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JOURNAL ARTICLE
Pietro Achilli, Davide Ferrari, Giacomo Calini, Camillo L Bertoglio, Carmelo Magistro, Matteo Origi, Pietro Carnevali, Bruno D Alampi, Irene Giusti, Giovanni Ferrari, Eleonora Calafiore, Antonino Spinelli, Fabian Grass, Philip Deslarzes, Dieter Hahnloser, Solafah Abdalla, David W Larson
AIM: Locally advanced rectal cancer (LARC) is commonly treated with neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME) to reduce local recurrence (LR) and improve survival. However, LR, particularly associated with lateral lymph node (LLN) involvement, remains a concern. The aim of this study was to investigate preoperative factors associated with LLN involvement and their impact on LR rates in LARC patients undergoing nCRT and curative surgery. METHOD: This multicentre retrospective study, including four academic high-volume institutions, involved 301 consecutive adult LARC patients treated with nCRT and curative surgery between January 2014 and December 2019 who did not undergo lateral lymph node dissection (LLND)...
January 19, 2024: Colorectal Disease
#2
JOURNAL ARTICLE
J Carballo, A Achilli, F Hernández, M Bocchini, M C Pasten, G Marconi, E Albertini, D Zappacosta, V Echenique
Epigenetics studies changes in gene activity without changes in the DNA sequence. Methylation is an epigenetic mechanism important in many pathways, such as biotic and abiotic stresses, cell division, and reproduction. Eragrostis curvula is a grass species reproducing by apomixis, a clonal reproduction by seeds. This work employed the MCSeEd technique to identify deferentially methylated positions, regions, and genes in the CG, CHG, and CHH contexts in E. curvula genotypes with similar genomic backgrounds but with different reproductive modes and ploidy levels...
December 6, 2023: Plant Reproduction
#3
JOURNAL ARTICLE
Ningbo Chen, Xiaoting Xia, Quratulain Hanif, Fengwei Zhang, Ruihua Dang, Bizhi Huang, Yang Lyu, Xiaoyu Luo, Hucai Zhang, Huixuan Yan, Shikang Wang, Fuwen Wang, Jialei Chen, Xiwen Guan, Yangkai Liu, Shuang Li, Liangliang Jin, Pengfei Wang, Luyang Sun, Jicai Zhang, Jianyong Liu, Kaixing Qu, Yanhong Cao, Junli Sun, Yuying Liao, Zhengzhong Xiao, Ming Cai, Lan Mu, Amam Zonaed Siddiki, Muhammad Asif, Shahid Mansoor, Masroor Ellahi Babar, Tanveer Hussain, Gamamada Liyanage Lalanie Pradeepa Silva, Neena Amatya Gorkhali, Endashaw Terefe, Gurja Belay, Abdulfatai Tijjani, Tsadkan Zegeye, Mebrate Genet Gebre, Yun Ma, Yu Wang, Yongzhen Huang, Xianyong Lan, Hong Chen, Nicola Rambaldi Migliore, Giulia Colombo, Ornella Semino, Alessandro Achilli, Mikkel-Holger S Sinding, Johannes A Lenstra, Haijian Cheng, Wenfa Lu, Olivier Hanotte, Jianlin Han, Yu Jiang, Chuzhao Lei
Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral communities across a wide range of agro-ecosystems, from extremely hot semiarid regions to hot humid tropical regions. However, their adaptive genetic changes following their dispersal into East Asia from the Indian subcontinent have remained poorly documented. Here, we characterize their global genetic diversity using high-quality whole-genome sequencing data from 354 indicine cattle of 57 breeds/populations, including major indicine phylogeographic groups worldwide...
November 28, 2023: Nature Communications
#4
JOURNAL ARTICLE
Camilla Gesi, Rita Cafaro, Francesco Achilli, Maria Boscacci, Matteo Cerioli, Giovanna Cirnigliaro, Fotios Loupakis, Massimo di Maio, Bernardo Dell'Osso
No abstract text is available yet for this article.
September 27, 2023: CNS Spectrums
#5
JOURNAL ARTICLE
Kuharajan Ramalingam, Divaagar Perumal, Harswini Balan, Juzaily F Leong, Tharumaraja Thiruselvam
Aim Musculus Gastrocnemius Tightness (MGT) has been linked with common foot and ankle pathologies. These symptoms sometimes are not severe enough for the patient to seek treatment. This study aims to determine the incidence rate of MGT among our clinical personnel and if there is any association between foot and ankle symptoms with MGT. Materials and methods This observational cross-sectional study involves clinical personnel from our Specialist Clinics at Hospital Kulim, Malaysia. We interviewed and assessed 85 volunteers of which, we measured the passive ankle dorsiflexion of the volunteers (the Silfverskiöld) test, to diagnose MGT...
