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https://www.readbyqxmd.com/read/29050286/a-prospective-study-of-serum-metabolites-and-glioma-risk
#1
Jiaqi Huang, Stephanie J Weinstein, Cari M Kitahara, Edward D Karoly, Joshua N Sampson, Demetrius Albanes
Malignant glioma is one of the most lethal adult cancers, yet its etiology remains largely unknown. We conducted a prospective serum metabolomic analysis of glioma based on 64 cases and 64 matched controls selected from Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Median time from collection of baseline fasting serum to diagnosis was nine years (inter-decile range 3-20 years). LC/MS-MS identified 730 known metabolites, and conditional logistic regression models estimated odds ratios for one-standard deviation differences in log-metabolite signals...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29046208/-clinical-and-genetic-study-of-an-infant-with-alagille-syndrome-identification-of-a-novel-chromosomal-interstitial-deletion-including-jag1-gene
#2
Hua Li, Jia-Jia Liu, Mei Deng, Li Guo, Ying Cheng, Yuan-Zong Song
Alagille syndrome (ALGS) is an autosomal dominant disease affecting multiple systems including the liver, heart, skeleton, eyes, kidneys and face. This paper reports the clinical and genetic features of an infant with this disease. A 3-month-and-10-day-old female infant was referred to the hospital with jaundiced skin and sclera for 3 months. Physical examination revealed wide forehead and micromandible. A systolic murmur of grade 3-4/6 was heard between the 2th and 3th intercostal spaces on the left side of the sternum...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29046204/-clinical-features-and-vps33b-mutations-in-a-family-affected-by-arthrogryposis-renal-dysfunction-and-cholestasis-syndrome
#3
Da-Gui Huang, Jia-Jia Liu, Li Guo, Yuan-Zong Song
Arthrogryposis, renal dysfunction, and cholestasis (ARC) syndrome is an autosomal recessive disorder caused by mutations in the VPS33B or VIPAS39 gene. The aim of this study was to investigate the clinical features and VPS33B gene mutations of an infant with ARC syndrome. A 47-day-old female infant was referred to the hospital with the complaint of jaundiced skin and sclera for 45 days and abnormal liver function for 39 days. The patient had been managed in different hospitals, but the therapeutic effects were unsatisfactory due to undetermined diagnosis...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29045336/bile-acid-receptors-and-the-kidney
#4
Michal Herman-Edelstein, Talia Weinstein, Moshe Levi
PURPOSE OF REVIEW: Bile acids act as activating signals of endogenous renal receptors: the nuclear receptor farnesoid X receptor (FXR) and the membrane-bound G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5). In recent years, bile acids have emerged as important for renal pathophysiology by activating FXR and TGR5 and transcription factors relevant for lipid, cholesterol and carbohydrate metabolism, as well as genes involved in inflammation and renal fibrosis. RECENT FINDINGS: Activation of bile acid receptors has a promising therapeutic potential in prevention of diabetic nephropathy and obesity-induced renal damage, as well as in nephrosclerosis...
October 16, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29042438/the-serum-protein-renalase-reduces-injury-in-experimental-pancreatitis
#5
Thomas R Kolodecik, Anamika M Reed, Kimie Date, Christine Shugrue, Vikhil Patel, Shang-Lin Chung, Gary V Desir, Fred S Gorelick
Acute pancreatitis is a disease associated with inflammation and tissue damage. One protein that protects against acute injury, including ischemic injury to both the kidney and heart, renalase, which is secreted into the blood by the kidney and other tissues. However, whether renalase reduces acute injury associated with pancreatitis is unknown. Here, we used both in vitro and in vivo murine models of acute pancreatitis to study renalase effects on this condition. In isolated pancreatic lobules, pretreatment with recombinant human renalase (rRNLS) blocked zymogen activation caused by cerulein, carbachol, and a bile acid...
October 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29040577/metabolomics-of-postprandial-plasma-alterations-a-comprehensive-japanese-study
#6
Takeo Moriya, Yoshinori Satomi, Hiroyuki Kobayashi
While endogenous metabolites in plasma can be used as clinical biomarkers, intra-day variations should be carefully considered. The postprandial effect is a large contributing factor and is dependent on regional features (e.g., meals, ethnicity). Thus, for clinical application, regional-specific postprandial baseline data are required. In this study, 10 healthy Japanese volunteers of different ages and genders ate the same meal, and blood samples were taken 30 min before and one hour after the meal challenge...
