Mara Klöhn, Thomas Burkard, Juliana Janzen, Jil Alexandra Haase, André Gömer, Rebecca Fu, George Ssebyatika, Maximilian K Nocke, Richard J P Brown, Thomas Krey, Viet Loan Dao Thi, Volker Kinast, Yannick Brüggemann, Daniel Todt, Eike Steinmann
BACKGROUND AND AIMS: The hepatitis E virus (HEV) is estimated to be responsible for 70,000 deaths annually, yet therapy options remain limited. In the pursuit of effective antiviral therapies, targeting viral entry holds promise and has proven effective for other viruses. However, the precise mechanisms and host factors required during HEV entry remain unclear. Cellular proteases have emerged as host factors required for viral surface protein activation and productive cell entry by many viruses...
May 10, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases