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Hydroxybutyrate

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https://www.readbyqxmd.com/read/28937622/specificities-of-human-hepatocellular-carcinoma-developed-on-non-alcoholic-fatty-liver-disease-in-absence-of-cirrhosis-revealed-by-tissue-extracts-%C3%A2-h-nmr-spectroscopy
#1
Camille Teilhet, Daniel Morvan, Juliette Joubert-Zakeyh, Anne-Sophie Biesse, Bruno Pereira, Sylvie Massoulier, Pierre Dechelotte, Denis Pezet, Emmanuel Buc, Géraldine Lamblin, Michel Peoc'h, Jack Porcheron, Marie-Paule Vasson, Armando Abergel, Aicha Demidem
There is a rising incidence of non-alcoholic fatty liver disease (NAFLD) as well as of the frequency of Hepato-Cellular Carcinoma (HCC) associated with NAFLD. To seek for putative metabolic pathways specific of the NAFLD etiology, we performed comparative metabolomics between HCC associated with NAFLD and HCC associated with cirrhosis. The study included 28 pairs of HCC tissue versus distant Non-Tumoral Tissue (NTT) collected from patients undergoing hepatectomy. HCC was associated with cirrhosis (n = 9), normal liver (n = 6) and NAFLD (n = 13)...
September 22, 2017: Metabolites
https://www.readbyqxmd.com/read/28934007/herbicidal-activity-of-slow-release-herbicide-formulations-in-wheat-stands-infested-by-weeds
#2
Natalia Zhila, Anastasiya Murueva, Anna Shershneva, Ekaterina Shishatskaya, Tatiana Volova
The present study reports the herbicidal activity of metribuzin and tribenuron-methyl embedded in the degradable matrix of natural poly-3-hydroxybutyrate [P(3HB)/MET and P(3HB)/TBM]. The developed formulations were constructed as films and microgranules, which were tested against the weeds such as white sweet clover Melilotus albus and lamb's quarters Chenopodium album in the presence of soft spring wheat (Triticum aestivum, cv. Altaiskaya 70) as the subject crop for investigation. The activity was measured in laboratory scale experiments by determining the density and weight of the vegetative organs of weeds...
September 21, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28931870/inactivation-of-hmgcl-promotes-proliferation-and-metastasis-of-nasopharyngeal-carcinoma-by-suppressing-oxidative-stress
#3
Wenqi Luo, Liting Qin, Bo Li, Zhipeng Liao, Jiezhen Liang, Xiling Xiao, Xue Xiao, Yingxi Mo, Guangwu Huang, Zhe Zhang, Xiaoying Zhou, Ping Li
Altered metabolism is considered as a hallmark of cancer. Here we investigated expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) 2 lyase (HMGCL), an essential enzyme in ketogenesis, which produces ketone bodies by the breakdown of fatty acids to supply energy, in nasopharyngeal carcinoma (NPC). The expression of HMGCL was silenced in NPC tissue. Downregulation of HMGCL in NPC was associated with low intracellular β-hydroxybutyrate (β-HB) production, thereby reducing reactive oxygen species (ROS) generation...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28928660/-1-h-nmr-based-metabolomics-study-of-the-toxicological-effects-in-rats-induced-by-renqing-mangjue-pill-a-traditional-tibetan-medicine
#4
Can Xu, Caidan Rezeng, Jian Li, Lan Zhang, Yujing Yan, Jian Gao, Yingfeng Wang, Zhongfeng Li, Jianxin Chen
"RenqingMangjue" pill (RMP), as an effective prescription of Traditional Tibetan Medicine (TTM), has been widely used in treating digestive diseases and ulcerative colitis for over a thousand years. In certain classical Tibetan Medicine, heavy metal may add as an active ingredient, but it may cause contamination unintentionally in some cases. Therefore, the toxicity and adverse effects of TTM became to draw public attention. In this study, 48 male Wistar rats were orally administrated with different dosages of RMP once a day for 15 consecutive days, then half of the rats were euthanized on the 15th day and the remaining were euthanized on the 30th day...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28927621/in-vitro-degradation-and-possible-hydrolytic-mechanism-of-phbv-nanocomposites-by-incorporating-cellulose-nanocrystal-zno-nanohybrids
#5
Somia Yassin Hussain Abdalkarim, Hou-Yong Yu, Mei-Li Song, Ying Zhou, Juming Yao, Qing-Qing Ni
Fabrication and characterization of bbiodegradable nanocomposites based on poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) matrix reinforced with cellulose nanocrystal (CNC)-ZnO nanohybrids via simple solution casting for possible use as antibacterial biomedical materials is reported. The obtained nanocomposites exhibited an excellent antibacterial ratio of 95.2-100% for both types of bacteria namely S. aureus and E. coli and showed 9-15% degradation after one week. The addition of CNC-ZnO showed a positive effect on hydrophilicity and barrier properties...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28927234/metabolic-profiling-of-central-nervous-system-disease-in-trypanosoma-brucei-rhodesiense-infection
#6
Sabrina D Lamour, Vincent P Alibu, Elaine Holmes, Jeremy M Sternberg
Background: The progression of Human African Trypanosomiasis from the early hemolymphatic stage to the late meningoencephalitic stage is of critical diagnostic importance as it determines the choice of potentially toxic drug regimens. Current diagnostic criteria involving analysis of cerebrospinal fluid (CSF) for parasites and/or pleiocytosis are sensitive, but recent evidence suggests that specificity may be poor. Methods: We used an untargeted global metabolic profiling approach for the discovery of novel candidate stage diagnostic markers in CSF from Trypanosoma brucei rhodesiense patients using 1H nuclear magnetic resonance (NMR) spectroscopy...
September 12, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28924478/a-rare-cause-of-metabolic-acidosis-ketoacidosis-in-a-non-diabetic-lactating-woman
#7
Gordon Sloan, Amjad Ali, Jonathan Webster
Ketoacidosis occurring during lactation has been described infrequently. The condition is incompletely understood, but it appears to be associated with a combination of increased metabolic demands during lactation, reduction in carbohydrate intake and acute illness. We present a case of a 27-year-old woman, 8 weeks post-partum, who was exclusively breastfeeding her child whilst following a low carbohydrate diet. She developed gastroenteritis and was unable to tolerate an oral diet for several days. She presented with severe metabolic acidosis on admission with a blood 3-hydroxybutyrate of 5...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28923436/changes-in-hepatic-gene-expression-and-serum-metabolites-after-oral-administration-of-overdosed-vitamin-e-loaded-nanoemulsion-in-rats
#8
Chae Young Park, Chul Ho Jang, Do Yup Lee, Hyung Taek Cho, Young Jun Kim, Yoo Heon Park, Jee-Young Imm
Vitamin-E-loaded nanoemulsion (Vit E-NE) was produced, and the effects of repeated oral administration of Vit E-NE (2 g/kg/day) for five days on hepatic gene expression and serum metabolites were investigated in rats. The mean particle diameter and zeta potential of Vit E-NE was 112 nm and 56 mV, respectively. Vit E-NE administered rats showed significantly higher triglyceride content than of standard diet (control) or Vit E control emulsion (Vit E-CE) group but no toxicity symptoms were found in blood biochemical analysis...
September 15, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28922379/elevating-serotonin-pre-partum-alters-the-holstein-dairy-cow-hepatic-adaptation-to-lactation
#9
Samantha R Weaver, Allan S Prichard, Noah L Maerz, Austin P Prichard, Elizabeth L Endres, Lorenzo E Hernández-Castellano, Matthew S Akins, Rupert M Bruckmaier, Laura L Hernandez
Serotonin is known to regulate energy and calcium homeostasis in several mammalian species. The objective of this study was to determine if pre-partum infusions of 5-hydroxytryptophan (5-HTP), the immediate precursor to serotonin synthesis, could modulate energy homeostasis at the level of the hepatocyte in post-partum Holstein and Jersey dairy cows. Twelve multiparous Holstein cows and twelve multiparous Jersey cows were intravenously infused daily for approximately 7 d pre-partum with either saline or 1 mg/kg bodyweight of 5-HTP...
