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Ketogenic diet performance

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https://www.readbyqxmd.com/read/29910305/the-three-month-effects-of-a-ketogenic-diet-on-body-composition-blood-parameters-and-performance-metrics-in-crossfit-trainees-a-pilot-study
#1
Wesley C Kephart, Coree D Pledge, Paul A Roberson, Petey W Mumford, Matthew A Romero, Christopher B Mobley, Jeffrey S Martin, Kaelin C Young, Ryan P Lowery, Jacob M Wilson, Kevin W Huggins, Michael D Roberts
Adopting low carbohydrate, ketogenic diets remains a controversial issue for individuals who resistance train given that this form of dieting has been speculated to reduce skeletal muscle glycogen levels and stifle muscle anabolism. We sought to characterize the effects of a 12-week ketogenic diet (KD) on body composition, metabolic, and performance parameters in participants who trained recreationally at a local CrossFit facility. Twelve participants (nine males and three females, 31 ± 2 years of age, 80...
January 9, 2018: Sports (Basel)
https://www.readbyqxmd.com/read/29901816/effect-of-modified-atkins-diet-in-adults-with-drug-resistant-focal-epilepsy-a-randomized-clinical-trial
#2
Magnhild Kverneland, Ellen Molteberg, Per O Iversen, Marit B Veierød, Erik Taubøll, Kaja K Selmer, Karl O Nakken
OBJECTIVE: Ketogenic diets reduce seizures in children with drug-resistant epilepsy. Whether adults benefit from similar treatment has not been clarified. We therefore examined the efficacy of the modified Atkins diet in adults with drug-resistant focal epilepsy. METHODS: We performed a randomized clinical trial (RCT) with patients >16 years who had at least 3 seizures per month despite having tried at least 3 antiepileptic drugs. They were randomized to either 12 weeks on the modified Atkins diet (diet group) or habitual diet (control group)...
June 14, 2018: Epilepsia
https://www.readbyqxmd.com/read/29896790/de-novo-mutations-of-stxbp1-in-chinese-children-with-early-onset-epileptic-encephalopathy
#3
Tingsong Li, Min Cheng, Juan Wang, Siqi Hong, Mei Li, Shuang Liao, Lingling Xie, Yajun Qin, Li Jiang
OBJECTIVE: To detect syntaxin-binding protein 1 (STXBP1) mutations in Chinese patients with early onset epileptic encephalopathy (EOEE) of unknown etiology. METHODS: Targeted next-generation sequencing was used to identify STXBP1 mutations in 143 Chinese patients with EOEE of unknown etiology. A filtering process was applied to prioritize rare variants of potential functional significance. Then Sanger sequencing was employed to validate the parental origin of the variants...
June 13, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29799502/an-8-week-ketogenic-low-carbohydrate-high-fat-diet-enhanced-exhaustive-exercise-capacity-in-mice
#4
Sihui Ma, Qingyi Huang, Koichi Yada, Chunhong Liu, Katsuhiko Suzuki
Current fueling tactics for endurance exercise encourage athletes to ingest a high carbohydrate diet. However, athletes are not generally encouraged to use fat, the largest energy reserve in the human body. A low carbohydrate, high fat ketogenic diet (KD) is a nutritional approach ensuring that the body utilizes lipids. Although KD has been associated with weight-loss, enhanced fat utilization in muscle and other beneficial effects, there is currently no clear proof whether it could lead to performance advantage...
May 25, 2018: Nutrients
https://www.readbyqxmd.com/read/29777386/substrate-metabolism-during-ironman-triathlon-different-horses-on-the-same-courses
#5
Ed Maunder, Andrew E Kilding, Daniel J Plews
Ironman triathlons are ultra-endurance events of extreme duration. The performance level of those competing varies dramatically, with elite competitors finishing in ~ 8:00:00, and lower performing amateurs finishing in ~ 14-15:00:00. When applying appropriate values for swimming, cycling and running economies to these performance times, it is demonstrated that the absolute energy cost of these events is high, and the rate of energy expenditure increases in proportion with the athlete's competitive level...