October 4, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29039071/potential-applications-of-gliclazide-in-treating-type-1-diabetes-mellitus-formulation-with-bile-acids-and-probiotics
#7
Momir Mikov, Maja Đanić, Nebojša Pavlović, Bojan Stanimirov, Svetlana Goločorbin-Kon, Karmen Stankov, Hani Al-Salami
A major advancement in therapy of type 1 diabetes mellitus (T1DM) is the discovery of new treatment which avoids and even replaces the absolute requirement for injected insulin. The need for multiple drug therapy of comorbidities associated with T1DM increases demand for developing novel therapeutic alternatives with new mechanisms of actions. Compared to other sulphonylurea drugs used in the treatment of type 2 diabetes mellitus, gliclazide exhibits a pleiotropic action outside pancreatic β cells, the so-called extrapancreatic effects, such as antiinflammatory and cellular protective effects, which might be beneficial in the treatment of T1DM...
October 16, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29038146/use-of-metabolomics-in-improving-assessment-of-dietary-intake
#8
REVIEW
Marta Guasch-Ferré, Shilpa N Bhupathiraju, Frank B Hu
BACKGROUND: Nutritional metabolomics is rapidly evolving to integrate nutrition with complex metabolomics data to discover new biomarkers of nutritional exposure and status. CONTENT: The purpose of this review is to provide a broad overview of the measurement techniques, study designs, and statistical approaches used in nutrition metabolomics, as well as to describe the current knowledge from epidemiologic studies identifying metabolite profiles associated with the intake of individual nutrients, foods, and dietary patterns...
October 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29037249/a-novel-self-micro-emulsifying-delivery-system-smeds-formulation-significantly-improves-the-fasting-absorption-of-epa-and-dha-from-a-single-dose-of-an-omega-3-ethyl-ester-concentrate
#9
Yan Qin, Hilde Nyheim, Else Marie Haram, Joseph M Moritz, Svein Olaf Hustvedt
BACKGROUND: Absorption of EPA and DHA from Omega-3-acid ethyl ester (EE) concentrate supplements occurs most efficiently when taken in context of a fatty meal; adequate fat intake is required to release bile salts that emulsify and pancreatic enzymes that digest omega-3-containing lipids in the intestine. Current guidelines recommend reduction in fat intake and therefore there is a need to optimize the absorption of Omega-3 in those consuming low-fat or no-fat meals. To this end, BASF has developed an Absorption Acceleration Technology, a novel self-micro-emulsifying delivery system (SMEDS) formulation of highly concentrated Omega-3-acid EE which enables rapid emulsification and microdroplet formation upon entering the aqueous environment of the gut therefore enhances the absorption...
October 16, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29036927/chinese-olive-canarium-album-l-fruit-extract-attenuates-metabolic-dysfunction-in-diabetic-rats
#10
Yu-Te Yeh, An-Na Chiang, Shu-Chen Hsieh
Hyperglycemia and dysregulation of lipid metabolism play a crucial role in metabolic dysfunction. The aims of present study were to evaluate the ameliorative effect of the ethyl acetate fraction of Chinese olive fruit extract (CO-EtOAc) on high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic rats. CO-EtOAc, rich in gallic acid and ellagic acid, could markedly decreased the body weight and epididymal adipose mass. In addition, CO-EtOAc increased serum HDL-C levels, hepatic GSH levels, and antioxidant enzyme activities; lowered blood glucose, serum levels of total cholesterol (TC), triglycerides (TG), bile acid, and tumor necrosis factor alpha (TNFα); and reduced TC and TG in liver...
October 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29034530/gene-expression-and-morphological-changes-in-the-intestinal-mucosa-associated-with-increased-permeability-induced-by-short-term-fasting-in-chickens
#11
S Gilani, G S Howarth, G Nattrass, S M Kitessa, R Barekatain, R E A Forder, C D Tran, R J Hughes
Short-term fasting for 4.5 and 9 hr has been demonstrated to increase intestinal permeability (IP) in chickens. This study aimed to investigate the effects of 0, 4.5, 9 and 19.5 hr fasting on intestinal gene expression and villus-crypt architecture of enterocytes in jejunal and ileal samples. On day 38, Ross-308 male birds were fasted according to their group and then euthanised. Two separate intestinal sections (each 2 cm long, jejunum and ileum) were collected. One section was utilised for villus height and crypt depth measurements...
