keyword
MENU ▼
Read by QxMD icon Read
search

Neuroregeneration

keyword
https://www.readbyqxmd.com/read/27901327/stem-cell-therapy-for-sequestering-neuroinflammation-in-traumatic-brain-injury-an-update-on-exosome-targeting-to-the-spleen
#1
Marci G Crowley, Michael G Liska, Cesar V Borlongan
Traumatic brain injury (TBI), manifests with acute and chronic cell death pathways leading to initial impacted injury and subsequent neurodegeneration. In particular, the secondary cell death, plagued by a massive and lingering neuroinflammatory response, contributes significantly to worsening outcomes of the progressive TBI pathology. Fortunately, neuroinflammation also provides an opportunity for therapeutic interventions. Limited treatment options currently exist for the disease, but stem cell-based therapies offer promise in promoting neuroprotection and neuroregeneration by mitigating central neuroinflammation as well as modulating peripheral inflammation via the spleen...
November 30, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27879599/total-human-eye-allotransplantation-developing-surgical-protocols-for-donor-and-recipient-procedures
#2
Edward H Davidson, Eric W Wang, Jenny Y Yu, Juan C Fernandez-Miranda, Dawn J Wang, Nikisha Richards, Maxine Miller, Joel S Schuman, Kia M Washington
BACKGROUND: Vascularized composite allotransplantation of the eye is an appealing, novel method for reconstruction of the nonfunctioning eye. The authors' group has established the first orthotopic model for eye transplantation in the rat. With advancements in immunomodulation strategies together with new therapies in neuroregeneration, parallel development of human surgical protocols is vital for ensuring momentum toward eye transplantation in actual patients. METHODS: Cadaveric donor tissue harvest (n = 8) was performed with orbital exenteration, combined open craniotomy, and endonasal approach to ligate the ophthalmic artery with a cuff of paraclival internal carotid artery, for transection of the optic nerve at the optic chiasm and transection of cranial nerves III to VI and the superior ophthalmic vein at the cavernous sinus...
December 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27871507/use-of-gabaergic-sedatives-after-subarachnoid-hemorrhage-is-associated-with-worse-outcome-preliminary-findings
#3
Daniel N Hertle, Christopher Beynon, Jan O Neumann, Edgar Santos, Renan Sánchez-Porras, Andreas W Unterberg, Oliver W Sakowitz
STUDY OBJECTIVE: Recent experimental evidence identified GABAergic sedation as a possible cause for deprived neuroregeneration and poor outcome after acute brain injury. Patients with aneurysmal subarachnoid hemorrhage are often sedated, and GABAergic sedation, such as midazolam and propofol, is commonly used. DESIGN: Retrospective cohort study based on a prospectively established database. SETTING: Single-center neurointensive care unit. PATIENTS: Twenty-nine patients after subarachnoid hemorrhage...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27861413/neuroregeneration-north-america-s-first-human-stem-cell-trial-for-stroke
#4
Hsuan-Kan Chang, Anand Veeravagu, Michael Y Wang
No abstract text is available yet for this article.
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27797681/proteomics-identification-of-potential-candidates-involved-in-cell-proliferation-for-early-stage-of-brain-regeneration-in-the-adult-zebrafish
#5
Fei Tieng Lim, Satoshi Ogawa, A Ian Smith, Ishwar S Parhar
The central nervous system (CNS) of the non-mammalian vertebrates has better neuroregenerative capability as compared with the mammalian CNS. Regeneration of habenula was observed 40 days after damage in zebrafish. During the early stage of regeneration, we found a significant increase of apoptotic cells on day-1 post-damage and of proliferative cells on day-3 post-damage. To identify the molecular factor(s) involved in the early stages of neuroregeneration, differentially expressed proteins during sham, 20- and 40-h post-habenula damage were investigated by proteomic approach by using two-dimensional differential gel electrophoresis (2D-DIGE) coupled with Matrix-Assisted Laser Desorption/Ionization-Time-of-Flight (MALDI-ToF) and tandem mass spectrometry...
October 31, 2016: Zebrafish
https://www.readbyqxmd.com/read/27754293/br-09-3-at2r-stimulation-and-its-effect-on-target-organ-damage-therapeutic-implications
#6
Thomas Unger
The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty-five years, protective actions of the RAS, not only in the cardiovascular- but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS includes AT2- and Mas receptors (AT2R and MasR) and is characterized by effects different from and often opposing those of the AT1R...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748416/microrna-127-targeting-of-mitoneet-inhibits-neurite-outgrowth-induces-cell-apoptosis-and-contributes-to-physiological-dysfunction-after-spinal-cord-transection
#7
Qin-Qin He, Liu-Lin Xiong, Fei Liu, Xiang He, Guo-Ying Feng, Fei-Fei Shang, Qing-Jie Xia, You-Cui Wang, De-Lu Qiu, Chao-Zhi Luo, Jia Liu, Ting-Hua Wang
Neuroregeneration and apoptosis are two important pathophysiologic changes after spinal cord injury (SCI), but their underlying mechanisms remain unclear. MicroRNAs (miRNAs) play a crucial role in the regulation of neuroregeneration and neuronal apoptosis, research areas that have been greatly expanded in recent years. Here, using miRNA arrays to profile miRNA transcriptomes, we demonstrated that miR-127-3p was significantly down-regulated after spinal cord transection (SCT). Then, bioinformatics analyses and experimental detection showed that miR-127-3p exhibited specific effects on the regulation of neurite outgrowth and the induction of neuronal apoptosis by regulating the expression of the mitochondrial membrane protein mitoNEET...
