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https://www.readbyqxmd.com/read/27922179/a-carbon-dioxide-stripping-model-for-mammalian-cell-culture-in-manufacturing-scale-bioreactors
#1
Zizhuo Xing, Amanda M Lewis, Michael C Borys, Zheng Jian Li
Control of carbon dioxide within the optimum range is important in mammalian bioprocesses at the manufacturing scale in order to ensure robust cell growth, high protein yields, and consistent quality attributes. The majority of bioprocess development work is done in laboratory bioreactors, in which carbon dioxide levels are more easily controlled. Some challenges in carbon dioxide control can present themselves when cell culture processes are scaled up, because carbon dioxide accumulation is a common feature due to longer gas-residence time of mammalian cell culture in large scale bioreactors...
December 6, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27920877/simultaneous-duodenal-stenosis-and-duodenal-web-in-a-newborn
#2
James Erickson, Michele Retrouvey, Jennifer Rush, Anthony P Trace
Failure of duodenal recanalization results in a spectrum of proximal bowel obstruction from stenosis to atresia. Associations between congenital duodenal obstruction and other congenital anomalies have been well documented although the coincidence of duodenal stenosis and duodenal web is incredibly rare, posing a unique diagnostic challenge. We report a case of a full-term 4-day-old female child presented with forceful, bilious emesis and poor oral intake with decreased frequency of urination, and stooling whose initial abdominal radiograph showed several loops of gas-filled bowel in the distal stomach and proximal duodenum mimicking the classic "double-bubble" sign...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27920021/venous-and-arterial-air-embolism-a-rare-phenomenon-with-fatal-consequences
#3
Jatan Shah, Nasheena Jiwa, Natasha Mamdani, David Hill
Air embolism is often an iatrogenic complication which may occur in venous or arterial circulation depending on the port of entry. We present two cases in which air embolism occurred in venous and arterial circulation after contrast medium injection (CMI) and coronary artery bypass graft (CABG) surgery, respectively. In one case, accumulation of air bubbles was observed in the pulmonary artery after CMI. This was attributed to inadvertent injection of air owing to improper connection of the injector and the catheter...
December 5, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27915136/dynamics-of-two-interacting-bubbles-in-a-nonspherical-ultrasound-field
#4
Jinfu Liang, Xun Wang, Jing Yang, Lunxun Gong
In this paper, we present and analyze a model of the oscillations of a pair of gas bubbles driven by nonspherical ultrasound. We derived our model based on the perturbation and potential flow theories and use it to study three cases of oscillation of two bubbles under driving ultrasound with different initial phases, different separation distances between the bubbles and different sound pressure amplitudes. For the driving ultrasound with different initial phases, we obtain the in-phase and anti-phase radial pulsations of the bubbles in incompressible liquid...
November 22, 2016: Ultrasonics
https://www.readbyqxmd.com/read/27914399/dynamics-and-acoustics-of-a-spherical-bubble-rising-under-gravity-in-an-inviscid-liquid
#5
Giorgio Riccardi, Enrico De Bernardis
The rising motion and the acoustic emission of a pulsating spherical gas/vapour bubble in an isochoric, inviscid liquid are investigated. The motion is driven by the uniform and constant force field due to the gravity. The liquid is assumed at rest at the initial time. Unlike previous work on this subject, the mass of the bubble is not neglected, so that the bubble motion is accurately simulated also in the presence of large volume variations. After developing the relationships between the bubble motion to the liquid flow, a system of two nonlinear ordinary differential equations (ODEs) for the radius and the position of the center of mass of the bubble is written...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27912131/preparation-of-a-magnetic-n-fe-ac-catalyst-for-aqueous-pharmaceutical-treatment-in-heterogeneous-sonication-system
#6
Nan Zhang, He Zhao, Guangming Zhang, Shan Chong, Yucan Liu, Liyan Sun, Huazhen Chang, Ting Huang
High efficiency and facile separation are desirable for catalysts used in water treatment. In this study, a magnetic catalyst (nitrogen doped iron/activated carbon) was prepared and used for pharmaceutical wastewater treatment. The catalyst was characterized using BET, SEM, XRD, VSM and XPS. Results showed that iron and nitrogen were successfully loaded and doped, magnetic Fe2N was formed, large amount of active surface oxygen and Fe(II) were detected, and the catalyst could be easily separated from water. Diclofenac was then degraded using the catalyst in ultrasound system...
