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https://www.readbyqxmd.com/read/29458229/primary-closure-versus-bedside-silo-and-delayed-closure-for-gastroschisis-a-truncated-prospective-randomized-trial
#1
Ashwini S Poola, Pablo Aguayo, Jason D Fraser, Richard J Hendrickson, Katrina L Weaver, Katherine W Gonzalez, Shawn D St Peter
BACKGROUND: We report a prospective randomized trial comparing primary closure (PC) to bedside silo and delayed closure (DC) for babies with gastroschisis. METHODS: Patients were randomized to PC versus DC. We excluded those with atresia/necrosis, <34 weeks' gestation, or congenital anomalies. The primary outcome was length of stay (LOS). RESULTS: A total of 38 patients were included from August 2011 to August 2016; 18 patients underwent DC and 20 PC...
February 19, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29458200/influence-of-treatment-modality-on-morbidity-and-mortality-in-periprosthetic-femoral-fracture-a-comparative-study-of-71-fractures-treated-by-internal-fixation-or-femoral-implant-revision
#2
S Cohen, X Flecher, S Parratte, M Ollivier, J N Argenson
INTRODUCTION: The incidence of periprosthetic femoral fracture is constantly increasing, with high associated morbidity and mortality. Surgical treatment is guided by the Vancouver classification, but the influence of type of treatment on morbidity and mortality has been little analyzed. The theoretic advantage of implant revision over internal fixation is that it should allow earlier weight-bearing, although the impact of this on morbidity and mortality and autonomy has not been demonstrated...
February 16, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29458171/toxicology-studies-of-furosine-in-vitro-in-vivo-and-exploration-of-the-related-mechanism
#3
Hui-Ying Li, Lei Xing, Jia-Qi Wang, Nan Zheng
AIM: Furosine is one of the Maillard reaction products (MRPs) and is found in a variety of heat-processed food. Yet its toxicity is still unclear. The present study was designed to assess furosine toxicity in cell models and in CD-1 mice, respectively. METHODS: In vitro, the effects of furosine on the cell viability, cell cycle and apoptosis (Hek293, HepG2, SK-N-SH and Caco2) were detected and evaluated, sensitive cell lines and proper dosage of furosine for further animal experiment were determined, and the mechanisms of toxicity were explored...
February 16, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29458121/the-paradox-of-marrow-adipose-tissue-in-anorexia-nervosa
#4
Pouneh K Fazeli, Anne Klibanski
Anorexia nervosa (AN) is a psychiatric disorder characterized by inappropriate nutrient intake resulting in low body weight. Multiple hormonal adaptations facilitate decreased energy expenditure in this state of caloric deprivation including non-thyroidal illness syndrome, growth hormone resistance, and hypogonadotropic hypogonadism. Although these hormonal adaptations confer a survival advantage during periods of negative energy balance, they contribute to the long-term medical complications associated with AN, the most common of which is significant bone loss and an increased risk of fracture...
February 16, 2018: Bone
https://www.readbyqxmd.com/read/29458115/effect-of-acek-acesulfame-potassium-on-brain-function-under-dietary-restriction-in-mice
#5
Daisuke Ibi, Fumika Suzuki, Masayuki Hiramatsu
People preferably take zero or low-calorie beverages and foods with artificial sweeteners even though it has been recently suggested that long-term artificial sweetener use affects physiological functions. In addition, a lower body weight was considered to be more healthful, but an abnormally low body weight caused by an excessive diet has been reported to cause health problems. Acesulfame potassium (AceK) is one of the most commonly used for foods and beverages because of its resistance to thermal degradation and marked sweetness...
February 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29458113/poorer-positive-affect-in-response-to-self-paced-exercise-among-the-obese
#6
Hassan M Elsangedy, Paulo H D Nascimento, Daniel G S Machado, Kleverton Krinski, Sarah J Hardcastle, Sérgio G DaSilva
We aimed to investigate the association between body mass index (BMI) and affective response, ratings of perceived exertion (RPE), and physiological responses during self-paced exercise. Sixty-six women were divided into three groups accordingly with the BMI: obese (n = 22: 33.5 ± 8.5 yr; 34.9 ± 4.1 kg∙m-2 ), overweight (n = 22: 34.8 ± 8.6 yr; 26.4 ± 1.3 kg∙m-2 ), and normal-weight (n = 22: 30.8 ± 9.3 yr; 22.0 ± 1.6 kg∙m-2 ). They underwent a graded exercise test and a 20-min self-paced walking session on a treadmill...
