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https://www.readbyqxmd.com/read/29050459/third-party-regulatory-t-cells-prevent-murine-acute-graft-versus-host-disease
#1
Jung-Yeon Lim, Keon-Il Im, Yunejin Song, Nayoun Kim, Young-Sun Nam, Young-Woo Jeon, Seok-Goo Cho
Background/Aims: Adoptive therapy with regulatory T (Treg) cells to prevent graft-versus-host disease (GVHD) would benefit from a strategy to improve homing to the sites of inflammation following hematopoietic stem cell transplantation (HSCT). Although donor-derived Treg cells have mainly been used in these models, third-party-derived Treg cells are a promising alternative for cell-based immunotherapy, as they can be screened for pathogens and cell activity, and banked for GVHD prevention...
October 19, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29050322/microrna-466-with-tumor-markers-for-cervical-cancer-screening
#2
Li-Li Zhou, Yong Shen, Jiao-Mei Gong, Ping Sun, Jia-He Sheng
Cervical cancer is the second most common cancer in women in the world. In this study, we explore tumor markers and microRNA-466 combination for cervical cancer screening. Tumor markers were measured by the methods of electro-chemiluminescent immunoassay and enzyme immunoassay. The microRNA-466 was performed by quantitative real-time polymerase chain reaction. Among normal group, hyperplasia group and cancer group, the CEA expression levels were 2.26 ng/ml, 3.85 ng/ml and 16.08 ng/ml, respectively. While the CA125 expression levels were 13...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050167/-serum-procalcitonin-in-patients-with-pulmonary-infection-and-central-nervous-system-injury
#3
J C Li, L Y Wang, Y F Wang, M H Mei, L Shi, M L Yao, X D Guan, B Ouyang
Objective: To evaluate the influence of serum procalcitonin in the diagnosis and treatment of pulmonary infection in patients with central nervous system injury. Methods: From October 2014 to February 2017, a retrospective study was performed. A total of 1 852 patients were screened in Department of Intensive Care Unite, First Affiliated Hospital of Sun Yat-sen University.Among them, 173 patients were identified with different kinds of infection. Finally, a total of 42 patients with pulmonary infection were enrolled...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29050165/-ovarian-tumor-associated-with-anti-n-methyl-d-aspartate-receptor-encephalitis-a-report-of-15-cases
#4
X M Li, H Y Jiang, Y F Wang, W Qiu, Y Wang, H T Wu
Objective: To summarize the clinical features of patients with ovarian tumor and anti-N-methyl-D-aspartate receptor(NMDAR) encephalitis, and to explore the influence of operation patterns on the prognosis. Methods: The clinical information of patients with ovarian tumor and anti-NMDAR encephalitis in The 3rd Affiliated Hospital of Sun Yat-Sen University and The Zhujiang Hospital of Southern Medical University were collected and analyzed. Results: There were 15 patients were enrolled in this study, with the average age of 24...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29048894/immunomodulatory-polyketides-from-a-phoma-like-fungus-isolated-from-a-soft-coral
#5
Yi-Zhe Sun, Tibor Kurtán, Attila Mándi, Hua Tang, Yalan Chou, Keryea Soong, Li Su, Peng Sun, Chun-Lin Zhuang, Wen Zhang
Fourteen new polyketides with a trans-fused decalin ring system, libertalides A-N (3-16), together with two known analogues, aspermytin A and its acetate (1, 2), were isolated from the fermentation extract of a coral-derived Libertasomyces sp. fungus. Their relative configurations were elucidated on the basis of detailed spectroscopic analysis, and the absolute configurations were determined by TDDFT-ECD and optical rotation (OR) calculations. The OR of 1 and 2 were found to have opposite signs in CH3CN and CHCl3, which was in agreement with the OR calculations producing alternating signs for the optical rotation depending on the applied conditions...
October 19, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29047874/optimized-calibration-methodology-of-viirs-day-night-band-low-gain-stage-using-a-solar-diffuser
#6
Junqiang Sun, Menghua Wang
An enhanced methodology of the standard on-orbit calibration of the day-night band (DNB) of the visible infrared imaging radiometer suite on board the Suomi National Polar-orbiting Partnership satellite is presented, specifically for the low-gain stage. The range of the "sweet spot" for the fully illuminated scans in the calibration events is expanded from 4° to 7.8° in order to increase the number of fully illuminated scans to 72, which then permits a complete calibration of the DNB to be carried out within one orbit for all 36 aggregated modes and the two mirror sides...
