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Neuroregeneration

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https://www.readbyqxmd.com/read/28213098/gelatin-based-3d-conduits-for-transdifferentiation-of-mesenchymal-stem-cells-into-schwann-cell-like-phenotypes
#1
Metin Uz, Melda Büyüköz, Anup D Sharma, Donald S Sakaguchi, Sacide Alsoy Altinkaya, Surya K Mallapragada
: In this study, gelatin-based 3D conduits with three different microstructures (nanofibrous, macroporous and ladder-like) were fabricated for the first time via combined molding and thermally induced phase separation (TIPS) technique for peripheral nerve regeneration. The effects of conduit microstructure and mechanical properties on the transdifferentiation of bone marrow-derived mesenchymal stem cells (MSCs) into Schwann cell (SC) like phenotypes were examined to help facilitate neuroregeneration and understand material-cell interfaces...
February 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28199018/preface-60th-anniversary-of-the-japanese-society-for-neurochemistry
#2
REVIEW
Kazunori Imaizumi
To welcome the 60th anniversary of the Japanese Society for Neurochemistry, in this issue, we publish five Review articles from the society's leading groups in the Journal of Neurochemistry, and introduce what we have achieved in the neurochemical fields of research, including Ca2+ neurobiology, synaptic plasticity, neurogenesis and neuroregeneration. With the achievements in the past decades in mind, we will continue to contribute to the development of neurochemistry from now on too. This article is protected by copyright...
February 15, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28173860/ccl11-promotes-migration-and-proliferation-of-mouse-neural-progenitor-cells
#3
Feifei Wang, Nobuyasu Baba, Yuan Shen, Tatsuyuki Yamashita, Emi Tsuru, Masayuki Tsuda, Nagamasa Maeda, Yusuke Sagara
BACKGROUND: Neonatal hypoxia-ischemia induces massive brain damage during the perinatal period, resulting in long-term consequences to central nervous system structural and functional maturation. Although neural progenitor cells (NPCs) migrate through the parenchyma and home in to injury sites in the rodent brain, the molecular mechanisms are unknown. We examined the role of chemokines in mediating NPC migration after neonatal hypoxic-ischemic brain injury. METHODS: Nine-day-old mice were exposed to a 120-minute hypoxia following unilateral carotid occlusion...
February 7, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28153091/effect-of-fingolimod-on-neural-stem-cells-a-novel-mechanism-and-broadened-application-for-neural-repair
#4
Yuan Zhang, Xing Li, Bogoljub Ciric, Cun-Gen Ma, Bruno Gran, Abdolmohamad Rostami, Guang-Xian Zhang
Inflammatory demyelination and axonal damage of the CNS are hallmarks of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Fingolimod (FTY720), the first FDA-approved oral medication for MS, suppresses acute disease but is less effective at the chronic stage, and whether it has a direct effect on neuroregeneration in MS and EAE remains unclear. Here we show that FTY720, at nanomolar concentrations, effectively protected survival of neural stem cells (NSCs) and enhanced their development into mature oligodendrocytes (OLGs) in vitro, primarily through the S1P3 and S1P5 receptors...
February 1, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28112256/fsd-c10-a-fasudil-derivative-promotes-neuroregeneration-through-indirect-and-direct-mechanisms
#5
Yan-Hua Li, Chong Xie, Yuan Zhang, Xing Li, Hai-Fei Zhang, Qing Wang, Zhi Chai, Bao-Guo Xiao, Rodolfo Thome, Guang-Xian Zhang, Cun-Gen Ma
FSD-C10, a Fasudil derivative, was shown to reduce severity of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), through the modulation of the immune response and induction of neuroprotective molecules in the central nervous system (CNS). However, whether FSD-C10 can promote neuroregeneration remains unknown. In this study, we further analyzed the effect of FSD-C10 on neuroprotection and remyelination. FSD-C10-treated mice showed a longer, thicker and more intense MAP2 and synaptophysin positive signal in the CNS, with significantly fewer CD4(+) T cells, macrophages and microglia...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28107800/neuroregeneration-of-ips-cells-in-polyacrylamide-chitosan-inverted-colloidal-crystal-scaffolds-with-poly-lactide-co-glycolide-nanoparticles-and-tatvhl-peptide
#6
Yung-Chih Kuo, Chun-Wei Chen
Polyacrylamide (PAAM) and chitosan were fabricated by inverted colloidal crystal (ICC) method for scaffolds comprising regular pores. The hybrid PAAM-chitosan ICC scaffolds were grafted with poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) for a rougher pore surface and grafted with TATVHL peptide for a better differentiation of induced pluripotent stem (iPS) cells toward neural lineage. By scanning electron microscopy, we found that iPS cells cultured in PAAM-chitosan ICC scaffolds with PLGA NPs at 1...