October 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27658513/spinal-cord-injury-changes-cytokine-transport
#8
Weihong Pan, Abba J Kastin
Here we summarize three aspects of our understanding of the interactions of cytokines and neurotrophic peptides/proteins with the blood-brain and bloodspinal cord barriers (BBB): (a) pharmacokinetic analysis that has been reported for native cytokines and neurotrophic peptides/proteins; (b) landmark work on conjugated proteins to enhance their delivery across the normal BBB; and (c) regulatory changes under pathophysiological conditions in rodents, particularly after spinal cord injury (SCI). First, though the BBB restricts the permeation of large proteins, some cytokines and neurotrophic peptides/proteins in the periphery can reach the central nervous system (CNS) by specific transport systems...
2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27651755/trpv1-may-increase-the-effectiveness-of-estrogen-therapy-on-neuroprotection-and-neuroregeneration
#9
REVIEW
Ricardo Ramírez-Barrantes, Ivanny Marchant, Pablo Olivero
Aging induces physical deterioration, loss of the blood brain barrier, neuronal loss-induced mental and neurodegenerative diseases. Hypotalamus-hypophysis-gonad axis aging precedes symptoms of menopause or andropause and is a major determinant of sensory and cognitive integrated function. Sexual steroids support important functions, exert pleiotropic effects in different sensory cells, promote regeneration, plasticity and health of the nervous system. Their diminution is associated with impaired cognitive and mental health and increased risk of neurodegenerative diseases...
August 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27643291/br-09-3-at2r-stimulation-and-its-effect-on-target-organ-damage-therapeutic-implications
#10
Thomas Unger
The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty-five years, protective actions of the RAS, not only in the cardiovascular- but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS includes AT2- and Mas receptors (AT2R and MasR) and is characterized by effects different from and often opposing those of the AT1R...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27630683/how-does-zebrafish-support-new-strategies-for-neuroprotection-and-neuroregeneration-in-hypoxia-related-diseases
#11
Emerson S Silva, João Batista T Rocha, Diogo O Souza, Marcos M Braga
No abstract text is available yet for this article.
July 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27593486/erythropoietin-enhanced-recovery-after-traumatic-nerve-injury-myelination-and-localized-effects
#12
Leigh Sundem, Kuang-Ching Chris Tseng, Haiyan Li, John Ketz, Mark Noble, John Elfar
PURPOSE: We previously found that administration of erythropoietin (EPO) shortens the course of recovery after experimental crush injury to the mouse sciatic nerve. The course of recovery was more rapid than would be expected if EPO's effects were caused by axonal regeneration, which raised the question of whether recovery was instead the result of promoting remyelination and/or preserving myelin on injured neurons. This study tested the hypothesis that EPO has a direct and local effect on myelination in vivo and in vitro...
October 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27592818/transplantation-of-rada16-bdnf-peptide-scaffold-with-human-umbilical-cord-mesenchymal-stem-cells-forced-with-cxcr4-and-activated-astrocytes-for-repair-of-traumatic-brain-injury
#13
W Shi, C J Huang, X D Xu, G H Jin, R Q Huang, J F Huang, Y N Chen, S Q Ju, Y Wang, Y W Shi, J B Qin, Y Q Zhang, Q Q Liu, X B Wang, X H Zhang, J Chen
: Due to the poor self-regeneration of brain tissue, stem cell transplantation therapy is purported to enable the replacement of lost neurons after traumatic brain injury (TBI). The main challenge of brain regeneration is whether the transplanted cells can survive and carry out neuronal functions in the lesion area. The brain is a complex neuronal network consisting of various types of cells that significantly influence on each other, and the survival of the implanted stem cells in brain is critically influenced by the surrounding cells...
November 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27540320/recent-updates-in-neuroprotective-and-neuroregenerative-potential-of-centella-asiatica
#14
REVIEW
Yogeswaran Lokanathan, Norazzila Omar, Nur Nabilah Ahmad Puzi, Aminuddin Saim, Ruszymah Hj Idrus
Centella asiatica, locally well known in Malaysia as pegaga, is a traditional herb that has been used widely in Ayurvedic medicine, traditional Chinese medicine, and in the traditional medicine of other Southeast Asian countries including Malaysia. Although consumption of the plant is indicated for various illnesses, its potential neuroprotective properties have been well studied and documented. In addition to past studies, recent studies also discovered and/or reconfirmed that C. asiatica acts as an antioxidant, reducing the effect of oxidative stress in vitro and in vivo...