May 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047471/teaching-rainbows-with-simulations-revisiting-minnaert-s-lab-experiment
#7
Francisco L Naranjo-Correa, Guadalupe Martinez-Borreguero, Angel Luis Pérez-Rodriguez, Pedro J Pardo-Fernandez, Maria Isabel Suero-Lopez
This work presents an educational simulation to support students' learning about the formation of the rainbow. The main aim of the simulation is to provide our students with a didactic tool in addition to their traditional laboratory practice, which can be easily implemented in e-learning teaching platforms. A system consisting of a flask filled with water and a screen with a rounded aperture placed between the sun and the flask was simulated; this way a faint rainbow was seen on the simulated screen. The interactive nature of the simulation allowed the students to perform some alterations that would be impossible to do in the real world; thus, the observed rainbow deviated from the simplest model...
July 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29045636/the-diagnostic-accuracy-of-the-ascertain-dementia-8-questionnaire-for-detecting-cognitive-impairment-in-primary-care-in-the-community-clinics-and-hospitals-a-systematic-review-and-meta-analysis
#8
Hsin-Hao Chen, Fang-Ju Sun, Tzu-Lin Yeh, Hsueh-Erh Liu, Hsiu-Li Huang, Benjamin Ing-Tiau Kuo, Hsin-Yi Huang
Background: The prevalence of cognitive impairment is increasing due to the aging population, and early detection is essential clinically. The Ascertain Dementia 8 (AD8) questionnaire is a brief informant-based measure recently developed to assess early cognitive impairment, however, its overall diagnostic performance is controversial. The objective of this meta-analysis was to assess the diagnostic accuracy of the AD8 for cognitive impairment. Methods: All relevant studies were collected from databases including MEDLINE, EMBASE and the Cochrane Library up to April 2017...
October 14, 2017: Family Practice
https://www.readbyqxmd.com/read/29045436/development-and-characterization-of-novel-chimeric-monoclonal-antibodies-for-broad-spectrum-neutralization-of-rabies-virus
#9
Pan Kyeom Kim, Sun Ju Keum, Modupe O V Osinubi, Richard Franka, Ji Young Shin, Sang Tae Park, Man Su Kim, Mi Jung Park, Soo Young Lee, William Carson, Lauren Greenberg, Pengcheng Yu, Xiaoyan Tao, Wang Lihua, Qing Tang, Guodong Liang, Madhusdana Shampur, Charles E Rupprecht, Shin Jae Chang
Current post-exposure prophylaxis for rabies virus infection has several limitations in terms of supply, cost, safety, and efficacy. Attempts to replace human or equine rabies immune globulins (HRIG or ERIG) have been made by several companies and institutes. We developed potent monoclonal antibodies to neutralize a broad spectrum of rabies viruses by screening hybridomas received from the U.S. Centers for Disease Control and Prevention (CDC). Two kinds of chimeric human antibodies (chimeric #7 and #17) were constructed by cloning the variable regions from selected hybridomas and the constant region of a human antibody...
2017: PloS One
https://www.readbyqxmd.com/read/29045170/high-glucose-variability-in-hospitalized-patients-with-type-1-diabetes-mellitus
#10
Vikash Dadlani, Shrikant U Tamhane, Aidong Sun, Anu Sharma, Danae A Delivanis, Prabin Thapa, Ricky E Carter, Yogish C Kudva
BACKGROUND: Glucose variability (GV) has been increasingly (or more extensively) studied in patients with type 1 diabetes (T1D) in the ambulatory setting; limited data exist on GV in hospitalized patients with T1D. MATERIALS AND METHODS: Retrospective single center cohort study, we analyzed in-hospital glucose measurements to assess GV in 736 hospitalized patients in different units over a consecutive 5-year period of time. GV was assessed by mean blood glucose (BG), Average daily risk range (ADRR), high BG index, and low BG index...