November 29, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27911524/nanobubble-fragmentation-and-bubble-free-channel-shear-localization-in-helium-irradiated-submicron-sized-copper
#7
Ming-Shuai Ding, Lin Tian, Wei-Zhong Han, Ju Li, Evan Ma, Zhi-Wei Shan
Helium bubbles are one of the typical radiation microstructures in metals and alloys, significantly influencing their deformation behavior. However, the dynamic evolution of helium bubbles under straining is less explored so far. Here, by using in situ micromechanical testing inside a transmission electron microscope, we discover that the helium bubble not only can coalesce with adjacent bubbles, but also can split into several nanoscale bubbles under tension. Alignment of the splittings along a slip line can create a bubble-free channel, which appears softer, promotes shear localization, and accelerates the failure in the shearing-off mode...
November 18, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27910306/a-high-speed-two-frame-1-2-ns-gated-x-ray-cmos-imager-used-as-a-hohlraum-diagnostic-on-the-national-ignition-facility-invited
#8
Hui Chen, N Palmer, M Dayton, A Carpenter, M B Schneider, P M Bell, D K Bradley, L D Claus, L Fang, T Hilsabeck, M Hohenberger, O S Jones, J D Kilkenny, M W Kimmel, G Robertson, G Rochau, M O Sanchez, J W Stahoviak, D C Trotter, J L Porter
A novel x-ray imager, which takes time-resolved gated images along a single line-of-sight, has been successfully implemented at the National Ignition Facility (NIF). This Gated Laser Entrance Hole diagnostic, G-LEH, incorporates a high-speed multi-frame CMOS x-ray imager developed by Sandia National Laboratories to upgrade the existing Static X-ray Imager diagnostic at NIF. The new diagnostic is capable of capturing two laser-entrance-hole images per shot on its 1024 × 448 pixels photo-detector array, with integration times as short as 1...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908050/modeling-and-parametric-investigation-of-thick-encapsulated-microbubble-s-nonspherical-oscillations
#9
Ganesh Tamadapu, Dmitry Grishenkov, Anders Eriksson
Numerous studies have been carried out in the past few decades to investigate the radial oscillations of encapsulated microbubbles (MBs). Nonspherical oscillations also have gained attention, being unavoidable in actual applications of these bubbles. The present paper is intended to describe the nature of resonance trends of such spherical and nonspherical modes of a thick encapsulated MB filled with air and suspended in water. The shell material is assumed to be linear viscoelastic and quasi-incompressible...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27906386/formation-of-surface-nanobubbles-on-nanostructured-substrates
#10
Lei Wang, Xingya Wang, Liansheng Wang, Jun Hu, Chun Lei Wang, Binyu Zhao, Xuehua Zhang, Renzhong Tai, Mengdong He, Liqun Chen, Lijuan Zhang
The nucleation and stability of nanoscale gas bubbles located at a solid/liquid interface are attracting significant research interest. It is known that the physical and chemical properties of the solid surface are crucial for the formation and properties of the surface nanobubbles. Herein, we experimentally and numerically investigated the formation of nanobubbles on nanostructured substrates. Two kinds of nanopatterned surfaces, namely, nanotrenches and nanopores, were fabricated using an electron beam lithography technique and used as substrates for the formation of nanobubbles...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27902639/air-tamponade-combined-with-nonsupine-positioning-in-macular-hole-surgery-for-pseudophakic-eyes
#11
Vegard A Forsaa, Jørgen Krohn
PURPOSE: To investigate the closure rate of primary full-thickness macular hole, following intraocular air tamponade combined with a nonsupine positioning regimen. METHODS: A prospective study of patients with full-thickness macular hole, who underwent pars plana vitrectomy with internal limiting membrane peeling and intraocular air tamponade followed by 3 days of nonsupine positioning. Outcome measures were primary full-thickness macular hole closure and improvement in best-corrected visual acuity after 6 months...
