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https://www.readbyqxmd.com/read/29923872/glial-fibrillary-acidic-protein-antibody-another-antibody-in-the-multiple-sclerosis-diagnostic-mix
#1
Meagan Seay, Steven Galetta
No abstract text is available yet for this article.
June 19, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29922746/reduced-intraepidermal-nerve-fibre-density-glial-activation-and-sensory-changes-in-hiv-type-1-tat-expressing-female-mice-involvement-of-tat-during-early-stages-of-hiv-associated-painful-sensory-neuropathy
#2
Rachel Wodarski, Deniz Bagdas, Jason J Paris, Tim Pheby, Wisam Toma, Ruqiang Xu, M Imad Damaj, Pamela E Knapp, Andrew S C Rice, Kurt F Hauser
Introduction: HIV infection is associated with chronic pain states, including sensory neuropathy, which affects greater than 40% of patients. Objectives and Methods: To determine the impact of HIV-Tat induction on nociceptive behaviour in female mice conditionally expressing HIV Tat1-86 protein through a doxycycline (DOX)-driven glial fibrillary acidic protein promoter, intraepidermal nerve fibre density and immune cell activation in the dorsal root ganglion (DRG) and spinal cord were assessed by immunohistochemistry...
May 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29922524/fibrillary-glomerulonephritis-in-a-patient-with-sjogren-s-syndrome
#3
Muhammad Uzair Lodhi, Tahira Sabeen Saleem, Muhammad Shariq Usman, Waliul Chowdhury, Aaron R Kuzel, Hafiz Imran Iqbal, Mustafa Rahim
Fibrillary glomerulonephritis (FGN) is an uncommon cause of primary glomerular disease. FGN is usually idiopathic; however, it has been associated with underlying malignancy or autoimmune diseases in some patients as well. The most commonly found autoimmune diseases in FGN patients include Graves' disease, systemic lupus nephritis, Chron's disease, and idiopathic thrombocytopenia purpura. FGN in a patient with underlying asymptomatic Sjogren's syndrome is very rare in the literature, with only two previously reported cases of this association...
April 15, 2018: Curēus
https://www.readbyqxmd.com/read/29921916/the-thrombin-receptor-restricts-subventricular-zone-neural-stem-cell-expansion-and-differentiation
#4
Chan-Il Choi, Hyesook Yoon, Kristen L Drucker, Monica R Langley, Laurel Kleppe, Isobel A Scarisbrick
Thrombin is frequently increased in the CNS after injury yet little is known regarding its effects on neural stem cells. Here we show that the subventricular zone (SVZ) of adult mice lacking the high affinity receptor for thrombin, proteinase activated receptor 1 (PAR1), show increased numbers of Sox2+ and Ki-67+ self-renewing neural stem cells (NSCs) and Olig2+ oligodendrocyte progenitors. SVZ NSCs derived from PAR1-knockout mice, or treated with a PAR1 small molecule inhibitor (SCH79797), exhibited enhanced capacity for self-renewal in vitro, including increases in neurosphere formation and BrdU incorporation...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29915801/uterine-corpus-tumor-with-neuroectodermal-differentiation-and-frequent-ganglion-like-cells-in-a-postmenopausal-woman
#5
Taku Homma, Takehiro Nakao, Toshiya Maebayashi, Toshiyuki Ishige, Hiroyuki Hao
•Uterine neuroectodermal tumors (NETs) are uncommon malignant neoplasm with poor prognosis.•Ganglion-like cells with fibrillary background as major component of uterine NETs are extremely rare.•We present a patient affected by uterine NET with frequent ganglion-like cells, resembling ganglioneuroblastoma.•This case report is important to define the pathogenesis and establish better treatments for neuroectodermal tumors.