January 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28087447/structures-biological-activities-and-industrial-applications-of-the-polysaccharides-from-hericium-erinaceus-lion-s-mane-mushroom-a-review
#7
REVIEW
Xirui He, Xiaoxiao Wang, Jiacheng Fang, Yu Chang, Ning Ning, Hao Guo, Linhong Huang, Xiaoqiang Huang, Zefeng Zhao
Hericium erinaceus (Bull.) Pers., also known as Yamabushitake, Houtou and Lion's Mane, is capable of fortifying the spleen and nourishing the stomach, tranquilizing the mind, and fighting cancer. Over the past decade, it has been demonstrated that H. erinaceus polysaccharides possess various promising bioactivities, including antitumor and immunomodulation, anti-gastric ulcer, neuroprotection and neuroregeneration, anti-oxidation and hepatoprotection, anti-hyperlipidemia, anti-hyperglycemia, anti-fatigue and anti-aging...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28012153/zero-valent-zinc-nanoparticles-promote-neuroglial-cell-proliferation-a-biodegradable-and-conductive-filler-candidate-for-nerve-regeneration
#8
Umran Aydemir Sezer, Kevser Ozturk, Basak Aru, Gulderen Yanıkkaya Demirel, Serdar Sezer, Mehmet Recep Bozkurt
Regeneration of nerve, which has limited ability to undergo self-healing, is one of the most challenging areas in the field of tissue engineering. Regarding materials used in neuroregeneration, there is a recent trend toward electrically conductive materials. It has been emphasized that the capacity of conductive materials to regenerate such tissue having limited self-healing ability improves their clinical utility. However, there have been concerns about the safety of materials or fillers used for conductance due to their lack of degradability...
January 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27933584/matrine-treatment-blocks-nogoa-induced-neural-inhibitory-signaling-pathway-in-ongoing-experimental-autoimmune-encephalomyelitis
#9
Quan-Cheng Kan, Hui-Jun Zhang, Yuan Zhang, Xing Li, Yu-Ming Xu, Rodolfo Thome, Ming-Liang Zhang, Nan Liu, Yao-Juan Chu, Guang-Xian Zhang, Lin Zhu
Myelin-associated inhibitors, such as NogoA, myelin-associated glycoprotein (MAG), and oligodendrocyte myelin glycoprotein (OMgp), play a pivotal role in the lack of neuroregeneration in multiple sclerosis, an inflammatory demyelinating disease of the central nervous system (CNS). Matrine (MAT), a monomer that is used in traditional Chinese medicine as an anti-inflammatory agent, has shown beneficial effects in experimental autoimmune encephalomyelitis (EAE), an animal model of MS. However, the underlying mechanisms of MAT-induced EAE amelioration are not fully understood...
December 9, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27901327/stem-cell-therapy-for-sequestering-neuroinflammation-in-traumatic-brain-injury-an-update-on-exosome-targeting-to-the-spleen
#10
Marci G Crowley, Michael G Liska, Cesar V Borlongan
Traumatic brain injury (TBI), manifests with acute and chronic cell death pathways leading to initial impacted injury and subsequent neurodegeneration. In particular, the secondary cell death, plagued by a massive and lingering neuroinflammatory response, contributes significantly to worsening outcomes of the progressive TBI pathology. Fortunately, neuroinflammation also provides an opportunity for therapeutic interventions. Limited treatment options currently exist for the disease, but stem cell-based therapies offer promise in promoting neuroprotection and neuroregeneration by mitigating central neuroinflammation as well as modulating peripheral inflammation via the spleen...
November 30, 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27879599/total-human-eye-allotransplantation-developing-surgical-protocols-for-donor-and-recipient-procedures
#11
Edward H Davidson, Eric W Wang, Jenny Y Yu, Juan C Fernandez-Miranda, Dawn J Wang, Nikisha Richards, Maxine Miller, Joel S Schuman, Kia M Washington
BACKGROUND: Vascularized composite allotransplantation of the eye is an appealing, novel method for reconstruction of the nonfunctioning eye. The authors' group has established the first orthotopic model for eye transplantation in the rat. With advancements in immunomodulation strategies together with new therapies in neuroregeneration, parallel development of human surgical protocols is vital for ensuring momentum toward eye transplantation in actual patients. METHODS: Cadaveric donor tissue harvest (n = 8) was performed with orbital exenteration, combined open craniotomy, and endonasal approach to ligate the ophthalmic artery with a cuff of paraclival internal carotid artery, for transection of the optic nerve at the optic chiasm and transection of cranial nerves III to VI and the superior ophthalmic vein at the cavernous sinus...
December 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27871507/use-of-gabaergic-sedatives-after-subarachnoid-hemorrhage-is-associated-with-worse-outcome-preliminary-findings
#12
Daniel N Hertle, Christopher Beynon, Jan O Neumann, Edgar Santos, Renan Sánchez-Porras, Andreas W Unterberg, Oliver W Sakowitz
STUDY OBJECTIVE: Recent experimental evidence identified GABAergic sedation as a possible cause for deprived neuroregeneration and poor outcome after acute brain injury. Patients with aneurysmal subarachnoid hemorrhage are often sedated, and GABAergic sedation, such as midazolam and propofol, is commonly used. DESIGN: Retrospective cohort study based on a prospectively established database. SETTING: Single-center neurointensive care unit. PATIENTS: Twenty-nine patients after subarachnoid hemorrhage...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27861413/neuroregeneration-north-america-s-first-human-stem-cell-trial-for-stroke
#13
Hsuan-Kan Chang, Anand Veeravagu, Michael Y Wang
No abstract text is available yet for this article.
