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https://www.readbyqxmd.com/read/29682745/calcium-binding-protein-and-some-neuropeptides-in-the-retina-of-octopus-vulgaris-a-morpho-histochemical-study
#1
Giovanna G Altobelli, Susan Van Noorden, Vincenzo Cimini
The existence of both calcium-binding proteins (CBPs) and neuropeptides in the retina and brain of various species of vertebrates and invertebrates is well documented. Octopus retina is particularly interesting because it represents a case of convergent evolution. The aim of this study was to characterize the distribution of two CBPs, calretinin and calbindin, in Octopus retina using morphology, in situ hybridization, immunocytochemistry and Western blot. Calretinin-like immunoreactivity was found in the photoreceptor cells, but unexpectedly also in the supporting cells...
April 22, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29682047/idh1-mutation-in-brain-stem-glioma-case-report-and-review-of-literature
#2
Seyed Amirhossein Javadi, Christian Hartmann, Gerhard Franz Walter, Roozbeh Banan, Amir Samii
The role of isocitrate dehydrogenase 1 (IDH1) mutation in brain stem glioma is not clear. To the best of our knowledge, six cases of brain stem gliomas carrying IDH1/2 mutations are currently reported in the literature. One case of diffuse brain stem glioma with IDH1 mutation, which was followed for 2 years, is presented and compared with IDH1 negative tumors. A 22-year-old lady was referred with diplopia and left arm palsy. Neuroimaging detected a nonenhancing, nonhomogeneous diffuse infiltrating brain stem tumor extending from pons to medulla...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681857/a-synthesized-glucocorticoid-induced-leucine-zipper-peptide-inhibits-retinal-m%C3%A3-ller-cell-gliosis
#3
Ruiping Gu, Xinyi Ding, Wenyi Tang, Boya Lei, Chen Jiang, Gezhi Xu
Purpose: The anti-inflammatory activities of protein glucocorticoid-induced leucine zipper (GILZ) have been demonstrated in vivo and in vitro . Here, we examined the potential effect of a synthetic peptide derived from the leucine zipper motif and proline-rich region of GILZ on suppressing inflammatory responses in primary cultured rat Müller cells. Methods: Peptides were selected from amino acids 98-134 of the GILZ protein (GILZ-p). Solid-phase peptide synthesis was used to generate the cell-penetrating peptide TAT, which was bound to the amino terminus of GILZ-p...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29680832/differential-fatty-acid-binding-protein-expression-in-persistent-radial-glia-in-the-human-and-sheep-subventricular-zone
#4
Birger Victor Dieriks, Justin M Dean, Eleonora Aronica, Henry J Waldvogel, Richard L M Faull, Maurice A Curtis
Fatty acid-binding proteins (FABPs) are a family of transport proteins that facilitate intracellular transport of fatty acids. Despite abundant expression in the brain, the role that FABPs play in the process of cell proliferation and migration in the subventricular zone (SVZ) remains unclear. Our results provide a detailed characterisation of FABP3, 5, and 7 expression in adult and fetal human and sheep SVZ. High FABP5 expression was specifically observed in the adult human SVZ and co-labelled with polysialylated neural cell adhesion molecule (PSA-NCAM), glial fibrillary acidic protein (GFAP), GFAPδ, and proliferating cell nuclear antigen (PCNA), indicating a role for FABP5 throughout the full maturation process of astrocytes and neuroblasts...
April 20, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29678455/different-behavioral-and-pathological-changes-between-epilepsy-associated-depression-and-primary-depression-models
#5
Wei-Feng Peng, Fan Fan, Xin Li, Qian-Qian Zhang, Jing Ding, Xin Wang
PURPOSE: Comorbid depression is common in patients with epilepsy. However, the epilepsy-associated depression is generally atypical and has not been fully recognized by neurologists. This study aimed to compare the behavioral and pathological changes between the chronic lithium chloride-pilocarpine rat epilepsy model (Licl-pilocarpine model) and the Chronic Unpredictable Mild Stress rat depression model (CUMS model), to evaluate for differences between epilepsy-associated depression and primary depression...
