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"Cardiac tissue engineering"

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https://www.readbyqxmd.com/read/29782947/multifunctional-degradable-electronic-scaffolds-for-cardiac-tissue-engineering
#1
Ron Feiner, Sharon Fleischer, Assaf Shapira, Or Kalish, Tal Dvir
The capability to on-line sense tissue function, provide stimulation to control contractility and efficiently release drugs within an engineered tissue microenvironment may enhance tissue assembly and improve the therapeutic outcome of implanted engineered tissues. To endow cardiac patches with such capabilities we developed elastic, biodegradable, electronic scaffolds. The scaffolds were composed of electrospun albumin fibers that served as both a substrate and a passivation layer for evaporated gold electrodes...
May 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29767196/strategies-for-directing-cells-into-building-functional-hearts-and-parts
#2
REVIEW
Mahboubeh Jafarkhani, Zeinab Salehi, Reza Kowsari-Esfahan, Mohammad Ali Shokrgozar, M Rezaa Mohammadi, Jayakumar Rajadas, Masoud Mozafari
The increasing population of patients with heart disease and the limited availability of organs for transplantation have encouraged multiple strategies to fabricate healthy implantable cardiac tissues. One of the main challenges in cardiac tissue engineering is to direct cell behaviors to form functional three-dimensional (3D) biomimetic constructs. This article provides a brief review on various cell sources used in cardiac tissue engineering and highlights the effect of scaffold-based signals such as topographical and biochemical cues and stiffness...
May 16, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29745340/problems-in-stem-cell-therapy-for-cardiac-repair-and-tissue-engineering-approaches-based-on-graphene-and-its-derivatives
#3
Ayca Aslan, Adil Allahverdiyev, Melahat Bagirova, Emrah Abamor
BACKGROUND: Today, coronary artery disease is still one of the most important causes of mortality despite advanced surgical methods, pharmacotherapies and organ transplantation. These treatment modalities are intended to prevent further progression of myocardial infarction and do not involve the repair of the damaged part. Therefore, stem cell therapy has emerged as a new approach for the treatment of coronary artery disease. However, there are some restrictions that limit the use of these cells for desired repair...
May 9, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29737043/bioreactors-for-cardiac-tissue-engineering
#4
REVIEW
Jesus Paez-Mayorga, Gustavo Hernández-Vargas, Guillermo U Ruiz-Esparza, Hafiz M N Iqbal, Xichi Wang, Yu Shrike Zhang, Roberto Parra-Saldivar, Ali Khademhosseini
The advances in biotechnology, biomechanics, and biomaterials can be used to develop organ models that aim to accurately emulate their natural counterparts. Heart disease, one of the leading causes of death in modern society, has attracted particular attention in the field of tissue engineering. To avoid incorrect prognosis of patients suffering from heart disease, or from adverse consequences of classical therapeutic approaches, as well as to address the shortage of heart donors, new solutions are urgently needed...
