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https://www.readbyqxmd.com/read/29233738/prevalence-of-transforming-growth-factor-%C3%AE-induced-gene-corneal-dystrophies-in-chinese-refractive-surgery-candidates
#1
Yanzheng Song, Mingshen Sun, Ningli Wang, Xingtao Zhou, Jing Zhao, Qinmei Wang, Shihao Chen, Yingping Deng, Lemei Qiu, Yueguo Chen, Anthony J Aldave, Fengju Zhang
PURPOSE: To determine the prevalence of the transforming growth factor (TGF) β-induced gene corneal dystrophies in refractive surgery candidates in China. SETTING: Five hospitals in China. DESIGN: Prospective case series. METHOD: Refractive surgical candidates from 5 preselected eye hospitals/centers in China were recruited after providing informed consent. All patients had slitlamp biomicroscopy and collection of a buccal swab as a source of DNA for screening of the TGF β-induced gene for the 5 most common mutations associated with Reis-Bückler corneal dystrophy, Thiel-Behnke corneal dystrophy, granular corneal dystrophy type 1, granular corneal dystrophy type 2, and lattice corneal dystrophy type 1...
December 9, 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29233651/identification-of-bicyclic-hexafluoroisopropyl-alcohol-sulfonamides-as-retinoic-acid-receptor-related-orphan-receptor-gamma-ror%C3%AE-rorc-inverse-agonists-employing-structure-based-drug-design-to-improve-pregnane-x-receptor-pxr-selectivity
#2
Hua Gong, David S Weinstein, Zhonghui Lu, James J-W Duan, Sylwia Stachura, Lauren Haque, Ananta Karmakar, Hemalatha Hemagiri, Dhanya Kumar Raut, Arun Kumar Gupta, Javed Khan, Dan Camac, John S Sack, Andrew Pudzianowski, Dauh-Rurng Wu, Melissa Yarde, Ding-Ren Shen, Virna Borowski, Jenny H Xie, Huadong Sun, Celia D'Arienzo, Marta Dabros, Michael A Galella, Faye Wang, Carolyn A Weigelt, Qihong Zhao, William Foster, John E Somerville, Luisa M Salter-Cid, Joel C Barrish, Percy H Carter, T G Murali Dhar
We disclose the optimization of a high throughput screening hit to yield benzothiazine and tetrahydroquinoline sulfonamides as potent RORγt inverse agonists. However, a majority of these compounds showed potent activity against pregnane X receptor (PXR) and modest activity against liver X receptor α (LXRα). Structure-based drug design (SBDD) led to the identification of benzothiazine and tetrahydroquinoline sulfonamide analogs which completely dialed out LXRα activity and were less potent at PXR. Pharmacodynamic (PD) data for compound 35 in an IL-23 induced IL-17 mouse model is discussed along with the implications of a high Ymax in the PXR assay for long term preclinical pharmacokinetic (PK) studies...
December 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29232000/efficient-resolution-of-venlafaxine-and-mechanism-study-via-x-ray-crystallography
#3
Zhi-Jin Liu, Han Liu, Xuan-Wen Chen, Min Lin, Yu Hu, Xun Tuo, Zhong-Yi Yuan, Xiao-Xia Sun
Numbers of resolving factors were investigated to improve resolution of venlafaxine 1. An effective resolving agent, O,O'-di-p-toluoyl-(R, R)-tartaric acid 2, was screened using similar method of 'Dutch resolution' from tartaric acid derivatives. The resolution efficiency was up to 88.4%, when the ratio of rac-1 and 2 was 1:0.8 in THF with little water (10:1 v/v). Enantiomerically pure venlafaxine was prepared with 99.1% ee in 82.2% yield. The chiral resolution mechanism was first explained through X-ray crystallographic study...
