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https://www.readbyqxmd.com/read/29150862/randomised-crossover-trial-showed-that-using-breast-milk-or-sucrose-provided-the-same-analgesic-effect-in-preterm-infants-of-at-least-28-weeks
#1
L Collados-Gómez, P Ferrera-Camacho, E Fernandez-Serrano, V Camacho-Vicente, C Flores-Herrero, A M García-Pozo, R Jiménez-García
AIM: Repeated, on-going exposure to pain influences the growth, cognitive and motor functions, behaviour, personality and neurodevelopment of preterm infants. We compared the analgesic effects of expressed breast milk and 24% oral sucrose on preterm neonates during venipuncture. METHODS: This multicentre randomised, non-inferiority, cross-over trial focused on five neonatal university units in Madrid, Spain, from October 2013 to October 2014. It comprised 66 preterm infants born at less than 37 weeks and randomly split into two groups...
November 18, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29150469/impact-of-preterm-birth-on-parental-separation-a-french-population-based-longitudinal-study
#2
Simon Nusinovici, Bertrand Olliac, Cyril Flamant, Jean-Baptiste Müller, Marion Olivier, Valérie Rouger, Géraldine Gascoin, Hélène Basset, Charlotte Bouvard, Jean-Christophe Rozé, Matthieu Hanf
OBJECTIVE: The objective of this study was to investigate both the effects of low gestational age and infant's neurodevelopmental outcome at 2 years of age on the risk of parental separation within 7 years of giving birth. DESIGN: Prospective. SETTING: 24 maternity clinics in the Pays-de-la-Loire region. PARTICIPANTS: This study included 5732 infants delivered at <35 weeks of gestation born between 2005 and 2013 who were enrolled in the population-based Loire Infant Follow-up Team cohort and who had a neurodevelopmental evaluation at 2 years...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29149620/the-dopamine-d4-receptor-gene-birth-weight-maternal-depression-maternal-attention-and-the-prediction-of-disorganized-attachment-at-36-months-of-age-a-prospective-gene%C3%A3-environment-analysis
#3
Justin Graffi, Ellen Moss, Alexia Jolicoeur-Martineau, Gal Moss, Vanessa Lecompte, Katherine Pascuzzo, Vanessa Babineau, Cathryn Gordon-Green, Viara R Mileva-Seitz, Klaus Minde, Roberto Sassi, Meir Steiner, James L Kennedy, Helene Gaudreau, Robert Levitan, Michael J Meaney, Ashley Wazana
BACKGROUND: Efforts to understand the developmental pathways for disorganized attachment reflect the importance of disorganized attachment on the prediction of future psychopathology. The inconsistent findings on the prediction of disorganized attachment from the dopamine D4 receptor (DRD4) gene, birth weight, and maternal depression as well as the evidence supporting the contribution of early maternal care, suggest the importance of exploring a gene by environment model. METHODS: Our sample is from the Maternal Adversity, Vulnerability, and Neurodevelopment project; consisting of 655 mother-child dyads...
November 14, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/29149272/use-of-paracetamol-ibuprofen-or-aspirin-in-pregnancy-and-risk-of-cerebral-palsy-in-the-child
#4
Tanja Gram Petersen, Zeyan Liew, Anne-Marie Nybo Andersen, Guro L Andersen, Per Kragh Andersen, Torben Martinussen, Jørn Olsen, Cristina Rebordosa, Mette Christophersen Tollånes, Peter Uldall, Allen J Wilcox, Katrine Strandberg-Larsen
Background: It has been debated whether mild analgesics, mainly paracetamol, adversely affect aspects of neurodevelopment. We examined whether mother's use of paracetamol, aspirin or ibuprofen in pregnancy is associated with increased risk of cerebral palsy (CP) in the child. Method: We included 185 617 mother-child pairs from the Danish National Birth Cohort and the Norwegian Mother and Child Cohort Study. We created harmonized definitions of analgesic use in pregnancy, as well as indications for analgesic use and other potential confounders...
November 14, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29140226/childhood-inflammatory-markers-and-intelligence-as-predictors-of-subsequent-persistent-depressive-symptoms-a-longitudinal-cohort-study
#5
G M Khandaker, J Stochl, S Zammit, I Goodyer, G Lewis, P B Jones
BACKGROUND: To identify developmental sub-groups of depressive symptoms during the second decade of life, a critical period of brain development, using data from a prospective birth cohort. To test whether childhood intelligence and inflammatory markers are associated with subsequent persistent depressive symptoms. METHODS: IQ, a proxy for neurodevelopment, was measured at age 8 years. Interleukin 6 (IL-6) and C-reactive protein, typical inflammatory markers, were measured at age 9 years...
