keyword
https://read.qxmd.com/read/38547369/overcoming-endosomal-escape-barriers-in-gene-drug-delivery-using-de-novo-designed-ph-responsive-peptides
#21
JOURNAL ARTICLE
Zixuan Wang, Jiaxing Zhang, Yuefei Wang, Jialin Zhou, Xinhao Jiao, Mingshan Han, Xuelin Zhang, Hailiang Hu, Rongxin Su, Yumiao Zhang, Wei Qi
A major challenge in using nanocarriers for intracellular drug delivery is their restricted capacity to escape from endosomes into the cytosol. Here, we significantly enhance the drug delivery efficiency by accurately predicting and regulating the transition pH (pH0 ) of peptides to modulate their endosomal escape capability. Moreover, by inverting the chirality of the peptide carriers, we could further enhance their ability to deliver nucleic acid drugs as well as antitumor drugs. The resulting peptide carriers exhibit versatility in transfecting various cell types with a high efficiency of up to 90% by using siRNA, pDNA, and mRNA...
March 28, 2024: ACS Nano
https://read.qxmd.com/read/38547362/development-of-anisotropic-electrically-conductive-gnp-reinforced-pcl-collagen-scaffold-for-enhanced-neurogenic-differentiation-under-electrical-stimulation
#22
JOURNAL ARTICLE
Souvik Ghosh, Partha Roy, Debrupa Lahiri
The internal electric field of the human body plays a crucial role in regulating various biological processes, such as, cellular interactions, embryonic development and the healing process. Electrical stimulation (ES) modulates cytoskeleton and calcium ion activities to restore nervous system functioning. When exposed to electrical fields, stem cells respond similarly to neurons, muscle cells, blood vessel linings, and connective tissue (fibroblasts), depending on their environment. This study develops cost-effective electroconductive scaffolds for regenerative medicine...
March 28, 2024: Chemistry, An Asian Journal
https://read.qxmd.com/read/38547355/k33-only-mutant-ubiquitin-augments-bone-marrow-derived-dendritic-cell-mediated-ctl-priming-via-pi3k-akt-pathway
#23
JOURNAL ARTICLE
Yi Yun Liang, Xiao Yan Liao, Jun Jun Jia, Yi Zhen Yin, Yue Hua Zhang, Feng Guang Gao
To explore the effect of K33 only mutant ubiquitin (K33O) on bone marrow-derived dendritic cells' (BMDCs') maturity, antigen uptake capability, surface molecule expressions and BMDC-mediated CTL priming, and further investigate the role of PI3K-Akt engaged in K33O-increased BMDC maturation, antigen uptake and presentation, surface molecule expressions and BMDC-based CTL priming. BMDCs were conferred K33O and other ubiquitin mutants (K33R, K48R, K63R-mutant ubiquitin) incubation or LY294002 and wortmannin pretreatment...
March 28, 2024: Immunology
https://read.qxmd.com/read/38547353/correction-to-root-prr7-improves-the-accuracy-of-the-shoot-circadian-clock-through-nutrient-transport
#24
(no author information available yet)
No abstract text is available yet for this article.
March 28, 2024: Plant & Cell Physiology
https://read.qxmd.com/read/38547341/igg4-related-disease-complicated-with-diffuse-and-chronic-gastrointestinal-inflammation-leading-to-small-intestinal-perforation
#25
JOURNAL ARTICLE
Kazuma Ino, Yoshiyuki Arinuma, Masashi Akiya, Sabine Kajita, Sosei Okina, Junichi Sakamoto, Tomoki Tanaka, Yu Matsueda, Tatsuhiko Wada, Sumiaki Tanaka, Kenji Oku, Kunihiro Yamaoka
Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a systemic inflammatory disease characterized by elevated serum IgG4, IgG4+ cell infiltration, storiform fibrosis, and obliterative phlebitis. While IgG4-RD can affect various organs, gastrointestinal tract involvement is less common. Here, we report a 70-year-old female with IgG4-RD complicated with diffuse and chronic gastrointestinal inflammation which led to small intestinal perforation. She had been suffering from anorexia, abdominal pain, vomiting, and diarrhea, and hospitalized due to recurrent ileus...