December 12, 2017: Chirality
https://www.readbyqxmd.com/read/29231353/-efficacy-of-filiform-needle-manipulation-on-primary-dysmenorrhea-a-systematic-review
#4
Junjun Sun, Yafeng Wang, Zhuang Zhang, Huijuan Cao, Pei Wang, Minyi Zhao, Nijuan Hu, Guiwen Wu, Shangqing Hu, Jiang Zhu
The paper is a systematic review on the efficacy of acupuncture manipulation on primary dysmenorrhea. Ten medical literatures database at home and abroad were retrieved, including CNKI, VIP, CBM, WANFANG, MEDLINE, Cochrane, CENTRAL, CINAHL PLUS, EMBASE, AMED and PsycINFO, as well as 6 clinical trial registration platforms. All of randomized controlled trials (RCTs) on primary dysmenorrhea treated with different acupuncture manipulations were collected. The data were extracted by two persons. Finally, RevMa 5...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230583/mutation-screening-of-chinese-treacher-collins-syndrome-patients-identified-novel-tcof1-mutations
#5
Ying Chen, Luo Guo, Chen-Long Li, Jing Shan, Hai-Song Xu, Jie-Ying Li, Shan Sun, Shao-Juan Hao, Lei Jin, Gang Chai, Tian-Yu Zhang
Treacher Collins syndrome (TCS) (OMIM 154500) is a rare congenital craniofacial disorder with an autosomal dominant manner of inheritance in most cases. To date, three pathogenic genes (TCOF1, POLR1D and POLR1C) have been identified. In this study, we conducted mutational analysis on Chinese TCS patients to reveal a mutational spectrum of known causative genes and show phenotype-genotype data to provide more information for gene counselling and future studies on the pathogenesis of TCS. Twenty-two TCS patients were recruited from two tertiary referral centres, and Sanger sequencing for the coding exons and exon-intron boundaries of TCOF1, POLR1D and POLR1C was performed...
December 11, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29226322/mir-1290-promotes-proliferation-migration-and-invasion-of-glioma-cells-by-targeting-lhx6
#6
Lei Yan, Kai Sun, Yang Liu, Jun Liang, Kerui Cai, Jinqiu Gui
OBJECTIVE: To investigate the interaction of miR-1290 and LHX6 in gliomas, and their influence on the propagation and metastasis of glioma cells. METHODS: The differential expression of miR-1290 in glioma cells was identified by chip screening. The expression level of miR-1290 and LHX6 were determined by qRT-PCR and western blot. The influence of miR-1290 on propagation of glioma cells were analyzed by MTT assay, EdU incorporation and colony formation, while the impact of miR-1290 on metastasis was assessed by transwell assay...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29225663/high-throughput-detection-of-antioxidants-in-mulberry-fruit-using-correlations-between-high-resolution-mass-and-activity-profiles-of-chromatographic-fractions
#7
Ye Ji Park, Si Hyun Seong, Min Sun Kim, Sang Wan Seo, Mee Ree Kim, Hyun Sik Kim
Background: Plant extracts contain a huge variety of pharmacologically active substances. Conventionally, various chromatographic methods must be applied several times to purify functional compounds to measure their functional activity. However, conventional purification methods are time-consuming and expensive due to the laborious purification process. Recently, a high-throughput discovery method that replaces such time-consuming purification processes was introduced; this method uses 15 T ultra-high-resolution Fourier transform ion cyclotron resonance mass spectrometry (15 T FT-ICR MS) and a high-throughput screening method...
2017: Plant Methods
https://www.readbyqxmd.com/read/29225594/overexpression-of-oscipk30-enhances-plant-tolerance-to-rice-stripe-virus
#8
Zhiyang Liu, Xuejuan Li, Feng Sun, Tong Zhou, Yijun Zhou
Rice stripe virus (RSV) causes a severe disease in Oryza sativa (rice) in many Eastern Asian countries. The NS3 protein of RSV is a viral suppressor of RNA silencing, but plant host factors interacting with NS3 have not been reported yet. Here, we present evidence that expression of RSV NS3 in Arabidopsis thaliana causes developmental abnormalities. Through yeast two-hybrid screening and a luciferase complementation imaging assay, we demonstrate that RSV NS3 interacted with OsCIPK30, a CBL (calcineurin B-like proteins)-interaction protein kinase protein...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29224924/prevalence-of-spontaneous-brugada-ecg-pattern-recorded-at-standard-intercostal-leads-a-meta-analysis
#9
Shaobo Shi, Hector Barajas-Martinez, Tao Liu, Yaxun Sun, Bo Yang, Congxin Huang, Dan Hu
OBJECTIVE: Typical Brugada ECG pattern is the keystone in the diagnosis of Brugada syndrome. However, the exact prevalence remains unclear, especially in Asia. The present study was designed to systematically evaluate the prevalence of spontaneous Brugada ECG pattern recorded at standard leads. METHODS: We searched the Medline, Embase and Chinese National Knowledge Infrastructure (CNKI) for studies of the prevalence of Brugada ECG pattern, published between Jan 1, 2003, and September 1, 2016...
