keyword
https://read.qxmd.com/read/38301301/diosgenin-as-a-substitute-for-cholesterol-alleviates-nafld-by-affecting-cyp7a1-and-npc1l1-related-pathway
#21
JOURNAL ARTICLE
Mengyao Yan, Yixin Zhao, Shuli Man, Yujie Dai, Long Ma, Wenyuan Gao
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) rapidly becomes the leading cause of end-stage liver disease or liver transplantation. Nowadays, there has no approved drug for NAFLD treatment. Diosgenin as the structural analogue of cholesterol attenuates hypercholesterolemia by inhibiting cholesterol metabolism, which is an important pathogenesis in NAFLD progression. However, there has been no few report concerning its effects on NAFLD so far. METHODS: Using a high-fat diet & 10% fructose-feeding mice, we evaluated the anti-NAFLD effects of diosgenin...
January 20, 2024: Phytomedicine
https://read.qxmd.com/read/38285537/-bifidobacterium-animalis-subsp-lactis-f1-7-alleviates-lipid-accumulation-in-atherosclerotic-mice-via-modulating-bile-acid-metabolites-to-downregulate-intestinal-fxr
#22
JOURNAL ARTICLE
Xi Liang, Xiumei Zheng, Peng Wang, Huaqi Zhang, Yiqing Ma, Hui Liang, Zhe Zhang
The dysfunction of intestinal microbiota and bile acid metabolism is related to the pathogenesis of atherosclerosis. This study we explored the mechanism of Bifidobacterium animalis subsp. lactis F1-7 ( Bif. animalis F1-7), improving atherosclerosis by regulating the bile acid metabolism and intestinal microbiota in the ApoE-/- mice. The Bif. animalis F1-7 effectively reduced aortic plaque accumulation and improved the serum and liver lipid levels in atherosclerotic mice. The untargeted metabolomics revealed that Bif...
January 29, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38268974/quantitative-determination-of-cholesterol-hydroxylase-specificities-by-gc-ms-ms-in-living-mammalian-cells
#23
JOURNAL ARTICLE
Hodaka Saito, Mizuki Nishimura, Ryuichiro Sato, Yoshio Yamauchi
Cholesterol is oxygenated by a variety of cholesterol hydroxylases; oxysterols play diverse important roles in physiological and pathophysiological conditions by regulating several transcription factors and cell-surface receptors. Each oxysterol has distinct and overlapping functions. The expression of cholesterol hydroxylases is highly regulated, but their physiological and pathophysiological roles are not fully understood. Although the activity of cholesterol hydroxylases has been characterized biochemically using radiolabeled cholesterol as the substrate, their specificities remain to be comprehensively determined quantitatively...
January 20, 2024: Bio-protocol
https://read.qxmd.com/read/38262588/sex-dimorphic-effects-of-bile-acid-metabolism-in-liver-cancer-in-mice
#24
JOURNAL ARTICLE
Rachel M Golonka, Beng San Yeoh, Piu Saha, Yuan Tian, John Y L Chiang, Andrew D Patterson, Andrew T Gewirtz, Bina Joe, Matam Vijay-Kumar
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is a male-dominant disease, but targeted sex hormone therapies have not been successful. Bile acids are a potential liver carcinogen and are biomolecules with hormone-like effects. A few studies highlight their potential sex dimorphism in physiology and disease. We hypothesized that bile acids could be a potential molecular signature that explains sex disparity in HCC. APPROACH & RESULTS: We employed the farnesoid X receptor knockout (FxrKO) mouse model to study bile acid-dependent HCC...
January 21, 2024: Cellular and Molecular Gastroenterology and Hepatology
https://read.qxmd.com/read/38256841/therapeutic-role-of-polyphenol-extract-from-prunus-cerasifera-ehrhart-on-non-alcoholic-fatty-liver
#25
JOURNAL ARTICLE
Jiabao Ren, Xing Zhang, S U Heiyan-Perhat, Po Yang, Helong Han, Yao Li, Jie Gao, Enpeng He, Yanhong Li
Prunus cerasifera Ehrhart ( P. cerasifera ) flourishes uniquely in the arid landscapes of Xinjiang, China. Preliminary studies have revealed the therapeutic potential of its polyphenol extract (PPE) in mitigating liver lipid accumulation in mice fed a high-fat diet. We established a mouse model that was subjected to a continuous high-fat diet for 24 weeks and administered PPE to investigate the effects of PPE on cholesterol and BA metabolism in NAFLD mice. The results showed that PPE administration (200 and 400 mg/kg/day, BW) led to a reduction in liver TC, an increase in liver T-BAs, and normalization of the disrupted fecal BA profile...
