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Polycystic ovary disease

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https://www.readbyqxmd.com/read/28338181/gene-expression-of-inflammatory-markers-in-adipose-tissue-between-obese-women-with-polycystic-ovary-and-normal-obese-women
#1
G Alshammari, R Khan, J Brameld, S Amer, M A Lomax
OBJECTIVE: The pathogenesis of polycystic ovary syndrome (PCOS), a common endocrine disease and metabolic disturbance, is still unknown. The aim of the study was to investigate whether patients with PCOS display increased expression of inflammatory markers in adipose tissue. PATIENTS AND METHODS: Two groups of women were investigated, those diagnosed with PCOS (n = 8) and age and BMI-matched normal women (n = 12). Their age was between 20-45 years and all subjects were apparently healthy and did not take any medications...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28333180/influence-of-the-disease-label-polycystic-ovary-syndrome-on-intention-to-have-an-ultrasound-and-psychosocial-outcomes-a-randomised-online-study-in-young-women
#2
Tessa Copp, Kirsten McCaffery, Lamiae Azizi, Jenny Doust, Ben W J Mol, Jesse Jansen
STUDY QUESTION: Does the disease label 'polycystic ovary syndrome' (PCOS) have an impact on desire for medical testing and psychosocial outcomes? SUMMARY ANSWER: When given the disease label PCOS in a hypothetical scenario, participants had higher intention to have an ultrasound, perceived the condition to be more severe and had lower self-esteem than those not given the disease label. WHAT IS KNOWN ALREADY: Widening diagnostic criteria and improved imaging sensitivity have increased the number of reproductive-aged women diagnosed with PCOS from 4% to 8% to up to 21%...
February 18, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28324041/line1-cpg-dna-hypomethylation-in-granulosa-cells-and-blood-leukocytes-is-associated-with-pcos-and-related-traits
#3
Pooja Sagvekar, Vijay Mangoli, Sadhana Desai, Anushree Patil, Srabani Mukherjee
CONTEXT: Altered global DNA methylation is indicative of epigenomic instability concerning chronic disease-states. Investigating its incidence and association with polycystic ovary syndrome (PCOS) is essential towards understanding the etiopathogenesis of this disorder. OBJECTIVES: To assess, global DNA methylation differences in peripheral blood leukocytes (PBLs) and cumulus granulosa cells (CGCs) of PCOS and controls and their association with PCOS and its traits...
January 9, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28320416/effect-of-the-r92h-and-a379v-genotypes-of-platelet-activating-factor-acetylhydrolase-on-its-enzyme-activity-oxidative-stress-and-metabolic-profile-in-chinese-women-with-polycystic-ovary-syndrome
#4
Renjiao Zhang, Qi Song, Hongwei Liu, Huai Bai, Yujin Zhang, Qingqing Liu, Linbo Guan, Ping Fan
BACKGROUND: The G994T polymorphism in platelet-activating factor acetylhydrolase (PAF-AH) gene is associated with the risk of polycystic ovary syndrome (PCOS). The aim of this study was to investigate the relationship between R92H and A379V variants of the PAF-AH gene and the risk of PCOS and to evaluate the effects of the genotypes on PAF-AH activities and clinical, metabolic and oxidative stress indexes in Chinese women. METHODS: A total of 862 patients with PCOS based on the Rotterdam consensus criteria and 750 control women from a population of Chinese Han nationality in the Chengdu area were studied from 2006-2015...
March 20, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28315565/heart-rate-variability-in-normal-weight-patients-with-polycystic-ovary-syndrome
#5
Celal Kilit, Türkan Paşalı Kilit
OBJECTIVE: Polycystic ovary syndrome (PCOS) is an endocrine disease closely related to several risk factors of cardiovascular disease. Obese women with PCOS show altered autonomic modulation. The results of studies investigating cardiac autonomic functions of normal-weight women with PCOS are conflicting. The aim of the study was to assess the reactivity of cardiac sympathovagal balance in normal-weight women with PCOS by heart rate variability analysis. METHODS: We examined the heart rate variability in 60 normal-weight women with PCOS and compared them with that in 60 age-matched healthy women having a similar metabolic profile...
