keyword
MENU ▼
Read by QxMD icon Read
search

Polycystic ovary disease

keyword
https://www.readbyqxmd.com/read/28620546/ovarian-morphology-is-associated-with-insulin-resistance-in-women-with-polycystic-ovary-syndrome-a-cross-sectional-study
#1
Sara Pittenger Reid, Chia-Ning Kao, Lauri Pasch, Kanade Shinkai, Marcelle I Cedars, Heather G Huddleston
BACKGROUND: Polycystic ovary syndrome (PCOS) is a very common disorder well known to be associated with insulin resistance and metabolic disease. Insulin resistance is likely involved in the promotion of the PCOS reproductive phenotype and may mediate some of the ovarian morphology seen in the disorder. The phenotype of each individual woman with PCOS can vary widely as can her metabolic risk. METHODS: This is a cross-sectional study of patients seen in a multidisciplinary PCOS clinic at the University of California at San Francisco between 2006 and 2014...
2017: Fertility Research and Practice
https://www.readbyqxmd.com/read/28617068/nuclear-factor-%C3%AE%C2%BAb-expression-in-the-endometrium-of-normal-and-overweight-women-with-polycystic-ovary-syndrome
#2
Onder Koc, Safak Ozdemirici, Mustafa Acet, Ummugulsum Soyturk, Suleyman Aydin
The aim of this study was to investigate whether the expression levels of endometrial NFκB p65 differ between normal weight and overweight PCOS women and to compare them with BMI-matched control subjects without PCOS. The study group comprised 20 normal weight (BMI: 18.5-24.9 kg/m(2)) and 15 overweight PCOS women (BMI: 25-29.9 kg/m(2)) with infertility. Healthy fertile women without PCOS were recruited as the control group. The patients in the normal weight PCOS group and control group were age and BMI-matched...
June 15, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28614003/biochemical-control-during-long-term-follow-up-of-230-adult-patients-with-cushing-s-disease-a-multi-center-retrospective-study
#3
Eliza B Geer, Ismat Shafiq, Murray B Gordon, Vivien Bonert, Alejandro Ayala, Ronald S Swerdloff, Laurence Katznelson, Yelena Lalazar, Ekaterina Manuylova, Karen J Pulaski-Liebert, John D Carmichael, Zeina Hannoush, Vijaya Surampudi, Michael S Broder, Dasha Cherepanov, Marianne Eagan, Jackie Lee, Qayyim Said, Maureen P Neary, Beverly Mk Biller
OBJECTIVES: Cushing's disease (CD) results from excessive exposure to glucocorticoids caused by an adrenocorticotropic hormone-secreting pituitary tumor. Inadequately-treated CD is associated with significant morbidity and elevated mortality. Multi-center data on CD patients treated in routine clinical practice are needed to assess treatment outcomes in this rare disorder. The study purpose was to describe the burden of illness and treatment outcomes for CD patients. METHODS: Eight pituitary centers in 4 US regions participated in this multi-center retrospective chart review study...
June 14, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28612285/non-alcoholic-fatty-liver-disease-in-women-with-polycystic-ovary-syndrome-systematic-review-and-meta-analysis
#4
REVIEW
A L L Rocha, L C Faria, T C M Guimarães, G V Moreira, A L Cândido, C A Couto, F M Reis
PURPOSE: Non-alcoholic fatty liver disease (NAFLD) is an insidious pathologic condition that can manifest from simple steatosis to steatohepatitis (NASH) with potential progression to cirrhosis. Like the polycystic ovary syndrome (PCOS), NAFLD is associated with obesity, diabetes mellitus, insulin resistance and metabolic syndrome. PCOS women have an increased risk of NAFLD, but it is debatable which features of PCOS, either specific (androgen excess) or unspecific (metabolic derangements) affect the NAFLD risk...
