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https://www.readbyqxmd.com/read/28944848/cmip-is-oncogenic-in-human-gastric-cancer-cells
#1
Jianlin Zhang, Jin Huang, Xingyu Wang, Weidong Chen, Qinqing Tang, Maoyong Fang, Yeben Qian
Gastric cancer is one of the most common cancers and the second leading cause of cancer‑associated mortality worldwide. Recurrence, metastasis and resistance to drug treatment are the main barrier to survival of patients with advanced stage gastric cancer. Further study of the molecular mechanisms involved will improve the therapeutic options for gastric cancer. In a previous study, c‑Maf was discovered as an oncogene transduced in the avian AS42 retrovirus, and was found to be overexpressed in multiple myeloma and angioimmunoblastic T‑cell lymphoma...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944818/metal-free-c-h-functionalization-of-2h-imidazole-1-oxides-with-pyrrolyl-fragments-in-the-design-of-novel-azaheterocyclic-ensembles
#2
Mikhail Varaksin, Timofey Moseev, Oleg Chupakhin, Valery Charushin, Boris Trofimov
The methodology of direct C(sp(2))-H functionalization has for the first time been applied as an efficient and advanced approach to carry out C-H/C-H coupling of 2H-imidazole 1-oxides and pyrroles. The atom-economical method used does not require either any auxiliary group in the starting substrates, or catalysis by transition metals. As a result, a number of novel 1H-pyrrol-2-yl-2H-imidazoles, that are particularly of interest in the design of bioactive molecules, have been prepared under mild conditions and in good to excellent yields...
September 25, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28944281/adenovirus-mediated-gene-delivery-potential-applications-for-gene-and-cell-based-therapies-in-the-new-era-of-personalized-medicine
#3
Cody S Lee, Elliot S Bishop, Ruyi Zhang, Xinyi Yu, Evan M Farina, Shujuan Yan, Chen Zhao, Zongyue Zheng, Yi Shu, Xingye Wu, Jiayan Lei, Yasha Li, Wenwen Zhang, Chao Yang, Ke Wu, Ying Wu, Sherwin Ho, Aravind Athiviraham, Michael J Lee, Jennifer Moriatis Wolf, Russell R Reid, Tong-Chuan He
With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology, it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies. Despite numerous setbacks, efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases. It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies...
June 2017: Genes & Diseases
https://www.readbyqxmd.com/read/28942913/a-focused-review-of-safety-considerations-in-cancer-rehabilitation
#4
REVIEW
Susan Maltser, Adrian Cristian, Julie K Silver, G Stephen Morris, Nicole L Stout
Cancer and its treatments introduce various adverse effects that may affect survivors' physical, cognitive and psychological functioning. Frequently both tolerance to activity and exercise are affected as well. Rehabilitation providers should have substantive knowledge about the effect of cancer progression and common side effects associated with antineoplastic treatment to safely integrate rehabilitation interventions. Rehabilitation may mitigate loss of function and disability; however, these patients are among the most medically complex that providers treat...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28942908/integrating-function-directed-treatments-into-palliative-care
#5
REVIEW
Andrea L Cheville, Melissa Morrow, Sean Robinson Smith, Jeffrey R Basford
The growing acceptance of palliative care has created opportunities to increase the use of rehabilitation services among populations with advanced disease, particularly those with cancer. Broader delivery has been impeded by the lack of a shared definition for palliative rehabilitation and a mismatch between patient needs and established rehabilitation service delivery models. We propose the definition that, in the advanced cancer population, palliative rehabilitation is function-directed care delivered in partnership with other clinical disciplines and aligned with the values of patients who have serious and often incurable illnesses in contexts marked by intense and dynamic symptoms, psychological stress, and medical morbidity to realize potentially time-limited goals...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28942527/psychological-pathways-from-racial-discrimination-to-cortisol-in-african-american-males-and-females
#6
Daniel B Lee, Melissa K Peckins, Justin E Heinze, Alison L Miller, Shervin Assari, Marc A Zimmerman
The association between racial discrimination (discrimination) and stress-related alterations in the neuroendocrine response-namely, cortisol secretion-is well documented in African Americans (AAs). Dysregulation in production of cortisol has been implicated as a contributor to racial health disparities. Guided by Clark et al. (Am Psychol 54(10):805-816, 1999. doi: 10.1037/0003-066X.54.10.805 ) biopsychosocial model of racism and health, the present study examined the psychological pathways that link discrimination to total cortisol concentrations in AA males and females...
