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https://www.readbyqxmd.com/read/29684559/a-novel-approach-to-support-formulation-design-on-twin-screw-wet-granulation-technology-understanding-the-impact-of-overarching-excipient-properties-on-drug-product-quality-attributes
#1
N Willecke, A Szepes, M Wunderlich, J P Remon, C Vervaet, T De Beer
The overall objective of this work is to understand how excipient characteristics influence the drug product quality attributes and process performance of a continuous twin screw wet granulation process. The knowledge gained in this study is intended to be used for Quality by Design (QbD)-based formulation design and formulation optimization. Three principal components which represent the overarching properties of 8 selected pharmaceutical fillers were used as factors, whereas factors 4 and 5 represented binder type and binder concentration in a design of experiments (DoE)...
April 20, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29684289/lonely-young-adults-in-modern-britain-findings-from-an-epidemiological-cohort-study
#2
Timothy Matthews, Andrea Danese, Avshalom Caspi, Helen L Fisher, Sidra Goldman-Mellor, Agnieszka Kepa, Terrie E Moffitt, Candice L Odgers, Louise Arseneault
BACKGROUND: The aim of this study was to build a detailed, integrative profile of the correlates of young adults' feelings of loneliness, in terms of their current health and functioning and their childhood experiences and circumstances. METHODS: Data were drawn from the Environmental Risk Longitudinal Twin Study, a birth cohort of 2232 individuals born in England and Wales in 1994 and 1995. Loneliness was measured when participants were aged 18. Regression analyses were used to test concurrent associations between loneliness and health and functioning in young adulthood...
April 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29683524/fetal-sex-determination-in-twin-pregnancies-using-cell-free-fetal-dna-analysis
#3
Miguel Milan, Emilia Mateu, David Blesa, Monica Clemente-Ciscar, Carlos Simon
OBJECTIVE(S): We sought to develop an accurate sex classification method in twin pregnancies using data obtained from a standard commercial non-invasive prenatal test. STUDY DESIGN: A total of 706 twin pregnancies were included in this retrospective analytical data study. Normalized chromosome values for chromosomes X and Y were used and adapted into a sex-score to predict fetal sex in each fetus and results were compared to the clinical outcome at birth. RESULTS: Outcome information at birth for sex chromosomes was available for 232 twin pregnancies...
April 23, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29683187/early-warm-rewarding-parenting-moderates-the-genetic-contributions-to-callous-unemotional-traits-in-childhood
#4
Jeffrey Henry, Ginette Dionne, Essi Viding, Frank Vitaro, Mara Brendgen, Richard E Tremblay, Michel Boivin
BACKGROUND: Previous gene-environment interaction studies of CU traits have relied on the candidate gene approach, which does not account for the entire genetic load of complex phenotypes. Moreover, these studies have not examined the role of positive environmental factors such as warm/rewarding parenting. The aim of the present study was to determine whether early warm/rewarding parenting moderates the genetic contributions (i.e., heritability) to callous-unemotional (CU) traits at school age...
April 23, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29683105/a-discordance-weighting-approach-estimating-occupational-and-income-returns-to-education
#5
Matthew A Andersson
Schooling differences between identical twins are often utilized as a natural experiment to estimate returns to education. Despite longstanding doubts about the truly random nature of within-twin-pair schooling discordance, such discordance has not yet been understood comprehensively, in terms of diverse between- and within-family peer, academic, familial, social, and health exposures. Here, a predictive analysis using national U.S. midlife twin data shows that within-pair schooling differences are endogenous to a variety of childhood exposures...
April 23, 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29682734/the-role-of-pericardial-adipose-tissue-in-the-heart-of-obese-minipigs
#6
Chia-Yu Wang, Sin-Jin Li, Twin-Way Wu, Han-Jen Lin, Jyun-Wei Chen, Harry J Mersmann, Shih-Torng Ding, Ching-Yi Chen
BACKGROUND: Pericardial adipose tissue (PAT) volume is highly associated with the presence and severity of cardiometabolic diseases, but the underlying mechanism is unknown. We previously demonstrated that a high-fat diet (HFD) induced metabolic dysregulation, cardiac fibrosis, and accumulation of more PAT in minipigs. This study used our obese minipig model to investigate the characteristics of PAT and omental visceral fat (VAT) induced by a HFD, and the potential link between PAT and HFD-related myocardial fibrosis...