February 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29458104/a-new-l-glutaminase-from-streptomyces-pratensis-nrc-10-gene-identification-enzyme-purification-and-characterization
#7
Sanaa E Tork, Magda M Aly, Omar Elsemin
In the current study, the purified l-glutaminase from Streptomyces pratensis NRC10 (GenBank number KC857622) was characterized. Its molecular weight was estimated to be 46 kDa and isoelectric point 7.4. Its Vmax was calculated to be 2.19 U/mg/min, while Km was 0.175 mM. The optimum pH and temperature were 9 and 45 °C, respectively. It was thermostable at 45 °C but thermally inactivated at 60 °C after 50 min. Moreover, its enzymatic activity was enhanced by K+ ions and inhibited by Mg2+ , Cu2+ , Ag+ , Hg2+ , Ni2+ , Fe2+ , Cr2 , Na+ , Ca2+ , and EDTA...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458102/%C3%AE-irradiated-chitosan-based-injectable-hydrogels-for-controlled-release-of-drug-montelukast-sodium
#8
Sadaf Hafeez, Atif Islam, Nafisa Gull, Abbas Ali, Shahzad Maqsood Khan, Saba Zia, Kalsoom Anwar, Saba Urooge Khan, Tahir Jamil
Novel pH-sensitive γ-irradiated low molecular weight chitosan (CS) (pre-irradiated) and poly (vinyl alcohol) (PVA) blended injectable hydrogels, crosslinked with varying concentrations of glycerol, were fabricated for drug delivery application. The effect of low molecular weight irradiated CS on controlled drug release was evaluated to address the problem of higher viscosity and lower solubility of high molecular weight CS. The FTIR spectra of hydrogels depicted the presence of all the incorporated functional groups and the developed interactions (physical and chemical)...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458100/characterization-and-antioxidant-activities-of-polysaccharides-from-thirteen-boletus-mushrooms
#9
Lan Zhang, Yu Hu, Xiaoyu Duan, Tingting Tang, Yingbin Shen, Bin Hu, Aiping Liu, Hong Chen, Cheng Li, Yuntao Liu
Water-soluble polysaccharides were extracted from the caps and stipes of thirteen boletus mushrooms representing five different species collected in Southwest China. Investigations of their structures and antioxidant activities allowed an evaluation of structure-function relationships. The polysaccharides were composed mainly of the monosaccharides arabinose, xylose, mannose, glucose and galactose. Most samples displayed a broad molecular weight range, with significant differences observed between the molecular weight ranges of the polysaccharides from the caps and the stipes...
February 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29458093/protective-efficacy-of-mucuna-pruriens-l-seed-meal-enriched-diet-on-growth-performance-innate-immunity-and-disease-resistance-in-oreochromis-mossambicus-against-aeromonas-hydrophila
#10
Mohamed Saiyad Musthafa, Syed Mohideen Asgari, Amitha Kurian, Elumalai Preetham, Abdul Rahman Jawahar Ali, Bilal Ahmad Paray, Mohammad K Al-Sadoon
The impact of Mucuna pruriens (L.) seed meal diet on growth performance, innate immune response, and disease resistance in Oreochromis mossambicus against Aeromonas hydrophila is reported for the first time. Infected O. mossambicus was fed with 2 g kg-1 , 4 g kg-1 , and 6 g kg-1 of M. pruriens seed meal diets significantly increased initial body weight (IBW) and final body weight (FBW) over control, for a period of 4 weeks. At 4 g kg-1 and 6 g kg-1 the enriched diet significantly (P < 0.05) enhanced the survival rate, weight gain (WG), protein efficiency ratio (PER), specific growth rate (SGR), feed conversion ratio (FCR), and feed efficiency (FE) when compared to the control; besides, from weeks 2-4 these diets significantly (P < 0...