2017: PloS One
https://www.readbyqxmd.com/read/28918137/reticulo-rumen-mass-epithelium-gene-expression-and-systemic-biomarkers-of-metabolism-and-inflammation-in-holstein-dairy-cows-fed-a-high-energy-diet
#10
J M Arroyo, A Hosseini, Z Zhou, A Alharthi, E Trevisi, J S Osorio, J J Loor
Feeding a higher-energy diet by increasing cereal grains at the expense of forage during the last 3 to 4 wk prepartum is a traditional approach to help the rumen "adapt" to the traditional diets fed at the onset of lactation. Increasing grain/concentrate in the diet changes ruminal fermentation and in sheep and goats elicits marked changes in mRNA expression of immune-related genes in ruminal epithelium. Whether such changes at the epithelial and systemic levels occur in dairy cows when the dietary energy content increases at a fixed level of concentrate is unknown...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917149/a-comparison-study-between-electrospun-polycaprolactone-and-piezoelectric-poly-3-hydroxybutyrate-co-3-hydroxyvalerate-scaffolds-for-bone-tissue-engineering
#11
Svetlana N Gorodzha, Albert R Muslimov, Dina S Syromotina, Alexander S Timin, Nikolai Y Tcvetkov, Kirill V Lepik, Aleksandra V Petrova, Maria A Surmeneva, Dmitry A Gorin, Gleb B Sukhorukov, Roman A Surmenev
In this study, bone scaffolds composed of polycaprolactone (PCL), piezoelectric poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and a combination of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and silicate containing hydroxyapatite (PHBV-SiHA) were successfully fabricated by a conventional electrospinning process. The morphological, chemical, wetting and biological properties of the scaffolds were examined. All fabricated scaffolds are composed of randomly oriented fibres with diameters from 800nm to 12μm...
September 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28916979/ventral-hernia-repair-with-poly-4-hydroxybutyrate-mesh
#12
Margaret A Plymale, Daniel L Davenport, Adam Dugan, Amanda Zachem, John Scott Roth
BACKGROUND: Biomaterial research has made available a biologically derived fully resorbable poly-4-hydroxybutyrate (P4HB) mesh for use in ventral and incisional hernia repair (VIHR). This study evaluates outcomes of patients undergoing VIHR with P4HB mesh. METHODS: An IRB-approved prospective pilot study was conducted to assess clinical and quality of life (QOL) outcomes for patients undergoing VIHR with P4HB mesh. Perioperative characteristics were defined. Clinical outcomes, employment status, QOL using 12-item short form survey (SF-12), and pain assessments were followed for 24 months postoperatively...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916461/metabolic-engineering-of-escherichia-coli-for-the-synthesis-of-the-quadripolymer-poly-glycolate-co-lactate-co-3-hydroxybutyrate-co-4-hydroxybutyrate-from-glucose
#13
Zheng-Jun Li, Kangjian Qiao, Xue-Mei Che, Gregory Stephanopoulos
Escherichia coli was metabolically engineered to effectively produce a series of biopolymers consisted of four types of monomers including glycolate, lactate, 3-hydroxybutyrate and 4-hydroxybutyrate from glucose as the carbon source. The biosynthetic route of novel quadripolymers was achieved by the overexpression of a range of homologous and heterologous enzymes including isocitrate lyase, isocitrate dehydrogenase kinase/phosphatase, glyoxylate/hydroxypyruvate reductase, propionyl-CoA transferase, β-ketothiolase, acetoacetyl-CoA reductase, succinate semialdehyde dehydrogenase, 4-hydroxybutyrate dehydrogenase, CoA transferase and PHA synthase...
September 13, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28905672/the-influence-of-ketogenic-therapy-on-the-5-r-s-of-radiobiology
#14
Rainer J Klement
PURPOSE: Radiotherapy (RT) is a mainstay in the treatment of solid tumors and works by inducing free radical stress in tumor cells, leading to loss of reproductive integrity. The optimal treatment strategy has to consider damage to both tumor and normal cells and is determined by five factors known as the 5 R's of radiobiology: Reoxygenation, DNA Repair, Radiosensitivity, Redistribution in the cell cycle and Repopulation. The aim of this review is (i) to present evidence that these 5 R's are strongly influenced by cellular and whole body metabolism that in turn can be modified through ketogenic therapy in form of ketogenic diets and short term fasting, and (ii) to stimulate new research into this field including some research questions deserving further study...