April 17, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29677029/kindlin-1-regulates-astrocyte-activation-and-pain-sensitivity-in-rats-with-neuropathic-pain
#6
Baisong Zhao, Yongying Pan, Haiping Xu, Xingrong Song
BACKGROUND AND OBJECTIVES: Astrocyte activation has been implicated in the pathogenesis of neuropathic pain, but the involvement of kindlin-1 in astrocyte activation and neuropathic pain has not yet been illustrated. Using a chronic constriction injury (CCI) rat model of neuropathic pain, we investigated the expression levels of kindlin-1 during neuropathic pain and the influences of kindlin-1 on regulating pain sensitivity. METHODS: Neuropathic pain was induced in rats by CCI of the sciatic nerve...
April 19, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29676021/detection-of-alpha-synuclein-conformational-variants-from-gastro-intestinal-biopsy-tissue-as-a-potential-biomarker-for-parkinson-s-disease
#7
Claudio Ruffmann, Nora Bengoa-Vergniory, Ilaria Poggiolini, Diane Ritchie, Michele T Hu, Javier Alegre-Abarrategui, Laura Parkkinen
AIMS: Gastrointestinal (GI) α-synuclein (aSyn) detection as a potential biomarker of Parkinson's disease (PD) is challenged by conflicting results of recent studies. To increase sensitivity and specificity, we applied three techniques to detect different conformations of aSyn in GI biopsies obtained from a longitudinal, clinically well-characterized cohort of PD patients and healthy controls (HC). METHODS: With immunohistochemistry (IHC), we used antibodies reactive for total, phosphorylated and oligomeric aSyn; with aSyn proximity ligation assay (AS-PLA), we targeted oligomeric aSyn species specifically; and with paraffin-embedded tissue blot (AS-PET-blot) we aimed to detect fibrillary, synaptic aSyn...
April 19, 2018: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/29673456/-intracerebroventricular-injection-of-mir-7-inhibits-secondary-brain-injury-induced-by-intracerebral-hemorrhage-via-egfr-stat3-pathway-in-rats
#8
Hong Qian, Ke Hu, Ming Xie, Heng Wu, Wenjun Li, Bin Wu, Rongyong Man, Meng Nie
Objective To observe the effects of microRNA-7 (miR-7) on intracerebral hemorrhage-induced brain injury in rats and explore the underlying mechanism. Methods Seventy-five SD rats were used to establish intracerebral hemorrhage model through injection of VII collagenase into the pallidum. These rats were then divided into control, miR-7 agomir, agomir control, miR-7 antagomir and antagomir control groups, containing 15 animals in each group. On day 2 after modeling, rats were injected with 10 μL of physiological saline, miR-7 agomir, agomir control, miR-7 antagomir and antagomir control via the lateral ventricle, respectively...
February 2018: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29671042/hyperbaric-oxygen-therapy-reduces-astrogliosis-and-helps-to-recovery-brain-damage-in-hydrocephalic-young-rats
#9
Stephanya Covas da Silva, Omar Feres, Pâmella da Silva Beggiora, Hélio Rubens Machado, Rafael Menezes-Reis, João Eduardo Araújo, Ricardo Andrade Brandão, Luiza da Silva Lopes
PURPOSE: We investigated the possible beneficial effects that hyperbaric oxygen therapy could offer in different brain structures affected by ventriculomegaly in pup rats submitted to experimental hydrocephalus. METHODS: Seven-day-old Wistar rats were submitted to hydrocephalus by intracisternal injection of 10% kaolin into the cisterna magna. The animals were divided into four groups: control (n = 5); control with HBOT (3ATA/2 h/day) (n = 5); untreated hydrocephalic (n = 10); hydrocephalic treated with HBOT (3ATA/2 h/day) (n = 10)...