March 28, 2024: Modern rheumatology case reports
https://read.qxmd.com/read/38547340/the-multifaceted-nature-of-hiv-tissue-reservoirs
#26
JOURNAL ARTICLE
Riddhima Banga, Matthieu Perreau
PURPOSE OF REVIEW: To underline the complexity and the heterogeneity of the HIV reservoir. RECENT FINDINGS: While lymphoid tissues (spleen, lymph nodes, gut-associated lymphoid tissue) harbor specific subsets of specialized CD4+ T cells enriched in HIV-infected cells, non-CD4+ T cell reservoirs such as tissue-resident macrophages and dendritic cells have also been implicated to contribute to viral persistence. Moreover, studies have applied highly sensitive tools to detect transcriptional activity within HIV-infected cells during prolonged ART and revealed a broader spectrum of transcriptional activity for proviruses than previously thought...
March 12, 2024: Current Opinion in HIV and AIDS
https://read.qxmd.com/read/38547338/humanized-mice-for-studying-hiv-latency-and-potentially-its-eradication
#27
JOURNAL ARTICLE
Moa F Hasler, Roberto F Speck, Nicole P Kadzioch
PURPOSE OF THE REVIEW: The quest for an HIV cure faces a formidable challenge: the persistent presence of latent viral infections within the cells and tissues of infected individuals. This review provides a thorough examination of discussions surrounding HIV latency, the use of humanized mouse models, and strategies aimed at eliminating the latent HIV reservoir. It explores the hurdles and advancements in understanding HIV pathogenesis, mainly focusing on establishing latent reservoirs in CD4+ T cells and macrophages...
March 28, 2024: Current Opinion in HIV and AIDS
https://read.qxmd.com/read/38547337/the-sounds-of-silencing-dynamic-epigenetic-control-of-hiv-latency
#28
JOURNAL ARTICLE
Kien Nguyen, Jonathan Karn
PURPOSE OF REVIEW: This review highlights advances in understanding the epigenetic control mechanisms that regulate HIV-1 latency mechanisms in T-cells and microglial cells and describes the potential of current therapeutic approaches targeting the epigenetic machinery to eliminate or block the HIV-1 latent reservoir. RECENT FINDINGS: Large-scale unbiased CRISPR-Cas9 library-based screenings, coupled with biochemical studies, have comprehensively identified the epigenetic factors pivotal in regulating HIV-1 latency, paving the way for potential novel targets in therapeutic development...
March 13, 2024: Current Opinion in HIV and AIDS
https://read.qxmd.com/read/38547331/circulating-factors-in-cancer-cachexia-recent-opportunities-for-translational-research
#29
JOURNAL ARTICLE
Marina de Castro Coêlho, Giovana Parreira de Aquino, Amanda Soares Santos, Marilia Seelaender
PURPOSE OF REVIEW: To discuss the recent discoveries and limitations of the available literature on emerging circulating biomarkers of cancer cachexia. RECENT FINDINGS: Studies on circulating factors in cancer cachexia show promising alternatives for diagnosing the syndrome in a minimally invasive manner in the clinic setting, as well as potential targets for cancer cachexia treatment. Factors secreted by the tumor and the adipose tissue, such as extracellular vesicles and soluble proteins, respectively, have been shown to either directly induce wasting in vitro and in vivo or to be altered in the cachectic phenotype...
March 27, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547317/analysis-of-temporal-artery-biopsy-by-provider-across-a-large-multi-state-health-care-network
#30
JOURNAL ARTICLE
Karling Gravenstein, Mikalah Maury, Priya Arya, Robert Liebman
Temporal artery biopsy (TAB) is the standard test for diagnosing giant cell arteritis. Our objective was to determine which specialists perform TABs and if there is variation across the United States. We performed a cross-sectional analysis in a multi-state health care system, evaluating differences between observed counts of surgical specialty by region, positive diagnoses by region, and positive diagnoses by specialty. Temporal arterial biopsy was performed on 3825 patients with the proportion of specialties performing TAB differing between regions...