October 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29044846/socio-demographic-factors-drive-regional-differences-in-participation-in-the-national-bowel-cancer-screening-program-an-ecological-analysis
#11
Jiandong Sun, Sonja March, Michael J Ireland, Fiona Crawford-Williams, Belinda Goodwin, Melissa K Hyde, Suzanne K Chambers, Joanne F Aitken, Jeff Dunn
OBJECTIVE: To examine if geographic variations in the participation rates in the National Bowel Cancer Screening Program (NBCSP) are related to population-level socio-demographic characteristics. METHODS: Data reflecting participation in the NBCSP for 504 Local Government Areas (LGAs) between July 2011 and June 2013 were extracted from the Social Health Atlas of Australia. Logistic regression models were used to examine independent associations (odds ratios [ORs]) between participation, Remoteness Area (RA) and selected socio-demographic variables...
October 18, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29043394/in-silico-analyses-reveal-the-relationship-between-six1-eya1-mutations-and-conotruncal-heart-defects
#12
Bojian Li, Lijuan Xu, Nanchao Hong, Sun Chen, Rang Xu
Conotruncal heart defects (CTDs) represent a group of severe and complicated congenital cardiovascular malformations and require opportune clinical interventions once diagnosed. Occurrence of CTD is related to the functional abnormality of the second heart field (SHF), and variants of genes which regulate the development of the second heart field have been recognized as the main genetic factors leading to CTDs. Previous studies indicated that transcriptional complex SIX1/EYA1 may contribute to SHF development, and SIX1/EYA1 knockout mice exhibited a series of conotruncal malformations...
October 17, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29042372/awareness-and-willingness-towards-pre-exposure-prophylaxis-against-hiv-infection-among-individuals-seeking-voluntary-counselling-and-testing-for-hiv-in-taiwan-a-cross-sectional-questionnaire-survey
#13
Yi-Chieh Lee, Sui-Yuan Chang, Kuan-Yin Lin, Lan-Hsin Chang, Wen-Chun Liu, Cheng-Hsin Wu, Hsin-Yun Sun, Chien-Ching Hung, Shan-Chwen Chang
OBJECTIVES: We aimed to investigate the awareness and willingness towards pre-exposure prophylaxis (PrEP) among individuals seeking voluntary counselling and testing (VCT) for HIV in Taiwan, where PrEP is currently not reimbursed by the insurance. METHODS: Between April and October 2016, a questionnaire interview was conducted among VCT clients to inquire about the attitudes towards PrEP against HIV infection. Multivariate logistic regression analysis was performed to identify the associated factors with willingness to initiate PrEP...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29040830/combined-toxicity-of-prevalent-mycotoxins-studied-in-fish-cell-line-and-zebrafish-larvae-revealed-that-type-of-interactions-is-dose-dependent
#14
Hongyuan Zhou, Saji George, Caixia Li, Subramaniam Gurusamy, Xiulan Sun, Zhiyuan Gong, He Qian
While, Aflatoxin B1 (AFB1), deoxynivalenol (DON) and zearalenone (ZEN) are the most prevalent mycotoxins co-existing in grain products and animal feeds, little is known about their combinatorial toxicities on aquatic life-forms. We studied the individual and combined effects of these mycotoxins in a fish cell line (BF-2) and zebrafish larvae (wild-type and transgenic). The types of interactions in mycotoxins combinations on cell viability were determined by using Chou-Talalay model. Induction of oxidative stress pathway in mycotoxins-exposed BF-2 cells was assessed using high content screening (HCS)...
