Oguzhan Birdal, Irmak Ferah Okkay, Ufuk Okkay, Cemil Bayram, Behzad Mokthare, Muhammed Sait Ertugrul, Ahmet Hacimuftuoglu, Emrah Aksakal, Yavuzer Koza, Mehmet Saygi, Huseyin Senocak
BACKGROUND: Doxorubicin is an effective antineoplastic agent but has limited clinical application because of its cumulative toxicities, including cardiotoxicity. Cardiotoxicity causes lipid peroxidation, genetic impairment, oxidative stress, inhibition of autophagy, and disruption of calcium homeostasis. Doxorubicin-induced cardiotoxicity is frequently tried to be mitigated by phytochemicals, which are derived from plants and possess antioxidant, anti-inflammatory, and anti-apoptotic properties...
April 18, 2024: Molecular Biology Reports