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Gestational diabetes mellitus

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https://www.readbyqxmd.com/read/27904548/the-effect-of-vitamin-d-supplementation-on-gestational-diabetes-in-high-risk-women-results-from-a-randomized-placebo-controlled-trial
#1
Shole Shahgheibi, Fariba Farhadifar, Bahar Pouya
BACKGROUND: Vitamin D deficiency is common in pregnancy, leading to increase in the frequency of preeclampsia, cesarean delivery, neonatal bacterial vaginosis, and gestational diabetes. The current study was designed and implemented to investigate the effect of vitamin D during the first and second trimesters of pregnancy in reducing the risk of gestational diabetes mellitus (GDM) in women who are at high risk [history of GDM, birth macrosomia, family history, and high body mass index (BMI)]...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903516/metabolic-abnormalities-and-obesity-s-impact-on-the-risk-for-developing-preeclampsia
#2
Frank T Spradley
Preeclampsia (PE), a hypertensive disorder of pregnancy, is increasing as a major contributor to perinatal and long-term morbidity of mother and offspring. PE is thought to originate from ischemic insults in the placenta driving the release of pro-hypertensive anti-angiogenic (sFlt-1) and pro-inflammatory (TNFα) factors into the maternal circulation. While the increased incidence of PE is hypothesized to be largely due to the obesity pandemic, the mechanisms whereby obesity increases this risk are unknown...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27903295/prevalence-and-risk-factors-of-periodontal-disease-among-pre-conception-chinese-women
#3
Hong Jiang, Yi Su, Xu Xiong, Emily Harville, Hongqiao Wu, Zhijun Jiang, Xu Qian
BACKGROUND: Periodontal disease is one of the most common chronic infectious diseases. It has been reported that periodontal disease is associated with various adverse pregnancy outcomes including preterm birth, low birth weight, and gestational diabetes mellitus. Given the fact that the treatment for periodontal disease during pregnancy was ineffective in improving pregnancy outcomes by most of studies, the pre-conception period has been put forward as a more optimal time. However, very few studies have reported the prevalence of periodontal disease among pre-conception women...
December 1, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27901638/atlantic-dip-insulin-therapy-for-women-with-iadpsg-diagnosed-gestational-diabetes-mellitus-does-it-work
#4
D Bogdanet, A M Egan, C Reddin, O Kgosidialwa, B Kirwan, L Carmody, F P Dunne
INTRODUCTION: Approximately 40% of women with gestational diabetes mellitus (GDM) diagnosed using IADPSG criteria require insulin therapy. OBJECTIVE: To assess if the outcomes for women with GDM treated with insulin are comparable to women with normal glucose tolerance (NGT). MATERIALS AND METHODS: This retrospective cohort study included 752 women with insulin-treated GDM and 2496 women with NGT during pregnancy. Maternal and foetal outcomes were examined...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27891368/is-the-mean-platelet-volume-a-predictive-marker-of-a-low-apgar-score-and-insulin-resistance-in-gestational-diabetes-mellitus-a-retrospective-case-control-study
#5
Levent Kebapcilar, Ayse Gul Kebapcilar, Tolgay Tuyan Ilhan, Suleyman Hilmi Ipekci, Suleyman Baldane, Aybike Pekin, Mustafa Kulaksizoglu, Cetin Celik
INTRODUCTION: Gestational diabetes is defined as various degrees of glucose intolerance diagnosed or detected for the first time during pregnancy and is the most common metabolic complication of pregnancy. Early diagnosis and adequate treatment are important to prevent complications. Pre-eclampsia, polyhydramnios, fetalmacrosomia, and operative delivery are some of the complications seen in pregnant women diagnosed with Gestational Diabetes Mellitus (GDM). AIM: The present study was designed to determine whether there was an association between Mean Platelet Volume (MPV) in predicting poor fetal outcome, insulin resistance, neonatal Apgar scores and gestational age for women with GDM...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27886341/clinical-efficacy-of-therapeutic-intervention-for-subclinical-hypothyroidism-during-pregnancy
#6
R Ju, L Lin, Y Long, J Zhang, J Huang
This study explored the effects of levothyroxine (L-T4) replacement therapy on pregnancy outcomes in patients with subclinical hypothyroidism (SCH). We analyzed the effects on pregnancy outcomes with respect to gestational week when the desired thyroid-stimulating hormone (TSH) level was reached as well as the length of time required to reach the target level during L-T4 treatment. This study enrolled 457 patients diagnosed with SCH upon initial thyroid function screening. Subjects were assigned to the treatment group (N = 184), and the control group (N = 273)...
November 21, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27884913/reducing-the-risk-of-type-2-diabetes-mellitus-in-primary-care-after-gestational-diabetes-a-role-for-mobile-technology-to-improve-current-care
#7
Brian McMillan, Reem Abdelgalil, Priya Madhuvrata, Katherine Easton, Caroline Mitchell
No abstract text is available yet for this article.