May 18, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29763602/a-ketogenic-diet-reduces-metabolic-syndrome-induced-allodynia-and-promotes-peripheral-nerve-growth-in-mice
#6
Michael A Cooper, Blaise W Menta, Consuelo Perez-Sanchez, Megan M Jack, Zair W Khan, Janelle M Ryals, Michelle Winter, Douglas E Wright
Current experiments investigated whether a ketogenic diet impacts neuropathy associated with obesity and prediabetes. Mice challenged with a ketogenic diet were compared to mice fed a high-fat diet or a high-fat diet plus exercise. Additionally, an intervention switching to a ketogenic diet following 8 weeks of high-fat diet was performed to compare how a control diet, exercise, or a ketogenic diet affects metabolic syndrome-induced neural complications. When challenged with a ketogenic diet, mice had reduced bodyweight and fat mass compared to high-fat-fed mice, and were similar to exercised, high-fat-fed mice...
May 12, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29710809/anti-oxidant-and-anti-inflammatory-activity-of-ketogenic-diet-new-perspectives-for-neuroprotection-in-alzheimer-s-disease
#7
REVIEW
Alessandro Pinto, Alessio Bonucci, Elisa Maggi, Mariangela Corsi, Rita Businaro
The ketogenic diet, originally developed for the treatment of epilepsy in non-responder children, is spreading to be used in the treatment of many diseases, including Alzheimer’s disease. The main activity of the ketogenic diet has been related to improved mitochondrial function and decreased oxidative stress. B-Hydroxybutyrate, the most studied ketone body, has been shown to reduce the production of reactive oxygen species (ROS), improving mitochondrial respiration: it stimulates the cellular endogenous antioxidant system with the activation of nuclear factor erythroid-derived 2-related factor 2 (Nrf2), it modulates the ratio between the oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD⁺/NADH) and it increases the efficiency of electron transport chain through the expression of uncoupling proteins...
April 28, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29658772/the-role-of-ketogenic-diets-in-the-therapeutic-management-of-adult-and-paediatric-gliomas-a-systematic-review
#8
Kirsty J Martin-McGill, Nisaharan Srikandarajah, Anthony G Marson, Catrin Tudur Smith, Michael D Jenkinson
AIM: We performed a systematic review of the evidence for effectiveness and acceptability of different ketogenic diets (KDs) in the therapeutic management of gliomas. METHODS: The search strategy included searches of seven electronic databases. Data extraction and quality assessment were undertaken independently by two authors. RESULTS: No randomized clinical trials were identified. Six studies (n = 39) met the eligibility criteria for this review - all were case series or reports and therefore at high risk of bias...
April 2018: CNS Oncology
https://www.readbyqxmd.com/read/29619799/low-carbohydrate-ketogenic-diet-impairs-anaerobic-exercise-performance-in-exercise-trained-women-and-men-a-randomized-sequence-crossover-trial
#9
Kymberly A Wroble, Morgan N Trott, George G Schweitzer, Rabia S Rahman, Patrick V Kelly, Edward P Weiss
BACKGROUND: Low-carbohydrate, ketogenic diets cause mild, sub-clinical systemic acidosis. Anaerobic exercise performance is limited by acidosis. Therefore, we evaluated the hypothesis that a low-carbohydrate, ketogenic diet impairs anaerobic exercise performance, as compared to a high-carbohydrate diet. METHODS: Sixteen men and women (BMI, 23±1 kg/m2, age 23±1 yr) participated in a randomized-sequence, counterbalanced crossover study in which they underwent exercise testing after four days of either a low-carbohydrate, ketogenic diet (LC; <50 g/day and <10% of energy from carbohydrates) or a high-carbohydrate diet (HC; 6-10 g/kg/day carbohydrate)...
April 4, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29588960/the-relationship-between-d-beta-hydroxybutyrate-blood-concentrations-and-seizure-control-in-children-treated-with-the-ketogenic-diet-for-medically-intractable-epilepsy
#10
Jeffrey R Buchhalter, Sabrina D'Alfonso, Mary Connolly, Ernest Fung, Aspasia Michoulas, David Sinasac, Rachel Singer, Jacklyn Smith, Narender Singh, Jong M Rho
Objective: The ketogenic diet (KD) is a proven treatment for drug-resistant (DR) seizures in children and adolescents. However, the relationship between seizure control and the most commonly measured metabolite of the diet, the ketone body d-beta-hydroxybutyrate (D-BHB), is controversial. This study was performed to clarify the relationship because specific ketone bodies may be useful as biomarkers of diet efficacy. Methods: Families of children with DR seizures were approached for participation in this open-label, prospective study when they were referred for the KD at two western Canadian children's hospitals...