March 28, 2024: American Surgeon
https://read.qxmd.com/read/38547316/chronic-viral-infection-impairs-immune-memory-to-a-different-pathogen
#31
JOURNAL ARTICLE
Cheng Yang, Zhicui Liu, Ying Yang, Luis J Cocka, Yongguo Li, Weihong Zeng, Hao Shen
Chronic viral infections cause T cell dysfunction in both animal models and human clinical settings, thereby affecting the ability of the host immune system to clear viral pathogens and develop proper virus-specific immune memory. However, the impact of chronic viral infections on the host's immune memory to other pathogens has not been well described. In this study, we immunized mice with recombinant Listeria monocytogenes expressing OVA (Lm-OVA) to generate immunity to Lm and allow analysis of OVA-specific memory T (Tm) cells...
March 28, 2024: PLoS Pathogens
https://read.qxmd.com/read/38547315/one-shot-single-cell-proteome-and-metabolome-analysis-strategy-for-the-same-single-cell
#32
JOURNAL ARTICLE
Jie Wu, Qin-Qin Xu, Yi-Rong Jiang, Jian-Bo Chen, Wei-Xin Ying, Qian-Xi Fan, Hui-Feng Wang, Yu Wang, Shao-Wen Shi, Jian-Zhang Pan, Qun Fang
Characterizing the profiles of proteome and metabolome at the single-cell level is of great significance in single-cell multiomic studies. Herein, we proposed a novel strategy called one-shot single-cell proteome and metabolome analysis (scPMA) to acquire the proteome and metabolome information in a single-cell individual in one injection of LC-MS/MS analysis. Based on the scPMA strategy, a total workflow was developed to achieve the single-cell capture, nanoliter-scale sample pretreatment, one-shot LC injection and separation of the enzyme-digested peptides and metabolites, and dual-zone MS/MS detection for proteome and metabolome profiling...
March 28, 2024: Analytical Chemistry
https://read.qxmd.com/read/38547312/aryl-hydrocarbon-receptor-as-a-drug-target-in-advanced-prostate-cancer-therapy-obstacles-and-perspectives
#33
REVIEW
Jiřina Procházková, Zuzana Kahounová, Jan Vondráček, Karel Souček
Aryl hydrocarbon receptor (AhR) is a transcription factor that is primarily known as an intracellular sensor of environmental pollution. After five decades, the list of synthetic and toxic chemicals that activate AhR signaling has been extended to include a number of endogenous compounds produced by various types of cells via their metabolic activity. AhR signaling is active from the very beginning of embryonal development throughout the life cycle and participates in numerous biological processes such as control of cell proliferation and differentiation, metabolism of aromatic compounds of endogenous and exogenous origin, tissue regeneration and stratification, immune system development and polarization, control of stemness potential, and homeostasis maintenance...
March 28, 2024: Transcription
https://read.qxmd.com/read/38547310/the-wolbachia-wale1-effector-alters-drosophila-endocytosis
#34
JOURNAL ARTICLE
MaryAnn Martin, Sergio López-Madrigal, Irene L G Newton
The most common intracellular bacterial infection is Wolbachia pipientis, a microbe that manipulates host reproduction and is used in control of insect vectors. Phenotypes induced by Wolbachia have been studied for decades and range from sperm-egg incompatibility to male killing. How Wolbachia alters host biology is less well understood. Previously, we characterized the first Wolbachia effector-WalE1, which encodes an alpha-synuclein domain at the N terminus. Purified WalE1 sediments with and bundles actin and when heterologously expressed in flies, increases Wolbachia titer in the developing oocyte...
March 28, 2024: PLoS Pathogens
https://read.qxmd.com/read/38547309/identification-and-validation-of-key-mirnas-and-a-microrna-mrna-regulatory-network-associated-with-liver-cancer
#35
JOURNAL ARTICLE
Jie Tang, Song Li, Zixiao Zhou, Weicai Chang, Yongqiang Wang, Juan Mei, Shaobo Zhou
MiRNAs play crucial regulatory roles in the growth and development of tumor cells by serving as carriers of post-transcriptional regulatory information derived from genes. Investigating the potential function and clinical significance of miRNA-mediated mRNA regulatory networks in liver cancer can offer novel insights and therapeutic strategies for the treatment of this disease. We identified 300 differentially expressed miRNAs, and five miRNAs were identified to be correlated with overall survival and could be used as an independent prognostic...