April 18, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29670662/effect-of-qingxin-kaiqiao-fang-on-hippocampus-mrna-expression-of-the-inflammation-related-genes-il-1-%C3%AE-gfap-and-a-%C3%AE-in-an-alzheimer-s-disease-rat-model
#10
Dan-Dan Mao, Wen-Yu Yang, Yan Li, Jian-Wei Lin, Shi-Yu Gao, Yi-Ru Wang, Hai-Yan Hu
Objective: To investigate the effects of QKF on expression of amyloid-beta (A β ), interleukin-1 beta (IL-1 β ), and glial fibrillary acidic protein (GFAP) using a rat model of AD. Materials and Methods: Fifty-six male Sprague-Dawley rats were randomly divided into seven groups (eight rats each): control group, sham-operated group, AD model group, groups of AD rats administered with low, medium, and high doses of QKF, and the donepezil group. AD was established by bilateral injection of β -amyloid (A β ) 1-40 into the hippocampus...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29668456/review-on-retinal-gliosis-illustrated-with-a-series-of-massive-glioses-and-focal-nodular-gliosis-cases-in-regard-to-potential-pitfalls-of-ocular-reactive-tumor-like-lesions-of-this-type
#11
REVIEW
Andrzej Wincewicz, Sławka Urbaniak-Wasik, Antoinette Urbaniak, Marlena Mościcka-Rylska, Martyna Woltanowska, Mariusz Koda, Stanislaw Sulkowski, Joanna Reszeć
This paper presents a review on retinal gliosis illustrated by series of three cases of patients (a 39-year-old man and a 35-year-old woman with massive retinal gliosis (MRG) and a 51-year-old man with truly focal nodular gliosis of retina) with intraocular tumor-like masses and loss of vision, who recently suffered from painful inflammation of eyeball and who classically had a history of remote ocular trauma, onset of blindness early in lifetime or gradual but progressive loss of sight. The diagnosis of this pathological entity is given for the lesions that are composed of GFAP strongly positive, elongated, fusiform cells consistent with fibrillary astrocytes...
March 1, 2018: Folia Medica
https://www.readbyqxmd.com/read/29666360/signaling-pathways-responsible-for-the-rapid-antidepressant-like-effects-of-a-glun2a-preferring-nmda-receptor-antagonist
#12
Marta Gordillo-Salas, Fuencisla Pilar-Cuéllar, Yves P Auberson, Albert Adell
In a previous study we found that the preferring GluN2A receptor antagonist, NVP-AAM077, elicited rapid antidepressant-like effects in the forced swim test that was related to the release of glutamate and serotonin in the medial prefrontal cortex. In the present work we sought to examine the duration of this behavioral effect as well as the molecular readouts involved. Our results showed that NVP-AAM077 reduced the immobility in the forced swim test 30 min and 24 h after its administration. However, this effect waned 7 days later...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29665816/selective-localization-of-igg-from-cerebrospinal-fluid-to-brain-parenchyma
#13
Marlene Thorsen Mørch, Sofie Forsberg Sørensen, Reza Khorooshi, Nasrin Asgari, Trevor Owens
BACKGROUND: Encounter of autoantibodies with specific antigens can lead to hypersensitivity reactions and pathology. In multiple sclerosis and neuromyelitis optica spectrum disease (NMOSD), immunoglobulin-G (IgG) deposition has been observed in pathological lesions in the central nervous system. The paradigmatic autoantibodies in NMOSD are specific for the water channel aquaporin-4, localized to astrocytic end-feet at the blood-brain barrier and ependymal cells at the cerebrospinal fluid-brain barrier...
April 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29663739/neurotoxic-effects-of-domoic-acid-on-dopaminergic-neurons-in-primary-mesencephalic-cell-culture
#14
Khaled Radad, Mubarak Al-Shraim, Ahmed Al-Emam, Rudolf Moldzio, Wolf-Dieter Rausch
INTRODUCTION: Domoic acid is a potent marine neurotoxin produced by certain species of the diatom genus Pseudonitzschia. To our knowledge, there are no studies that have investigated neurotoxic effects of domoic acid on dopaminergic neurons. Accordingly, the present study was carried out to investigate the potential neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture. MATERIAL AND METHODS: Cultures prepared from embryonic mouse mesencephala (total of 250 embryos) were treated with different concentrations of domoic acid (0...
2018: Folia Neuropathologica
https://www.readbyqxmd.com/read/29663175/gfap-positive-progenitor-cell-production-is-concentrated-in-specific-encephalic-regions-in-young-adult-mice
#15
Zhibao Guo, Yingying Su, Huifang Lou
Previous genetic fate-mapping studies have indicated that embryonic glial fibrillary acidic protein-positive (GFAP+ ) cells are multifunctional progenitor/neural stem cells that can produce astrocytes as well as neurons and oligodendrocytes throughout the adult mouse central nervous system (CNS). However, emerging evidence from recent studies indicates that GFAP+ cells adopt different cell fates and generate different cell types in different regions. Moreover, the fate of GFAP+ cells in the young adult mouse CNS is not well understood...