October 16, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29031874/an-update-on-the-physiopathology-and-therapeutic-management-of-cholestatic-pruritus-in-children
#12
A Thébaut, D Debray, E Gonzales
Pruritus is a disabling symptom accompanying chronic cholestasis. In extreme cases, the refractory nature of pruritus can result in a need for invasive therapies including liver transplantation. The pathogenesis of pruritus in cholestatic disease is poorly understood. It may involve a specific neural pathway (similar to that associated with pain) regulated by several pruritogenic substances such as bile acids, opioids, serotonin, and the more recently identified lysophosphatidic acid. While the therapeutic management of cholestatic pruritus is well established in adults, there is no consensus in children, in light of the difficulty of conducting controlled clinical studies...
October 11, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29031784/isobarictags-for-relative-and-absolute-quantitation-itraq-based-proteomics-for-the-investigation-of-the-effect-of-huganqingzhi-on-non-alcoholic-fatty-liver-disease-in-rats
#13
Fan Xia, Xiaorui Yao, Waijiao Tang, Chunxin Xiao, Miaoting Yang, Benjie Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Hugan Qingzhi tablet (HQT), a traditional Chinese medicine formula has been adopted for preventing and treating nonalcoholic fatty liver disease (NAFLD). AIM: In order to explore the anti-NAFLD mechanisms of HQT, iTRAQ-based proteomics was employed to investigate the expression profiles of proteins in NAFLD rats induced by high-fat diet after HQT treatment. MATERIALS AND METHODS: The NAFLD rat model was administration of high-fat diet (HFD) for 12weeks and administering HQT in a daily basis to the HFD groups...
October 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29031685/comparison-of-the-composition-of-bile-acids-in-bile-of-patients-with-adenocarcinoma-of-the-pancreas-and-benign-disease
#14
David O Rees, Peter J Crick, Gareth J Jenkins, Yuqin Wang, William J Griffiths, Tim H Brown, Bilal Al-Sarireh
Bile acids have been implicated in the development of gastrointestinal malignancies. Both the specific nature of individual bile acids and their concentration appear key factors in the carcinogenic potency of bile. Using liquid chromatography mass spectrometry (LC-MS) we performed quantitative profiling of bile extracted directly from the common bile duct in 30 patients (15 patients with pancreatic cancer and 15 patients with benign disease). Separation and detection of bile acids was performed using a 1.7μm particle size reversed-phase C18 LC column at a flow rate of 200μL/min with negative electrospray ionization MS...
October 11, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29030666/lc-pda-apciitms-identification-of-algal-carotenoid-and-oxysterol-precursors-to-fatty-acid-esters-in-hydrolyzed-extracts-of-the-freshwater-mussel-dreissena-bugensis
#15
Maxime C Bridoux, Monika Sobiechowska, Alicia Pérez-Fuentetaja, Katherine T Alben
Carotenyl fatty acid esters (carotenyl-FAEs) were extracted in acetone from freeze-dried Dreissena bugensis (Lakes Erie and Ontario) and hydrolyzed to identify the carotenoid precursors. Analysis by liquid chromatography (LC) with photodiode array (PDA) and atmospheric pressure chemical ionization-ion trap mass spectrometry (APCIitMS) revealed the major hydrolysis products: fucoxanthinol (FOH) from fucoxanthin (FX, diatoms); mactraxanthin (MX) from violaxanthin (VX, chlorophytes); 4-fold higher levels of an unknown, tentatively identified as an adduct of two closely eluting C27H46O3 and C27H48O3 steryl triols...
October 13, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29029700/lipid-components-of-bile-increase-the-protective-effect-of-conjugated-bile-salts-against-antifungal-drugs
#16
Shih-Hung Hsieh, Matthias Brock
Fungi and bacteria can persist in the human gall bladder. Previous studies have shown that bile protects Candida albicans in this cryptic host niche from antifungals, providing a reservoir for intestinal re-colonization after discontinuation of antifungal therapy. Bile and conjugated bile salts trap antifungals in micelles, thereby reducing their bioavailability and possibly promoting the development of drug resistance. Here we show that the protective effect of bile and conjugated bile salts is not limited to C...