September 23, 2017: Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28942268/computational-fluid-dynamics-and-additive-manufacturing-to-diagnose-and-treat-cardiovascular-disease
#7
REVIEW
Amanda Randles, David H Frakes, Jane A Leopold
Noninvasive engineering models are now being used for diagnosing and planning the treatment of cardiovascular disease. Techniques in computational modeling and additive manufacturing have matured concurrently, and results from simulations can inform and enable the design and optimization of therapeutic devices and treatment strategies. The emerging synergy between large-scale simulations and 3D printing is having a two-fold benefit: first, 3D printing can be used to validate the complex simulations, and second, the flow models can be used to improve treatment planning for cardiovascular disease...
September 20, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28942061/the-behavioral-and-cognitive-relevance-of-time-varying-dynamic-changes-in-functional-connectivity
#8
REVIEW
Jessica R Cohen
Recent advances in neuroimaging methods and analysis have led to an expanding body of research that investigates how large-scale brain network organization dynamically adapts to changes in one's environment, including both internal state changes and external stimulation. It is now possible to detect changes in functional connectivity that occur on the order of seconds, both during an unconstrained resting state and during the performance of constrained cognitive tasks. It is thought that these dynamic, time-varying changes in functional connectivity, often referred to as dynamic functional connectivity (dFC), include features that are relevant to behavior and cognition...
September 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28941857/a-cross-sectional-study-to-assess-the-stigma-associated-with-tuberculosis-among-tuberculosis-patients-in-udupi-district-karnataka
#9
R Shivapujimath, A P Rao, A R Nilima, D M Shilpa
BACKGROUND: For decades, tuberculosis and other communicable diseases like human immunodeficiency virus/acquired immune deficiency syndrome, leprosy, etc., have been associated with stigma and discrimination by the society; this can interfere with the lifestyle and disease management among these patients. OBJECTIVE: To assess the stigma experienced by tuberculosis patients and to find the factors associated with stigma. METHODS: A cross-sectional study was conducted among 209 sputum-positive and sputum-negative tuberculosis patients...
October 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28941804/mir-132-promotes-the-proliferation-invasion-and-migration-of-human-pancreatic-carcinoma-by-inhibition-of-the-tumor-suppressor-gene-pten
#10
REVIEW
Hui Zhang, Aixiang Liu, Xielin Feng, Lang Tian, Wentao Bo, Haiqing Wang, Yong Hu
MicroRNA (miRNAs) emerges as key oncogene or tumor suppressor in a variety of cancers including pancreatic carcinoma. In this study, we detected the role of miR-132 in development and progression of pancreatic cancer and the underlying mechanism. First, the expression of miR-132 in pancreatic carcinoma and adjacent non-cancerous tissues were detected by qRT-PCR. Then, the role of miR-132 in biological function of pancreatic carcinoma cells was investigated. Our results identified that miR-132 was generally upregulated in pancreatic carcinoma, and phosphatase and tensin homolog (PTEN) was generally downregulated...
