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https://www.readbyqxmd.com/read/28339674/family-history-of-systemic-lupus-erythematosus-and-risk-of-autoimmune-disease-nationwide-cohort-study-in-denmark-1977-2013
#1
Constance Jensina Ulff-Møller, Jacob Simonsen, Kirsten Ohm Kyvik, Søren Jacobsen, Morten Frisch
Objective.: To provide population-based estimates of relative risk of SLE and other autoimmune diseases (ADs) in relatives of SLE patients. Methods.: A cohort of 5 237 319 Danish residents identified through the Civil Registration System was coupled to their relatives through the parental link and followed for SLE and other ADs between 1977 and 2013 through linkage to the National Patient Register. Twin zygosity was established through the Danish Twin Registry. Hazard ratios (HRs) with 95% CIs were calculated using Cox proportional hazards regression analyses...
February 20, 2017: Rheumatology
https://www.readbyqxmd.com/read/28339591/comparison-of-the-force-levels-among-labial-and-lingual-self-ligating-and-conventional-brackets-in-simulated-misaligned-teeth
#2
Ahmad Alobeid, Tarek El-Bialy, Said Khawatmi, Cornelius Dirk, Andreas Jäger, Christoph Bourauel
Background/objective: The aim of this study was to evaluate force levels exerted by levelling arch wires with labial and lingual conventional and self-ligating brackets. Materials/methods: The tested orthodontic brackets were of the 0.022-in slot size for labial and 0.018-in for lingual brackets and were as follows: 1. Labial brackets: (i) conventional bracket (GAC-Twin, Dentsply), (ii) passive self-ligating (SL) brackets (Damon-Q®, ORMCO; Ortho classic H4™, Orthoclassic; FLI®SL, Rocky Mountain Orthodontics) and (iii) active SL brackets (GAC In-Ovation®C, DENTSPLY and SPEED™, Strite)...
January 25, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28339258/atomistic-origin-of-deformation-twinning-in-biomineral-aragonite
#3
Jialin Liu, Zaiwang Huang, Zhiliang Pan, Qiuming Wei, Xiaodong Li, Yue Qi
Deformation twinning rarely occurs in mineral materials which typically show brittle fracture. Surprisingly, it has recently been observed in the biomineral aragonite phase in nacre under high rate impact loading. In this Letter, the twinning tendency and the competition between fracture and deformation twinning were revealed by first principles calculations. The ratio of the unstable stacking fault energy and the stacking fault energy in orthorhombic aragonite is hitherto the highest in a broad range of metallic and oxide materials...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28334760/twin-primer-non-enzymatic-dna-assembly-an-efficient-and-accurate-multi-part-dna-assembly-method
#4
Jing Liang, Zihe Liu, Xi Z Low, Ee L Ang, Huimin Zhao
DNA assembly forms the cornerstone of modern synthetic biology. Despite the numerous available methods, scarless multi-fragment assembly of large plasmids remains challenging. Furthermore, the upcoming wave in molecular biological automation demands a rethinking of how we perform DNA assembly. To streamline automation workflow and minimize operator intervention, a non-enzymatic assembly method is highly desirable. Here, we report the optimization and operationalization of a process called Twin-Primer Assembly (TPA), which is a method to assemble polymerase chain reaction-amplified fragments into a plasmid without the use of enzymes...
February 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334662/the-association-between-personality-disorders-with-alcohol-use-and-misuse-a-population-based-twin-study
#5
E C Long, S H Aggen, M C Neale, G P Knudsen, R F Krueger, S C South, N Czajkowski, R Nesvåg, E Ystrom, F A Torvik, K S Kendler, N A Gillespie, T Reichborn-Kjennerud
BACKGROUND: A clearer understanding of the etiological overlap between DSM-IV personality disorders (PDs) and alcohol use (AU) and alcohol use disorder (AUD) is needed. To our knowledge, no study has modeled the association between all 10 DSM-IV PDs and lifetime AU and AUD. The aim of the present study is to identify which PDs are most strongly associated with the phenotypic, genetic, and environmental risks of lifetime AU and AUD, and to determine if these associations are stable across time...