December 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29224418/the-characteristics-and-age-effects-of-emotional-lability-in-adhd-children-with-and-without-oppositional-defiant-disorder
#10
Lu Liu, Wai Chen, Li Sun, Jia Cheng, Yi Su, Daniel Rudaizky, Hai-Mei Li, Li Yang, Qiu-Jin Qian, Yu-Feng Wang
OBJECTIVE: This study evaluated the concurrent validity of emotional lability (EL) in children with ADHD. METHOD: A total of 2,015 children with ADHD and 745 typically developed controls (TDCs) were assessed and compared on EL. RESULTS: ADHD participants expressed higher EL scores than TDCs, not influenced by gender or IQ. Higher levels of EL symptoms were found in children with comorbid oppositional defiant disorder (ODD) and with ADHD-combined subtype...
December 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29223458/determination-of-zinc-oxide-content-of-mineral-medicine-calamine-using-near-infrared-spectroscopy-based-on-miv-and-bp-ann-algorithm
#11
Xiaodong Zhang, Long Chen, Yangbo Sun, Yu Bai, Bisheng Huang, Keli Chen
Near-infrared (NIR) spectroscopy has been widely used in the analysis fields of traditional Chinese medicine. It has the advantages of fast analysis, no damage to samples and no pollution. In this research, a fast quantitative model for zinc oxide (ZnO) content in mineral medicine calamine was explored based on NIR spectroscopy. NIR spectra of 57 batches of calamine samples were collected and the first derivative (FD) method was adopted for conducting spectral pretreatment. The content of ZnO in calamine sample was determined using ethylenediaminetetraacetic acid (EDTA) titration and taken as reference value of NIR spectroscopy...
December 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29222918/large-scale-screening-and-characterization-of-lemna-aequinoctialis-and-spirodela-polyrhiza-strains-for-starch-production
#12
Yubin Ma, Ming Zhu, Changjiang Yu, Yu Wang, Yu Liu, Mingliang Li, Youde Sun, Jinshan Zhao, Gongke Zhou
Duckweed has been considered as a promising feedstock for bioethanol production due to its high biomass and starch production. Selection of duckweed strain with high starch accumulation is an essential process in application of duckweeds for bioethanol production. Geographic differentiation had great influence on genetic diversity of duckweed. Biomass production, starch content and starch production of 20 Lemna aequinoctialis and Spirodela polyrhiza geographically isolated strains were calculated to evaluate their potential for bioethanol production...
December 9, 2017: Plant Biology
https://www.readbyqxmd.com/read/29221802/inflammation-in-the-prediction-of-type-2-diabetes-and-hypertension-in-healthy-adults
#13
Ki-Chul Sung, Seungho Ryu, Joo-Wook Sung, Yong Bum Kim, Yu Sam Won, Dong Sik Cho, Sun H Kim, Alice Liu
BACKGROUND: While inflammation is associated with obesity and insulin resistance, their inter-relationships in the development of type 2 diabetes or hypertension are not clear. AIM OF THE STUDY: To evaluate inflammatory markers in prediction of type 2 diabetes and hypertension. METHODS: The study population of this retrospective cohort study consisted of individuals who participated in a comprehensive health screening program with measurement of white blood cell count and C-reactive protein from 2002-2010 (N = 96,606) in nondiabetic and normotensive Koreans...
December 5, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29221264/continuation-of-gefitinib-plus-chemotherapy-prolongs-progression-free-survival-in-advanced-non-small-cell-lung-cancer-patients-who-get-acquired-resistance-to-gefitinib-without-t790m-mutations
#14
Ting Ding, Fei Zhou, Xiaoxia Chen, Shijia Zhang, Yinan Liu, Hui Sun, Shengxiang Ren, Xuefei Li, Chao Zhao, Heyong Wang, Caicun Zhou
Background: Aimed to identify the benefit population from continuation of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), this study investigated the efficacy of continuation of EGFR-TKIs plus chemotherapy beyond the response evaluation criteria in solid tumors-progressive disease (RECIST-PD) according to different progression modes and T790M mutational status. Methods: From November 2009 to July 2015, 630 patients with advanced non-small cell lung cancer (NSCLC) receiving gefitinib as initial EGFR-TKI treatment were screened in Shanghai Pulmonary Hospital...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221207/chst6-mutation-screening-and-endoplasmatic-reticulum-stress-in-macular-corneal-dystrophy
#15
Liyuan Wang, Xianling Tang, Xiaolin Lv, Encheng Sun, Donglai Wu, Changlin Wang, Ping Liu
