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Rosai dorfman

Dominick S DeFelice, Megan L Srinivas, Sara E Wobker, Jonathan B Parr
A patient presented for medical care on three separate occasions over the course of two years with recurrent right knee pain attributed to chronic osteomyelitis. Careful assessment revealed that his symptoms were caused by osseous Rosai-Dorfman disease. This case presents an alternative diagnostic possibility for culture-negative chronic osteomyelitis.
2018: Case Reports in Infectious Diseases
J J Subash, C Kesty, K R Kesty, M Asgari, J Jorizzo
No abstract text is available yet for this article.
June 4, 2018: Clinical and Experimental Dermatology
Rashid Al Umairi, Danielle Blunt, Wedad Hana, Matthew Cheung, Anastasia Oikonomou
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare nonmalignant lymphohistiocytic proliferative disorder. We report a patient with RDD who presented with multiple skin lesions, pulmonary involvement, and CT manifestations mimicking Langerhans cell histiocytosis, which improved after initiation of corticosteroid treatment.
2018: Case Reports in Radiology
Andrew R Orr, Daniel Lefler, C Deshpande, Pallavi Kumar
Rosai-Dorfman disease (RDD) is a rare, nonmalignant disorder of histiocyte proliferation typically involving the cervical lymph nodes. However, a subset of patients with RDD will display extranodal manifestations that are highly variable in presentation, more challenging to diagnose, and less likely to spontaneously regress compared to nodal disease. While case reports of extranodal involvement in nearly every organ system exist, documented instances of mediastinal and pulmonary artery involvement are particularly rare...
2018: Case Reports in Hematology
Anil Nanda, Amey R Savardekar, Devi Prasad Patra, Rimal Hanif Dossani, Maria-Magdalena Georgescu
Rosai-Dorfman disease, originally described by Juan Rosai and Ronald F. Dorfman, is a rare benign histiocytic proliferative disorder, classically presenting with massive lymphadenopathy and a self-limiting clinical course.1 Isolated intracranial skull base involvement is extremely rare and often resembles meningiomas, schwannomas, or other benign skull base lesions.2 The disease is difficult to diagnose radiographically, and tissue diagnosis with open skull base approaches has significant perioperative risks...
May 21, 2018: Operative Neurosurgery (Hagerstown, Md.)
Giancarlo Fatobene, Julien Haroche, Zofia Hélias-Rodzwicz, Frédéric Charlotte, Valérie Taly, Aliana Meneses Ferreira, André Néder Ramires Abdo, Vanderson Rocha, Jean-François Emile
No abstract text is available yet for this article.
May 10, 2018: Haematologica
Ansuman T Satpathy, Ryanne A Brown, Ellen Gomulia, Carlos G Briseño, Maxwell R Mumbach, Zenggang Pan, Kenneth M Murphy, Yasodha Natkunam, Howard Y Chang, Jinah Kim
Distinguishing classical dendritic cells from other myeloid cell types is complicated by the shared expression of cell surface markers. ZBTB46 is a zinc finger and BTB domain-containing transcription factor, which is expressed by dendritic cells and committed dendritic cell precursors, but not by plasmacytoid dendritic cells, monocytes, macrophages, or other immune cell populations. In this study, we demonstrate that expression of ZBTB46 identifies human dendritic cell neoplasms. We examined ZBTB46 expression in a range of benign and malignant histiocytic disorders and found that ZBTB46 is able to clearly define the dendritic cell identity of many previously unclassified histiocytic disease subtypes...
May 9, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Oussama Abla, Eric Jacobsen, Jennifer Picarsic, Zdenka Krenova, Ronald Jaffe, Jean-Francois Emile, Benjamin H Durham, Jorge Braier, Frédéric Charlotte, Jean Donadieu, Fleur Cohen Aubart, Carlos Rodriguez-Galindo, Carl Allen, James A Whitlock, Sheila Weitzman, Kenneth L McClain, Julien Haroche, Eli L Diamond
Rosai-Dorfman-Destombes disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by accumulation of activated histiocytes within affected tissues. RDD, which now belongs to the R group of the 2016 revised histiocytoses classification, is a widely heterogeneous entity with a range of clinical phenotypes occurring in isolation or in association with autoimmune or malignant diseases. Recent studies have found NRAS, KRAS, MAP2K1 and ARAF mutations in lesional tissues, raising the possibility of a clonal origin in some forms of RDD...
May 2, 2018: Blood
Amanda Meindl, M Sambasiva Rao, Guang-Yu Yang
Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, has been described involving both lymph nodes and extranodal sites, but extranodal RDD rarely involves the gastrointestinal tract. Although the etiology is unclear, several risk factors have been shown to be highly associated with this disease process, including viral infection and immune alterations. In this article, we present a case of a 79-year-old male with a history of autoimmune atrophic gastritis and multiple carcinoid tumors of the stomach presenting with a new stomach mass...