January 18, 2024: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38237767/chronic-arsenic-exposure-provoked-biotoxicity-involved-in-liver-microbiota-gut-axis-disruption-in-chickens-based-on-multi-omics-technologies
#26
JOURNAL ARTICLE
Jiayi Li, Changming Guo, Yan Liu, Biqi Han, Zhanjun Lv, Huijie Jiang, Siyu Li, Zhigang Zhang
INTRODUCTION: Arsenic has been ranked as the most hazardous substance by the U.S. Agency for Toxic Substances and Disease Registry. Environmental arsenic exposure-evoked health risks have become a vital public health concern worldwide owing to the widespread existence of arsenic. Multi-omics is a revolutionary technique to data analysis providing an integrated view of bioinformation for comprehensively and systematically understanding the elaborate mechanism of diseases. OBJECTIVES: This study aimed at uncovering the potential contribution of liver-microbiota-gut axis in chronic inorganic arsenic exposure-triggered biotoxicity in chickens based on multi-omics technologies...
January 16, 2024: Journal of Advanced Research
https://read.qxmd.com/read/38232620/betaine-supplementation-alleviates-corticosterone-induced-hepatic-cholesterol-accumulation-through-epigenetic-modulation-of-hmgcr-and-cyp7a1-genes-in-laying-hens
#27
JOURNAL ARTICLE
Yulin Wu, Mengwei Zhang, Fanchi Meng, Kunpeng Ren, Ding Li, Xugang Luo, Yun Hu
Excessive corticosterone (CORT) exposure could cause hepatic cholesterol accumulation in chickens and maternal betaine supplementation could decrease hepatic cholesterol deposition through epigenetic modifications in offspring chickens. Nevertheless, it remains uncertain whether providing betaine to laying hens could protect CORT-induced hepatic cholesterol accumulation via epigenetic mechanisms. This study aimed to examine the effects of dietary betaine on plasma and hepatic cholesterol contents, expression of cholesterol metabolic genes, as well as DNA methylation on their promoters in the liver of laying hens exposed to CORT...
January 6, 2024: Poultry Science
https://read.qxmd.com/read/38225846/-impact-of-lithocholic-acid-on-the-osteogenic-and-adipogenic-differentiation-balance-of-bone-marrow-mesenchymal-stem-cells
#28
JOURNAL ARTICLE
Cui Wang, Jiao Li, Lingyun Lu, Lu Liu, Xijie Yu
OBJECTIVE: To Investigate the effects of lithocholic acid (LCA) on the balance between osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). METHODS: Twelve 10-week-old SPF C57BL/6J female mice were randomly divided into an experimental group (undergoing bilateral ovariectomy) and a control group (only removing the same volume of adipose tissue around the ovaries), with 6 mice in each group. The body mass was measured every week after operation...
January 15, 2024: Chinese Journal of Reparative and Reconstructive Surgery
https://read.qxmd.com/read/38225060/impacts-of-prothioconazole-and-prothioconazole-desthio-on-bile-acid-and-glucolipid-metabolism-upregulation-of-cyp7a1-expression-in-hepg2-cells
#29
JOURNAL ARTICLE
Lingyu Hu, Xiaofang Wang, Mingrong Qian, Hu Zhang, Yuanxiang Jin
As an efficient triazole fungicide, prothioconazole (PTC) is widely used for the prevention and control of plant fungal pathogens. It was reported that the residues of PTC and prothioconazole-desthio (PTC-d) have been detected in the environment and crops, and the effects of PTC-d may be higher than that of PTC. Currently, PTC and PTC-d have been proven to induce hepatic metabolic disorders. However, their toxic effects on cellular bile acid (BA) and glucolipid metabolism remain unknown. In this study, HepG2 cells were exposed to 1-500 μM of PTC or PTC-d...
January 2024: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/38205623/cholesterol-lowering-in-diet-induced-hypercholesterolemic-mice-using-lactobacillus-bile-salt-hydrolases-with-different-substrate-specificities
#30
JOURNAL ARTICLE
Menghuan Zhao, Weijia Kuang, Jiaxin Yang, Yanrong Liu, Miao Yang, Ying Chen, Huanjing Zhu, Yao Yang
The cholesterol-lowering effect of lactic acid bacteria with high activity of bile salt hydrolase (BSH) is unclear. We believe that distinguishing BSH substrate specificity is necessary to study the effect of various BSH enzymes. We engineered a BSH mutant enzyme recombinant strain named F67A, which exclusively hydrolyzes taurocholic acid (TCA) using site-directed mutagenesis, and a previously lab-constructed BSH recombinant strain, YB81 that exclusively hydrolyzes glycocholic acid (GCA). We also constructed the recombinant strain named NB5462, which carries the empty pSIP411 plasmid and was used as a blank control strain...
