Alson, A Rasamindrakotroka
No abstract text is available yet for this article.
August 24, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28838727/primary-hemophagocytic-lymphohistiocytosis-and-macrophage-activation-syndrome-the-importance-of-timely-clinical-differentiation
#15
EDITORIAL
Alexei A Grom
No abstract text is available yet for this article.
August 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28836562/a-novel-case-of-pulmonary-nocardiosis-with-secondary-hemophagocytic-lymphohistiocytosis
#16
Teng Han, Ying-Mei Liu, Ting Yang, Hua-Ping Dai, Xiao-Lei Zhang
No abstract text is available yet for this article.
September 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28835859/bone-marrow-liver-spleen-type-of-large-b-cell-lymphoma-associated-with-hemophagocytic-syndrome-a-rare-aggressive-extranodal-lymphoma
#17
Kirill A Lyapichev, Jennifer R Chapman, Oleksii Iakymenko, Offiong F Ikpatt, Uygar Teomete, Sandra Patricia Sanchez, Francisco Vega
Recently, an unusual subtype of large B-cell lymphoma (LBCL) with distinctive clinicopathologic features has been recognized; it is characterized by involvement of bone marrow with or without liver and/or spleen, but no lymph node or other extranodal sites, usually associated with fever, anemia, and hemophagocytic lymphohistiocytosis (HLH). Because of this distinctive clinical presentation, it has been designated "bone marrow-liver-spleen" (BLS) type of LBCL. To date there is only one series of 11 cases of BLS type of LBCL with detailed clinical, pathologic, and cytogenetic data...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28834694/ruxolitinib-for-secondary-hemophagocytic-lymphohistiocytosis-first-case-report
#18
Jonathan H Sin, Mark L Zangardi
Hemophagocytic lymphohistiocytosis (HLH) is an immune-mediated disorder resulting in hyper-activation of inflammatory cytokines. If left untreated, the uncontrolled inflammatory response can lead to significant tissue injury and potentially life-threatening multi-organ dysfunction. Conventional immunosuppressive agents are available for the management of HLH, including dexamethasone, cyclosporine, and etoposide; however, patients may not respond to these therapies. Clinicians may turn toward alternative pharmacologic agents that likely have less clinical evidence...
August 16, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28829754/aggressive-natural-killer-cell-leukemia-associated-with-hemophagocytic-lymphohistiocytosis
#19
Sabine Dressler, Volker Mordstein
No abstract text is available yet for this article.
November 10, 2016: Blood
https://www.readbyqxmd.com/read/28829111/aggressive-natural-killer-cell-leukemia-associated-with-hemophagocytic-lymphohistiocytosis
#20
Sabine Dressler, Volker Mordstein
No abstract text is available yet for this article.
November 10, 2016: Blood
keyword
keyword
26835
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"