September 2017: Epilepsia open
https://www.readbyqxmd.com/read/29576959/the-use-of-nutritional-supplements-to-induce-ketosis-and-reduce-symptoms-associated-with-keto-induction-a-narrative-review
#11
Cliff J D C Harvey, Grant M Schofield, Micalla Williden
Background: Adaptation to a ketogenic diet (keto-induction) can cause unpleasant symptoms, and this can reduce tolerability of the diet. Several methods have been suggested as useful for encouraging entry into nutritional ketosis (NK) and reducing symptoms of keto-induction. This paper reviews the scientific literature on the effects of these methods on time-to-NK and on symptoms during the keto-induction phase. Methods: PubMed, Science Direct, CINAHL, MEDLINE, Alt Health Watch, Food Science Source and EBSCO Psychology and Behavioural Sciences Collection electronic databases were searched online...
2018: PeerJ
https://www.readbyqxmd.com/read/29455050/targeted-gene-panel-and-genotype-phenotype-correlation-in-children-with-developmental-and-epileptic-encephalopathy
#12
Ara Ko, Song Ee Youn, Se Hee Kim, Joon Soo Lee, Sangwoo Kim, Jong Rak Choi, Heung Dong Kim, Seung-Tae Lee, Hoon-Chul Kang
OBJECTIVE: We performed targeted gene-panel sequencing for children with developmental and epileptic encephalopathy (DEE) and evaluated the clinical implications of genotype-phenotype correlations. METHODS: We assessed 278 children with DEE using a customized gene panel that included 172 genes, and extensively reviewed their clinical characteristics, including therapeutic efficacy, according to genotype. RESULTS: In 103 (37.1%) of the 278 patients with DEE, 35 different disease-causing monogenic mutations were identified...
March 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29422679/effects-of-the-ketogenic-diet-in-overweight-divers-breathing-enriched-air-nitrox
#13
Gerardo Bosco, Alex Rizzato, Silvia Quartesan, Enrico Camporesi, Devanand Mangar, Matteo Paganini, Lorenzo Cenci, Sandro Malacrida, Simona Mrakic-Sposta, Sara Moretti, Antonio Paoli
Central Nervous System Oxygen Toxicity (CNS-OT) is one of the most harmful effects of Enriched Air Nitrox (EAN) diving. Protective factors of the Ketogenic Diet (KD) are antioxidant activity, the prevention of mitochondrial damage and anti-inflammatory mechanisms. We aimed to investigate if a short-term KD may reduce oxidative stress and inflammation during an hyperoxic dive. Samples from six overweight divers (mean ± SD, age: 55.2 ± 4.96 years; BMI: 26.7 ± 0.86 kg/m2 ) were obtained a) before and after a dive breathing Enriched Air Nitrox and performing 20-minute mild underwater exercise, b) after a dive (same conditions) performed after 7 days of KD...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322234/-efficacy-of-a-ketogenic-diet-in-urological-cancers-patients-a-systematic-review
#14
P Maisch, J E Gschwend, M Retz
BACKGROUND: Beside the classical anticancer treatment tumor patients try to find proactive alternative therapies to fight their disease. Lifestyle changes such as introducing a ketogenic diet is one of the most popular among them. The German Association of Urological Oncology (AUO, Arbeitsgemeinschaft Urologische Onkologie) presents a systematic review investigating the evidence of ketogenic diet in cancer patients. MATERIALS AND METHODS: A systematic literature research was conducted in the databases Medline, Livivo, and the Cochrane Library...
March 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29199027/10-patients-10-years-long-term-follow-up-of-cardiovascular-risk-factors-in-glut1-deficiency-treated-with-ketogenic-diet-therapies-a-prospective-multicenter-case-series
#15
Nicole Heussinger, Adela Della Marina, Andreas Beyerlein, Baerbel Leiendecker, Sofia Hermann-Alves, Robert Dalla Pozza, Joerg Klepper
BACKGROUND AND AIMS: Glut1 Deficiency (Glut1D) is caused by impaired glucose transport into brain. The resulting epileptic encephalopathy and movement disorders can be treated effectively by high-fat carbohydrate-restricted ketogenic diet therapies (KDT) mimicking fasting and providing ketones as an alternative cerebral fuel. Recently 6-24 months follow-ups of epileptic patients reported elevated blood lipids and intima thickening of the carotid artery raising concerns about potential cardiovascular risks by KDT...