May 8, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29733514/injectable-hydrogels-for-cardiac-tissue-engineering
#5
REVIEW
Brisa Peña, Melissa Laughter, Susan Jett, Teisha J Rowland, Matthew R G Taylor, Luisa Mestroni, Daewon Park
In light of the limited efficacy of current treatments for cardiac regeneration, tissue engineering approaches have been explored for their potential to provide mechanical support to injured cardiac tissues, deliver cardio-protective molecules, and improve cell-based therapeutic techniques. Injectable hydrogels are a particularly appealing system as they hold promise as a minimally invasive therapeutic approach. Moreover, injectable acellular alginate-based hydrogels have been tested clinically in patients with myocardial infarction (MI) and show preservation of the left ventricular (LV) indices and left ventricular ejection fraction (LVEF)...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29712965/head-to-head-comparison-of-two-engineered-cardiac-grafts-for-myocardial-repair-from-scaffold-characterization-to-pre-clinical-testing
#6
Isaac Perea-Gil, Carolina Gálvez-Montón, Cristina Prat-Vidal, Ignasi Jorba, Cristina Segú-Vergés, Santiago Roura, Carolina Soler-Botija, Oriol Iborra-Egea, Elena Revuelta-López, Marco A Fernández, Ramon Farré, Daniel Navajas, Antoni Bayes-Genis
Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. We developed two engineered cardiac grafts, based on decellularized scaffolds from myocardial and pericardial tissues and repopulated them with adipose tissue mesenchymal stem cells (ATMSCs). The structure, macromechanical and micromechanical scaffold properties were preserved upon the decellularization and recellularization processes, except for recellularized myocardium micromechanics that was ∼2-fold stiffer than native tissue and decellularized scaffolds...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29688622/cardiac-progenitor-cells-the-matrix-has-you
#7
Clotilde Castaldo, Isotta Chimenti
Components of the cardiac extracellular matrix (ECM) are synthesized by residing cells and are continuously remodeled by them. Conversely, residing cells (including primitive cells) receive constant biochemical and mechanical signals from the ECM that modulate their biology. The pathological progression of heart failure affects all residing cells, inevitably causing profound changes in ECM composition and architecture that, in turn, impact on cell phenotypes. Any regenerative medicine approach must aim at sustaining microenvironment conditions that favor cardiogenic commitment of therapeutic cells and minimize pro-fibrotic signals, while conversely boosting the capacity of therapeutic cells to counteract adverse remodeling of the ECM...
April 24, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29687502/paintable-and-rapidly-bondable-conductive-hydrogels-as-therapeutic-cardiac-patches
#8
Shuang Liang, Yinyu Zhang, Hongbo Wang, Ziyang Xu, Jingrui Chen, Rui Bao, Baoyu Tan, Yuanlu Cui, Guanwei Fan, Wenxin Wang, Wei Wang, Wenguang Liu
In recent years, cardiac patches have been developed for the treatment of myocardial infarction. However, the fixation approaches onto the tissue through suture or phototriggered reaction inevitably cause new tissue damage. Herein, a paintable hydrogel is constructed based on Fe3+ -triggered simultaneous polymerization of covalently linked pyrrole and dopamine in the hyperbranched chains where the in situ formed conductive polypyrrole also uniquely serves to crosslink network. This conductive and adhesive hydrogel can be conveniently painted as a patch onto the heart surface without adverse liquid leakage...
April 24, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29684268/conducting-polymers-for-tissue-engineering
#9
Baolin Guo, Peter X Ma
Electrically conducting polymers such as polyaniline, polypyrrole, polythiophene and their derivatives (mainly aniline oligomer and poly(3,4-ethylenedioxythiophene)) with good biocompatibility find wide applications in biomedical fields including bioactuators, biosensors, neural implants, drug delivery systems and tissue engineering scaffolds. This review focuses on these conductive polymers for tissue engineering application. Conductive polymers exhibited promising conductivity as bioactive scaffolds for tissue regeneration and their conductive nature allows cells or tissue cultured on them to be stimulated by electrical signals...
April 23, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29665002/three-dimensional-collagenous-niche-and-azacytidine-selectively-promote-time-dependent-cardiomyogenesis-from-human-bone-marrow-derived-msc-spheroids
#10
Jyotsna Joshi, Gautam Mahajan, Chandrasekhar R Kothapalli
Endogenous adult cardiac regenerative machinery is not capable of replacing the lost cells following myocardial infarction, often leading to permanent alterations in structure-function-mechanical properties. Regenerative therapies based on delivering autologous stem cells within an appropriate 3D milieu could meet such demand, by enabling homing and directed differentiation of the transplanted cells into lost specialized cell populations. Since type I collagen is the predominant cardiac tissue matrix protein, we here optimized the 3D niche which could promote time-dependent evolution of cardiomyogenesis from human bone marrow-derived mesenchymal stem cells (BM-MSC)...
