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https://www.readbyqxmd.com/read/28719876/photoelectrocatalytic-degradation-of-methylene-blue-using-f-doped-tio2-photoelectrode-under-visible-light-irradiation
#1
Dong Liu, Renwen Tian, Jianqiao Wang, Er Nie, Xianqing Piao, Xin Li, Zhuo Sun
Photoelectrocatalysis (PEC) has attracted great interest due to cost effectiveness and high efficiency in water treatment. In this study, F doped TiO2 (F-TiO2) photoelectrodes with honeycomb like morphology were prepared, and the PEC performance was investigated. F-TiO2 particles that showed enhanced absorption of visible light were synthesized via a sol-gel method. F-TiO2 particles were anchored onto the surface of F-doped SnO2 glass by a screen-printing method to prepare the F-TiO2 photoelectrodes. The PEC performance of the F-TiO2 photoelectrodes was investigated via the degradation of methylene blue (MB) under visible light irradiation...
July 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28716650/the-use-of-prostate-specific-antigen-screening-in-purchased-versus-direct-care-settings-data-from-the-tricare-military-database
#2
Alexander P Cole, Wei Jiang, Stuart R Lipsitz, Peter A Learn, Maxine Sun, Toni K Choueiri, Paul L Nguyen, Adam S Kibel, Mani Menon, Jesse D Sammon, Tracey Koehlmoos, Adil Haider, Quoc-Dien Trinh
PURPOSE: Fee for service (FFS) reimbursement incentives may affect care. We sought to compare odds of PSA screening among former and active duty United States (US) military service members based on receipt of primary care from integrated military health facilities versus community providers reimbursed via FFS. MATERIALS AND METHODS: We performed a retrospective study of all active duty and retired male service members (40-64) covered by the TRICARE military health benefit in 2010...
July 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28716547/cellular-senescence-regulated-by-swi-snf-complex-subunits-through-p53-p21-and-p16-prb-pathway
#3
Ling He, Ying Chen, Jianguo Feng, Weichao Sun, Shun Li, Mengting Ou, Liling Tang
SWI/SNF complex is an evolutionarily well-conserved chromatin-remodeling complex, which is implicated in the nucleosomes removing or sliding, impacting on the DNA repair, replication and genes expression regulation. The SWI/SNF complex consists up to 12 protein subunits. The catalytic subunits are BRG1 or BRM, which are exclusive ATPase subunits. BRG1 has been reported to play an important role in cellular senescence. However, The function of non-catalytic subunits involved in cellular senescence is rarely investigated...
July 14, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28716507/a-novel-topoisomerase-2a-inhibitor-cryptotanshinone-suppresses-the-growth-of-pc3-cells-without-apparent-cytotoxicity
#4
Eun Ju Kim, Sun Young Kim, Sang-Man Kim, Minyoung Lee
DNA topoisomerase 2, which is ubiquitously expressed in eukaryotic cells, is an essential nuclear enzyme that promotes cell survival by regulating DNA topology and chromatid separation. This enzyme has been validated as a target for anticancer agent screening. It can be poisoned by common chemotherapeutics, such as etoposide and doxorubicin, which leads to the accumulation of cytotoxic enzyme-linked DNA double-stranded breaks. However, recent studies have suggested that the topoisomerase 2a isozyme is predominantly responsible for the carcinogenic side effects associated with etoposide and doxorubicin chemotherapy...
July 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28715582/iris-freckles-a-potential-biomarker-for-chronic-sun-damage
#5
Christoph Schwab, Christoph Mayer, Iris Zalaudek, Regina Riedl, Markus Richtig, Werner Wackernagel, Rainer Hofmann-Wellenhof, Georg Richtig, Gerald Langmann, Lisa Tarmann, Andreas Wedrich, Erika Richtig
Purpose: To investigate the role of sunlight exposure in iris freckles formation. Methods: We prospectively examined volunteers attending a skin cancer screening program conducted by ophthalmologists and dermatologists. Frequency and topographical variability of iris freckles were noted and associated with behavioral and dermatologic characteristics indicating high sun exposure. Results: Six hundred thirty-two participants (n = 360; 57% female) were examined...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28715400/a-novel-method-to-model-chronic-traumatic-encephalopathy-in-drosophila
#6
Mingkuan Sun, Liam L Chen
Chronic Traumatic Encephalopathy (CTE) is an established neurodegenerative disease that is closely associated with exposure to repetitive mild Traumatic Brain Injury (mTBI). The mechanisms responsible for its complex pathological changes remain largely elusive, despite a recent consensus to define the neuropathological criteria. Here, we describe a novel method to develop a model of CTE in Drosophila melanogaster (Drosophila ) in an attempt to identify the key genes and pathways that lead to the characteristic hyperphosphorylated tau accumulation and neuronal death in the brain...