November 2017: Fungal Biology
https://www.readbyqxmd.com/read/29029322/a-dynamic-mathematical-model-of-bile-acid-clearance-in-heparg-cells
#17
Daniel Kaschek, Ahmad Sharanek, André Guillouzo, Jens Timmer, Richard J Weaver
A dynamic model based on ordinary differential equations that describes uptake, basolateral and canalicular export of taurocholic acid in human HepaRG cells is presented. The highly reproducible inter-assay experimental data were used to reliably estimate model parameters. Primary human hepatocytes were similarly evaluated to establish a mathematical model, but with notably higher inter-assay differences in taurocholic acid clearance and bile canaliculi dynamics. By use of the HepaRG cell line, the simultaneous taurocholic acid clearance associated to basolateral uptake, canalicular and sinusoidal efflux, was predicted...
September 18, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29028769/activation-of-the-nuclear-receptor-fxr-improves-intestinal-cell-tolerance-to-ischemia-reperfusion-injury
#18
Xuan Wang, Shuo Li, Man Chen, Jing Liu, Ruirui Dong, Humin Wang, Shigong Zhu
The farnesoid X receptor (FXR) plays an important role in bile acid metabolism, intestinal homeostasis, and intestinal ischemia-reperfusion (I/R) injury. We aimed to clarify the potential effects of FXR on intestinal epithelial cell tolerance to intestinal I/R injury and reveal the underlying mechanisms. An intestinal I/R injury model was established by the occlusion of the superior mesenteric artery for ischemia for 1 h, followed by reperfusion for 4 h in C57BL/6 (wild-type; WT)and FXR mice. The small intestine injury was assessed by histological analysis...
October 12, 2017: Shock
https://www.readbyqxmd.com/read/29028359/complex-interaction-between-circadian-rhythm-and-diet-on-bile-acid-homeostasis-in-male-rats
#19
Hannah M Eggink, Johanneke E Oosterman, Paul de Goede, Emmely M de Vries, Ewout Foppen, Martijn Koehorst, Albert K Groen, Anita Boelen, Johannes A Romijn, Susanne E la Fleur, Maarten R Soeters, Andries Kalsbeek
Desynchronization between the master clock in the brain, which is entrained by (day) light, and peripheral organ clocks, which are mainly entrained by food intake, may have negative effects on energy metabolism. Bile acid metabolism follows a clear day/night rhythm. We investigated whether in rats on a normal chow diet the daily rhythm of plasma bile acids and hepatic expression of bile acid metabolic genes is controlled by the light/dark cycle or the feeding/fasting rhythm. In addition, we investigated the effects of high caloric diets and time-restricted feeding on daily rhythms of plasma bile acids and hepatic genes involved in bile acid synthesis...
October 13, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29027248/ursodeoxycholic-acid-protects-cardiomyocytes-against-cobalt-chloride-induced-hypoxia-by-regulating-transcriptional-mediator-of-cells-stress-hypoxia-inducible-factor-1%C3%AE-and-p53-protein
#20
Anis Syamimi Mohamed, Noorul Izzati Hanafi, Siti Hamimah Sheikh Abdul Kadir, Julina Md Noor, Narimah Abdul Hamid Hasani, Sharaniza Ab Rahim, Rosfaiizah Siran
In hepatocytes, ursodeoxycholic acid (UDCA) activates cell signalling pathways such as p53, intracellular calcium ([Ca(2+) ]i ), and sphingosine-1-phosphate (S1P)-receptor via Gαi -coupled-receptor. Recently, UDCA has been shown to protect the heart against hypoxia-reoxygenation injury. However, it is not clear whether UDCA cardioprotection against hypoxia acts through a transcriptional mediator of cells stress, HIF-1α and p53. Therefore, in here, we aimed to investigate whether UDCA could protect cardiomyocytes (CMs) against hypoxia by regulating expression of HIF-1α, p53, [Ca(2+) ]i , and S1P-Gαi -coupled-receptor...
October 12, 2017: Cell Biochemistry and Function
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