June 13, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28610405/the-investigation-of-polymorphisms-in-dna-repair-genes-xrcc1-ape1-and-xpd-in-women-with-polycystic-ovary-syndrome
#5
Gonca Gulbay, Elif Yesilada, Onder Celik, Saim Yologlu
Background: PCOS was reported to arise from the interaction of genetic and environmental factors. Some studies reported that women with PCOS have DNA damage and chromosome breakage. Such studies bring to mind the genes that are involved in DNA repairing. At present, several DNA repair genes and, as products of these genes, certain polymorphisms that alter the activity of proteins are known in the literature. The aim of this dissertation is to study the genomic instability that have been reported in PCOS cases along with the relationship between XRCC1 Arg194Trp, XRCC1 Arg399Gln, APE1 Asp148Glu, and XPD Lys751Gln polymorphisms in order to contribute to the pathogenesis of PCOS...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28608465/effect-of-bisphenol-a-on-reproductive-processes-a-review-of-in-vitro-in-vivo-and-epidemiological-studies
#6
REVIEW
Agnieszka Tomza-Marciniak, Paulina Stępkowska, Jarosław Kuba, Bogumiła Pilarczyk
As bisphenol A (BPA) is characterized by a pronounced influence on human hormonal regulation, particular attention has been aimed at understanding its role in reproductive processes in males and females, as well as on fetal development. Owing to the increasing number of alarming reports on the negative consequences of the presence of BPA in human surroundings, more and more studies are being undertaken to clarify the negative effects of BPA on human reproductive processes. The aim of this work was to collect and summarize data on the influence of BPA exposure on reproductive health...
June 13, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28602111/genetics-of-polycystic-ovary-syndrome
#7
Kateryna Mykhalchenko, Daria Lizneva, Tatiana Trofimova, Walidah Walker, Larisa Suturina, Michael P Diamond, Ricardo Azziz
Polycystic ovary syndrome (PCOS) is a hormonal and metabolic disorder affecting 5 to 20% of reproductive-aged women worldwide that results in androgen excess, menstrual dysfunction and oligo-ovulatory subfertility, with increased risks for type 2 diabetes, endometrial adenocarcinoma, and potentially vascular disease, among other morbidities. PCOS is a complex genetic trait with strong heritability accounting for as high as 70% of the development of the disorder. Areas covered: The authors summarize the historical and recent findings of genetic studies of PCOS, such as familial studies, twin studies, and molecular genetic studies, including the results of recent genome wide associated studies...
July 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28595284/infertility-diagnosis-has-a-significant-impact-on-the-transcriptome-of-developing-blastocysts
#8
Blair R McCallie, Jason C Parks, Darren K Griffin, William B Schoolcraft, Mandy G Katz-Jaffe
STUDY QUESTION: Is the human blastocyst transcriptome associated with infertility diagnosis, specifically: polycystic ovaries (PCO), male factor (MF), and unexplained (UE)? SUMMARY ANSWER: The global blastocyst transcriptome was significantly altered in association with a PCO, MF, and UE infertility diagnosis. WHAT IS KNOWN ALREADY: Infertility diagnosis has an impact on the probability for a successful outcome following an IVF cycle. Limited information is known regarding the relationship between a specific infertility diagnosis and blastocyst transcription during pre-implantation development...
June 8, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28582566/non-classic-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency-revisited-an-update-with-a-special-focus-on-adolescent-and-adult-women
#9
Enrico Carmina, Didier Dewailly, Héctor F Escobar-Morreale, Fahrettin Kelestimur, Carlos Moran, Sharon Oberfield, Selma F Witchel, Ricardo Azziz
BACKGROUND: Non-classic congenital hyperplasia (NCAH) due to 21-hydroxylase deficiency is a common autosomal recessive disorder characterized by androgen excess. OBJECTIVE AND RATIONALE: We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of NCAH. A meta-analysis of epidemiological data was also performed. SEARCH METHODS: Peer-reviewed studies evaluating NCAH published up to October 2016 were reviewed...
June 5, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28569589/cytokine-signal-suppressor-socs-1-1478-ca-del-gene-polymorphism-in-turkish-patients-with-polycystic-ovary-syndrome
#10
Ozen Oz Gul, Soner Cander, Cuma Bulent Gul, Ferah Budak, Barbaros Oral, Canan Ersoy
Eighty-four subjects, premenopausal female patients (n = 42, mean (SD) age: 26.4 (4.2) years) diagnosed with polycystic ovary syndrome (PCOS) and age-matched healthy volunteers (n = 42, mean (SD) age: 27.6(3.4) years), were included in this study. Data on physical examination, anthropometric measurements and blood biochemistry analysis were recorded for each subject along with analysis for SOCS1-1478 CA/del polymorphism by polymerase chain reaction-restriction fragment length polymorphism. The relation of SOCS1-1478 CA/del polymorphism to PCOS status and insulin resistance was analysed via logistic regression analysis...