November 15, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29138588/rai1-gene-mutations-mechanisms-of-smith-magenis-syndrome
#6
REVIEW
Mariateresa Falco, Sonia Amabile, Fabio Acquaviva
Smith-Magenis syndrome (SMS; OMIM #182290) is a complex genetic disorder characterized by distinctive physical features, developmental delay, cognitive impairment, and a typical behavioral phenotype. SMS is caused by interstitial 17p11.2 deletions, encompassing multiple genes and including the retinoic acid-induced 1 gene (RAI1), or by mutations in RAI1 itself. About 10% of all the SMS patients, in fact, carry an RAI1 mutation responsible for the phenotype. RAI1 (OMIM *607642) is a dosage-sensitive gene expressed in many tissues and highly conserved among species...
2017: Application of Clinical Genetics
https://www.readbyqxmd.com/read/29138398/characterization-of-macrophages-from-schizophrenia-patients
#7
Paul R Ormel, Hans C van Mierlo, Manja Litjens, Miriam E van Strien, Elly M Hol, René S Kahn, Lot D de Witte
Genetic, epidemiological and post mortem studies have described an association between schizophrenia (SCZ) and the immune system. Microglia, the tissue-resident macrophages of the brain, not only play an essential role in inflammatory processes, but also in neurodevelopment and synapse refinement. It has therefore been hypothesized that aberrant functioning of these myeloid immune cells is involved in SCZ pathogenesis. Until now cellular research into the role of myeloid cells in SCZ has been limited to monocytes and functional assays are lacking...
November 14, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29137191/maternal-iodine-intake-and-offspring-attention-deficit-hyperactivity-disorder-results-from-a-large-prospective-cohort-study
#8
Marianne Hope Abel, Eivind Ystrom, Ida Henriette Caspersen, Helle Margrete Meltzer, Heidi Aase, Liv Elin Torheim, Ragna Bugge Askeland, Ted Reichborn-Kjennerud, Anne Lise Brantsæter
Current knowledge about the relationship between mild to moderately inadequate maternal iodine intake and/or supplemental iodine on child neurodevelopment is sparse. Using information from 77,164 mother-child pairs in the Norwegian Mother and Child Cohort Study, this study explored associations between maternal iodine intake and child attention-deficit/hyperactivity disorder (ADHD) diagnosis, registered in the Norwegian Patient Registry and maternally-reported child ADHD symptoms at eight years of age. Pregnant women reported food and supplement intakes by questionnaire in gestational week 22...
November 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29136542/cognition-and-behaviour-in-children-with-congenital-abdominal-wall-defects
#9
Alice C Burnett, Julia K Gunn, Esther A Hutchinson, Margaret M Moran, Lisa M Kelly, Ursula C Sevil, Peter J Anderson, Rod W Hunt
AIM: To characterise neurodevelopment at age two years and cognition and behaviour at age five years in children born with abdominal wall defects (gastroschisis or exomphalos). STUDY DESIGN: Participants were treated as neonates for gastroschisis or exomphalos and invited for routine clinical follow-up at ages two and five years. Thirty-nine two year-olds and 20 five year-olds with gastroschisis and 20 two year-olds and 10 five year-olds with exomphalos returned for age-appropriate assessments of development (two years) and intellectual functioning (IQ), executive function, and behavioural problems...