March 9, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28303702/studies-on-the-quality-nutrition-in-women-with-polycystic-ovary-syndrome-pcos
#6
Małgorzata Szczuko, Patrycja Sankowska, Marta Zapałowska-Chwyć, Paweł Wysokiński
Background: Polycystic ovary syndrome (PCOS) manifests itself with various symptoms, therefore it interests representatives of many medical specializations: general practitioners, gynecologists, endocrinologists, dermatologists, cardiologists and those who deal with metabolic disorders, such as dieticians. Objective: The aim of this study was perform the qualitative assessment of components of diets of women with PCOS as one of the major factor contributing to the disease...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28294594/the-anti-inflammatory-protein-kallistatin-is-associated-with-carotid-intima-media-thickness-in-women-with-polycystic-ovary-syndrome
#7
Mehmet Calan, Aslı Guler, Gokcen Unal Kocabas, Pınar Alarslan, Merve Bicer, Cetin Imamoglu, Arif Yuksel, Giray Bozkaya, Oktay Bilgir
BACKGROUND: Kallistatin is a secreted protein that acts as a tissue kallikrein inhibitor. It has antiinflammatory, antioxidant and vasoprotective properties. Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disease associated with low-grade chronic inflammation and multiple risk factors for cardiovascular diseases. The aims of this study were to ascertain whether circulating kallistatin levels are altered in women with PCOS, and whether there is an association between kallistatin and carotid intima media thickness (cIMT) as well as inflammatory markers high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α)...
March 14, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28293234/dysbiosis-of-gut-microbiota-associated-with-clinical-parameters-in-polycystic-ovary-syndrome
#8
Rui Liu, Chenhong Zhang, Yu Shi, Feng Zhang, Linxia Li, Xuejiao Wang, Yunxia Ling, Huaqing Fu, Weiping Dong, Jian Shen, Andrew Reeves, Andrew S Greenberg, Liping Zhao, Yongde Peng, Xiaoying Ding
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women. Gut microbiota has been implicated to play a critical role in metabolic diseases and may modulate the secretion of mediators of the brain-gut axis. Interaction between gut microbiota and the endocrine and biochemical disturbances in PCOS still remains elusive. Here, we showed an altered gut microbiota significantly correlated with PCOS phenotype. There were 33 patients with PCOS (non-obese PCOS individuals, PN, n = 12; obese PCOS individuals, PO, n = 21) as well as 15 control subjects (non-obese control individuals, CN, n = 9; obese control individuals, CO, n = 6) enrolled in our study...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28288674/cytochrome%C3%A2-p450-oxidoreductase-deficiency-caused-by-r457h-mutation-in-por-gene-in-chinese-case-report-and-literature-review
#9
Yang Bai, Jinhui Li, Xiaoli Wang
BACKGROUND: Cytochrome P450 oxidoreductase deficiency (PORD) is a rare disease exhibiting a variety of clinical manifestations. It can be difficult to differentiate with other diseases such as 21-hydroxylase deficiency (21-OHD), polycystic ovary syndrome (PCOS) and Antley-Bixler syndrome (ABS). Nearly 100 cases of PORD have been reported worldwide. However, the genetic characters and clinical management are still unclear, especially in China. CASE PRESENTATION: In this study, we report a 27-year-old female Chinese patient who first presented with amenorrhea and recurrence of large ovary cyst...
March 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28285614/effectiveness-of-co-treatment-with-traditional-chinese-medicine-and-letrozole-for-polycystic-ovary-syndrome-a-meta-analysis
#10
Qian-Wen Ma, Yong Tan
BACKGROUND: Polycystic ovary syndrome (PCOS) is an endocrine disease that affects gynecological health. Treatment of PCOS remains a big challenge for clinicians. OBJECTIVE: This meta-analysis was developed to compare the efficacy of co-treatment with traditional Chinese medicine (TCM) and letrozole against letrozole monotherapy in the treatment of PCOS. SEARCH STRATEGY: Randomized controlled trials (RCTs) were electronically retrieved from PubMed, Cochrane Library, China Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang Data; related papers that were not available electronically were manually checked...