March 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28333916/genetic-susceptibility-to-bilateral-tinnitus-in-a-swedish-twin-cohort
#6
Iris Lianne Maas, Petra Brüggemann, Teresa Requena, Jan Bulla, Niklas K Edvall, Jacob V B Hjelmborg, Agnieszka J Szczepek, Barbara Canlon, Birgit Mazurek, Jose A Lopez-Escamez, Christopher R Cederroth
PURPOSE: Genetic contributions to tinnitus have been difficult to determine due to the heterogeneity of the condition and its broad etiology. Here, we evaluated the genetic and nongenetic influences on self-reported tinnitus from the Swedish Twin Registry (STR). METHODS: Cross-sectional data from the STR was obtained. Casewise concordance rates (the risk of one twin being affected given that his/her twin partner has tinnitus) were compared for monozygotic (MZ) and dizygotic (DZ) twin pairs (N = 10,464 concordant and discordant twin pairs) and heritability coefficients (the proportion of the total variance attributable to genetic factors) were calculated using biometrical model fitting procedures...
March 23, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28333599/a-community-driven-implementation-of-the-body-and-soul-program-in-churches-in-the-twin-cities-minnesota-2011-2014
#7
Erika Ashley Pinsker, Andrew W Enzler, Megan C Hoffman, Kathleen Thiede Call, Sylvia Amos, Alfred Babington-Johnson, Kolawole Stephen Okuyemi
BACKGROUND: African Americans have high disease and death rates due to cancer and cardiovascular disease. Health promotion efforts to improve diet have the potential to reduce these rates. COMMUNITY CONTEXT: Given their importance in the community and the extent of their reach, churches are effective avenues for health promotion efforts targeting African Americans. The objectives of this project were to promote healthy eating among African American church members, engage African American churches in the implementation of Body and Soul (an evidenced-based program that encourages healthy eating), and implement the program in the community with minimal resources...
March 23, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28333527/reading-self-perceived-ability-enjoyment-and-achievement-a-genetically-informative-study-of-their-reciprocal-links-over-time
#8
Margherita Malanchini, Zhe Wang, Ivan Voronin, Victoria J Schenker, Robert Plomin, Stephen A Petrill, Yulia Kovas
Extant literature has established a consistent association between aspects of reading motivation, such as enjoyment and self-perceived ability, and reading achievement, in that more motivated readers are generally more skilled readers. However, the developmental etiology of this relation is yet to be investigated. The present study explores the development of the motivation-achievement association and its genetic and environmental underpinnings. Applying cross-lagged design in a sample of 13,825 twins, we examined the relative contribution of genetic and environmental factors to the association between reading enjoyment and self-perceived ability and reading achievement...
April 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28333502/temporal-dynamics-of-cognitive-performance-and-anxiety-across-older-adulthood
#9
Andrew J Petkus, Chandra A Reynolds, Julie Loebach Wetherell, William S Kremen, Margaret Gatz
Cognitive decline and anxiety symptoms commonly co-occur in later life, but the temporal order of changes on these two attributes is unclear. Specifically, it is unknown if greater anxiety leads to subsequent declines in cognitive performance or if worse cognitive performance leads to increased anxiety. In this study, we sought to elucidate the temporal dynamics between anxiety symptoms and cognitive performance across old age-that is, the extent to which level and change in one variable influence subsequent changes in a second variable...
March 23, 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28333325/triple-paternal-contribution-to-a-normal-complete-molar-chimeric-singleton-placenta
#10
I Ariel, D Goldman-Wohl, S Yagel, E Gazit, R Loewenthal
A comprehensive study of unusual cases of placental pathology may provide insight into mechanisms of normal human fertilization and early embryonic development by examining the exception to the rule. A gravida three para two 39-year-old woman was monitored by ultrasound from 16 weeks of gestation for cystic placenta. A female newborn was born at 36 weeks gestation. Pathologic examination of the partially cystic placenta revealed a singleton placenta comprised of 2/3 normal placenta and 1/3 complete hydatidiform mole, largely degenerated...