Macular corneal dystrophy (MCD) is an autosomal recessive disorder mainly caused by gene mutations of carbohydrate sulfotransferase (CHST6) leading to bilateral visual impairment. Because the mechanism underlying this degeneration remains poorly understood, we investigated molecular alterations and pathways that may be involved in MCD in this issue. Different mutation sites were screened by direct sequencing of the coding region of CHST6. In addition, we described morphological changes in MCD keratocytes by light microscopy and electron microscopy and determined the relationship between the development of this disease and the occurrence of apoptosis through flow cytometry, cell counting kit-8, colony formation assay and other experiments...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221129/long-non-coding-rna-polymorphisms-in-6p21-1-are-associated-with-atrophic-gastritis-risk-and-gastric-cancer-prognosis
#16
Zhi Lv, Liping Sun, Qian Xu, Yuehua Gong, Jingjing Jing, Chengzhong Xing, Yuan Yuan
It has been suggested that the genetic variation in human chromosome 6p21.1 has potential importance for the susceptibility to gastric cancer (GC). The study aims to explore the relationship between the long non-coding RNA (lncRNA) polymorphisms in 6p21.1 and the risk of GC as well as atrophic gastritis (AG). Genotyping for eight single nucleotide polymorphisms (SNPs) was conducted using Sequenom MassARRAY platform in a total of 2507 northern Chinese subjects, including 749 GC cases, 878 AG cases and 880 controls...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218950/-meta-analysis-of-yiqi-huoxue-method-in-treating-idiopathic-membranous-nephropathy
#17
Qi-Yan Zheng, Lu-Ying Sun, Hua-Nan Jin, Qian Zhou, Wen Zhang, Ya-Hui Wang
The incidence of idiopathic membranous nephropathy (IMN) is increasing year by year, and the clinical research on Chinese medicine treatment of INM is also growing. This study aims to evaluate the efficiency and safety of Yiqi Huoxue method for IMN. Data sources used were from PubMed, EMbase, the Cochrane Library, CBM, CNKI, Wanfang and VIP database. Two researchers independently screened the literature and extracted data. RevMan 5.3 software was used for Meta analysis, and the evidences were graded for the outcomes according to GRADE system by using GRADEprofiler 3...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29218938/-analysis-of-chemical-markers-in-sulfur-fumigated-anemarrhenae-rhizoma
#18
Wei Zheng, Fang-Xu Wang, Xin-Guang Sun, Li-Ping Kang, Yang Zhao, Jie Zhang, Bai-Ping Ma
Sulfur-containing Anemarrhenae Rhizoma decoction pieces were prepared by using sulfur-fumigating procedure. The difference components before and after sulfur fumigation in Anemarrhenae Rhizoma were analyzed and on-line identified by UPLC-Q-TOF-MSE combined with UNIFI informatics platform, principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) respectively. As a result, 16 major differences components were identified, and among them, 9 components were mainly from sulfur-fumigated samples...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29216774/chinese-fetal-biometry-reference-equations-and-comparison-with-charts-from-other-populations
#19
Yixiu Zhang, Hua Meng, Yuxin Jiang, Zhonghui Xu, Yunshu Ouyang, Shengli Li, Qian Chen, Qingqing Wu, Rui Li, Tong Ru, Aailu Cai, Xinlin Chen, Taizhu Yang, Ping Chen, Hongning Xie, Hong Lu, Qing Dai, Fen Dong, Meng Yang, Xiao Yang, Jia Lu, Jiawei Tian, Kun Sun, Hui Li
OBJECTIVE: This study aimed to construct new reference charts and equations for fetal biometry from Chinese fetuses at 15-40 weeks and to compare them with previous references. METHOD: This was a prospective, cross-sectional study of singleton pregnancies in patients with a confirmed gestational age who underwent ultrasound examinations between the 15th and 40th weeks of gestation. Each woman was selected only once for this study. Biparietal diameter (BPD), head circumference (HC), abdominal circumference (AC), and femur length (FL) were recorded...
December 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29215878/ultra-fast-screening-of-a-novel-moderate-hydrophilic-angiotensin-converting-enzyme-inhibitory-peptide-ryl-from-silkworm-pupa-using-fe-doped-silkworm-excrement-derived-biocarbon-waste-conversion-by-waste
#20
Long Liu, Yanan Wei, Qing Chang, Huaju Sun, Kungang Chai, Zuqiang Huang, Zhenxia Zhao, Zhongxing Zhao
A novel moderate hydrophilic peptide (RYL) with high ACE inhibitory activity was ultra-fast screened via a concept of waste conversion using waste. This novel peptide was screened from silkworm Pupa using Fe-doped porous biocarbon (FL/Z-SE) derived from silkworm excrement. FL/Z-SE possessed magnetic property and specific selection for peptides due to Fe's dual functions. The selected RYL with moderate hydrophilicity (LogP=-0.22) exhibited a comparatively high ACE inhibitory activity (IC<u>50</u>=3...
December 7, 2017: Journal of Agricultural and Food Chemistry
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