March 28, 2024: Cell Cycle
https://read.qxmd.com/read/38547304/characterization-of-a-hemolytic-and-antibiotic-resistant-pseudomonas-aeruginosa-strain-s3-pathogenic-to-fish-isolated-from-mahananda-river-in-india
#36
JOURNAL ARTICLE
Dipanwita Ghosh, Preeti Mangar, Abhinandan Choudhury, Anoop Kumar, Aniruddha Saha, Protip Basu, Dipanwita Saha
Virulent strain Pseudomonas aeruginosa isolated from Mahananda River exhibited the highest hemolytic activity and virulence factors and was pathogenic to fish as clinical signs of hemorrhagic spots, loss of scales, and fin erosions were found. S3 was cytotoxic to the human liver cell line (WRL-68) in the trypan blue dye exclusion assay. Genotype characterization using whole genome analysis showed that S3 was similar to P. aeruginosa PAO1. The draft genome sequence had an estimated length of 62,69,783 bp, a GC content of 66...
2024: PloS One
https://read.qxmd.com/read/38547301/17%C3%AE-estradiol-promotes-metastasis-in-triple-negative-breast-cancer-through-the-calpain-yap-%C3%AE-catenin-signaling-axis
#37
JOURNAL ARTICLE
Xuemei Niu, Jianan Wang, Jinguang Liu, Qinglong Yu, Mingwei Ci
β-catenin is an important regulator of malignant progression. 17β-Estradiol (E2), an important sex hormone in women, promotes the growth and metastasis of triple-negative breast cancer (TNBC). However, whether β-catenin is involved in E2-induced metastasis of TNBC remains unknown. In this study, we show that E2 induces the proliferation, migration, invasion, and metastasis of TNBC cells. E2 induces β-catenin protein expression and nuclear translocation, thereby regulating the expression of target genes such as Cyclin D1 and MMP-9...
2024: PloS One
https://read.qxmd.com/read/38547295/a-mitotic-stopwatch-determines-cell-fate
#38
COMMENT
Agustina P Bertolin, Vanesa Gottifredi
Surveillance of mitotic timing prevents amplification of damaged cells.
March 29, 2024: Science
https://read.qxmd.com/read/38547292/control-of-cell-proliferation-by-memories-of-mitosis
#39
JOURNAL ARTICLE
Franz Meitinger, Hazrat Belal, Robert L Davis, Mallory B Martinez, Andrew K Shiau, Karen Oegema, Arshad Desai
Mitotic duration is tightly constrained, and extended mitosis is characteristic of problematic cells prone to chromosome missegregation and genomic instability. We show here that mitotic extension leads to the formation of p53-binding protein 1 (53BP1)-ubiquitin-specific protease 28 (USP28)-p53 protein complexes that are transmitted to, and stably retained by, daughter cells. Complexes assembled through a Polo-like kinase 1-dependent mechanism during extended mitosis and elicited a p53 response in G1 that prevented the proliferation of the progeny of cells that experienced an approximately threefold extended mitosis or successive less extended mitoses...
March 29, 2024: Science
https://read.qxmd.com/read/38547269/biodegradable-ferroelectric-molecular-crystal-with-large-piezoelectric-response
#40
JOURNAL ARTICLE
Han-Yue Zhang, Yuan-Yuan Tang, Zhu-Xiao Gu, Peng Wang, Xiao-Gang Chen, Hui-Peng Lv, Peng-Fei Li, Qing Jiang, Ning Gu, Shenqiang Ren, Ren-Gen Xiong
Transient implantable piezoelectric materials are desirable for biosensing, drug delivery, tissue regeneration, and antimicrobial and tumor therapy. For use in the human body, they must show flexibility, biocompatibility, and biodegradability. These requirements are challenging for conventional inorganic piezoelectric oxides and piezoelectric polymers. We discovered high piezoelectricity in a molecular crystal HOCH2 (CF2 )3 CH2 OH [2,2,3,3,4,4-hexafluoropentane-1,5-diol (HFPD)] with a large piezoelectric coefficient d 33 of ~138 picocoulombs per newton and piezoelectric voltage constant g 33 of ~2450 × 10-3  volt-meters per newton under no poling conditions, which also exhibits good biocompatibility toward biological cells and desirable biodegradation and biosafety in physiological environments...
March 29, 2024: Science
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