November 11, 2017: Early Human Development
https://www.readbyqxmd.com/read/29136227/developmental-outcome-of-9-year-old-children-born-after-pgs-follow-up-of-a-randomized-trial
#10
Derk Kuiper, Anne Bennema, Sacha la Bastide-van Gemert, Jorien Seggers, Pamela Schendelaar, Sebastiaan Mastenbroek, Annemieke Hoek, Maas Jan Heineman, Tessa J Roseboom, Joke H Kok, Mijna Hadders-Algra
STUDY QUESTION: Does Day-3 cleavage-stage PGS affect neurodevelopment of 9-year-old IVF offspring? SUMMARY ANSWER: We did not find evidence of adverse consequences of Day-3 cleavage-stage PGS on neurodevelopment of 9-year-old IVF offspring, although children born after IVF with or without PGS often had a non-optimal neurological condition. WHAT IS KNOWN ALREADY: Knowledge on long-term sequelae for development and health of children born following PGS is lacking...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29133434/pkd1-promotes-functional-synapse-formation-coordinated-with-n-cadherin-in-hippocampus
#11
Cheng Cen, Li-Da Luo, Wen-Qi Li, Gang Li, Na-Xi Tian, Ge Zheng, Dong-Min Yin, Yimin Zou, Yun Wang
Functional synapse formation is critical for the wiring of neural circuits in the developing brain. The cell adhesion molecule N-cadherin plays important roles in target recognition and synaptogenesis. However, the molecular mechanisms that regulate the localization of N-cadherin and the subsequent effects remain poorly understood. Here, we show that protein kinase D1 (PKD1) directly binds to N-cadherin at amino acid residues 836-871 and phosphorylates it at Ser 869, 871, 872, thereby increasing the surface localization of N-cadherin and promoting functional synapse formation in primary cultured hippocampal neurons obtained from embryonic day 18 rat embryos of either sex...
November 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29130702/-short-medium-and-long-term-benefits-of-human-milk-intake-in-very-low-birth-weight-infants
#12
Bibiana Chinea Jiménez, Yumana Awad Parada, Antonio Villarino Marín, Miguel Sáenz de Pipaón Marcos
AIM: The aim of the present study is to evaluate the effect of human milk feeding during the first weeks of life in very low birth weight infants on weight gain at discharge, length of hospitalization, postmenstrual age at discharge and nutritional assessment, growth and neurodevelopment at two and five years. MATERIAL AND METHODS: Longitudinal study of very-low-birth-weight infants (< 1,500 grams) admitted to the Neonatal Intensive Care Unit of La Paz University Hospital, from January 1st 2009 to December 31st 2009, followed in the follow-up clinic...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29130288/optimising-early-neonatal-nutrition-using-translational-research-methodology
#13
Denise Page, Melissa Gilroy, Elizabeth Hurrion, Lisa Clark, Shelley Wilkinson
AIM: Preterm birth has been described as a 'nutritional emergency', with these infants often born with minimal nutrition reserves. Failure to provide adequate early nutrition jeopardises growth and neurodevelopment. Consensual nutrition guidelines exist for infants who weigh <1500 g; however, audits have identified shortfalls in their adherence, consequently highlighting an evidence-practice gap. This work aimed to identify the barriers to the delivery of early optimal nutrition in a tertiary-level Neonatal Critical Care Unit to inform an implementation project to ensure best practice care...
November 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29129673/making-an-unknown-unknown-a-known-unknown-missing-data-in-longitudinal-neuroimaging-studies
#14
REVIEW
Tyler H Matta, John C Flournoy, Michelle L Byrne
The analysis of longitudinal neuroimaging data within the massively univariate framework provides the opportunity to study empirical questions about neurodevelopment. Missing outcome data are an all-to-common feature of any longitudinal study, a feature that, if handled improperly, can reduce statistical power and lead to biased parameter estimates. The goal of this paper is to provide conceptual clarity of the issues and non-issues that arise from analyzing incomplete data in longitudinal studies with particular focus on neuroimaging data...
October 28, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29128679/early-onset-epileptic-encephalopathy-with-de-novo-scn8a-mutation
#15
Yangyang Xiao, Jie Xiong, Ding'an Mao, Lingjuan Liu, Jian Li, Xingfang Li, Haiyan Luo, Liqun Liu
Early-onset epileptic encephalopathies (EOEEs) are clinically and genetically heterogeneous disorders characterized by intractable seizures and unremitting interictal paroxysmal epileptiform activity. Consequently, these syndromes impair neurodevelopment during the first year of life. Currently, the etiology of these disorders is largely unknown. In this study, Childhood-Onset Epilepsy Gene Panel Testing (containing 511 epilepsy-related genes) was performed in a parent-offspring trio. In this family, the son had refractory seizures, intellectual disability, and motor abnormalities, and he was diagnosed with EOEE...