June 2023: Curēus
#6
JOURNAL ARTICLE
Michele Catalano, Chandra Bortolotto, Giovanna Nicora, Marina Francesca Achilli, Alessio Consonni, Lidia Ruongo, Giovanni Callea, Antonio Lo Tito, Carla Biasibetti, Antonella Donatelli, Sara Cutti, Federico Comotto, Giulia Maria Stella, Angelo Corsico, Stefano Perlini, Riccardo Bellazzi, Raffaele Bruno, Andrea Filippi, Lorenzo Preda
BACKGROUND: Artificial intelligence (AI) has proved to be of great value in diagnosing and managing Sars-Cov-2 infection. ALFABETO (ALL-FAster-BEtter-TOgether) is a tool created to support healthcare professionals in the triage, mainly in optimizing hospital admissions. METHODS: The AI was trained during the pandemic's "first wave" (February-April 2020). Our aim was to assess the performance during the "third wave" of the pandemics (February-April 2021) and evaluate its evolution...
December 2023: European Journal of Radiology Open
#7
JOURNAL ARTICLE
Sofia L Candido, Macarena Siri, Estefanía Achilli, Juan C Moreno, Cristian Lillo, Patricia H Risso, Jeffrey Bodycomb, Luis Martínez, Jorge Montanari, Silvia Del V Alonso, Fernando C Alvira
Anthocyanins are the main active compounds in blueberry. However, they have poor oxidation stability. If anthocyanins are encapsulated in protein nanoparticles, their oxidation resistance could be increased as a result of the slowing down of the oxidation process. This work describes the advantages of using a γ-irradiated bovine serum albumin nanoparticle bound to anthocyanins. The interaction was characterized biophysically, mainly by rheology. By computational calculation and simulation based on model nanoparticles, we estimated the number of molecules forming the albumin nanoparticles, which allowed us to infer the ratio of anthocyanin/nanoparticles...
June 8, 2023: Journal of Physical Chemistry. B
#8
JOURNAL ARTICLE
Epifanía Arango-Isaza, Marco Rosario Capodiferro, María José Aninao, Hiba Babiker, Simon Aeschbacher, Alessandro Achilli, Cosimo Posth, Roberto Campbell, Felipe I Martínez, Paul Heggarty, Scott Sadowsky, Kentaro K Shimizu, Chiara Barbieri
The southernmost regions of South America harbor some of the earliest evidence of human presence in the Americas. However, connections with the rest of the continent and the contextualization of present-day indigenous ancestries remain poorly resolved. In this study, we analyze the genetic ancestry of one of the largest indigenous groups in South America: the Mapuche. We generate genome-wide data from 64 participants from three Mapuche populations in Southern Chile: Pehuenche, Lafkenche, and Huilliche. Broadly, we describe three main ancestry blocks with a common origin, which characterize the Southern Cone, the Central Andes, and Amazonia...
June 1, 2023: Current Biology: CB
#9
JOURNAL ARTICLE
Michele Mazzola, Lorenzo Ripamonti, Alessandro Giani, Pietro Carnevali, Matteo Origi, BrunocDomenico Alampi, Irene Giusti, Pietro Achilli, Camillo Leonardo Bertoglio, Carmelo Magistro, Giovanni Ferrari
BACKGROUND: Despite its potential oncologic benefit, complete mesocolic excision (CME) has rarely been offered to elderly patients. The present study evaluated the effect of age on postoperative outcomes among patients undergoing laparoscopic right colectomies with CME for right-sided colon cancer (RCC). METHODS: Data of patients undergoing laparoscopic right colectomies with CME for RCC between 2015 and 2018 were retrospectively analyzed. Selected patients were divided into two groups: the under-80 group and the over-80 group...
May 13, 2023: Current Oncology
#10
JOURNAL ARTICLE
Mukta Hardikar, Varinia Felix, Andrew B Rabe, Luisa A Ikner, Kerri L Hickenbottom, Andrea Achilli
Membrane distillation (MD) is a thermally-driven process that can treat high concentration streams and provide a dual barrier for rejection and reduction of pathogens. Thus, MD has potential applications in treating concentrated wastewater brines for enhancing water recovery and potable water reuse. In bench-scale studies, it was demonstrated that MD can provide high rejection of MS2 and PhiX174 bacteriophage viruses, and when operating at temperatures greater than 55 °C, can reduce virus levels in the concentrate...