January 11, 2024: Food & Function
https://read.qxmd.com/read/38198044/evaluation-of-probiotic-bifidobacteria-strains-from-iranian-traditional-dairy-products-for-their-anti-hyperlipidemic-potential
#31
JOURNAL ARTICLE
Nasim Afshar, Kumarss Amini, Hamidreza Mohajerani, Sasan Saki
This study investigated the therapeutic potential of probiotic bifidobacteria, isolated from Iranian fermented dairy products, in a hyperlipidemic animal model. Bifidobacterium strains were extracted from traditional dairy samples and screened using physiological and phenotypic examinations, 16S rRNA analysis, and probiotic properties such as tolerance to gastrointestinal juice, antimicrobial activity, and antibiotic susceptibility. The ability of the screened bifidobacteria to reduce serum and liver lipids in vivo was tested using male Wistar rats...
January 10, 2024: Folia Microbiologica
https://read.qxmd.com/read/38192042/fermented-natto-powder-alleviates-obesity-by-regulating-lxr-pathway-and-gut-microbiota-in-obesity-rats
#32
JOURNAL ARTICLE
Ruiyue Sun, Honghong Niu, Yueqiao Li, Mubai Sun, Mei Hua, Xinyu Miao, Ying Su, Jinghui Wang, Da Li, Ying Wang
AIM: This study aimed to investigate the positive effect of natto powder on obese rats fed with a high-fat diet (HFD). METHODS AND RESULTS: Sprague-Dawley (SD) rats were fed with a high-fat diet for 8 weeks continuously and gavaged with natto powder respectively for 8 weeks starting from the ninth week. The results showed that natto powder significantly reduced the body weight of rats and maintained the balance of cholesterol metabolism in the body by inhibiting the activity of Liver X receptors (LXR) target genes, increasing the active expression of cholesterol 7 alpha-hydroxylase (CYP7A1) and reducing the active expression of Sterol-regulatory element-binding protein (SREBP-2) and HMG-CoA Reductase (HMGCR)...
January 8, 2024: Journal of Applied Microbiology
https://read.qxmd.com/read/38191842/a-novel-cholesterol-metabolism-related-ferroptosis-pathway-in-hepatocellular-carcinoma
#33
JOURNAL ARTICLE
Weiwei Fang, Jianyong Liu, Fanguo Zhang, Cheng Pang, Xiying Li
BACKGROUND: Emerging studies have reported the contribution of cholesterol to hepatocellular carcinoma (HCC) progression. However, the specific role and mechanism of cholesterol metabolism on spontaneous and progressive HCC development from the point of view of ferroptosis are still worth exploring. The present study aimed to reveal a novel mechanism of cholesterol metabolism-related ferroptosis in hepatocellular carcinoma cells. METHODS: Two microarray datasets (GSE25097, GSE22058) related to HCC were downloaded from Gene Expression Omnibus (GEO) datasets...
January 8, 2024: Discover. Oncology
https://read.qxmd.com/read/38191052/inhibition-of-pcsk9-prevents-and-alleviates-cholesterol-gallstones-through-ppar%C3%AE-mediated-cyp7a1-activation
#34
JOURNAL ARTICLE
Zhenmei Chen, Weiqing Shao, Yitong Li, Xiandi Zhang, Yan Geng, Xiaochen Ma, Baorui Tao, Yue Ma, Chenhe Yi, Bo Zhang, Rui Zhang, Jing Lin, Jinhong Chen
BACKGROUND & AIMS: Dysregulated cholesterol metabolism is the major factor responsible for cholesterol gallstones (CGS). Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a critical role in cholesterol homeostasis and its inhibitors secure approval for treating various cholesterol metabolic disorders such as hypercholesterolemia and cardiovascular diseases, but its role in CGS remains unclear. Our study aims to clarify mechanisms by which PCSK9 promotes CGS formation and explore the application of the PCSK9 inhibitor, alirocumab, in preventing and treating CGS...
January 6, 2024: Metabolism: Clinical and Experimental
https://read.qxmd.com/read/38181850/distinct-bile-acid-alterations-in-response-to-a-single-administration-of-pfoa-and-pfda-in-mice
#35
JOURNAL ARTICLE
Xiaoxiao Yu, Youcai Zhang, Bruno Cogliati, Curtis D Klaassen, Sanaya Kumar, Xingguo Cheng, Pengli Bu
Per- and polyfluoroalkyl substances (PFASs), a group of synthetic chemicals that were once widely used for industrial purposes and in consumer products, are widely found in the environment and in human blood due to their extraordinary resistance to degradation. Once inside the body, PFASs can activate nuclear receptors such as PPARα and CAR. The present study aimed to investigate the impact of perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) on liver structure and functions, as well as bile acid homeostasis in mice...