April 23, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29682271/eu-aims-longitudinal-european-autism-project-leap-the-autism-twin-cohort
#7
Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K Buitelaar, Eva Loth, Declan G M Murphy, Will Spooren, Sven Bölte
EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has recruited and comprehensively phenotyped a rare sample of 76 monozygotic and dizygotic twins, discordant, or concordant for ASD plus 30 typically developing twins. The aim of this letter is to complete previous descriptions of the LEAP case-control sample, clinically characterize, and investigate the suitability of the sample for ASD twin-control analyses purposes and share some 'lessons learnt...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29681134/an-audit-of-pregnancy-outcomes-in-solid-organ-transplant-recipients-at-a-metropolitan-hospital
#8
Yunjing E Fang, Roshini Nayyar, Hayley Diplock
BACKGROUND: Pregnancies in patients with solid organ transplants have higher rates of complications and caesarean sections (CS). AIM: To perform an audit of the pregnancy outcomes in transplant recipients, to determine the rate of CS in our cohort, the appropriate skin incision for CS in these patients and to formulate recommendations for preoperative planning. MATERIALS AND METHODS: This is a retrospective cohort study. All patients who had a solid organ transplant were identified from the obstetrics database...
April 22, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29680387/prevalence-of-twin-foaling-and-blood-chimaerism-in-purebred-spanish-horses
#9
G Anaya, M E Fernández, M Valera, A Molina, F Azcona, P Azor, M Solé, M Moreno-Millán, S Demyda-Peyrás
Twin foaling is associated with chimaerism in several domestic species and is recognised in horses. In this study, 21,097 purebred Spanish (Pura Raza Español) horse births from the 2015 to 2016 breeding season were investigated for chimaerism. Twin foaled and chimaeric individuals were assessed on the basis of foaling records, short-tandem repeat (STR) parentage test results and a sex-linked STR-based technique. Fourteen twin pregnancies with 23 twin foals born alive were identified (0.066% twin foaling prevalence), including five blood chimaeric cases (21...
April 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29679193/etiology-of-stability-and-growth-of-internalizing-and-externalizing-behavior-problems-across-childhood-and-adolescence
#10
Alexander S Hatoum, Soo Hyun Rhee, Robin P Corley, John K Hewitt, Naomi P Friedman
Internalizing and externalizing behaviors are heritable, and show genetic stability during childhood and adolescence. Less work has explored how genes influence individual differences in developmental trajectories. We estimated ACE biometrical latent growth curve models for the Teacher Report Form (TRF) and parent Child Behavior Checklist (CBCL) internalizing and externalizing scales from ages 7 to 16 years in 408 twin pairs from the Colorado Longitudinal Twin Study. We found that Intercept factors were highly heritable for both internalizing and externalizing behaviors (a2 = ...
April 20, 2018: Behavior Genetics
https://www.readbyqxmd.com/read/29678464/biofilm-inhibition-and-anti-candida-activity-of-a-cationic-lipo-benzamide-molecule-with-twin-nonyl-chain
#11
Tushar Jain, Prathap Reddy Muktapuram, Komal Sharma, Owk Ravi, Garima Pant, Kalyan Mitra, Surendar Reddy Bathula, Dibyendu Banerjee
A series of cationic lipo-benzamide compounds with varying lengths of hydrocarbon chains (C2M-C18M) were evaluated for anti-Candida activity. Four compounds harbouring 8-11 hydrocarbon chains demonstrated concentration-dependent inhibition of fungal cell growth with Minimum Inhibitory Concentration (MIC) of ≤6.2 µg ml-1 . The most active compound (C9M) inhibited growth of both Candida albicans and non-albicans strains and is equally active against pairs of azole sensitive and resistant clinical isolates of C...
April 12, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29678353/the-predictive-value-of-the-sflt-1-plgf-ratio-on-short-term-absence-of-preeclampsia-and-maternal-and-fetal-or-neonatal-complications-in-twin-pregnancies
#12
Langeza Saleh, Sarea I M Tahitu, A H Jan Danser, Anton H van den Meiracker, Willy Visser
OBJECTIVE: A sFlt-1/PlGF ratio of ≤38 has been reported to predict the absence of preeclampsia (PE) in singleton pregnancies. We evaluated whether a sFlt-1/PlGF ratio of ≤38 could be used to predict the absence of PE in twin pregnancies and maternal and fetal/neonatal complications. METHODS: This is a secondary analysis of a prospective multicenter cohort study that enrolled women with suspected or confirmed PE with the aim of evaluating the use of the sFlt-1, PlGF and their ratio to predict maternal and fetal/neonatal complications...
March 26, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29677780/microstructural-evolution-of-super304h-upon-ultrasonic-shot-peening-and-subsequent-annealing
#13
Kyeongae Nam, Yinsheng He, Keesam Shin
In this study we analyze the effect of shot peening on the microstructure and mechanical properties of Super304H, which is widely used for boiler tubes. Specimens were shot peened for 5, 10, and 15 minutes, and then heat treated at 600, 700, and 800 °C for 15 minutes. Vickers hardness was measured and the microstructure of cross sectional specimens was analyzed by scanning electron microscopy (SEM), electron backscattered diffraction (EBSD) and transmission electron microscopy (TEM). Heat treatment led to particle refinement on the upper layer of Super304H...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677622/genetic-correlations-between-wellbeing-depression-and-anxiety-symptoms-and-behavioral-responses-to-the-emotional-faces-task-in-healthy-twins
#14
Kylie M Routledge, Leanne M Williams, Anthony W F Harris, Peter R Schofield, C Richard Clark, Justine M Gatt
Currently there is a very limited understanding of how mental wellbeing versus anxiety and depression symptoms are associated with emotion processing behaviour. For the first time, we examined these associations using a behavioural emotion task of positive and negative facial expressions in 1668 healthy adult twins. Linear mixed model results suggested faster reaction times to happy facial expressions was associated with higher wellbeing scores, and slower reaction times with higher depression and anxiety scores...