April 29, 2023: Water Research
#11
JOURNAL ARTICLE
Yu-Chun Li, Zong-Liang Gao, Kai-Jun Liu, Jiao-Yang Tian, Bin-Yu Yang, Zia Ur Rahman, Li-Qin Yang, Su-Hua Zhang, Cheng-Tao Li, Alessandro Achilli, Ornella Semino, Antonio Torroni, Qing-Peng Kong
Although it is widely recognized that the ancestors of Native Americans (NAs) primarily came from Siberia, the link between mitochondrial DNA (mtDNA) lineage D4h3a (typical of NAs) and D4h3b (found so far only in East China and Thailand) raises the possibility that the ancestral sources for early NAs were more variegated than hypothesized. Here, we analyze 216 contemporary (including 106 newly sequenced) D4h mitogenomes and 39 previously reported ancient D4h data. The results reveal two radiation events of D4h in northern coastal China, one during the Last Glacial Maximum and the other within the last deglaciation, which facilitated the dispersals of D4h sub-branches to different areas including the Americas and the Japanese archipelago...
April 20, 2023: Cell Reports
#12
JOURNAL ARTICLE
Simona Achilli, Daya Sagar Dhungana, Federico Orlando, Carlo Grazianetti, Christian Martella, Alessandro Molle, Guido Fratesi
The synthesis of silicene by direct growth on silver is characterized by the formation of multiple phases and domains, posing severe constraints on the spatial charge conduction towards a technological transfer of silicene to electronic transport devices. Here we engineer the silicene/silver interface by two schemes, namely, either through decoration by Sn atoms, forming an Ag2 Sn surface alloy, or by buffering the interface with a stanene layer. Whereas in both cases Raman spectra confirm the typical features as expected from silicene, by electron diffraction we observe that a very well-ordered single-phase 4 × 4 monolayer silicene is stabilized by the decorated surface, while the buffered interface exhibits a sharp phase at all silicon coverages...
May 9, 2023: Nanoscale
#13
JOURNAL ARTICLE
Marco Rosario Capodiferro, Ana María Chero Osorio, Nicola Rambaldi Migliore, Dean Herman Tineo Tineo, Alessandro Raveane, Catarina Xavier, Martin Bodner, Filipa Simão, Linda Ongaro, Francesco Montinaro, John Lindo, Emilia Huerta-Sanchez, Gustavo Politis, Chiara Barbieri, Walther Parson, Leonor Gusmão, Alessandro Achilli
Despite its crucial location, the western side of Amazonia between the Andes and the source(s) of the Amazon River is still understudied from a genomic and archaeogenomic point of view, albeit possibly harboring essential information to clarify the complex genetic history of local Indigenous groups and their interactions with nearby regions,1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 including central America and the Caribbean.9 , 10 , 11 , 12 Focusing on this key region, we analyzed the genome-wide profiles of 51 Ashaninka individuals from Amazonian Peru, observing an unexpected extent of genomic variation...
March 14, 2023: Current Biology: CB
#14
JOURNAL ARTICLE
Camilla Gesi, Giovanna Cirnigliaro, Francesco Achilli, Matteo Cerioli, Rita Cafaro, Maria Boscacci, Bernardo Dell'Osso
Post-traumatic growth (PTG) and specific traumatic events have been poorly explored in the literature focusing on post-traumatic stress disorder (PTSD) among healthcare workers (HWs) tackling the COVID-19 pandemic. In a large sample of Italian HWs, we investigated the kinds of traumatic events and whether PTG affects the risk of PTSD, along with its prevalence and features, during the first COVID-19 wave. COVID-19-related stressful events, Impact of Event Scale-Revised (IES-R) and PTG Inventory-Short Form (PTGI-SF) scores were collected through an online survey...
February 27, 2023: Journal of Clinical Medicine
#15
REVIEW
Nicoletta Basla, Domenico Sfondrini, Marina Francesca Achilli, Michele Catalano, Francesco Sanvito, Maria Gabriella Sala, Stefano Marelli, Marco Benazzo, Lorenzo Preda
No abstract text is available yet for this article.
February 2023: Acta Otorhinolaryngologica Italica
#16
JOURNAL ARTICLE
Sophie K Joseph, Nicola Rambaldi Migliore, Anna Olivieri, Antonio Torroni, Amanda C Owings, Michael DeGiorgio, Wladimir Galarza Ordóñez, J J Ortiz Aguilú, Fabricio González-Andrade, Alessandro Achilli, John Lindo
Most studies focusing on human high-altitude adaptation in the Andean highlands have thus far been focused on Peruvian populations. We present high-coverage whole genomes from Indigenous people living in the Ecuadorian highlands and perform multi-method scans to detect positive natural selection. We identified regions of the genome that show signals of strong selection to both cardiovascular and hypoxia pathways, which are distinct from those uncovered in Peruvian populations. However, the strongest signals of selection were related to regions of the genome that are involved in immune function related to tuberculosis...