March 14, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333269/twin-layer-biosensor-for-real-time-monitoring-of-alkane-metabolism
#11
Tapio Lehtinen, Ville Santala, Suvi Santala
Intracellular metabolic sensors can be used for efficient screening and optimization of microbial cell factories. In particular, the sensors are useful in acquiring information about pathway dynamics and bottlenecks in a straightforward manner. Here, we developed a twin-layer biosensor which functions simultaneously at two levels: through transcription factor mediated sensing and enzyme-metabolite interaction, providing insights into the dynamics of alkane metabolism. In addition, the sensor can be used for monitoring either alkane degradation or biosynthesis, depending on the used cellular context...
March 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28333027/transfer-of-more-than-two-embryos-regardless-of-the-age-of-the-female-partner-is-not-beneficial-for-neither-the-mothers-nor-the-babies-lessons-from-the-latin-american-registry-of-assisted-reproductive-techniques
#12
Juan Enrique Schwarze, Javier Crosby
OBJECTIVE: ART has helped millions of infertile couples worldwide to overcome their childlessness. These successes have been accompanied by an increase in multiple deliveries, and perinatal complications associated. The explanation for this complication is the transfer of more than one embryo, to increase the odds of delivery. Our objective was to compare the outcome of elective dual embryo transfer (eDET) to that of the transfer of more than two embryos without embryo cryopreservation (TET), terms of delivery rate and multiple delivery...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28332220/perspectives-on-risk-assessment-of-risk-profiles-and-outcomes-among-women-planning-community-birth-in-the-united-states
#13
Marit L Bovbjerg, Melissa Cheyney, Jennifer Brown, Kim J Cox, Lawrence Leeman
BACKGROUND: There is little agreement on who is a good candidate for community (home or birth center) birth in the United States. METHODS: Data on n=47 394 midwife-attended, planned community births come from the Midwives Alliance of North America Statistics Project. Logistic regression quantified the independent contribution of 10 risk factors to maternal and neonatal outcomes. Risk factors included: primiparity, advanced maternal age, obesity, gestational diabetes, preeclampsia, postterm pregnancy, twins, breech presentation, history of cesarean and vaginal birth, and history of cesarean without history of vaginal birth...
March 22, 2017: Birth
https://www.readbyqxmd.com/read/28329721/how-many-embryos-should-be-transferred-a-validated-score-to-predict-ongoing-implantation-rate
#14
Nicolas Gatimel, Melissa Ladj, Carole Teston, Florence Lesourd, Carole Fajau, Clémentine Cohade, Jean Parinaud, Roger D Léandri
OBJECTIVE: To developed a prognostic score to predict ongoing implantation rate according to clinical and biological parameters and to choose the number of embryos to be transferred in patients undergoing IVF/ICSI. STUDY DESIGN: The transfer score was established using multivariate analysis of biological and clinical parameters in 3211 fresh embryo transfers in a retrospective study. Then we validated the score in 694 fresh embryo transfers in a prospective study...
March 8, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28327781/differentiation-between-palatal-rugae-patterns-of-twins-by-means-of-the-bri%C3%A3-%C3%A3-n-method-and-an-improved-technique
#15
Lara Maria Herrera, Raíssa Ananda Paim Strapasson, Luiz Eugênio Nigro Mazzilli, Rodolfo Francisco Haltenhoff Melani
Palatal rugae patterns are anatomic structures considered unique to each person. Monozygotic twins present similarities, however, Rugoscopy in particular, may contribute to their individualization for forensic purposes. The aims of this study were: to study the palatal rugae classifications of Briñón; to propose improvements to facilitate use of this method, if pertinent; and to characterize palatal rugae in a sample of Brazilian monozygotic twins and singletons. Precise reproducibility of the two methods of Briñón, from 1982 and 2011, was prevented by poor intra-examiner agreement (70% and 13% respectively)...