February 16, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29458053/circulating-bile-acids-in-healthy-adults-respond-differently-to-a-dietary-pattern-characterized-by-whole-grains-legumes-and-fruits-and-vegetables-compared-to-a-diet-high-in-refined-grains-and-added-sugars-a-randomized-controlled-crossover-feeding-study
#11
Bigina N R Ginos, Sandi L Navarro, Yvonne Schwarz, Haiwei Gu, Dongfang Wang, Timothy W Randolph, Ali Shojaie, Meredith A J Hullar, Paul D Lampe, Mario Kratz, Marian L Neuhouser, Daniel Raftery, Johanna W Lampe
OBJECTIVE: The effects of diets high in refined grains on biliary and colonic bile acids have been investigated extensively. However, the effects of diets high in whole versus refined grains on circulating bile acids, which can influence glucose homeostasis and inflammation through activation of farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5), have not been studied. MATERIALS AND METHODS: We conducted a secondary analysis from a randomized controlled crossover feeding trial (NCT00622661) in 80 healthy adults (40 women/40 men, age 18-45 years) from the greater Seattle Area, half of which were normal weight (BMI 18...
February 16, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29458038/diagnosing-distensible-venous-malformations-of-the-orbit-with-diffusion-weighted-magnetic-resonance-imaging
#12
Evan Kalin-Hajdu, John B Colby, Oluwatobi Idowu, F Lawson Grumbine, Jessica M Kang, Kristin S Hirabayashi, Christine M Glastonbury, M Reza Vagefi, Robert C Kersten
PURPOSE: To compare the diffusion-weighted imaging characteristics of non-thrombosed distensible venous malformations of the orbit with that of other histologically-proven orbital tumors. DESIGN: Retrospective case-control study. METHODS: Patients with non-thrombosed distensible venous malformations of the orbit and patients with other histologically-proven orbital tumors were selected for chart review. The main outcome measure was the apparent diffusion coefficient of these lesions...
February 16, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29458021/increased-mortality-from-influenza-infection-in-long-chain-acyl-coa-dehydrogenase-knockout-mice
#13
Apurva Shinde, Jiadi Luo, Sivakama S Bharathi, Huifang Shi, Megan E Beck, Kevin J McHugh, John F Alcorn, Jieru Wang, Eric S Goetzman
We previously showed that the mitochondrial fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase (LCAD) is expressed in alveolar type II pneumocytes and that LCAD-/- mice have altered breathing mechanics and surfactant defects. Here, we hypothesized that LCAD-/- mice would be susceptible to influenza infection. Indeed, LCAD-/- mice demonstrated increased mortality following infection with 2009 pandemic influenza (A/CA/07/09). However, the mortality was not due to increased lung injury, as inflammatory cell counts, viral titers, and histology scores all showed non-significant trends toward milder injury in LCAD-/- mice...
February 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29458014/topical-delivery-of-l-theanine-ameliorates-tpa-induced-acute-skin-inflammation-via-downregulating-endothelial-pecam-1-and-neutrophil-infiltration-and-activation
#14
Wei-Jie Zeng, Zhi Tan, Xing-Fei Lai, Ya-Nan Xu, Chun-Lin Mai, Jun Zhang, Zhen-Jia Lin, Xian-Guo Liu, Shi-Li Sun, Li-Jun Zhou
l-theanine, the most abundant free amino acid in tea, has been documented to possess many different bioactive properties through oral or intragastrical delivery. However, little is known about the effect of topical delivery of l-theanine on acute inflammation. In the present study, by using 12-O-tetradecanoylphorbol-13-acetate (TPA, 2.5 μg/ear)-induced ear edema model in mice, we first found that single-dose local pretreatment of l-theanine 30 min before TPA time- and dose-dependently suppressed the increases in both skin thickness and weight...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29457986/effect-of-oral-stimulation-on-feeding-performance-and-weight-gain-in-preterm-neonates-a-randomised-controlled-trial
#15
Pareshkumar A Thakkar, H R Rohit, Rashmi Ranjan Das, Ukti P Thakkar, Amitabh Singh
Background In preterm infants, oral stimulation enhances muscle tone and movement which facilitates normal oral motor developmental patterns improving oral feeding performance. Aim To study the effects on feeding performance, transition to independent oral feeding, weight gain and length of hospital stay of an oral stimulation programme in preterm neonates. Study design This randomised controlled trial was conducted in a tertiary care teaching hospital over a period of 10 months. Altogether, 102 preterm neonates (30-34 weeks gestation) were randomised into the intervention group (oro-motor stimulation for 5 min twice a day, n = 51) or the control group (routine care only, n = 51)...