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29915328/presymptomatic-change-in-micrornas-modulates-tau-pathology
#6
Salil Sharma, Ines Khadimallah, Adam Williamson Corya, Yousuf Omar Ali, Xi Rao, Yunlong Liu, Hui-Chen Lu
MicroRNAs (miRs) are 18~23 nucleotides long non-coding RNAs that regulate gene expression. To explore whether miR alterations in tauopathy contribute to pathological conditions, we first determined which hippocampal miRs are altered at the presymptomatic and symptomatic stages of tauopathy using rTg4510 mice (Tau mice), a well-characterized tauopathy model. miR-RNA pairing analysis using QIAGEN Ingenuity Pathway Analysis (IPA) revealed 401 genes that can be regulated by 71 miRs altered in Tau hippocampi at the presymptomatic stage...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29912966/adenosine-a1-receptor-a-neuroprotective-target-in-light-induced-retinal-degeneration
#7
Manuel Soliño, Ester María López, Manuel Rey-Funes, César Fabián Loidl, Ignacio M Larrayoz, Alfredo Martínez, Elena Girardi, Juan José López-Costa
Light induced retinal degeneration (LIRD) is a useful model that resembles human retinal degenerative diseases. The modulation of adenosine A1 receptor is neuroprotective in different models of retinal injury. The aim of this work was to evaluate the potential neuroprotective effect of the modulation of A1 receptor in LIRD. The eyes of rats intravitreally injected with N6-cyclopentyladenosine (CPA), an A1 agonist, which were later subjected to continuous illumination (CI) for 24 h, showed retinas with a lower number of apoptotic nuclei and a decrease of Glial Fibrillary Acidic Protein (GFAP) immunoreactive area than controls...
2018: PloS One
https://www.readbyqxmd.com/read/29912715/ectomesenchymal-chondromyxoid-tumor-a-neoplasm-characterized-by-recurrent-rreb1-mkl2-fusions
#8
Brendan C Dickson, Cristina R Antonescu, Prokopios P Argyris, Elizabeth A Bilodeau, Martin J Bullock, Paul D Freedman, Douglas R Gnepp, Richard C Jordan, Ioannis G Koutlas, Cheng-Han Lee, Iona Leong, Mihai Merzianu, Bibianna M Purgina, Lester D R Thompson, Bret Wehrli, John M Wright, David Swanson, Lei Zhang, Justin A Bishop
Ectomesenchymal chondromyxoid tumor is a rare and benign neoplasm with a predilection for the anterior dorsal tongue. Despite morphologic heterogeneity, most cases are characterized by a proliferation of bland spindle cells with a distinctive reticular growth pattern and myxoid stroma. The immunophenotype of these neoplasms is likewise variable; most cases express glial fibrillary acid protein and S100 protein, with inconsistent reports of keratin and myoid marker expression. The molecular pathogenesis is poorly understood; however, a subset of cases has been reported to harbor EWSR1 gene rearrangement...
June 15, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29912176/mk-0677-a-ghrelin-agonist-alleviates-amyloid-beta-related-pathology-in-5xfad-mice-an-animal-model-of-alzheimer-s-disease
#9
Yu-On Jeong, Soo Jung Shin, Jun Yong Park, Bo Kyeong Ku, Ji Soo Song, Jwa-Jin Kim, Seong Gak Jeon, Sang Min Lee, Minho Moon
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive deficits, neuroinflammation, and neuronal death. The primary pathogenic cause is believed to be the accumulation of pathogenic amyloid beta (Aβ) assemblies in the brain. Ghrelin, which is a peptide hormone predominantly secreted from the stomach, is an endogenous ligand for the growth hormone secretagogue-receptor type 1a (GHS-R1a). MK-0677 is a ghrelin agonist that potently stimulates the GHS-R1a ghrelin receptor...
June 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29909460/modulation-of-brain-ace-and-ace2-may-be-a-promising-protective-strategy-against-cerebral-ischemia-reperfusion-injury-an-experimental-trial-in-rats
#10
Maha Mohammed Abdel-Fattah, Basim Anwar Shehata Messiha, Ahmed Mohamed Mansour
The brain renin-angiotensin system (RAS) is considered a crucial regulator for physiological homeostasis and disease progression. We evaluated the protective effects of the angiotensin receptor blocker (ARB) telmisartan and the angiotensin-converting enzyme 2 (ACE2) activator xanthenone on experimental cerebral ischemia/reperfusion (I/R) injury. Rats were divided into a sham control, a cerebral I/R control, a standard treatment (nimodipine, 10 mg/kg/day, 15 days, p.o.), three telmisartan treatments (1, 3, and 10 mg/kg/day, 15 days, p...