April 17, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29509034/myocardial-healing-using-cardiac-fat
#11
Santiago Roura, Carolina Gálvez-Montón, Antoni Bayes-Genis
Chronic diseases, including myocardial scar healing and heart failure remission, impose huge social and economic burdens, and novel approaches are needed. Several therapeutic modalities are currently being evaluated, including cell therapy, stem cell conditioning, and cardiac tissue engineering. Areas covered: This review discusses the restoration of cardiac function after myocardial infarction using a vascularized flap of autologous cardiac adipose tissue over an akinetic scar. It addresses the risks and benefits of using cardiac adipose progenitors and the adipose graft transposition procedure (AGTP) to ameliorate cardiac dysfunction in preclinical and clinical trials...
April 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29452273/3d-bioprinted-functional-and-contractile-cardiac-tissue-constructs
#12
Zhan Wang, Sang Jin Lee, Heng-Jie Cheng, James J Yoo, Anthony Atala
Bioengineering of a functional cardiac tissue composed of primary cardiomyocytes has great potential for myocardial regeneration and in vitro tissue modeling. However, its applications remain limited because the cardiac tissue is a highly organized structure with unique physiologic, biomechanical, and electrical properties. In this study, we undertook a proof-of-concept study to develop a contractile cardiac tissue with cellular organization, uniformity, and scalability by using three-dimensional (3D) bioprinting strategy...
April 1, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29378324/adhesive-free-standing-multilayer-films-containing-sulfated-levan-for-biomedical-applications
#13
Tiago D Gomes, Sofia G Caridade, Maria P Sousa, Sara Azevedo, Muhammed Y Kandur, Ebru T Öner, Natália M Alves, João F Mano
This work is the first reporting the use of layer-by-layer to produce adhesive free-standing (FS) films fully produced using natural-based macromolecules: chitosan (CHI), alginate (ALG) and sulfated levan (L-S). The deposition conditions of the natural polymers were studied through zeta potential measurements and quartz crystal microbalance with dissipation monitoring analysis. The properties of the FS films were evaluated and compared with the control ones composed of only CHI and ALG in order to assess the influence of levan polysaccharide introduced in the multilayers...
March 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29371132/integrated-approaches-to-spatiotemporally-directing-angiogenesis-in-host-and-engineered-tissues
#14
REVIEW
Rajeev J Kant, Kareen L K Coulombe
The field of tissue engineering has turned towards biomimicry to solve the problem of tissue oxygenation and nutrient/waste exchange through the development of vasculature. Induction of angiogenesis and subsequent development of a vascular bed in engineered tissues is actively being pursued through combinations of physical and chemical cues, notably through the presentation of topographies and growth factors. Presenting angiogenic signals in a spatiotemporal fashion is beginning to generate improved vascular networks, which will allow for the creation of large and dense engineered tissues...
March 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29309993/engineered-cardiac-tissue-patch-maintains-structural-and-electrical-properties-after-epicardial-implantation
#15
Christopher P Jackman, Asvin M Ganapathi, Huda Asfour, Ying Qian, Brian W Allen, Yanzhen Li, Nenad Bursac
Functional cardiac tissue engineering holds promise as a candidate therapy for myocardial infarction and heart failure. Generation of "strong-contracting and fast-conducting" cardiac tissue patches capable of electromechanical coupling with host myocardium could allow efficient improvement of heart function without increased arrhythmogenic risks. Towards that goal, we engineered highly functional 1 cm × 1 cm cardiac tissue patches made of neonatal rat ventricular cells which after 2 weeks of culture exhibited force of contraction of 18...
March 2018: Biomaterials
https://www.readbyqxmd.com/read/29288823/high-resolution-3d-microscopy-study-of-cardiomyocytes-on-polymer-scaffold-nanofibers-reveals-formation-of-unusual-sheathed-structure
#16
Victor Balashov, Anton Efimov, Olga Agapova, Alexander Pogorelov, Igor Agapov, Konstantin Agladze
Building functional and robust scaffolds for engineered biological tissue requires a nanoscale mechanistic understanding of how cells use the scaffold for their growth and development. A vast majority of the scaffolds used for cardiac tissue engineering are based on polymer materials, the matrices of nanofibers. Attempts to load the polymer fibers of the scaffold with additional sophisticated features, such as electrical conductivity and controlled release of the growth factors or other biologically active molecules, as well as trying to match the mechanical features of the scaffold to those of the extracellular matrix, cannot be efficient without a detailed knowledge of how the cells are attached and strategically positioned with respect to the scaffold nanofibers at micro and nanolevel...