September 20, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28941455/glycation-glycolysis-and-neurodegenerative-diseases-is-there-any-connection
#11
REVIEW
V I Muronetz, A K Melnikova, Z N Seferbekova, K V Barinova, E V Schmalhausen
This review considers the interrelation between different types of protein glycation, glycolysis, and the development of amyloid neurodegenerative diseases. The primary focus is on the role of the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase in changing the concentration of carbonyl compounds - first and foremost, glyceraldehyde-3-phosphate and methylglyoxal. It has been suggested that various modifications of the enzyme - from the oxidation of the sulfhydryl groups of the active site to glycation with sugars - can lead to its inactivation, which causes a direct increase in glyceraldehyde-3-phosphate concentration and an indirect increase in the content of other aldehydes...
August 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28941347/-applications-of-synthetic-biology-in-materials-science
#12
Tianxin Zhao, Chao Zhong
Materials are the basis for human being survival and social development. To keep abreast with the increasing needs from all aspects of human society, there are huge needs in the development of advanced materials as well as high-efficiency but low-cost manufacturing strategies that are both sustainable and tunable. Synthetic biology, a new engineering principle taking gene regulation and engineering design as the core, greatly promotes the development of life sciences. This discipline has also contributed to the development of material sciences and will continuously bring new ideas to future new material design...
March 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28941317/concise-review-extracellular-vesicles-overcoming-limitations-of-cell-therapies-in-ischemic-stroke
#13
Thorsten R Doeppner, Mathias Bähr, Dirk M Hermann, Bernd Giebel
Despite recent advances in stroke therapy, current therapeutic concepts are still limited. Thus, additional therapeutic strategies are in order. In this sense, the transplantation of stem cells has appeared to be an attractive adjuvant tool to help boost the endogenous regenerative capacities of the brain. Although transplantation of stem cells is known to induce beneficial outcome in (preclinical) stroke research, grafted cells do not replace lost tissue directly. Rather, these transplanted cells like neural progenitor cells or mesenchymal stem cells act in an indirect manner, among which the secretion of extracellular vesicles (EVs) appears to be one key factor...
September 23, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28941127/a-comparison-of-the-fully-repositionable-and-retrievable-boston-lotus-and-direct-flow-medical-valves-for-the-treatment-of-severe-aortic-stenosis-a-single-center-experience
#14
Francesco Giannini, Azeem Latib, Matteo Montorfano, Neil Ruparelia, Vittorio Romano, Matteo Longoni, Luca Ferri, Richard Jabbour, Antonio Mangieri, Damiano Regazzoli, Marco Ancona, Nicola Buzzatti, Lorenzo Azzalini, Akihito Tanaka, Eustachio Agricola, Alaide Chieffo, Ottavio Alfieri, Antonio Colombo
BACKGROUND: Second generation transcatheter aortic valve implantation (TAVI) devices have been designed to reduce the rate of paravalvular leak (PVL) and other complications. An important technological advancement has been the ability to fully reposition devices to facilitate optimal implantation depth and position to reduce the likelihood of PVL. OBJECTIVES: To compare procedural and 30-day outcomes according to the Valve Academic Research Consortium (VARC)-2 criteria following TAVI with the fully repositionable and retrievable Lotus and DFM devices...
September 20, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28940991/guidewire-electrosurgery-assisted-trans-septal-puncture
#15
Jaffar M Khan, Toby Rogers, Marvin H Eng, Robert J Lederman, Adam B Greenbaum
OBJECTIVES: Electrifying a coronary guidewire may be a simple escalation strategy when trans-septal needle puncture is unsuccessful. BACKGROUND: Radiofrequency energy to facilitate trans-septal puncture through a dedicated device is costly and directly through a trans-septal needle may be less safe. Our technique overcomes these limitations. METHODS: The technique was used in patients when trans-septal needle penetration failed despite excessive force or tenting of the atrial septum...