July 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28713995/bioinformatic-analysis-of-computational-identified-differentially-expressed-genes-in-tumor-stoma-of-pregnancy%C3%A2-associated-breast-cancer
#7
Qian Zhou, Erhu Sun, Lijun Ling, Xiaofeng Liu, Min Zhang, Hong Yin, Cheng Lu
The present study aimed to screen the differentially expressed genes (DEGs) in tumor‑associated stroma of pregnancy‑associated breast cancer (PABC). By analyzing Affymetrix microarray data (GSE31192) from the Gene Expression Omnibus database, DEGs between tumor asso-ciated stromal cells and normal stromal cells in PABC were identified. Gene Ontology (GO) function and pathway enrichment analyses for the DEGs were then performed, followed by construction of a protein‑protein interaction (PPI) network. A total of 94 upregulated and 386 downregulated DEGs were identified between tumor associated stromal cells and normal stromal cells in patients with PABC...
July 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28712711/specificity-and-putative-mode-of-action-of-a-mosquito-larvicidal-toxin-from-the-bacterium-xenorhabdus-innexi
#8
Il-Hwan Kim, Jerald Ensign, Do-Young Kim, Hoe-Yune Jung, Na-Ri Kim, Bo-Hwa Choi, Sun-Min Park, Que Lan, Walter G Goodman
Reduction of mosquito-borne diseases relies, in part, on the use of synthetic pesticides to control pest mosquitoes. This reliance has led to genetic resistance, environmental contamination and the nondiscriminatory elimination of both pest and non-pest species. To expand our options for control, we screened entomopathogenic bacteria for potential larvicidal activity. A lipopeptide from the bacterium, Xenorhabdus innexi, was discovered that displayed potent larvicidal activity. The LC50s of the lipopeptide towards Aedes aegypti, Culex pipiens and Anopheles gambiae larvae were 1...
July 13, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28711831/application-of-magnetic-oms-2-in-sequencing-batch-reactor-for-treating-dye-wastewater-as-a-modulator-of-microbial-community
#9
Fei Pan, Yang Yu, Aihua Xu, Dongsheng Xia, Youmin Sun, Zhengqing Cai, Wen Liu, Jie Fu
The potential and mechanism of synthesized magnetic octahedral molecular sieve (Fe3O4@OMS-2) nanoparticles in enhancing the aerobic microbial ability of sequencing batch reactor (SBR) for treating dye wastewater have been revealed in this study. The addition of Fe3O4@OMS-2 of 0.25g/L enhanced the decolorization of SBRs with an operation cycle of 24h by more than 20%. The 16S rRNA gene high-throughput sequencing indicated Fe3O4@OMS-2 increased the microbial richness and diversity of SBRs, and more importantly, promoted the potential dye-degrading bacteria...
June 27, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28710982/occurrence-fate-and-mass-balance-of-different-classes-of-pharmaceuticals-and-personal-care-products-in-an-anaerobic-anoxic-oxic-wastewater-treatment-plant-in-xiamen-china
#10
Muhammad Ashfaq, Yan Li, Yuwen Wang, Wenjie Chen, Han Wang, Xiangqiang Chen, Wei Wu, Zhenyi Huang, Chang-Ping Yu, Qian Sun
In this study, the occurrence and fate of 49 pharmaceuticals and personal care products (PPCPs) were investigated in an anaerobic-anoxic-oxic (A2/O) wastewater treatment plant (WWTP) for seven consecutive days using 24-h composite sampling technique. Special emphasis was placed to understand the distribution of PPCPs in dissolved and adsorbed phase, and to evaluate PPCP fate in different treatment units. Among the 49 PPCPs, 40 PPCPs in influent, 36 in effluent, 29 in sludge and 23 in suspended solids were detected at least once during sampling...
July 7, 2017: Water Research
https://www.readbyqxmd.com/read/28708462/heterogeneous-enhancement-patterns-of-tumor-adjacent-parenchyma-at-mr-imaging-are-associated-with-dysregulated-signaling-pathways-and-poor-survival-in-breast-cancer
#11
Jia Wu, Bailiang Li, Xiaoli Sun, Guohong Cao, Daniel L Rubin, Sandy Napel, Debra M Ikeda, Allison W Kurian, Ruijiang Li
Purpose To identify the molecular basis of quantitative imaging characteristics of tumor-adjacent parenchyma at dynamic contrast material-enhanced magnetic resonance (MR) imaging and to evaluate their prognostic value in breast cancer. Materials and Methods In this institutional review board-approved, HIPAA-compliant study, 10 quantitative imaging features depicting tumor-adjacent parenchymal enhancement patterns were extracted and screened for prognostic features in a discovery cohort of 60 patients. By using data from The Cancer Genome Atlas (TCGA), a radiogenomic map for the tumor-adjacent parenchymal tissue was created and molecular pathways associated with prognostic parenchymal imaging features were identified...