January 3, 2024: Toxicology
https://read.qxmd.com/read/38165563/high-dietary-wheat-starch-negatively-regulated-growth-performance-glucose-and-lipid-metabolisms-liver-and-intestinal-health-of-juvenile-largemouth-bass-micropterus-salmoides
#36
JOURNAL ARTICLE
Bi-Yun Zhang, Hong-Ling Yang, Qing-Jie Nie, Yu Zhang, Guo-He Cai, Yun-Zhang Sun
Largemouth bass (Micropterus salmoides) were fed with three diets containing 6%, 12%, and 18% wheat starch for 70 days to examine their impacts on growth performance, glucose and lipid metabolisms, and liver and intestinal health. The results suggested that the 18% starch group inhibited the growth, and improved the hepatic glycogen content compared with the 6% and 12% starch groups (P < 0.05). High starch significantly improved the activities of glycolysis-related enzymes, hexokinase (HK), glucokinase (GK), phosphofructokinase (PFK), and pyruvate kinase (PK) (P < 0...
January 2, 2024: Fish Physiology and Biochemistry
https://read.qxmd.com/read/38154545/pharmacological-modulation-of-cholesterol-7%C3%AE-hydroxylase-cyp7a1-as-a-therapeutic-strategy-for-hypercholesterolemia
#37
REVIEW
Megan Yu Cai Lim, Han Kiat Ho
Despite the availability of many therapeutic options, the prevalence of hypercholesterolemia remains high. There exists a significant unmet medical need for novel drugs and/or treatment combinations to effectively combat hypercholesterolemia while minimizing adverse reactions. The modulation of cholesterol 7α-hydroxylase (CYP7A1) expression via perturbation of the farnesoid X receptor (FXR) - dependent pathways, primarily FXR/small heterodimer partner (SHP) and FXR/ fibroblast growth factor (FGF)-19/ fibroblast growth factor receptor (FGFR)-4 pathways, presents as a potential option to lower cholesterol levels...
December 26, 2023: Biochemical Pharmacology
https://read.qxmd.com/read/38151562/gut-microbiota-and-liver-metabolomics-reveal-the-potential-mechanism-of-lactobacillus-rhamnosus-gg-modulating-the-liver-toxicity-caused-by-polystyrene-microplastics-in-mice
#38
JOURNAL ARTICLE
Changhao Yu, Yawen Xu, Yiping Wei, Yuxue Guo, Yi Wang, Ping Song, Jing Yu
Microplastics (MPs) are known to cause liver toxicity as they can spread through the food chain. Most researches on their toxicity have focused on individual organs, neglecting the crucial "gut-liver axis"-a bidirectional communication pathway between the gut and liver. Probiotics have shown promise in modulating the effects of environmental pollutants. In this study, we exposed mice to Lactobacillus rhamnosus GG (LGG, 100 mg/kg b.w./d) and/or polystyrene microplastics (PS-MPs, 5 mg/kg b.w./d) for 28 d via gavage to investigate how probiotics influence live toxicity through the gut-liver axis...
December 28, 2023: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38135227/polymethoxyflavones-in-citrus-extract-has-a-beneficial-effect-on-hypercholesterolemia-rats-by-promoting-liver-cholesterol-metabolism
#39
JOURNAL ARTICLE
Yuzhong Du, Jie Su, Meiqiu Yan, Qirui Wang, Ting Wang, Su Gao, Yajuan Tian, Yibei Wang, Suhong Chen, Guiyuan Lv, Jingjing Yu
ETHNOPHARMACOLOGICAL RELEVANCE: Hyperlipidemia is characterized by the disorder of lipid metabolism accompanied by oxidative stress damage, and low-grade inflammation, with the pathway of cholesterol and bile acid metabolic are an important triggering mechanism. Polymethoxyflavones (PMFs) are the active constituents of Aurantii Fructus Immaturus, which have many biological effects, including anti-inflammatory, antioxidant activities, anti-obesity, suppressing adipogenesis in adipocytes, and ameliorate type 2 diabetes, with potential roles for regulation of lipid metabolism...
December 20, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/38090678/gardenia-iridoid-glucosides-protect-against-%C3%AE-naphthalene-isothiocya-nate-induced-cholestatic-rats-through-activation-of-the-fxr-shp-signaling-pathway
#40
JOURNAL ARTICLE
Meng Xu, Ke Che, Cong Wang, Ya-Ru Chen, Meng-Yuan Chen, Guang-Lei Zhang, Hao Yu, Hao-Nan Xu, Ya-Bao Li, Ping Sheng, Hao Chen
INTRODUCTION: Cholestasis is a common liver disorder that currently has limited treatment options. Gardenia Iridoid Glucosides (GIG) have been found to possess various physiological activities, such as cholagogic, hypoglycemic, antibacterial, and anti-inflammatory effects. The objective of this study was to investigate the effects of GIG on bile acid enterohepatic circulation and explore the underlying mechanism in cholestatic rats. METHODS: In order to identify key pathways associated with cholestasis, we conducted Gene Ontology (GO) Enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses...
2023: Clinical and Experimental Gastroenterology
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