September 20, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28940823/future-dietitian-2025-informing-the-development-of-a-workforce-strategy-for-dietetics
#16
M Hickson, J Child, A Collinson
BACKGROUND: Healthcare is changing and the professions that deliver it need to adapt and change too. The aim of this research was to inform the development of a workforce strategy for Dietetics for 2020-2030. This included an understanding of the drivers for change, the views of stakeholders and recommendations to prepare the profession for the future. METHODS: The research included three phases: (i) establishing the context which included a literature and document review (environmental scan); (ii) discovering the profession and professional issues using crowd-sourcing technology; and (iii) articulating the vision for the future using appreciative inquiry...
September 21, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28940253/pbrm1-restricts-the-basal-activity-of-innate-immune-system-through-repressing-rig-i-like-receptor-signaling-and-is-a-potential-prognostic-biomarker-for-colon-cancer
#17
Xing-Sheng Shu, Yingying Zhao, Yanmei Sun, Lan Zhong, Yingduan Cheng, Yixiang Zhang, Kaile Ning, Qian Tao, Yejun Wang, Ying Ying
It has long been known that patients suffering from inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). The innate immune system of host cells provides a first-line defence against pathogenic infection, whereas uncontrolled inflammatory response under homeostatic conditions usually leads to pathological consequences, as exemplified by the chronic inflammation of IBD. The key molecules and pathways keeping innate immunity in check are still poorly defined. Here, we report that chromatin remodeler polybromo-1 (PBRM1) is a repressor of innate immune signaling mediated by RIG-I-like receptors (RLRs)...
September 20, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28940122/prognostic-factors-affecting-survival-after-multivisceral-resection-in-patients-with-clinical-t4b-gastric-cancer
#18
Kazuhito Mita, Hideto Ito, Toshio Katsube, Ayaka Tsuboi, Nobuyoshi Yamazaki, Hideki Asakawa, Takashi Hayashi, Keiichi Fujino
BACKGROUND: The prognosis and survival of patients with advanced gastric cancer is poor. Although completeness of resection (R0) is one of the most important factors affecting survival, multivisceral resection (MVR) for locally advanced (clinical T4b, cT4b) gastric cancer remains controversial. The aim of this study was to evaluate the factors affecting prognosis and survival after MVR in patients with cT4b gastric cancer. METHODS: Between 2005 and 2015, we retrospectively reviewed the medical records of 103 patients who underwent MVR for cT4b gastric cancer with suspected direct invasion to adjacent organs...
September 22, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28939678/r-spondin1-lgr5-activates-tgf%C3%AE-signaling-and-suppresses-colon-cancer-metastasis
#19
Xiaolin Zhou, Liying Geng, Degeng Wang, Haowei Yi, Geoffrey Talmon, Jing Wang
Leucine rich repeat containing G protein-coupled receptor 5 (LGR5), an intestinal stem cell marker is known to exhibit tumor suppressor activity in colon cancer, the mechanism of which is not understood. Here we show that R-spondin 1 (RSPO1)/LGR5 directly activates TGFβ signaling cooperatively with TGFβ type II receptor in colon cancer cells, enhancing TGFβ-mediated growth inhibition and stress-induced apoptosis. Knockdown of LGR5 attenuated downstream TGFβ signaling and increased cell proliferation, survival, and metastasis in an orthotopic model of colon cancer in vivo...
September 22, 2017: Cancer Research
https://www.readbyqxmd.com/read/28939460/pharmacotherapy-use-in-older-patients-with-heart-failure-and-reduced-ejection-fraction-after-a-skilled-nursing-facility-stay
#20
Lin Li, Bill M Jesdale, Anne Hume, Giovanni Gambassi, Robert J Goldberg, Kate L Lapane
BACKGROUND: Little is known about guideline-directed pharmacotherapy use in patients with heart failure and reduced ejection fraction (HFrEF) discharged to skilled nursing facilities (SNFs). This study aimed to describe the use of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) and evidence-based β-blocker (EBBB) among older patients with HFrEF within 90 days after the SNF admission and to identify factors associated with receipt of these medications...
September 19, 2017: Journal of Cardiac Failure
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