December 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27883318/maternal-lipids-may-predict-fetal-growth-in-type-2-diabetes-mellitus-and-gestational-diabetes-mellitus-pregnancies
#8
Brankica Krstevska, Sasha Misevska Jovanovska, Slagjana Simeonova Krstevska, Valentina Velkoska Nakova, Vladimir Serafimoski
AIM: During diabetic pregnancy, complex metabolic changes occur in the lipid profile. The aim of the study was to determine the predictive values of maternal serum lipid levels on large-for-gestational age newborns during the third trimester in pregnancies of women with type 2 diabetes mellitus (DM2) and gestational diabetes mellitus (GDM). MATERIAL AND METHODS: Data of forty three pregnancies of women with DM2 and two hundred women with GDM were analyzed. The analysis encompassed the following parameters: age, body mass index (BMI), lipid parameters, HbA1c in first, second and third trimester of pregnancy, preeclampsia and baby birth weight...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27881298/engaging-patients-and-clinicians-in-establishing-research-priorities-for-gestational-diabetes-mellitus
#9
Sandra E Rees, Rati Chadha, Lois E Donovan, Adrienne L T Guitard, Sudha Koppula, Andreas Laupacis, Sara Simpson, Jeffrey A Johnson
OBJECTIVES: We involved patients and clinicians in Alberta, Canada, to establish research priorities in gestational diabetes mellitus (GDM), using an approach based on a model proposed by the James Lind Alliance (JLA). METHODS: We adapted the 4-step JLA process to engage women with GDM and clinicians to identify uncertainties about the management of GDM. Uncertainties were identified through a survey and a review of the clinical practice guidelines (CPG). Uncertainties were short-listed by a steering committee, followed by a 1-day facilitated workshop using a nominal group format and involving a similar number of patients and clinicians, who identified the top 10 research priorities...
November 21, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27881034/galanin-in-pregnancy-is-there-an-association-with-birth-weight-and-gestational-diabetes
#10
Eleni Bili, Evdokia Karagianni, Dimitrios G Goulis, Konstantinos Toulis, Grigoris Grimbizis, Basil C Tarlatzis
OBJECTIVE: To review the actions of galanin during pregnancy and to examine the existence of an association between galanin and birthweight as well as with gestational diabetes mellitus (GDM). RESULTS: Galanin concentrations in maternal circulation are similar in pregnant and non-pregnant status and have been correlated with body mass index (BMI). There is evidence of an association between birthweight and galanin concentrations in amniotic fluid during second trimester as well as galanin concentrations in umbilical cord at term...
November 23, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27880069/role-of-first-trimester-hba1c-as-a-predictor-of-adverse-obstetric-outcomes-in-a-multi-ethnic-cohort
#11
Laura Mañé, Juana Antonia Flores-Le Roux, David Benaiges, Marta Rodríguez, Irene Marcelo, Juan José Chillarón, Juan Pedro-Botet, Gemma Llauradó, Lucía Gortazar, Ramón Carreras, Antonio Payà
CONTEXT: Risk of obstetric complications increases linearly with rising maternal glycaemia. Testing HbA1c is an effective option to detect hyperglycemia but its association with adverse pregnancy outcomes remains unclear. Emerging data sustains that an early HbA1c≥5.9% could act as a pregnancy risk marker. OBJECTIVE: To determine, in a multi-ethnic cohort, whether an early ≥5.9% HbA1c could be useful to identify women without diabetes mellitus at increased pregnancy risk...
November 23, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27872389/promoting-fruit-and-vegetable-intake-in-childbearing-age-women-at-risk-for-gestational-diabetes-mellitus-a-randomised-controlled-trial
#12
Lydi-Anne Vézina-Im, Julie Perron, Simone Lemieux, Julie Robitaille
This randomised controlled trial verified the efficacy of an implementation intentions intervention (n = 24) to promote fruit and vegetable consumption among childbearing age women at risk for gestational diabetes mellitus against a control condition based on the question-behaviour effect (n = 26). There was only a significant time effect (F(2,85) = 5.69, p = 0.0048). Both groups increased their vegetable consumption compared to baseline at 3 months (p = 0.0022) and 6 months (p = 0...
November 21, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27872115/early-diagnosis-of-gestational-diabetes-mellitus-edogdm-study-a-protocol-for-a-prospective-longitudinal-cohort-study
#13
Bin Liu, Yun Xu, Ying Zhang, Jian Cai, Langhui Deng, Jianbo Yang, Yi Zhou, Yuhang Long, Jinxin Zhang, Zilian Wang
INTRODUCTION: A diagnosis of gestational diabetes mellitus (GDM) in low-risk pregnant women is based on an oral glucose tolerance test (OGTT) between 24 and 28 gestational weeks. However, there is insufficient evidence for why the test is performed in this time period. Moreover, the fetus may be exposed to hyperglycaemia prior to the current testing time frame, making earlier administration potentially advantageous. The main purpose of the present study is to investigate the GDM diagnostic value of an OGTT performed at 18-20 gestational weeks...