October 3, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29038510/lure-and-kill-yeast-interfering-rna-larvicides-targeting-neural-genes-in-the-human-disease-vector-mosquito-aedes-aegypti
#15
Limb K Hapairai, Keshava Mysore, Yingying Chen, Elizabeth I Harper, Max P Scheel, Alexandra M Lesnik, Longhua Sun, David W Severson, Na Wei, Molly Duman-Scheel
New mosquito control strategies are vitally needed to address established arthropod-borne infectious diseases such as dengue and yellow fever and emerging diseases such as Zika and chikungunya, all of which are transmitted by the disease vector mosquito Aedes aegypti. In this investigation, Saccharomyces cerevisiae (baker's yeast) was engineered to produce short hairpin RNAs (shRNAs) corresponding to the Aedes aegypti orthologs of fasciculation and elongation protein zeta 2 (fez2) and leukocyte receptor cluster (lrc) member, two genes identified in a recent screen for A...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038508/ottogi-inhibits-wnt-%C3%AE-catenin-signaling-by-regulating-cell-membrane-trafficking-of-frizzled8
#16
Hyun-Taek Kim, Mi-Sun Lee, Yun-Mi Jeong, Hyunju Ro, Dong-Il Kim, Yong-Hwan Shin, Ji-Eun Kim, Kyu-Seok Hwang, Jung-Hwa Choi, Minjin Bahn, Jeong-Ju Lee, Sang H Lee, Young-Ki Bae, Jin-Soo Lee, Joong-Kook Choi, Nam-Soon Kim, Chang-Yeol Yeo, Cheol-Hee Kim
Wnt signaling controls critical developmental processes including tissue/body patterning. Here we report the identification of a novel regulator of Wnt signaling, OTTOGI (OTG), isolated from a large-scale expression screening of human cDNAs in zebrafish embryos. Overexpression of OTG in zebrafish embryos caused dorso-anteriorized phenotype, inhibited the expression of Wnt target genes, and prevented nuclear accumulation of β-catenin. Conversely, knockdown of zebrafish otg using specific antisense morpholino promoted nuclear accumulation of β-catenin and caused ventralization...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037956/a-simple-and-cost-effective-assay-for-measuring-anti-drug-antibody-in-human-patients-treated-with-adalimumab
#17
Maohua Li, Hongzhen Li, Kai Gao, Muyang Wang, Wenqi An, Yaran Zhu, Li Ding, Lan Wang, Jingliang Gu, Conglin Zuo, Le Sun
It has been reported that 90% of the anti-drug antibody (ADA) to Adalimumab in human patients bound to the TNF-binding area, resulted in the annual loss of responses to Adalimumab up to 24%. It is of urgency to develop a cost-effective and easy-to-use ADA diagnostic kit for diagnosis of potential drug-resistance in patients treated with Adalimumab in clinic hospitals to avoid the tremendous economic and human costs to patients and health-care providers. In this study, we reported the generations of mouse monoclonal and monkey polyclonal antibodies against Adalimumab as assay standards and positive quality controls respectively...
October 13, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29037896/manipulation-of-the-response-of-human-endothelial-colony-forming-cells-by-focal-adhesion-assembly-using-gradient-nanopattern-plates
#18
Long-Hui Cui, Hyung Joon Joo, Dae Hwan Kim, Ha-Rim Seo, Jung Suk Kim, Seung-Cheol Choi, Li-Hua Huang, Ji Eun Na, I-Rang Lim, Jong-Ho Kim, Im Joo Rhyu, Soon Jun Hong, Kyu Back Lee, Do-Sun Lim
Nanotopography plays a pivotal role in the regulation of cellular responses. Nonetheless, little is known about how the gradient size of nanostructural stimuli alters the responses of endothelial progenitor cells without chemical factors. Herein, the fabrication of gradient nanopattern plates intended to mimic microenvironment nanotopography is described. The gradient nanopattern plates consist of nanopillars of increasing diameter ranges [120-200 nm (GP 120/200), 200-280 nm (GP 200/280), and 280-360 nm (GP 280/360)] that were used to screen the responses of human endothelial colony-forming cells (hECFCs)...
October 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29035732/development-and-validation-of-an-automated-delirium-risk-assessment-system-auto-delras-implemented-in-the-electronic-health-record-system
#19
Kyoung-Ja Moon, Yinji Jin, Taixian Jin, Sun-Mi Lee
BACKGROUND: A key component of the delirium management is prevention and early detection. OBJECTIVE: To develop an automated delirium risk assessment system (Auto-DelRAS) that automatically alerts health care providers of an intensive care unit (ICU) patient's delirium risk based only on data collected in an electronic health record (EHR) system, and to evaluate the clinical validity of this system. DESIGN: Cohort and system development designs were used...
September 23, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29029697/the-identification-of-transcriptional-regulation-related-gene-of-laccase-poxc-through-yeast-one-hybrid-screening-from-pleurotus-ostreatus
#20
Yuancheng Qi, Chao Liu, Xiankai Sun, Liyou Qiu, Jinwen Shen
Pleurotus ostreatus laccase gene poxc is transcriptionally induced by copper, and several putative MREs have been found and confirmed in its promoter region. However, the related transcription factors mediating copper response via MREs have not been reported. To isolate MRE binding proteins, we carried out yeast one-hybrid screens. Reporter genes containing two trimers of the cMRE2 and cMRE3 element were prepared and introduced into a yeast strain. The yeast was transformed with library cDNA that represents RNA isolated from CuSO4-treated fungi of P...
November 2017: Fungal Biology
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