March 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28284219/the-role-of-notch-signalling-in-ovarian-angiogenesis
#11
REVIEW
Qi Xie, Zuowang Cheng, Xiaocui Chen, Corrinne G Lobe, Ju Liu
In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corpus luteum to receive oxygen, nutrients and hormonal support. Abnormal angiogenesis is involved in the induction and development of pathological ovary, such as polycystic ovary syndrome and ovarian cancer. Notch signalling pathway is one of the primary regulators of angiogenesis and a therapeutic target for ovarian diseases...
March 11, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28280314/quality-of-life-in-overweight-obese-and-normal-weight-women-with-polycystic-ovary-syndrome
#12
Annalisa Panico, Giovanni Messina, Gelsy Arianna Lupoli, Roberta Lupoli, Marianna Cacciapuoti, Fiorenzo Moscatelli, Teresa Esposito, Ines Villano, Anna Valenzano, Vincenzo Monda, Antonietta Messina, Francesco Precenzano, Giuseppe Cibelli, Marcellino Monda, Giovanni Lupoli
OBJECTIVE: Polycystic ovary syndrome (PCOS) is characterized by phenotypic heterogeneity and has a wide variety of consequences. Approximately half of women with PCOS are overweight or obese, and their obesity may be a contributing factor to PCOS pathogenesis through different mechanisms. The aim of this study was to evaluate if PCOS alone affects the patients' quality of life and to what extent obesity contributes to worsen this disease. DESIGN: To evaluate the impact of PCOS on health-related quality-of-life (HRQoL), 100 Mediterranean women with PCOS (group A), 50 with a body mass index (BMI) >25 kg/m(2) (group A1) and 50 with BMI <25 kg/m(2) (group A2), were recruited...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28277130/low-birth-weight-is-a-pcos-risk-factor-for-southern-italian-women
#13
M Stracquadanio, L Ciotta
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder, characterized by chronic anovulation/oligomenorrhea, hyperandrogenism and insulin-resistance. Initial studies on the genetic basis of this disorder suggested both a maternal and paternal pattern of inheritance. Birth weight has become a main factor to consider when investigating the etiology of an adult-onset disease, since it is a simple indicator of intrauterine adverse conditions. The aim of our study is to validate the "low birth-weight" as risk factor for the development of PCOS...
February 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28277129/daytime-decrease-of-prolactin-levels-is-associated-with-pcos-regardless-to-nutritional-status-and-other-hormones-levels
#14
Grzegorz Franik, Paweł Madej, Magdalena Guz-Lem, Aleksander Owczarek, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz
OBJECTIVE: The aim of the study is to analyze daytime changes of prolactin level depending on nutritional status and polycystic ovary syndrome (PCOS). STUDY DESIGN: One hundred and fifteen (69 normal weight, 21 overweight and 25 obese) diagnosed with PCOS and 77 (37 normal weight, 18 overweight and 22 obese) women - Non-PCOS without concomitant diseases were enrolled. Body mass and height were measured and BMI was calculated. Serum concentrations of FSH, LH, E2, testosterone, TSH and PRL were determined morning 6...
February 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28276006/evaluation-of-serum-hepcidin-and-iron-levels-in-patients-with-pcos-a-case-control-study
#15
B Hossein Rashidi, S Shams, M Shariat, H Kazemi Jaliseh, M Mohebi, F Haghollahi
PURPOSE: Polycystic ovary syndrome (PCOS) is the most common cause of chronic anovulation with a prevalence of 5-10% in women of reproductive age. The etiology of this disease is not well known, and hepcidin is one of the factors affecting the pathogenesis of the disease. The aim of this study was to evaluate plasma levels of hepcidin in patients with PCOS and its correlation with serum iron level. METHODS: In this case-control study, plasma levels of hepcidin, IL-6, and ferritin using ELISA method and serum iron levels using a spectrophotometric method were tested on 56 women with PCOS (case group) and 41 healthy subjects (control group)...