June 17, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29908256/the-protective-effect-of-%C3%AE-lipoic-acid-against-bisphenol-a-induced-neurobehavioral-toxicity
#11
Jasim Khan, Shikha Salhotra, Shahzad Ahmad, Shikha Sharma, Sayed Aliul Hasan Abdi, Basu Dev Banerjee, Suhel Parvez, Sarika Gupta, Sheikh Raisuddin
Bisphenol A (BPA), a well-known xenoestrogen, is ubiquitously utilized in manufacturing of polycarbonated plastics. Convincing evidence suggests that BPA induces neurotoxicity and certain behavioral deficits. α-Lipoic acid (ALA) supplementation has shown protective effect against heart and liver diseases, diabetes, and neurological debility associated with aging. We studied the neuromodulatory effect of ALA against neurotoxicity of BPA in vitro in C8-D1A mouse astrocyte cell line and in vivo in C57BL/6J male mice...
June 13, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29906751/resveratrol-promotes-neuroprotection-and-attenuates-oxidative-and-nitrosative-stress-in-the-small-intestine-in-diabetic-rats
#12
Paulo Emilio Botura Ferreira, Evandro José Beraldi, Stephanie Carvalho Borges, Maria Raquel Marçal Natali, Nilza Cristina Buttow
Damages to the enteric nervous system caused by diabetes mellitus (DM) are frequently attributed to oxidative and nitrosative stress. We aimed to investigate the effect of Resveratrol (RSV) (10 mg/kg) on oxidative and nitrosative stress in the intestinal wall and morphoquantitative aspects of the myenteric plexus of the duodenum, jejunum and ileum in diabetic rats. Twenty-four rats were distributed into four groups (n = 6/group): control (C group), control treated with RSV (CR group), diabetic (D group), and diabetic treated with RSV (DR group) for 120 days...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906228/changes-in-cardiac-resident-fibroblast-physiology-and-phenotype-in-aging
#13
JoAnn Trial, Katarzyna A Cieslik
The cardiac fibroblast plays a central role in tissue homeostasis and in repair after injury. With aging, dysregulated cardiac fibroblasts have a reduced capacity to respond to transforming growth factor-β (TGF-β) and poorly differentiate into contractile myofibroblasts. That results in the formation of an insufficient scar after myocardial infarction (MI). By contrast, in the uninjured aged heart fibroblasts are activated and acquire a pro-fibrotic phenotype that leads to interstitial fibrosis, ventricular stiffness, and diastolic dysfunction, all conditions that may lead to heart failure...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29905055/-effect-of-chitosan-porous-scaffolds-combined-with-bone-marrow-mesenchymal-stem-cells-in-repair-of-neurological-deficit-after-traumatic-brain-injury-in-rats
#14
Keke Tan, Xiuxiu Wang, Jun Zhang, Zhigang Zhuang, Tieli Dong
Objective: To investigate the possibility and effect of chitosan porous scaffolds combined with bone marrow mesenchymal stem cells (BMSCs) in repair of neurological deficit after traumatic brain injury (TBI) in rats. Methods: BMSCs were isolated, cultured, and passaged by the method of bone marrow adherent culture. The 3rd generation BMSCs were identified by the CD29 and CD45 surface antigens and marked by 5-bromo-2-deoxyuridine (BrdU). The chitosan porous scaffolds were produced by the method of freeze-drying...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904612/proteomic-identification-of-potential-markers-of-myosteatosis-in-human-urine
#15
Holger Husi, Alisdair MacDonald, Richard J E Skipworth, Janice Miller, Andrew Cronshaw, Kenneth C H Fearon, James A Ross
Myosteatosis, the infiltration of fat in skeletal muscle, is associated with lower skeletal muscle density (SMD) as detected by computed tomography (CT). It increases with aging and obesity and is thought to play a role in the aetiology of insulin resistance and type II diabetes. The clinical significance of myosteatosis in cancer cachexia, however, remains to be determined. Along with demonstrable subcutaneous and visceral lipolysis, myosteatosis may also be a key component of the syndrome. We aimed to investigate the use of human urine as a non-invasive way to screen for molecular biomarkers of myosteatosis/reduced SMD using SELDI-TOF mass spectrometry...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29904346/rhes-counteracts-dopamine-neuron-degeneration-and-neuroinflammation-depending-on-gender-and-age