November 29, 2016: Retina
https://www.readbyqxmd.com/read/27901641/light-triggered-selective-nitration-of-psbo1-in-isolated-arabidopsis-thylakoid-membranes-is-inhibited-by-photosynthetic-electron-transport-inhibitors
#12
Misa Takahashi, Jun Shigeto, Atsushi Sakamoto, Hiromichi Morikawa
PSBO1 is exclusively nitrated when isolated thylakoid membranes are incubated in a buffer bubbled with nitrogen dioxide (NO2) containing NO2 and nitrite. NO2 is the primary intermediate for this selective nitration. Isolated thylakoid membranes were incubated in NO2-bubbled buffer at 25°C in the light or dark. Protein analysis confirmed the selective nitration of PSBO1. Illumination was found to be essential in PSBO1 nitration. A nitration mechanism whereby nitratable tyrosine residues of PSBO1 are, prior to nitration, selectively photo-oxidized by photosynthetic electron transport to tyrosyl radicals to combine with NO2 to form 3-nitrotyrosine was hypothesized...
November 30, 2016: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/27900838/periodic-oscillatory-motion-of-a-self-propelled-motor-driven-by-decomposition-of-h2-o2-by-catalase
#13
Satoshi Nakata, Mio Nomura, Hiroya Yamamoto, Shunsuke Izumi, Nobuhiko J Suematsu, Yumihiko Ikura, Takashi Amemiya
A self-propelled motor driven by the enzymatic reaction of catalase adsorbed onto a filter paper floating on an aqueous solution of H2 O2 was used to study nonlinear behavior in the motor's motion. An increase in the concentration of H2 O2 resulted in a change from no motion to irregular oscillatory motion, periodic oscillatory motion, and continuous motion. The mechanisms underlying oscillation and mode bifurcation are discussed based on experimental results on O2 bubble formation and growth on the underside of the motor...
November 30, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27896363/oxygen-ultra-fine-bubbles-water-administration-prevents-bone-loss-of-glucocorticoid-induced-osteoporosis-in-mice-by-suppressing-osteoclast-differentiation
#14
T Noguchi, K Ebina, M Hirao, T Morimoto, K Koizumi, K Kitaguchi, H Matsuoka, T Iwahashi, H Yoshikawa
: Oxygen ultra-fine bubbles (OUB) saline injection prevents bone loss of glucocorti\coid-induced osteoporosis in mice, and OUB inhibit osteoclastogenesis via RANK-TRAF6-c-Fos-NFATc1 signaling and RANK-p38 MAPK signaling in vitro. INTRODUCTION: Ultra-fine bubbles (<200 nm in diameter) have several unique properties, and they are tested in various medical fields. The purpose of this study was to investigate the effects of oxygen ultra-fine bubbles (OUB) on glucocorticoid-induced osteoporosis (GIO) model mice...