March 8, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28275229/association-between-periodontal-disease-and-polycystic-ovary-syndrome-a-systematic-review
#16
REVIEW
S V Kellesarian, V R Malignaggi, T V Kellesarian, A A Al-Kheraif, M M Alwageet, H Malmstrom, G E Romanos, F Javed
The purpose of the present study was to review systematically the association between periodontal diseases (PDs) and polycystic ovary syndrome (PCOS). To address the focused question, 'Is there a relationship between PD and PCOS?' indexed databases were searched up to October 2016 without time or language restrictions using different combinations of the following key words: PCOS, ovarian cysts, PD, periodontitis, gingival diseases and gingivitis. Letters to the Editor, commentaries, historic reviews, case-report, unpublished articles and animal/experimental studies were excluded...
March 9, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28246376/altered-circulating-inflammatory-cytokines-are-associated-with-anovulatory-polycystic-ovary-syndrome-pcos-women-resistant-to-clomiphene-citrate-treatment
#17
LianLian Wang, HongBo Qi, Philip N Baker, QianNa Zhen, Qing Zeng, Rui Shi, Chao Tong, Qian Ge
BACKGROUND Polycystic ovary syndrome (PCOS) is a common gynecological disease characterized by chronic oligoanovulation, clinical/biochemical hyperandrogenism, polycystic ovaries, and insulin resistance. Accumulating evidence has shown that PCOS-related ovarian dysfunction is the main cause of anovulatory infertility. Clomiphene citrate (CC) is the first-line therapy for PCOS patients; however, approximately 15-40% PCOS patients are resistant to CC treatment. It has been demonstrated that PCOS is a chronic pro-inflammatory state, as some pro-inflammatory cytokines were elevated in the peripheral circulation of PCOS patients, but whether altered inflammatory cytokines expression in PCOS patients is associated with blunted response to CC remains unknown...
March 1, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28240757/-anti-m%C3%A3-llerian-hormone-a-brief-review-of-the-literature
#18
G Ozzola
BACKGROUND: Anti-Müllerian hormone (AMH) is a dimeric glycoprotein, which was originally identified because of its role in male sexual differentiation. In fact, AMH is expressed by the Sertoli cellsof the foetal testes and induces the regression of the Müllerian ducts. In the absence of AMH, the Müllerian ducts evolve in the uterus, fallopian tubes and in the upper part of the vagina. In women AMH is produced by granulose cells, pre-antral and antral follicles and its major physiological role in the ovaries seems to be limited to inhibiting the development of the earliest stages of follicular development...
January 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28146139/is-cardiovascular-risk-in-women-with-pcos-a-real-risk-current-insights
#19
Georgios Papadakis, Eleni Kandaraki, Olga Papalou, Andromachi Vryonidou, Evanthia Diamanti-Kandarakis
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women. PCOS incorporates not only symptoms related to the reproductive system but also a clustering of systemic metabolic abnormalities that are linked with increased risk for cardiovascular disease (CVD). More specifically, metabolic aberrations such as impaired glucose and lipid metabolism, accompanied by increased low-grade inflammation as well as elevated coagulation factors appear to contribute to the increased cardiovascular risk...
January 31, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28128085/antiphospholipid-syndrome-with-anti%C3%AE-2glicoprotein-1-antibodies-as-the-cause-of-recurrent-tibial-vein-thrombosis-in-sapho-syndrome
#20
Hanna Przepiera-Będzak, Marek Brzosko
The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism (1). SAPHO syndrome is a rare disease, characterized by specific clinical manifestations of synovitis, acne pustulosis, hyperostosis, and osteitis. It is a disease that manifests with a combination of osseous and articular manifestations associated with skin lesions (2). Venous thrombosis complicating SAPHO syndrome seems to be uncommon with an unclear pathogenesis (3-9)...
December 2016: Acta Dermatovenerologica Croatica: ADC
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