October 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29127884/regional-dysregulation-of-taurine-and-related-amino-acids-in-the-fetal-rat-brain-following-gestational-alcohol-exposure
#16
Raine Lunde-Young, Katie Davis-Anderson, Vishal Naik, Matthew Nemec, Guoyao Wu, Jayanth Ramadoss
The fetal brain exhibits exquisite alcohol-induced regional neuronal vulnerability. A candidate mechanism for alcohol-mediated brain deficits is disruption of amino acid (AA) bioavailability. AAs are vitally important for proper neurodevelopment, as they comprise the most abundant neurotransmitters in the brain and act as neurotransmitter precursors, nitric oxide donors, antioxidants, and neurotrophic factors, which induce synaptogenesis, neuronal proliferation, and migration. We hypothesized that gestational alcohol alters brain AA concentrations, disrupts AAs associated with neuropathogenesis, and that alterations are region-specific...
September 30, 2017: Alcohol
https://www.readbyqxmd.com/read/29126965/brain-state-expression-and-transitions-are-related-to-complex-executive-cognition-in-normative-neurodevelopment
#17
John D Medaglia, Theodore D Satterthwaite, Apoorva Kelkar, Rastko Ciric, Tyler M Moore, Kosha Ruparel, Ruben C Gur, Raquel E Gur, Danielle S Bassett
Adolescence is marked by rapid development of executive function. Mounting evidence suggests that executive function in adults may be driven by dynamic control of neurophysiological processes. Yet, how these dynamics evolve over adolescence and contribute to cognitive development is unknown. In a sample of 780 youth aged 8-22 yr (42.7% male) from the Philadelphia Neurodevelopment Cohort, we use a dynamic graph approach to extract activation states in BOLD fMRI data from 264 brain regions. We construct a graph in which each observation in time is a node and the similarity in brain states at two different times is an edge...
November 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/29126910/impaired-oligodendrogenesis-and-myelination-by-elevated-s100b-levels-during-neurodevelopment
#18
Gisela Santos, Andreia Barateiro, Cláudio M Gomes, Dora Brites, Adelaide Fernandes
High levels of the inflammatory molecule S100B protein have been identified in sera from several perinatal inflammatory conditions involving myelin damage and associated with an adverse prognosis or the emergence of sequelea. S100B is essential for oligodendrocyte (OL) differentiation and maturation, but it remains to be established if excessive levels of released S100B upon early brain injury are deleterious in the neurodevelopmental period. Here, we investigated this possibility by evaluating how elevated S100B affects oligodendrogenesis during this period...
November 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29121595/from-the-psychosis-prodrome-to-the-first-episode-of-psychosis-no-evidence-of-a-cognitive-decline
#19
Ricardo E Carrión, Deborah J Walder, Andrea M Auther, Danielle McLaughlin, Heather O Zyla, Steven Adelsheim, Roderick Calkins, Cameron S Carter, Bentson McFarland, Ryan Melton, Tara Niendam, J Daniel Ragland, Tamara G Sale, Stephan F Taylor, William R McFarlane, Barbara A Cornblatt
Cognitive deficits have an important role in the neurodevelopment of schizophrenia and other psychotic disorders. However, there is a continuing debate as to whether cognitive impairments in the psychosis prodrome are stable predictors of eventual psychosis or undergo a decline due to the onset of psychosis. In the present study, to determine how cognition changes as illness emerges, we examined baseline neurocognitive performance in a large sample of helping-seeking youth ranging in clinical state from low-risk for psychosis through individuals at clinical high-risk (CHR) for illness to early first-episode patients (EFEP)...
October 19, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29119215/surgical-ligation-versus-percutaneous-closure-of-patent-ductus-arteriosus-in-very-low-weight-preterm-infants-which-are-the-real-benefits-of-the-percutaneous-approach
#20
A Rodríguez Ogando, I Planelles Asensio, A Rodríguez Sánchez de la Blanca, F Ballesteros Tejerizo, M Sánchez Luna, J M Gil Jaurena, C Medrano López, J L Zunzunegui Martínez
Percutaneous treatment of patent ductus arteriosus (PDA) in extreme premature infants is technically difficult, and therefore, often not consider as an alternative to surgery. The main objective of our work was to compare respiratory status prior and post ductal closure and morbi-mortality, in our series of preterm infants with percutaneous PDA closure versus surgical ligation in the same time-period. Retrospective review of all premature infants submitted to percutaneous and surgical PDA closure from January 2011 to December 2016...
November 8, 2017: Pediatric Cardiology
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