November 28, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27895847/efficacy-of-a-low-cost-bubble-cpap-system-in-treatment-of-respiratory-distress-in-a-neonatal-ward-in-malawi
#15
Kondwani Kawaza, Heather E Machen, Jocelyn Brown, Zondiwe Mwanza, Suzanne Iniguez, Al Gest, E O'Brian Smith, Maria Oden, Rebecca R Richards-Kortum, Elizabeth Molyneux
BACKGROUND: Respiratory failure is a leading cause of neonatal mortality in the developing world. Bubble continuous positive airway pressure (bCPAP) is a safe, effective intervention for infants with respiratory distress and is widely used in developed countries. Because of its high cost, bCPAP is not widely utilized in low-resource settings. We evaluated the performance of a new bCPAP system to treat severe respiratory distress in a low resource setting, comparing it to nasal oxygen therapy, the current standard of care...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27892582/lubrication-of-chocolate-during-oral-processing
#16
S A Rodrigues, N Selway, M P Morgenstern, L Motoi, J R Stokes, B J James
The structure of chocolate is drastically transformed during oral processing from a composite solid to an oil/water fluid emulsion. Using two commercial dark chocolates varying in cocoa solids content, this study develops a method to identify the factors that govern lubrication in molten chocolate and saliva's contribution to lubrication following oral processing. In addition to chocolate and its individual components, simulated boluses (molten chocolate and phosphate buffered saline), in vitro boluses (molten chocolate and whole human saliva) and ex vivo boluses (chocolate expectorated after chewing till the point of swallow) were tested...
November 28, 2016: Food & Function
https://www.readbyqxmd.com/read/27891248/synchrotron-4-dimensional-imaging-of-two-phase-flow-through-porous-media
#17
F H Kim, D Penumadu, P Patel, X Xiao, E J Garboczi, S P Moylan, M A Donmez
Near real-time visualization of complex two-phase flow in a porous medium was demonstrated with dynamic 4-dimensional (4D) (3D + time) imaging at the 2-BM beam line of the Advanced Photon Source (APS) at Argonne National Laboratory. Advancing fluid fronts through tortuous flow paths and their interactions with sand grains were clearly captured, and formations of air bubbles and capillary bridges were visualized. The intense X-ray photon flux of the synchrotron facility made 4D imaging possible, capturing the dynamic evolution of both solid and fluid phases...
2016: MRS Adv
https://www.readbyqxmd.com/read/27889888/characteristics-of-ash-and-particle-emissions-during-bubbling-fluidised-bed-combustion-of-three-types-of-residual-forest-biomass
#18
João Peres Ribeiro, Estela Domingos Vicente, Célia Alves, Xavier Querol, Fulvio Amato, Luís A C Tarelho
Combustion of residual forest biomass (RFB) derived from eucalypt (Eucalyptus globulus), pine (Pinus pinaster) and golden wattle (Acacia longifolia) was evaluated in a pilot-scale bubbling fluidised bed reactor (BFBR). During the combustion experiments, monitoring of temperature, pressure and exhaust gas composition has been made. Ash samples were collected at several locations along the furnace and flue gas treatment devices (cyclone and bag filter) after each combustion experiment and were analysed for their unburnt carbon content and chemical composition...
November 26, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27886294/the-formation-of-h-bubbles-at-small-angle-tilt-grain-boundaries-in-w-films
#19
Zhihai He, H Y He, R Ding, B C Pan, J L Chen
The accumulation of H at the small-angle tilt grain boundary (GB) in the W(001) surface is investigated, on the basis of the first-principles calculations. By exploring the solution and diffusion behaviors of H at the GB, we find that the small-angle GB can capture the H atoms nearby, serving as a nucleation site of H bubbles. With the increasing number of trapped H atoms, the GB expands gradually, and the GBs can be unripped with an areal density of H up to 5.0 × 10(15) H atoms per cm(2), leading to the formation of H bubbles...
November 25, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27885825/multiphase-fluid-solid-coupled-analysis-of-shock-bubble-stone-interaction-in-shockwave-lithotripsy
#20
K G Wang
A novel multiphase fluid-solid coupled computational framework is applied to investigate the interaction of a kidney stone immersed in liquid with a lithotripsy shock wave (LSW) and a gas bubble near the stone. The main objective is to elucidate the effects of a bubble in the shock path to the elastic and fracture behaviors of the stone. The computational framework couples a finite volume two-phase computational fluid dynamics (CFD) solver with a finite element (FE) computational solid dynamics (CSD) solver...
November 24, 2016: International Journal for Numerical Methods in Biomedical Engineering
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