November 11, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29108901/keto-adaptation-enhances-exercise-performance-and-body-composition-responses-to-training-in-endurance-athletes
#16
Fionn T McSwiney, Bruce Wardrop, Parker N Hyde, Richard A Lafountain, Jeff S Volek, Lorna Doyle
BACKGROUND: Low-carbohydrate diets have recently grown in popularity among endurance athletes, yet little is known about the long-term (>4wk) performance implications of consuming a low-carbohydrate high fat ketogenic diet (LCKD) in well-trained athletes. METHODS: Twenty male endurance-trained athletes (age 33±11y, body mass 80±11kg; BMI 24.7±3.1kg/m2 ) who habitually consumed a carbohydrate-based diet, self-selected into a high-carbohydrate (HC) group (n=11, %carbohydrate:protein:fat=65:14:20), or a LCKD group (n=9, 6:17:77)...
April 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29093663/selection-and-characterization-of-palmitic-acid-responsive-patients-with-an-oxphos-complex-i-defect
#17
Tom E J Theunissen, Mike Gerards, Debby M E I Hellebrekers, Florence H van Tienen, Rick Kamps, Suzanne C E H Sallevelt, Elvira N M M-D Hartog, Hans R Scholte, Robert M Verdijk, Kees Schoonderwoerd, Irenaeus F M de Coo, Radek Szklarczyk, Hubert J M Smeets
Mitochondrial disorders are genetically and clinically heterogeneous, mainly affecting high energy-demanding organs due to impaired oxidative phosphorylation (OXPHOS). Currently, effective treatments for OXPHOS defects, with complex I deficiency being the most prevalent, are not available. Yet, clinical practice has shown that some complex I deficient patients benefit from a high-fat or ketogenic diet, but it is unclear how these therapeutic diets influence mitochondrial function and more importantly, which complex I patients could benefit from such treatment...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29078087/epilepsy-in-tuberous-sclerosis-patients-in-sweden-healthcare-utilization-treatment-morbidity-and-mortality-using-national-register-data
#18
Karl-Olof Welin, Peter Carlqvist, Anders Svensson, Rikard Althin, Erik Eklund, Olof Rask
PURPOSE: This study is designed to estimate the prevalence of epilepsy associated with TSC in Sweden and to describe treatment, morbidity, and mortality of TSC patients with epilepsy. METHODS: Register data for 2004-2014 was obtained from the National Board of Health and Welfare in Sweden. Patients with TSC were identified using ICD-10 codes. Epilepsy was identified using ICD-10 codes, interventions aimed to treat epilepsy, or prescriptions for antiepileptic drugs...
December 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29046197/-prospective-study-of-ketogenic-diet-in-treatment-of-children-with-global-developmental-delay
#19
RANDOMIZED CONTROLLED TRIAL
Deng-Na Zhu, Ping Li, Jun Wang, Jun-Ying Yuan, Guang-Yu Zhang, Jiang-Fang Liang, Ming-Mei Wang, Yun-Xia Zhao, Shuang An, Na Ma, Dan-Dan Ma
OBJECTIVE: To study the effect of ketogenic diet (KD) on neurobehavioral development, emotional and social behaviors, and life ability in children with global developmental delay (GDD). METHODS: A prospective case-control study was performed for hospitalized children with GDD, who were randomly divided into KD treatment group (n=40) and conventional treatment group (n=37). The children in both groups were given comprehensive rehabilitation training, and those in the KD treatment group were given modified Atkins diet in addition to the comprehensive rehabilitation training...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29045796/the-modification-of-the-ketogenic-diet-mitigates-its-stunting-effects-in-rodents
#20
Arkadiusz Damian Liśkiewicz, Daniela Kasprowska-Liśkiewicz, Anna Sługocka, Marta Maria Nowacka-Chmielewska, Jan Wiaderkiewicz, Halina Jędrzejowska-Szypułka, Jarosław Jerzy Barski, Joanna Lewin-Kowalik
The high-fat and low-carbohydrate ketogenic diet (HFKD) is extensively studied within the fields of numerous diseases, including cancer and neurological disorders. Since most studies incorporate animal models, ensuring the quality of ketogenic rodent diets is important, both in the context of laboratory animal welfare as well as for the accuracy of the obtained results. In this study we implemented a modification to a commonly used ketogenic rodent chow by replacing non-resorbable cellulose with wheat bran...
February 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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