June 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28551304/polycystic-ovary-syndrome-understanding-the-role-of-the-brain
#11
REVIEW
Aleisha M Moore, Rebecca E Campbell
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and the leading cause of anovulatory infertility. Characterised by hyperandrogenism, menstrual dysfunction and polycystic ovaries, PCOS is a broad-spectrum disorder unlikely to stem from a single common origin. Although commonly considered an ovarian disease, the brain is now a prime suspect in both the ontogeny and pathology of PCOS. We discuss here the neuroendocrine impairments present in PCOS that implicate involvement of the brain and review evidence gained from pre-clinical models of the syndrome about the specific brain circuitry involved...
May 25, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28543550/polycystic-ovary-morphology-is-associated-with-insulin-resistance-in-women-with-polycystic-ovary-syndrome
#12
So-Hyeon Hong, Yeon-Ah Sung, Young Sun Hong, Kyungah Jeong, Hyewon Chung, Hyejin Lee
BACKGROUND/OBJECTIVES: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterised by chronic anovulation, hyperandrogenenism, polycystic ovary morphology (PCOM), and metabolic disturbances including insulin resistance and type 2 diabetes mellitus. Although insulin resistance could be associated with PCOM, recent studies have shown controversial results. The aim of this study was to determine the relationship between PCOM and insulin resistance. SUBJECTS/METHODS: This was a cross-sectional clinical study...
May 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28539732/influence-of-pcos-in-obese-vs-non-obese-women-from-mesenchymal-progenitors-stem-cells-and-other-endometrial-cells-an-in-silico-biomarker-discovery
#13
Ashvini Desai, Inamul Hasan Madar, Amjad Hussain Asangani, Hussain Al Ssadh, Iftikhar Aslam Tayubi
Polycystic ovary syndrome (PCOS) is endocrine system disease which affect women ages 18 to 44 where the women's hormones are imbalance. Recently it has been reported to occur in early age. Alteration of normal gene expression in PCOS has shown negative effects on long-term health issues. PCOS has been the responsible factor for the infertility in women of reproductive age group. Early diagnosis and treatment can improve the women's health suffering from PCOS. Earlier Studies shows correlation of PCOS upon insulin resistance with significant outcome, Current study shows the linkage between PCOS with obesity and non-obese patients...
2017: Bioinformation
https://www.readbyqxmd.com/read/28535403/the-predictive-effect-of-inflammatory-markers-and-lipid-accumulation-product-index-on-clinical-symptoms-associated-with-polycystic-ovary-syndrome-in-nonobese-adolescents-and-younger-aged-women
#14
Esra Nur Tola, Serenat Eris Yalcin, Nadiye Dugan
OBJECTIVE(S): The aim of our study is to analyse the inflammatory markers and lipid accumulation product (LAP) index in nonobese adolescents and younger aged women with polycystic ovary syndrome (PCOS) compared with age and body mass index (BMI)-matched healthy controls and to determine whether the investigated parameters are potential markers for the etiopathogenesis of PCOS. We also aim to determine whether these inflammatory markers are predictive for developing some clinical implications, such as cardiovascular disease (CVD) and insulin resistance (IR), associated with PCOS...
May 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28505284/pathogenic-anti-m%C3%A3-llerian-hormone-variants-in-polycystic-ovary-syndrome
#15
Lidija K Gorsic, Gulum Kosova, Brian Werstein, Ryan Sisk, Richard S Legro, M Geoffrey Hayes, Jose M Teixeira, Andrea Dunaif, Margrit Urbanek
CONTEXT: Polycystic ovary syndrome (PCOS), a common endocrine condition, is the leading cause of anovulatory infertility. OBJECTIVE: Given that common disease-susceptibility variants account for only a small percentage of the estimated PCOS heritability, we tested the hypothesis that rare variants contribute to this deficit in heritability. DESIGN, SETTING, AND PARTICIPANTS: Unbiased whole genome sequencing (WGS) of 80 PCOS cases and 24 reproductively normal control women identified potentially deleterious variants in AMH, the gene encoding anti-Müllerian hormone (AMH)...