July 14, 2017: Radiology
https://www.readbyqxmd.com/read/28706278/enhanced-photoelectrochemical-properties-of-nanocrystalline-tio2-electrode-by-surface-sensitization-with-cuxo-quantum-dots
#12
Jiajia Tao, Zhaoqi Sun, Yunlang Cheng, Miao Zhang, Jianguo Lv, Shiwei Shi, Gang He, Xishun Jiang, Xiaoshuang Chen, Xingzhi Wang, Zhuang Wang, Zezhou Gong
Nanoporous anatase TiO2 films were fabricated by a screen-printing method, and CuxO quantum dots (QDs) were deposited on the TiO2 films through successive ionic layer adsorption and reaction (SILAR). The amount of CuxO QDs on the TiO2 films are controlled by changing the number of SILAR cycles. The morphology, microstructure, optical, and photoelectrochemical properties of different CuxO sensitized TiO2 films (CuxO/TiO2) were investigated in detail. The nanoporous TiO2 film offers a large surface area for anchoring QDs...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704553/screening-and-characterizing-of-xylanolytic-and-xylose-fermenting-yeasts-isolated-from-the-wood-feeding-termite-reticulitermes-chinensis
#13
Sameh Samir Ali, Jian Wu, Rongrong Xie, Feng Zhou, Jianzhong Sun, Miao Huang
The effective fermentation of xylose remains an intractable challenge in bioethanol industry. The relevant xylanase enzyme is also in a high demand from industry for several biotechnological applications that inevitably in recent times led to many efforts for screening some novel microorganisms for better xylanase production and fermentation performance. Recently, it seems that wood-feeding termites can truly be considered as highly efficient natural bioreactors. The highly specialized gut systems of such insects are not yet fully realized, particularly, in xylose fermentation and xylanase production to advance industrial bioethanol technology as well as industrial applications of xylanases...
2017: PloS One
https://www.readbyqxmd.com/read/28702943/screening-and-identification-of-metabolites-of-two-kinds-of-main-active-ingredients-and-hepatotoxic-pyrrolizidine-alkaloids-hpas-in-rat-after-lavage-farfarae-flos-extract-by-uhplc-q-tof-ms-mass-spectrometry
#14
Xiaoye Cheng, Man Liao, Xinpeng Diao, Yupeng Sun, Lantong Zhang
Farfarae Flos, the dried flower buds of Tussilago farfara L., is usually used to treat coughs, bronchitic and asthmatic conditions as an important traditional Chinese medicine. Tussilagone and methl butyric acid tussilagin ester are seen as representatives of two kinds of active substances. Besides, the pyrrolizidine alkaloids (HPAs), mainly senkirkine and senecionine, presented in the herb can be hepatoxic. In this study, a rapid and sensitive ultra high performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS) method is successfully applied to identify the metabolites of tussilagone, methl butyric acid tussilagin ester , senkirkine and senecionine...
July 12, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28699907/contrast-enhanced-endoscopic-ultrasound-for-differential-diagnosis-of-pancreatic-cancer-an-updated-meta-analysis
#15
Xing-Kang He, Yue Ding, Lei-Min Sun
AIM: We aim to assess the diagnostic value of contrast-enhanced endoscopic ultrasound (CE-EUS) for pancreatic cancer and inflammatory lesions by pooling current evidence. MATERIALS AND METHODS: A systematical search of PubMed, Web of Science and the Cochrane Library was performed from inception to January 2016. Two authors independently screened and extracted detailed data from included studies. A random effect model was adopted to estimate the pooled sensitivity, specificity in order to determine the diagnostic ablitity of CE-EUS...
July 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28697442/portable-amperometric-immunosensor-for-histamine-detection-using-prussian-blue-chitosan-gold-nanoparticle-nanocomposite-films
#16
Xiu-Xiu Dong, Jin-Yi Yang, Lin Luo, Yi-Feng Zhang, Chuanbin Mao, Yuan-Ming Sun, Hong-Tao Lei, Yu-Dong Shen, Ross C Beier, Zhen-Lin Xu
Histamine (HA) is a biogenic amine that can accumulate to high concentration levels in food as a result of microbial activity and can cause toxic effects in consumers. In this work, a portable electrochemical immunosensor capable of detecting HA with high sensitivity and selectivity was developed. Prussian blue-chitosan-gold nanoparticle (PB-CS-AuNP) nanocomposite films with excellent biocompatibility were synthesized and characterized by scanning electron microscopy and energy dispersive X-ray analysis. The PB-CS-AuNP were coated onto a screen-printed electrode by one-step electrodeposition and used to conjugate the HA ovalbumin conjugate (HA-Ag)...