#16
Giulia Costa, Annalisa Pinna, Pier Francesca Porceddu, Maria Antonietta Casu, Anna Di Maio, Francesco Napolitano, Alessandro Usiello, Micaela Morelli
We have recently shown that male Rhes knockout (KO) mice develop a mild form of spontaneous Parkinson's disease (PD)-like phenotype, characterized by motor impairment and a decrease in nigrostriatal dopamine (DA) neurons. Experimental evidence has implicated neuroinflammation in PD progression, and the presence of activated glial cells has been correlated with DA neuron degeneration. Despite this, several factors, such as gender, have been found to affect DAergic neuron degeneration and influence neuroinflammation, explaining the differences between men and women in the etiology of PD...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29902616/billings-reservoir-water-used-for-human-consumption-presents-microbiological-contaminants-and-induces-both-behavior-impairments-and-astrogliosis-in-zebrafish
#17
Ednilse Leme, Ericka P Silva, Paula S Rodrigues, Igor R Silva, Maria F M Martins, Eduardo F Bondan, Maria M Bernardi, Thiago B Kirsten
The Billings reservoir is the largest water-storage facility in the São Paulo Metropolitan Region, with only a small part of the reservoir used for water supply. Recently, the São Paulo Metropolitan Region has experienced the greatest water collapse ever recorded. Thus, the intensification of use of the Billings reservoir should be considered. The objective of this study was to evaluate the quality of the water from different areas of the Billings reservoir related to human consumption (water supply and fishing): Rio Pequeno, Rio Grande, and Bororé rivers...
June 11, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29900207/data-on-the-effect-of-maternal-separation-coupled-with-social-isolation-in-a-forced-swim-test-and-gene-expression-of-glial-fibrillary-acid-protein-in-the-prefrontal-cortex-of-rats
#18
Yosuke Yamawaki, Misako Nishida, Kana Harada, Hiroyuki Akagi
Early life adversity, such as neglect, increases the risk for major depressive disorder and anxiety disorders. It is well-known that astrocytes have key roles in brain function. In this paper, we show the effect of maternal separation (MS) coupled with social isolation on stress response and gene expression of glial fibrillary acidic protein (GFAP) as a marker of astrocytes, in early life and adulthood. Stress response was evaluated by using a forced swim test. GFAP gene expression level was evaluated by using the quantitative polymerase chain reaction (qPCR) method...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29896989/correlation-among-decreased-regional-cerebral-oxygen-saturation-blood-levels-of-brain-injury-biomarkers-and-cognitive-disorder
#19
Birute Kumpaitiene, Milda Svagzdiene, Ingrida Drigotiene, Edmundas Sirvinskas, Ramune Sepetiene, Rolandas Zakelis, Rimantas Benetis
Objective This study was performed to investigate the correlation among decreased regional cerebral oxygen saturation (rSO2 ), blood levels of brain injury biomarkers, and postoperative cognitive disorder (POCD) after cardiac surgery with cardiopulmonary bypass (CPB). Methods This prospective observational study included 59 patients undergoing coronary artery bypass graft surgery with CPB. All patients underwent neuropsychological tests (Mini Mental State Evaluation, Rey Auditory Verbal Learning Test, digit span test, digit symbol substitution test, and Schulte table) the day before and 10 days after the surgery...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29893403/prenatal-histomorphological-development-of-the-rumen-in-dama-dama
#20
Eloy Redondo, Ángela García, Cristina Ortega, Fernando J Peña, A Javier Masot
This work studies the morphological changes taking place in the Dama dama rumen during prenatal development using histomorphometrics, surface micro-structure and immunohistochemistry analysis as well as carrying out a comparative analysis of this species with other wild (red deer) and domestic-type ruminants. A total of 25 fallow deer embryos and fetuses were used, from the first stage of prenatal life until birth. The appearance of the rumen from the primitive gastric tube was observed at 51 days of prenatal life (CRL 3 cm, 21% gestation)...
June 12, 2018: Histology and Histopathology
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