May 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28500248/the-association-of-the-lipidomic-profile-with-features-of-polycystic-ovary-syndrome
#16
Lisa Moran, Piyushkumar Mundra, Helena Teede, Peter J Miekle
Polycystic ovary syndrome (PCOS) affects up to 18% of reproductive-aged women with reproductive and metabolic complications. While lipidomics can identify associations between lipid species and metabolic diseases, no research has examined the association of lipid species with the pathophysiological features of PCOS. The aim of this study was to examine the lipidomic profile in women with and without PCOS. This study was a cross-sectional study in 156 age-matched pre-menopausal women (18-45 years, BMI>25 kg/m2; n=92 with PCOS, n=64 without PCOS)...
May 12, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28493804/hereditary-renal-cystic-disorders-imaging-of-the-kidneys-and-beyond
#17
Jonathan R Dillman, Andrew T Trout, Ethan A Smith, Alexander J Towbin
The purpose of this article is to review the hereditary renal cystic diseases that can manifest in children and adults, with specific attention to pathogenesis and imaging features. Various common and uncommon hereditary renal cystic diseases are reviewed in terms of their underlying etiology, including the involved genetic mutations and the affected proteins and cellular structures. Focus is placed on the morphologic findings in each condition and the features that distinguish one disorder from another. The two most common categories of hereditary renal cystic disease are (a) the ciliopathic disorders, which are related to mutations affecting the primary cilia (called "ciliopathies"), and (b) the phakomatoses...
May 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28487551/high-free-androgen-index-is-associated-with-increased-risk-of-non-alcoholic-fatty-liver-disease-in-women-with-polycystic-ovary-syndrome-independently-of-obesity-and-insulin-resistance
#18
C Jie, W Chunhua, Z Yi, W Yuying, X Wendi, L Tzuchun, L Shengxian, W Lihua, Z Jun, S Yun, L Wei, T Tao
BACKGROUND/OBJECTIVECentral obesity and insulin resistance are common conditions in women with PCOS and in subjects with non-alcoholic fatty liver disease (NAFLD). However, few studies have addressed the association between hyperandrogenism (HA) and NAFLD. We aimed to determine whether variations in the free androgen index (FAI) might be associated with NAFLD prevalence.SUBJECTS/METHODSA cross-sectional study was performed including 400 Chinese women with PCOS and 100 age and body mass index (BMI)-matched women...
May 10, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28480767/evaluation-of-tumor-necrosis-factor-alpha-serum-level-in-obese-and-lean-women-with-clomiphene-citrate-resistant-polycystic-ovary-disease
#19
Emaduldin Seyam, Momen Hasan, Eissa M Khalifa, Ahmad Ramadan, Enas Hefzy
OBJECTIVE: The aim of this work was to investigate the level of the serum level of tumor necrosis factor alpha (TNF-α) as an inflammatory biomarker in lean and obese women with polycystic ovary disease (PCOD), who are resistant to clomiphene citrate (CCR-PCOD). PATIENTS AND DESIGN: It is a case-controlled study, where 150 (n = 150) PCOD women (study group), who are resistant to clomiphene citrate (CCR-PCOD) had been recruited, in addition to 100 (n = 100) women with PCOD, who are not resistant to clomiphene citrate (NCCR-PCOD) as the first control group, and another 100 women (n = 100) fertile women with normal reproductive health, as the second control group...
May 8, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28478824/the-role-of-aquaporins-in-polycystic-ovary-syndrome-a-way-towards-a-novel-drug-target-in-pcos
#20
Agata Wawrzkiewicz-Jałowiecka, Karolina Kowalczyk, Dagmara Pluta, Łukasz Blukacz, Paweł Madej
Aquaporins (AQPs) are transmembrane proteins, able to transport water (and in some cases also small solutes, e. g. glycerol) through the cell membrane. There are twelve types of aquaporins (AQP1-AQP12) expressed in mammalian reproductive systems. According to literature, many diseases of the reproductive organs are correlated with changes of AQPs expression and their malfunction. That is the case in the polycystic ovary syndrome (PCOS), where dysfunctions of AQPs 7-9 and alterations in its levels occur. In this work, we postulate how AQPs are involved in PCOS-related disorders, in order to emphasize their potential therapeutic meaning as a drug target...
May 2017: Medical Hypotheses
keyword
keyword
26781
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"