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Joshua A Lile, William W Stoops, Lon R Hays, Craig R Rush
OBJECTIVES: This experiment determined the safety and tolerability of intranasal cocaine during aripiprazole maintenance. METHODS: Six cocaine-dependent human subjects were maintained on aripiprazole (15 mg) and placebo for 10 days in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine. RESULTS: Intranasal cocaine produced prototypical stimulant-like effects (e.g., increased blood pressure and heart rate, increased subject ratings of Like Drug and Stimulated), and aripiprazole enhanced these effects on several measures...
2008: American Journal of Drug and Alcohol Abuse
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