September 14, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28903871/prevalence-and-risk-factors-for-transition-period-diseases-in-grazing-dairy-cows-in-brazil
#15
Rolnei R Daros, Maria J Hötzel, Jose A Bran, Stephen J LeBlanc, Marina A G von Keyserlingk
The aim of this cross-sectional study was to describe the incidence risk of dystocia, retained placenta (RP), pathological recumbence (down cow), the prevalence of metritis and subclinical ketosis (SCK), and the risk factors for SCK, metritis, and RP in grazing dairy herds in Southern Brazil. Fifty-three herds were visited 2-6 times from February to October of 2015. Body condition score (BCS), breed, days in milk (DIM), parity and disease status were recorded for each cow that was between 3 and 21 DIM at the time of the visits...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28901994/biomineralized-conductive-pedot-pss-coated-pla-phbv-ha-nanofibrous-membranes
#16
Mohd Izzat Hassan, Noor Nabilah Masnawi, Naznin Sultana
Conductive materials are potential candidates for developing bone tissue engineering scaffolds as they are nontoxic and can enhance bone tissue regeneration. Their bioactivity can be enhanced by depositing biomineralization in simulated body fluid (SBF). In the current study, a composite electrospun membrane made up of poly(lactic) acid, poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and hydroxyapatite was fabricated using an electrospinning method. The fabricated membranes were dip-coated with a conductive polymer solution, poly(3,4-ethylenedioxythiophene) poly(4-styrenesulfonate), to induce conductivity...
September 7, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28900143/a-unique-case-of-human-zika-virus-infection-in-association-with-severe-liver-injury-and-coagulation-disorders
#17
Yanhua Wu, Xiaoyun Cui, Na Wu, Rui Song, Wei Yang, Wei Zhang, Dongying Fan, Zhihai Chen, Jing An
Zika virus (ZIKV) has caused major concern globally due to its rapid dissemination and close association with microcephaly in children and Gullian-Barr syndrome in adults. In this study, we identified a patient returned from Cambodia who experienced high fever, chill and myalgia. Lab tests discovered sign of severe liver injury including significantly elevated serum transaminases' level, decreased serum albumin level, and markedly increased levels of lactic dehydrogenase, alpha-hydroxybutyric dehydrogenase and creatine kinase in serum...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893334/metabolic-and-stress-responses-in-dairy-cows-fed-a-concentrate-rich-diet-and-submitted-to-intramammary-lipopolysaccharide-challenge
#18
S Aditya, E Humer, P Pourazad, R Khiaosa-Ard, Q Zebeli
Feeding dairy cows diets rich in grain often leads to subacute rumen acidosis (SARA), which might affect their responsiveness to immunogenic stimuli such as exogenous lipopolysaccharide (LPS), and can lead to metabolic alterations. The main objective of this study was to investigate if SARA affects the stress and metabolic health responses resulting from an intramammary LPS challenge. Before the intramammary LPS challenge, the SARA cows showed higher blood glucose and a tendency for higher lactate and aspartate aminotransferase as well as a trend toward lower β-hydroxybutyrate (BHBA) and γ-glutamyltransferase compared with control cows...
September 12, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28891296/non-invasive-body-fat-burn-monitoring-from-exhaled-acetone-with-si-doped-wo3-sensing-nanoparticles
#19
Andreas T Güntner, Noriane A Sievi, S Jonathan Theodore, Tobias Gulich, Malcolm Kohler, Sotiris E Pratsinis
Obesity is a global health threat on the rise and its prevalence continues to grow. Yet suitable biomedical sensors to monitor the body fat burn rates in situ to guide physical activity or dietary interventions toward efficient weight loss are missing. Here, we introduce a compact and inexpensive breath acetone sensor based on Si-doped WO3 nanoparticles that can accurately follow body fat burn rates in real-time. We tested this sensor on 20 volunteers during exercise and rest and measured their individual breath acetone concentrations in good agreement to bench-top proton transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS)...
September 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28889198/polyhydroxyalkanoate-production-from-sucrose-by-cupriavidus-necator-strains-harboring-csc-genes-from-escherichia-coli-w
#20
Hisashi Arikawa, Keiji Matsumoto, Tetsuya Fujiki
Cupriavidus necator H16 is the most promising bacterium for industrial production of polyhydroxyalkanoates (PHAs) because of their remarkable ability to accumulate them in the cells. With genetic modifications, this bacterium can produce poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx), which has better physical properties, as well as poly(3-hydroxybutyrate) (PHB) using plant oils and sugars as a carbon source. Considering production cost, sucrose is a very attractive raw material because it is inexpensive; however, this bacterium cannot assimilate sucrose...
September 9, 2017: Applied Microbiology and Biotechnology
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