March 19, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29676837/twelve-year-follow-up-of-chronic-pain-in-twins-changes-in-environmental-and-genetic-influence-over-time
#15
A Burri, S Ogata, D Rice, F M K Williams
BACKGROUND: While genetic influences on chronic pain have been repeatedly demonstrated, we do not know whether these effects are stable or dynamic over time. AIMS: To determine the temporal pattern of genetic and environmental effects to individual differences in chronic pain over 12 years, using a sample of N = 961 female twins. METHODS: Data on chronic pain was collected in 2004 (T1) and 2016 (T2) using the same comprehensive body map which divides the body into 31 distinct anatomical areas...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29676599/psoriasis-in-pregnancy-case-series-and-literature-review-of-data-concerning-exposure-during-pregnancy-to-ustekinumab
#16
M Galluzzo, S D'Adamio, L Bianchi, M Talamonti
Psoriasis tends to improve for approximately half of patients during pregnancy, but an equal number of patients report no change or worsening during this period, when lots of medications, like biologics, are not indicated. The aim of our study was to review data of patient that had been pregnant during ustekinumab treatment, analyzing data of our data set between September 2010 and February 2018. We found data of three patients that had been pregnant during ustekinumab treatment. All three patients successfully completed the pregnancy without complications...
April 20, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29676501/the-canary-in-the-coal-mine-continence-care-for-people-with-dementia-in-acute-hospital-wards-as-a-crisis-of-dehumanization
#17
Paula Boddington, Katie Featherstone
Continence is a key moment of care that can tell us about the wider care of people living with dementia within acute hospital wards. The spotlight is currently on the quality of hospital care of older people across the UK, yet concerns persist about their poor treatment, neglect, abuse, and discrimination within this setting. Thus, within hospitals, the care of people living with dementia is both a welfare issue and a human rights issue. The challenge of continence care for people living with dementia can be seen as the 'canary in the coal mine' for the unravelling of dignity within the acute setting...
May 2018: Bioethics
https://www.readbyqxmd.com/read/29675904/risk-factors-for-fetal-death-after-radiofrequency-ablation-for-complicated-monochorionic-twin-pregnancies
#18
Luming Sun, Gang Zou, Yingjun Yang, Fenhe Zhou, Duan Tao
OBJECTIVE: Radiofrequency ablation (RFA) is a management alternative for complicated monochorionic twin pregnancies. The purpose of this study is to evaluate risk factors for fetal death after RFA. METHODS: An observational study was performed to document the perinatal outcomes of all cases undergoing fetal reduction using RFA from 2010 to 2016 at the Shanghai First Maternity and Infant Hospital. A multiple regression model was built to identify predictors of the death of the remaining fetus after RFA...
April 19, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29675634/investigation-of-circle-of-willis-variants-and-hemodynamic-parameters-in-twins-using-transcranial-color-coded-doppler-sonography
#19
Bianka Forgó, Ádám Domonkos Tárnoki, Dávid László Tárnoki, Levente Littvay, Corrado Fagnani, Maria Antonietta Stazi, Giorgio Meneghetti, Emanuela Medda, Filippo Farina, Claudio Baracchini
Morphological and hemodynamic variations of the circle of Willis (CW) may have an important impact on cerebrovascular events. However, the environmental and genetic influence remains unclear. For this reason we studied the variations and hemodynamic parameters of the CW in twins using transcranial color-coded sonography (TCCS). Sixty-four twins, 19 monozygotic (MZ) and 13 dizygotic (DZ) pairs from the Italian Twin Registry (average age 45.0 ± 13.7 years) underwent TCCS and risk factor assessment. We examined CW morphology and recorded peak systolic velocity (PSV), end-diastolic velocity (EDV) and pulsatility index (PI)...
April 19, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29675585/saddle-slow-manifolds-and-canard-orbits-in-formula-see-text-and-application-to-the-full-hodgkin-huxley-model
#20
Cris R Hasan, Bernd Krauskopf, Hinke M Osinga
Many physiological phenomena have the property that some variables evolve much faster than others. For example, neuron models typically involve observable differences in time scales. The Hodgkin-Huxley model is well known for explaining the ionic mechanism that generates the action potential in the squid giant axon. Rubin and Wechselberger (Biol. Cybern. 97:5-32, 2007) nondimensionalized this model and obtained a singularly perturbed system with two fast, two slow variables, and an explicit time-scale ratio ε...
April 19, 2018: Journal of Mathematical Neuroscience
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