May 1, 2018: International Journal of Surgical Pathology
Shaolin Zhang, Jinsheng Huang, Yanling Chen
BACKGROUND: Intracranial involvement is an uncommon manifestation of Rosai-Dorfman disease (RDD) and had been rarely reported. In this study, we explore clinical characteristics, imageology manifestations and pathological features of primary intracranial RDD so as to improve the understanding for this disease. METHODS: One case (16-years-old boy) with primary intracranial RDD was analyzed and studied retrospectively by MRI features, histopathological observation and immunohistochemical staining, and the related literatures were reviewed...
December 27, 2017: Neurologia i Neurochirurgia Polska
O V Dolzhansky, E M Paltseva, M M Morozova, D V Bazarov, E V Boranov, D N Fedorov
The paper describes a case of solitary epithelioid hemangioendothelioma concurrent with nodular parenchymal AL amyloidosis of the lung and Rosai-Dorfman disease in a 70-year-old woman. The core of the tumor was represented by bone tissue with dendriform ossification, as well as by amyloid that showed green apple birefringence at polarized light microscopy. The peripheral portions of the tumor and the myxohyaline stroma exhibited slit-like structures, epithelioid and fusiform cells with small cytoplasmic vacuoles...
2018: Arkhiv Patologii
Ankur Kapoor, Pravin Salunke, Chirag K Ahuja, Debjyoti Chatterjee
Rosai-Dorfman disease (RDD) predominantly affects cervical lymph nodes and presents with fever and pancytopenia. Central nervous system involvement though uncommon is often reported. Hydrocephalus and paraparesis as a consequence of RDD is an extremely rare entity. We present a 58-year-old male, diagnosed and treated for RDD with cervical lymphadenopathy, who now presented with spastic paraparesis and on evaluation was found to have communicating hydrocephalus that resolved after ventriculoperitoneal shunt surgery...
April 2018: Asian Journal of Neurosurgery
Amit Parekh, Feroz Osmani, Nathan Aardsma, John Groth, Mark Gonzalez
Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a rare entity in which bone involvement occurs in less than 5% to 10% of patients and skeletal cases are usually multifocal. Extranodal solitary lesions of bone without nodal involvement or additional clinical manifestations are exceedingly rare. We present the clinical course and management of a 34-year-old African American woman who presented with the disease as a solitary lesion of the distal radius.
April 17, 2018: Journal of Hand Surgery
Valeria Lami, Lorenzo Ruggera, Alex Anh Ly Nguyen, Giuseppe Nicolò Fanelli, Fabio Vianello, Filiberto Zattoni
No abstract text is available yet for this article.
June 2018: Clinical Genitourinary Cancer
K Aradhana, B Thejaswini, A Shamsundar, R Nanda, Usha Amritham, G V Giri
AIM: To study the pattern of presentation and management of nodal and extranodal primary RDD. METHODOLOGY: From 2010 to 2015, eleven patients diagnosed with Rosai-Dorfman Disease (RDD) presented at our institute. Nine of them were analyzed as they received treatment at our center. We had five neck primaries, three intracranial and one cutaneous disease. Hematological, radiological, histopathological and immunohistochemistry evaluation along with the treatment data was collected and analyzed...
January 2018: Gulf Journal of Oncology
Fadi Badlissi, German Albert Pihan, Hèctor Corominas
Rosai-Dorfman disease (RDD) is uncommon in daily practice, but needs to be ruled out in rheumatologic conditions to elucidate a wide differential diagnosis. Beside its typical presentation, soft tissue masses can be easily seen in our Rheumatology clinics. Ultrasonography widely extended in our specialty, could also play a role in the diagnosis, to end up with the histological confirmation of the disease.
March 29, 2018: Reumatología Clinica
J M Conde, A Y Kim, R de Miguel, C H Nousari
No abstract text is available yet for this article.
March 28, 2018: Actas Dermo-sifiliográficas
Hannah Lee, Gentry King, Kavita Garg, Zenggang Pan, Jennifer Tobin, William A Robinson
No abstract text is available yet for this article.
March 29, 2018: Haematologica
Noman Lateef, Abdul Haseeb, Uzair K Ghori, Abubakar Tauseef, Mustafa Dawood, Syed M Hasan Kazmi
Rosai-Dorfman disease (RDD) is a rare, benign, and predominantly nodal disease that most commonly presents as bilateral, painless cervical lymphadenopathy; although inguinal, axillary, mediastinal, and hilar lymphadenopathy has also been reported. Apart from nodal involvement, RDD has extranodal manifestations involving bone, soft tissue, and liver as well as constitutional symptoms of fever, night sweats, and weight loss, which make it reasonable to rule out the infectious, autoimmune, and malignant conditions as the differential diagnosis...
January 2, 2018: Curēus
Amer A Lardhi, Abdullah K Al-Mutairi, Mohammed H Al-Qahtani, Atheer K Al-Mutairi
Rosai-Dorfman disease is a rare histiocytic proliferative disorder that commonly presents with a massive lymphadenopathy and a variety of constitutional symptoms. Severe hemolytic anemia is an infrequent complication of this disease. Although the etiology of the condition is unknown, infectious agents including viruses have been implicated. We describe a 2-year-old female child who presented with fever, pallor, and generalized lymphadenopathy complicated by the development of autoimmune hemolytic anemia. A review of the literature of this condition is also provided...
January 2018: Case Reports in Oncology
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