February 17, 2023: IScience
#17
JOURNAL ARTICLE
Beatrice Benatti, Nicolaja Girone, Dario Conti, Maddalena Cocchi, Francesco Achilli, Silvia Leo, Gianmarco Putti, Monica Bosi, Bernardo Dell'Osso
Introduction: Poor adherence to treatment is currently stated to be one of the causes of depression relapse and recurrence. The aim of the present study is to assess potential differences in terms of clinical and lifestyle features related to adherence to treatment in a sample of patients with unipolar and bipolar depression. Methods: One hundred and eight patients with a diagnosis of unipolar or bipolar depressive episode were recruited from January 2021 to October 2022. Adherence to psychopharmacological treatment was assessed using the clinician rating scale...
January 21, 2023: International Journal of Environmental Research and Public Health
#18
JOURNAL ARTICLE
J Ramirez-Diaz, S Cenadelli, V Bornaghi, G Bongioni, S M Montedoro, A Achilli, C Capelli, J C Rincon, M Milanesi, M M Passamonti, L Colli, M Barbato, J L Williams, P Ajmone Marsan
Sperm motility is directly related to the ability of sperm to move through the female reproductive tract to reach the ovum. Sperm motility is a complex trait that is influenced by environmental and genetic factors and is associated with male fertility, oocyte penetration rate, and reproductive success of cattle. In this study we carried out a GWAS in Italian Holstein bulls to identify candidate regions and genes associated with variations in progressive and total motility (PM and TM, respectively). After quality control, the final data set consisted of 5,960 records from 949 bulls having semen collected in 10 artificial insemination stations and genotyped at 412,737 SNPs (call rate >95%; minor allele frequency >5%)...
November 15, 2022: Journal of Dairy Science
#19
RANDOMIZED CONTROLLED TRIAL
Giulio Mari, Gaia Santambrogio, Jacopo Crippa, Roberto Cirocchi, Matteo Origi, Pietro Achilli, Giovanni Ferrari, Stefano Megna, Matteo Desio, Eugenio Cocozza, Dario Maggioni, Isacco Montroni, Antonino Spinelli, Walter Zuliani, Andrea Costanzi, Sara Crestale, Roberto Petri, Noemi Bicelli, Corrado Pedrazzani, Andrea Boccolini, Giovanni Taffurelli, Abe Fingerhut
INTRODUCTION: The oncological outcomes of low ligation (LL) compared to high ligation (HL) of the inferior mesenteric artery (IMA) during low-anterior rectal resection (LAR) with total mesorectal excision are still debated. The aim of this study is to report the 5 year oncologic outcomes of patients undergoing laparoscopic LAR with either HL vs. LL of the IMA MATERIALS AND METHODS: Between June 2014 and December 2016, patients who underwent elective laparoscopic LAR + TME in 6 Italian non-academic hospitals were randomized to HL or LL of IMA after meeting the inclusion criteria (HighLow trial; ClinicalTrials...
March 2023: European Journal of Surgical Oncology
#20
JOURNAL ARTICLE
Laurie J Reitsema, Alissa Mittnik, Britney Kyle, Giulio Catalano, Pier Francesco Fabbri, Adam C S Kazmi, Katherine L Reinberger, Luca Sineo, Stefano Vassallo, Rebecca Bernardos, Nasreen Broomandkhoshbacht, Kim Callan, Francesca Candilio, Olivia Cheronet, Elizabeth Curtis, Daniel Fernandes, Martina Lari, Ann Marie Lawson, Matthew Mah, Swapan Mallick, Kirsten Mandl, Adam Micco, Alessandra Modi, Jonas Oppenheimer, Kadir Toykan Özdogan, Nadin Rohland, Kristin Stewardson, Stefania Vai, Chiara Vergata, J Noah Workman, Fatma Zalzala, Valentina Zaro, Alessandro Achilli, Achilles Anagnostopoulos, Cristian Capelli, Varnavas Constantinou, Hovirag Lancioni, Anna Olivieri, Anastasia Papadopoulou, Nikoleta Psatha, Ornella Semino, John Stamatoyannopoulos, Ioanna Valliannou, Evangelia Yannaki, Iosif Lazaridis, Nick Patterson, Harald Ringbauer, David Caramelli, Ron Pinhasi, David Reich
Trade and colonization caused an unprecedented increase in Mediterranean human mobility in the first millennium BCE. Often seen as a dividing force, warfare is in fact another catalyst of culture contact. We provide insight into the demographic dynamics of ancient warfare by reporting genome-wide data from fifth-century soldiers who fought for the army of the Greek Sicilian colony of Himera, along with representatives of the civilian population, nearby indigenous settlements, and 96 present-day individuals from Italy and Greece...
October 11, 2022: Proceedings of the National Academy of Sciences of the United States of America
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