April 16, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29660801/evaluation-of-long-term-effects-of-artificial-sweeteners-on-rat-brain-a-biochemical-behavioral-and-histological-study
#16
Oytun Erbaş, Mümin Alper Erdoğan, Asghar Khalilnezhad, Volkan Solmaz, Fulya Tuzcu Gürkan, Gürkan Yiğittürk, Hüseyin Avni Eroglu, Dilek Taskiran
The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group (n = 6) received regular tap water, whereas other groups received aspartame (3 mg/kg/day, n = 6,) or saccharin (3 mg/kg/day, n = 6) or sucralose (1.5 mg/kg/day, n = 6) in the drinking water. Following 6 weeks, the passive avoidance learning (PAL) test was performed to evaluate the neurobehavioral effects of sweeteners...
April 16, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29660611/effect-of-in-vivo-exposure-to-ambient-fine-particles-pm-2-5-on-the-density-of-dopamine-d-2-like-receptors-and-dopamine-induced-35-s-gtp%C3%AE-s-binding-in-rat-prefrontal-cortex-and-striatum-membranes
#17
María-de-Los-Angeles Andrade-Oliva, Octavio-Gamaliel Aztatzi-Aguilar, Francisco García-Sierra, Andrea De Vizcaya-Ruiz, José-Antonio Arias-Montaño
Male Sprague-Dawley rats (8-9 weeks-old) were exposed for three days (acute exposure) or eight weeks (subchronic exposure) to purified air or concentrated ambient fine particles, PM2.5 (≤2.5 μm; 15 to 18-fold of ambient air; 370-445 μg/m3 ). In membranes from rat prefrontal cortex (PFC) or striatum, the density and function of dopamine D2 -like receptors (D2 Rs) were assessed by [3 H]-spiperone binding and dopamine-stimulated [35 S]-GTPγS binding, respectively. Glial activation was evaluated by immunoperoxidase labeling of the glial fibrillary acidic protein (GFAP)...
April 10, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29656620/the-effect-of-recombinant-tyrosine-hydroxylase-expression-on-the-neurogenic-differentiation-potency-of-mesenchymal-stem-cells
#18
Gizem Turac, Gokhan Duruksu, Erdal Karaoz
OBJECTIVE: Tyrosine hydroxylase (TH) is a rate-limiting enzyme in dopamine synthesis, making the enhancement of its activity a target for ensuring sufficient dopamine levels. Rat bone marrow mesenchymal stem cells (rBM-MSCs) are known to synthesize TH after differentiating into neuronal cells through chemical induction, but the effect of its ectopic expression on these cells has not yet been determined. This study investigated the effects of ectopic recombinant TH expression on the stemness characteristics of rBM-MSCs...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656190/effect-of-titanium-dioxide-nanoparticles-on-the-bioavailability-and-neurotoxicity-of-cypermethrin-in-zebrafish-larvae
#19
Meng Li, Qiong Wu, Qiangwei Wang, Dandan Xiang, Guonian Zhu
In aquatic environment, the presence of nanoparticles (NPs) has been reported to modify the bioavailability and toxicity of the organic toxicants. Nevertheless, the combined toxicity of NPs and the pesticides that were used world-widely still remains unclear. Cypermethrin (CYP), a synthetic pyrethroid insecticide, is commonly used for controlling agricultural and indoor pests. Therefore, the effects of titanium dioxide NPs (nTiO2 ) on CYP bioconcentration and its effects on the neuronal development in zebrafish were investigated in our study...
March 31, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29655639/glia-maturation-factor-beta-is-required-for-reactive-gliosis-after-traumatic-brain-injury-in-zebrafish
#20
Guo Yin, Mingjun Du, Rong Li, Ke Li, Xiaomin Huang, Dongbei Duan, Xiaolan Ai, Fang Yao, Lanlan Zhang, Ziyou Hu, Bingyi Wu
Gliosis is a hallmark of neural pathology that occurs after most forms of central nervous system (CNS) injuries including traumatic brain injury (TBI). Identification of genes that control gliosis may provide novel treatment targets for patients with diverse CNS injuries. Glia maturation factor beta (GMFB) is crucial in brain development and stress response. In the present study, GMFB was found to be widely expressed in adult zebrafish telencephalon. A gmfb mutant zebrafish was created using CRISPR/cas9. In the uninjured zebrafish telencephalon, glial fibrillary acidic protein (GFAP) fibers in gmfb mutants were disorganized and shorter than wild type zebrafish...
April 12, 2018: Experimental Neurology
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