January 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/27537482/in%C3%A2-vivo-reprogramming-for-cns-repair-regenerating-neurons-from-endogenous-glial-cells
#15
REVIEW
Hedong Li, Gong Chen
Neuroregeneration in the CNS has proven to be difficult despite decades of research. The old dogma that CNS neurons cannot be regenerated in the adult mammalian brain has been overturned; however, endogenous adult neurogenesis appears to be insufficient for brain repair. Stem cell therapy once held promise for generating large quantities of neurons in the CNS, but immunorejection and long-term functional integration remain major hurdles. In this Perspective, we discuss the use of in vivo reprogramming as an emerging technology to regenerate functional neurons from endogenous glial cells inside the brain and spinal cord...
August 17, 2016: Neuron
https://www.readbyqxmd.com/read/27510321/mesenchymal-stem-cells-enhance-nerve-regeneration-in-a-rat-sciatic-nerve-repair-and-hindlimb-transplant-model
#16
Damon S Cooney, Eric G Wimmers, Zuhaib Ibrahim, Johanna Grahammer, Joani M Christensen, Gabriel A Brat, Lehao W Wu, Karim A Sarhane, Joseph Lopez, Christoph Wallner, Georg J Furtmüller, Nance Yuan, John Pang, Kakali Sarkar, W P Andrew Lee, Gerald Brandacher
This study investigates the efficacy of local and intravenous mesenchymal stem cell (MSC) administration to augment neuroregeneration in both a sciatic nerve cut-and-repair and rat hindlimb transplant model. Bone marrow-derived MSCs were harvested and purified from Brown-Norway (BN) rats. Sciatic nerve transections and repairs were performed in three groups of Lewis (LEW) rats: negative controls (n = 4), local MSCs (epineural) injection (n = 4), and systemic MSCs (intravenous) injection (n = 4)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27499880/planarian-brain-regeneration-as-a-model-system-for-developmental-neurotoxicology
#17
REVIEW
Danielle Hagstrom, Olivier Cochet-Escartin, Eva-Maria S Collins
Freshwater planarians, famous for their regenerative prowess, have long been recognized as a valuable in vivo animal model to study the effects of chemical exposure. In this review, we summarize the current techniques and tools used in the literature to assess toxicity in the planarian system. We focus on the planarian's particular amenability for neurotoxicology and neuroregeneration studies, owing to the planarian's unique ability to regenerate a centralized nervous system. Zooming in from the organismal to the molecular level, we show that planarians offer a repertoire of morphological and behavioral readouts while also being amenable to mechanistic studies of compound toxicity...
April 2016: Regeneration
https://www.readbyqxmd.com/read/27477313/nestin-regulates-neural-stem-cell-migration-via-controlling-the-cell-contractility
#18
Sunxing Yan, Panlong Li, Yong Wang, Weihua Yu, Aiping Qin, Muyun Liu, Andy Peng Xiang, Wei Zhang, Weiqiang Li
Neural stem cells (NSCs) migration is essential for neurogenesis and neuroregeneration after brain injury. Nestin, a widely used marker of NSCs, is expressed abundantly in several cancers, where it may correlate with tumor migration and invasion. However, it is not yet known whether nestin participates in NSC migration. Here, we show that nestin down-regulation significantly inhibits the migration and contraction of murine neural stem cells, but does not obviously influence the proliferation, filamentous actin (F-actin) content, distribution or focal adhesion assembly of these cells...
September 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27468266/older-age-results-in-differential-gene-expression-after-mild-traumatic-brain-injury-and-is-linked-to-imaging-differences-at-acute-follow-up
#19
Young-Eun Cho, Lawrence L Latour, Hyungsuk Kim, L Christine Turtzo, Anlys Olivera, Whitney S Livingston, Dan Wang, Christiana Martin, Chen Lai, Ann Cashion, Jessica Gill
Older age consistently relates to a lesser ability to fully recover from a traumatic brain injury (TBI); however, there is limited data to explicate the nature of age-related risks. This study was undertaken to determine the relationship of age on gene-activity following a TBI, and how this biomarker relates to changes in neuroimaging findings. A young group (between the ages of 19 and 35 years), and an old group (between the ages of 60 and 89 years) were compared on global gene-activity within 48 h following a TBI, and then at follow-up within 1-week...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27468233/a-new-look-at-an-old-drug-neuroprotective-effects-and-therapeutic-potentials-of-lithium-salts
#20
REVIEW
Liliana Dell'Osso, Claudia Del Grande, Camilla Gesi, Claudia Carmassi, Laura Musetti
Increasing evidence highlights bipolar disorder as being associated with impaired neurogenesis, cellular plasticity, and resiliency, as well as with cell atrophy or loss in specific brain regions. This has led most recent research to focus on the possible neuroprotective effects of medications, and particularly interesting findings have emerged for lithium. A growing body of evidence from preclinical in vitro and in vivo studies has in fact documented its neuroprotective effects from different insults acting on cellular signaling pathways, both preventing apoptosis and increasing neurotrophins and cell-survival molecules...
2016: Neuropsychiatric Disease and Treatment
keyword
keyword
26818
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"