March 20, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28326449/functional-analysis-of-the-minimal-twin-arginine-translocation-system-components-from-streptococcus-thermophilus-cgmcc-7-179-in-escherichia-coli-de3
#16
Chenchen Zhang, Tingting Guo, Yongping Xin, Susu Zhang, Xudong Ouyang, Ruixia Gu, Jian Kong
The twin-arginine translocation (Tat) system, which is used for folded protein secretion, is rare in lactic acid bacteria (LAB). Previously, a Tat system composed of TatAS and TatCS subunits (the subscript S denotes a Streptococcus thermophilus origin) was identified in S. thermophilus CGMCC 7.179. In the present study, the tatA S and tatC S genes were cloned and functionally analyzed in Escherichia coli DE3 tat-deficient mutants. The E. coli tatABCDE-deficient mutant complemented with tatC S A S exhibited shortened cellular chains, but its ability to grow in the presence of sodium dodecyl sulfate (SDS) was not restored, suggesting that the S...
March 22, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28326187/a-novel-c-terminal-truncating-nr5a1-mutation-in-dizygotic-twins
#17
Atsushi Hattori, Hiroaki Zukeran, Maki Igarashi, Suzuka Toguchi, Yuji Toubaru, Takanobu Inoue, Yuko Katoh-Fukui, Maki Fukami
Nuclear receptor subfamily 5, group A, member 1 (NR5A1) is a nuclear receptor involved in gonadal and adrenal development. We identified a novel C-terminally truncating NR5A1 mutation, p.Leu423Trpfs*7, in dizygotic twins with 46,XY disorders of sex development. Our results highlight the functional importance of C-terminal region of NR5A1 and indicate that NR5A1 mutations can be associated with intrafamilial phenotypic variations, progressive testicular dysfunction, hypogonadotropic hypogonadism, and borderline adrenal dysfunction...
2017: Human Genome Variation
https://www.readbyqxmd.com/read/28325242/radiation-oncology-in-india-challenges-and-opportunities
#18
REVIEW
Surbhi Grover, Shivakumar Gudi, Ajeet Kumar Gandhi, Priya M Puri, Adam C Olson, Danielle Rodin, Onyi Balogun, Preet K Dhillon, Daya Nand Sharma, Goura Kishor Rath, Shyam Kishore Shrivastava, Akila N Viswanathan, Umesh Mahantshetty
Rising cancer incidence and mortality in India emphasize the need to address the increasing burden of this disease and the stark inequities in access to radiotherapy and other essential medical treatments. State-of-the-art technology is available within the private sector and a few hospitals in the public sector, but 75% of patients in the public sector in India do not have access to timely radiotherapy. This inequity in access to radiotherapy in the public sector is amplified in rural areas, where most of India׳s population lives...
April 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28325237/global-health-in-radiation-oncology-the-emergence-of-a-new-career-pathway
#19
REVIEW
Danielle Rodin, Mei Ling Yap, Surbhi Grover, John M Longo, Onyinye Balogun, Sandra Turner, Jesper G Eriksen, C Norman Coleman, Meredith Giuliani
The massive global shortfall in radiotherapy equipment and human resources in developing countries is an enormous challenge for international efforts in cancer control. This lack of access to treatment has been long-standing, but there is now a growing consensus about the urgent need to prioritize solutions to this problem and that a global strategy is required for them to be successful. An essential element of making radiotherapy universally accessible is a coordinated approach to clinical training and practice...
April 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28325122/the-predicting-factors-and-outcomes-of-caesarean-section-of-the-second-twin
#20
Choi Wah Kong, William Wing Kee To
The aim of this study was to review the indications for caesarean delivery of second twins after vaginal delivery of a first twin (combined delivery) and the associated foetal outcomes of the second twin. Possible factors that could be employed to predict combined delivery were explored. This was a retrospective review of all twin pregnancies delivered in a tertiary maternity unit between 2000 and 2013. All twins (> =24 week gestation) with vaginal delivery of the first twin were reviewed. Of a total of 1039 pairs of twins, 441 pairs had vaginal delivery of the first twin, of which 47 (10...
March 21, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
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