July 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28696694/discovery-of-potent-small-molecule-inhibitors-of-ubiquitin-conjugating-enzyme-ubch5c-from-%C3%AE-santonin-derivatives
#17
Hao Chen, Guozhen Wu, Shuang Gao, Ruihua Guo, Zeng Zhao, Hu Yuan, Shanxiang Liu, Jian Wu, Xiaolong Lu, Xing Yuan, Zongmin Yu, Xianpeng Zu, Ning Xie, Niao Yang, Zhenlin Hu, Qingyan Sun, Weidong Zhang
As a therapeutic target for anti-tumor necrosis factor (TNF)-α interventions, UbcH5c is one of the key ubiquitin-conjugating enzymes catalyzing ubiquitination during TNF-α-triggered nuclear factor kappa B (NF-κB) activation. In the present study, three series of analogs were designed and synthesized from α-santonin, and their UbcH5c inhibitory activities were screened by western blotting and NF-κB luciferase assay. Further BIAcore, in-gel fluorescence imaging and immunoprecipitation, assays demonstrated that compound 6d exhibited robust and specific inhibition of UbcH5c, exceeding that of the positive compound 1 (IJ-5)...
July 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28695806/illness-attribution-of-outpatients-with-multiple-somatic-symptoms-in-peking-union-medical-college-hospital
#18
Tao Li, Xia Hong, Nana Xiong, Jing Jiang, Xiayuan Sun, Liming Zhu, Guoqing Tian, Jing Wei
Objective To explore the characteristics of illness attribution of outpatients with multiple somatic symptoms in Peking Union Medical College Hospital. Methods It was a cross-sectional study conducted from March to October,2012. A total of 150 outpatients were recruited from the departments of Gastroenterology,Traditional Chinese Medicine and Psychological Medicine by convenience sampling. Somatic symptom scale of the Patient Health Questionnaire (PHQ-15) was used to screening each patient in the waiting list...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28694689/synthesis-and-cytotoxic-activities-of-novel-4-methoxy-substituted-and-5-methyl-substituted-3-s-4-s-cis-khellactone-derivatives-that-induce-apoptosis-via-the-intrinsic-pathway
#19
Jingrun Chen, Junjie Liu, Dongxiao Cui, Chaoqun Yan, Liqiang Meng, Liqian Sun, Shurong Ban, Rui Ge, Taigang Liang, Qingshan Li
This study deals with the design and synthesis of a series of novel 4-methoxy-substituted and 5-methyl-substituted (3'S,4'S)-(-)-cis-khellactones. The newly synthesized compounds were characterized by (1)H nuclear magnetic resonance (NMR), (13)C-NMR, mass spectrometry, and elemental analysis. All the derivatives were subjected to in vitro cytotoxicity screening against HEPG-2 (human liver carcinoma), SGC-7901 (human gastric carcinoma), and LS174T (human colon carcinoma), by using the MTT assay. The results revealed that several of the 4-methoxy-substituted compounds exhibited potent cytotoxicity...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28694201/use-of-quantiferon-tb-gold-in-tube-assay-in-screening-for-neutralizing-anti-interferon-gamma-autoantibodies-in-patients-with-disseminated-nontuberculous-mycobacterial-infection
#20
Un-In Wu, Yu-Chung Chuang, Wang-Huei Sheng, Hsin-Yun Sun, Yi-Ting Jhong, Jann-Yuan Wang, Shan-Chwen Chang, Jann-Tay Wang, Yee-Chun Chen
OBJECTIVE: Anti-interferon-gamma (IFN-γ) autoantibodies (anti-IFN-γ Abs) have been increasingly recognized as an important cause of disseminated nontuberculous mycobacterial (DNTM) infection, and identification of this immunodeficiency impacts clinical management. However, the protean disease manifestations and inaccessibility to diagnostic tests in clinical settings hamper its early diagnosis. Here, we sought to determine whether QuantiFERON-TB Gold In-tube (QFT-GIT), a commercialized IFN-γ release assay, could be used to screen for neutralizing anti-IFN-γ Abs among previously healthy adults with DNTM infection...
July 7, 2017: Clinical Microbiology and Infection
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