March 1, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29235444/contact-guidance-for-cardiac-tissue-engineering-using-3d-bioprinted-gelatin-patterned-hydrogel
#17
Ajay Tijore, Scott Alexander Irvine, Udi Sarig, Priyadarshini Mhaisalkar, Vrushali Baisane, Subbu Venkatraman
Here, we have developed a 3D bioprinted microchanneled gelatin hydrogel that promotes human mesenchymal stem cell (hMSC) myocardial commitment and supports native cardiomyocytes (CMs) contractile functionality. Firstly, we studied the effect of bioprinted microchanneled hydrogel on the alignment, elongation, and differentiation of hMSC. Notably, the cells displayed well defined F-actin anisotropy and elongated morphology on the microchanneled hydrogel, hence showing the effects of topographical control over cell behavior...
January 12, 2018: Biofabrication
https://www.readbyqxmd.com/read/29170757/human-pluripotent-stem-cell-derived-epicardial-progenitors-can-differentiate-to-endocardial-like-endothelial-cells
#18
Xiaoping Bao, Vijesh J Bhute, Tianxiao Han, Tongcheng Qian, Xiaojun Lian, Sean P Palecek
During heart development, epicardial progenitors contribute various cardiac lineages including smooth muscle cells, cardiac fibroblasts, and endothelial cells. However, their specific contribution to the human endothelium has not yet been resolved, at least in part due to the inability to expand and maintain human primary or pluripotent stem cell (hPSC)-derived epicardial cells. Here we first generated CDH5-2A-eGFP knock-in hPSC lines and differentiated them into self-renewing WT1+ epicardial cells, which gave rise to endothelial cells upon VEGF treatment in vitro ...
June 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29160940/morphological-transformation-of-hbmsc-from-2d-monolayer-to-3d-microtissue-on-low-crystallinity-sf-pcl-patch-with-promotion-of-cardiomyogenesis
#19
Hsin-Yu Lo, An-Li Huang, Pei-Chi Lee, Tze-Wen Chung, Shoei-Shen Wang
The effects of the stiffness of substrates on the cell behaviours of human bone marrow-derived mesenchymal stem cells (hBMSC) have been investigated, but the effects of the secondary structures of proteins in the substrates on the morphological transformation and differentiation of hBMSC have yet been elucidated. To investigate these issues, silk fibroin-poly(ε-caprolactone) SP cardiac patches of poly(ε-caprolactone; P), on which is grafted by silk fibroin (SF) with various β-sheet contents (or crystallinity) to provide various degrees of stiffness, were produced to examine the in vitro behaviours of hBMSC during proliferation, and cardiomyogenesis on the SP patches...
November 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29107590/human-pluripotent-stem-cell-derived-cardiac-tissue-like-constructs-for-repairing-the-infarcted-myocardium
#20
Junjun Li, Itsunari Minami, Motoko Shiozaki, Leqian Yu, Shin Yajima, Shigeru Miyagawa, Yuji Shiba, Nobuhiro Morone, Satsuki Fukushima, Momoko Yoshioka, Sisi Li, Jing Qiao, Xin Li, Lin Wang, Hidetoshi Kotera, Norio Nakatsuji, Yoshiki Sawa, Yong Chen, Li Liu
High-purity cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are promising for drug development and myocardial regeneration. However, most hiPSC-derived CMs morphologically and functionally resemble immature rather than adult CMs, which could hamper their application. Here, we obtained high-quality cardiac tissue-like constructs (CTLCs) by cultivating hiPSC-CMs on low-thickness aligned nanofibers made of biodegradable poly(D,L-lactic-co-glycolic acid) polymer. We show that multilayered and elongated CMs could be organized at high density along aligned nanofibers in a simple one-step seeding process, resulting in upregulated cardiac biomarkers and enhanced cardiac functions...
November 14, 2017: Stem Cell Reports
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