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27797681/proteomics-identification-of-potential-candidates-involved-in-cell-proliferation-for-early-stage-of-brain-regeneration-in-the-adult-zebrafish
#14
Fei Tieng Lim, Satoshi Ogawa, A Ian Smith, Ishwar S Parhar
The central nervous system (CNS) of the non-mammalian vertebrates has better neuroregenerative capability as compared with the mammalian CNS. Regeneration of habenula was observed 40 days after damage in zebrafish. During the early stage of regeneration, we found a significant increase of apoptotic cells on day-1 post-damage and of proliferative cells on day-3 post-damage. To identify the molecular factor(s) involved in the early stages of neuroregeneration, differentially expressed proteins during sham, 20- and 40-h post-habenula damage were investigated by proteomic approach by using two-dimensional differential gel electrophoresis (2D-DIGE) coupled with Matrix-Assisted Laser Desorption/Ionization-Time-of-Flight (MALDI-ToF) and tandem mass spectrometry...
February 2017: Zebrafish
https://www.readbyqxmd.com/read/27754293/br-09-3-at2r-stimulation-and-its-effect-on-target-organ-damage-therapeutic-implications
#15
Thomas Unger
The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty-five years, protective actions of the RAS, not only in the cardiovascular- but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS includes AT2- and Mas receptors (AT2R and MasR) and is characterized by effects different from and often opposing those of the AT1R...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27748416/microrna-127-targeting-of-mitoneet-inhibits-neurite-outgrowth-induces-cell-apoptosis-and-contributes-to-physiological-dysfunction-after-spinal-cord-transection
#16
Qin-Qin He, Liu-Lin Xiong, Fei Liu, Xiang He, Guo-Ying Feng, Fei-Fei Shang, Qing-Jie Xia, You-Cui Wang, De-Lu Qiu, Chao-Zhi Luo, Jia Liu, Ting-Hua Wang
Neuroregeneration and apoptosis are two important pathophysiologic changes after spinal cord injury (SCI), but their underlying mechanisms remain unclear. MicroRNAs (miRNAs) play a crucial role in the regulation of neuroregeneration and neuronal apoptosis, research areas that have been greatly expanded in recent years. Here, using miRNA arrays to profile miRNA transcriptomes, we demonstrated that miR-127-3p was significantly down-regulated after spinal cord transection (SCT). Then, bioinformatics analyses and experimental detection showed that miR-127-3p exhibited specific effects on the regulation of neurite outgrowth and the induction of neuronal apoptosis by regulating the expression of the mitochondrial membrane protein mitoNEET...
October 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27658513/spinal-cord-injury-changes-cytokine-transport
#17
Weihong Pan, Abba J Kastin
Here we summarize three aspects of our understanding of the interactions of cytokines and neurotrophic peptides/proteins with the blood-brain and bloodspinal cord barriers (BBB): (a) pharmacokinetic analysis that has been reported for native cytokines and neurotrophic peptides/proteins; (b) landmark work on conjugated proteins to enhance their delivery across the normal BBB; and (c) regulatory changes under pathophysiological conditions in rodents, particularly after spinal cord injury (SCI). First, though the BBB restricts the permeation of large proteins, some cytokines and neurotrophic peptides/proteins in the periphery can reach the central nervous system (CNS) by specific transport systems...
2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27651755/trpv1-may-increase-the-effectiveness-of-estrogen-therapy-on-neuroprotection-and-neuroregeneration
#18
REVIEW
Ricardo Ramírez-Barrantes, Ivanny Marchant, Pablo Olivero
Aging induces physical deterioration, loss of the blood brain barrier, neuronal loss-induced mental and neurodegenerative diseases. Hypotalamus-hypophysis-gonad axis aging precedes symptoms of menopause or andropause and is a major determinant of sensory and cognitive integrated function. Sexual steroids support important functions, exert pleiotropic effects in different sensory cells, promote regeneration, plasticity and health of the nervous system. Their diminution is associated with impaired cognitive and mental health and increased risk of neurodegenerative diseases...
August 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27643291/br-09-3-at2r-stimulation-and-its-effect-on-target-organ-damage-therapeutic-implications
#19
Thomas Unger
The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty-five years, protective actions of the RAS, not only in the cardiovascular- but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS includes AT2- and Mas receptors (AT2R and MasR) and is characterized by effects different from and often opposing those of the AT1R...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27630683/how-does-zebrafish-support-new-strategies-for-neuroprotection-and-neuroregeneration-in-hypoxia-related-diseases
#20
Emerson S Silva, João Batista T Rocha, Diogo O Souza, Marcos M Braga
No abstract text is available yet for this article.
July 2016: Neural Regeneration Research
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