February 19, 2018: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/29457937/support-with-nutrition-for-women-receiving-chemotherapy-for-breast-cancer
#16
Fiona Gilmour, Anne Williams
Nurses are in a unique position to provide nutritional advice and information to women with breast cancer who are undergoing chemotherapy, supporting them with making decisions regarding nutrition and diet. This narrative review evaluated the research evidence relating to the nutritional challenges experienced during chemotherapy and the most effective approaches for supporting women in dietary choice. Weight gain was identified as a specific problem for women undergoing chemotherapy. The evidence indicated that information about nutrition and food preparation support may go some way in assisting women to overcome some of the nutrition-related difficulties experienced during chemotherapy treatment for breast cancer...
February 22, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29457863/the-b-type-natriuretic-peptide-is-a-useful-biomarker-for-the-estimation-of-volume-overload-in-children-with-hypertension-in-children-on-peritoneal-dialysis
#17
Joo Hoon Lee, Young Seo Park
AIM: To evaluate the usefulness of serum B-type natriuretic peptide (BNP) as a biomarker of fluid retention in hypertensive children on peritoneal dialysis (PD). METHODS: We included hypertensive children on PD. We reviewed the changes (∆) of body weight (BWt), blood pressure (BP) and serum BNP at initial and follow-up periods. We presented data as mean±standard deviation (median, minimum - maximum). Wilcoxon signed-rank test was used to evaluate the changes in BWt, BP, and BNP...
February 19, 2018: Nephrology
https://www.readbyqxmd.com/read/29457842/long-term-outcomes-of-patients-undergoing-simultaneous-liver-transplantation-and-sleeve-gastrectomy
#18
Daniel Zamora-Valdes, Kymberly D Watt, Todd A Kellogg, John J Poterucha, Sara R Di Cecco, Nicki M Francisco-Ziller, Timucin Taner, Charles B Rosen, Julie K Heimbach
BACKGROUND: Obesity is increasingly common before and after liver transplantation (LT), yet optimal management remains unclear. AIM: To analyze the long term outcomes for obese patients undergoing LT including a non-invasive weight loss program and combined LT and sleeve gastrectomy (SG). METHODS: Since 2006, all patients referred for LT with a body mass index (BMI) ≥35 kg/m2 were enrolled. Patients who achieved weight loss (BMI<35) underwent LT alone, and those who did not underwent simultaneous LT+SG...
February 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29457805/urinary-metabolomic-study-of-the-antagonistic-effect-of-p-ginseng-in-rats-with-estrogen-decline-using-ultra-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#19
He Lin, Zhongying Liu, Zifeng Pi, Lihui Men, Weijia Chen, Zhiqiang Liu
Estrogens are biologically active steroid hormones mainly released from the ovary by ovarian secretion of estrogen into the circulating blood to regulate or function at the distal target. Estrogens play an important role in the central nervous system, cardiovascular system and immune system, especially for post-menopausal women. Panax ginseng Mayer has been reported to relieve women's menopausal symptoms and affect estrogen activities. However, the mechanism of its estrogen regulation has not yet been clearly investigated...
February 19, 2018: Food & Function
https://www.readbyqxmd.com/read/29457689/halloysite-nanotubes-induced-al-accumulation-and-oxidative-damage-in-liver-of-mice-after-30-day-repeated-oral-administration
#20
Xue Wang, Jiachun Gong, Zongxiang Gui, Tingting Hu, Xiaolong Xu
Halloysite (Al2 Si2 O5 (OH)4 ·nH2 O) nanotubes (HNTs) are natural clay materials and widely applied in many fields due to their natural hollow tubular structures. Many in vitro studies indicate that HNTs exhibit a high level of biocompatibility, however the in vivo toxicity of HNTs remains unclear. The objective of this study was to assess the hepatic toxicity of the purified HNTs in mice via oral route. The purified HNTs were orally administered to mice at 5, 50, and 300 mg/kg body weight (BW) every day for 30 days...
February 19, 2018: Environmental Toxicology
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