November 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27871471/endocan-expression-is-increased-in-the-placenta-from-obese-women-with-gestational-diabetes-mellitus
#14
Padma Murthi, Ramona Sarkis, Ratana Lim, Caitlyn Nguyen-Ngo, Anita Pratt, Stella Liong, Martha Lappas
INTRODUCTION: Endocan, a member of the proteoglycan family, is involved in a wide range of diseases including obesity and diabetes. The aim of this study was to determine the effect of (i) maternal obesity and gestational diabetes mellitus (GDM) on placental endocan expression; and (ii) endocan knockdown on markers of inflammation. METHODS: Endocan mRNA and protein expression was determined in human placenta from (i) lean and obese and normal glucose tolerant (NGT) pregnant women (n = 10 patients per group); and (ii) women with GDM and BMI-matched NGT women (n = 40 patients per group)...
December 2016: Placenta
https://www.readbyqxmd.com/read/27869777/the-effects-of-mild-gestational-hyperglycemia-on-exclusive-breastfeeding-cessation
#15
Sergio Verd, Diego de Sotto, Consuelo Fernández, Antonio Gutiérrez
Gestational diabetes increases the risk of a range of adverse perinatal outcomes, including breastfeeding failure, but the best cut-off point for gestational diabetes is unknown. The purpose of this study was to evaluate the association between mild gestational glucose tolerance impairment and the early cessation of exclusive breastfeeding (EBF). This is an observational study of 768 women with full term pregnancies that were screened for gestational diabetes at 24-28 weeks gestation. Subjects were divided into two groups: those with a normal 1-h glucose challenge test and those with an elevated 1-h glucose challenge test but still did not qualify for gestational diabetes...
November 19, 2016: Nutrients
https://www.readbyqxmd.com/read/27867874/serum-adiponectin-levels-in-gestational-diabetes-mellitus
#16
Abhijit Bhograj, K M Suryanarayana, Ashwini Nayak, N S Murthy, Mala Dharmalingam, Pramila Kalra
INTRODUCTION: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy.([1]) Pregnancy is a unique situation in which there is a physiological temporary increase in insulin resistance (IR). The mechanisms responsible for the gestational-induced IR are not completely understood. The current study was undertaken to compare adiponectin levels during 24-28 weeks period of gestation in drug-naive newly diagnosed GDM women with a cohort of normoglycemic pregnant women...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27863107/heterogeneity-of-glycometabolism-in-patients-with-gestational-diabetes-mellitus
#17
Yan Yan, Zhou Liu, Daqing Liu
BACKGROUND: To evaluate the glycometabolism and outcomes of gestational diabetes mellitus (GDM) patients according to the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria in China. METHODS: According to the results of a 75-g OGTT, 1683 pregnant women were divided into three groups: an increment GDM group (patients meet the IADPSG criteria but not the previous Chinese criteria), a stock GDM group (patients meet both criteria), and a normal glucose tolerance (NGT) group...
November 10, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27862741/assessment-of-fetal-myocardial-performance-index-in-women-with-pregestational-and-gestational-diabetes-mellitus
#18
Cem Yasar Sanhal, Halil Korkut Daglar, Ozgur Kara, Dilek Uygur, Aykan Yucel
AIM: Fetal cardiac left ventricular function in pregnant women with pregestational or gestational diabetes mellitus was investigated by exploring fetal myocardial performance index (MPI) and E wave/A wave peak velocity (E/A) ratio. METHODS: Seventy pregnant women with either pregestational or gestational diabetes mellitus and with no other systemic or pregnancy related disorders were compared with 70 gestational age matched healthy controls by means of fetal left ventricular MPI and E/A ratio...
November 12, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27858842/peroxisome-proliferator-activated-receptor-pro12ala-polymorphism-and-the-risks-of-gestational-diabetes-mellitus-an-updated-meta-analysis-of-12-studies
#19
Lihong Wang, Wenting Xu, Xu Wang
BACKGROUND: Peroxisome proliferator-activated receptors-λ (PPAR-λ) is a member of nuclear receptor superfamily and acts as a ligand-dependent transcription factor often found in the adrenal gland, the spleen, and adipose tissue. The Pro12Ala polymorphism of PPAR-λ has been associated with the risks of gestational diabetes mellitus (GDM); however, association studies have provided conflicting results. The aim of this Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) compliant meta-analysis is to reach a more up-to-date and accurate estimation of the relationship between Pro12Ala genetic polymorphisms and the risks of GDM...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856227/contraception-and-postpartum-follow-up-in-patients-with-gestational-diabetes
#20
Emily W Rosenthal, Sarah Rae Easter, Emma Morton-Eggleston, Caryn Dutton, Chloe Zera
OBJECTIVES: We sought to review the effect of immediate provision of postpartum contraception on postpartum follow-up and screening for type 2 diabetes in women with gestational diabetes mellitus (GDM). STUDY DESIGN: We performed multivariate logistic regression to identify the association between immediate provision of postpartum contraception and attendance at the 6-week postpartum visit and performance of a 6- to 12-week oral glucose tolerance test, controlling for age, type of insurance, parity and race...
November 14, 2016: Contraception
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