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11C Methionine

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https://www.readbyqxmd.com/read/29207622/the-performance-of-11c-methionine-pet-in-the-differential-diagnosis-of-glioma-recurrence
#1
Weilin Xu, Liansheng Gao, Anwen Shao, Jingwei Zheng, Jianmin Zhang
Despite the advancement of neuroimaging techniques, it often remains a diagnostic challenge to distinguish recurrent glioma from lesions representing treatment effect. Preliminary reports suggest that 11C-methionine Positron emission tomography (PET) can assist in diagnosing true glioma recurrence. We present here a meta-analysis to assess the accuracy of 11C-methionine PET in identifying recurrent glioma in patients who had undergone prior therapy. A comprehensive search of the PubMed, Embase and Chinese Biomedical (CBM) databases yielded 23 eligible articles comprising 29 studies listed prior to November 20, 2016, representing 891 patients...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206062/discrimination-between-primary-low-grade-and-high-grade-glioma-with-11c-methionine-pet-a-bivariate-diagnostic-test-accuracy-meta-analysis
#2
Anna F Delgado, Alberto F Delgado
OBJECTIVE: To perform a meta-analysis evaluating the diagnostic accuracy of 11C-methionine (MET) positron emission tomography (PET) to discriminate between primary low-grade glioma (LGG) and high-grade glioma (HGG). METHODS: A systematic database search was performed by a librarian in relevant databases with the latest search in November 7th, 2016. Hits were assessed for inclusion independently by two authors. Individual patient data (IPD) on relative MET uptake was extracted on patients examined preoperatively with MET PET and subsequent neuropathological diagnosis of astrocytoma or oligodendroglioma...
December 5, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29175980/glioma-survival-prediction-with-the-combined-analysis-of-in-vivo-11c-met-pet-ex-vivo-and-patient-features-by-supervised-machine-learning
#3
Laszlo Papp, Nina Poetsch, Marko Grahovac, Victor Schmidbauer, Adelheid Woehrer, Matthias Preusser, Markus Mitterhauser, Barbara Kiesel, Wolfgang Wadsak, Thomas Beyer, Marcus Hacker, Tatjana Traub-Weidinger
Gliomas are the most common types of tumors in the brain. While the definite diagnosis is routinely made ex vivo by histopathologic and molecular examination, diagnostic work-up of patients with suspected glioma is mainly done by using magnetic resonance imaging (MRI). Nevertheless, L-S-methyl-11C-methionine (11C-MET) Positron Emission Tomography (PET) holds a great potential in characterization of gliomas. The aim of this study was to establish machine learning (ML) driven survival models for glioma built on 11C-MET-PET, ex vivo and patient characteristics...
November 24, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29016947/visual-and-semiquantitative-11c-methionine-pet-an-independent-prognostic-factor-for-survival-of-newly-diagnosed-and-treatment-naive-gliomas
#4
Nina Poetsch, Adelheid Woehrer, Johanna Gesperger, Julia Furtner, Alexander R Haug, Dorothee Wilhelm, Georg Widhalm, Georgios Karanikas, Michael Weber, Ivo Rausch, Markus Mitterhauser, Wolfgang Wadsak, Marcus Hacker, Matthias Preusser, Tatjana Traub-Weidinger
Background: Few data exist regarding the prognostic value of L-[S-methyl- 11C]methionine (MET) PET for treatment-naive gliomas. Methods: A total of 160 glioma patients (89 men, 71 women, mean age: 45, range 18 - 84 yrs) underwent a MET PET prior to any therapy. The PET scans were evaluated visually and semiquantitatively by tumor to background (T/N) ratio thresholds chosen by ROC-Analysis. Additionally, isocitrate dehydrogenase 1-R132H (IDH1-R132H) immunohistochemistry was performed...
September 9, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28918564/mri-combined-with-pet-ct-of-different-tracers-to-improve-the-accuracy-of-glioma-diagnosis-a-systematic-review-and-meta-analysis
#5
REVIEW
Yihan Yang, Mike Z He, Tao Li, Xuejun Yang
Based on studies focusing on positron emission tomography (PET)-computed tomography (CT) combined with magnetic resonance imaging (MRI) in the diagnosis of glioma, we conducted a systematic review and meta-analysis evaluating the pros and cons and the accuracy of different examinations. PubMed and Cochrane Library were searched. The search was conducted until April 2017. Two reviewers independently conducted the literature search according to the criteria set initially. Based on the exclusion criteria, 15 articles are included in this study...
September 16, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28902730/dural-malt-lymphoma-detected-by-11c-methionine-pet-ct
#6
Salvatore Annunziata, Annarosa Cuccaro, Carmelo Caldarella, Stefan Hohaus
A 53-year-old man had a diagnosis of mucosa-associated lymphoid tissue lymphomas of the dura in the left tentorium. The patient underwent whole-body F-FDG PET/CT and C-methionine PET/CT in order to complete the staging of dural mucosa-associated lymphoid tissue lymphoma. C-methionine uptake was detected in multiple meningeal sites, including left tentorium, with no significant FDG uptake in the same regions.
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28879406/whole-tumor-histogram-analysis-of-the-cerebral-blood-volume-map-tumor-volume-defined-by-11c-methionine-positron-emission-tomography-image-improves-the-diagnostic-accuracy-of-cerebral-glioma-grading
#7
Rongli Wu, Yoshiyuki Watanabe, Atsuko Arisawa, Hiroto Takahashi, Hisashi Tanaka, Yasunori Fujimoto, Tadashi Watabe, Kayako Isohashi, Jun Hatazawa, Noriyuki Tomiyama
PURPOSE: This study aimed to compare the tumor volume definition using conventional magnetic resonance (MR) and 11C-methionine positron emission tomography (MET/PET) images in the differentiation of the pre-operative glioma grade by using whole-tumor histogram analysis of normalized cerebral blood volume (nCBV) maps. MATERIALS AND METHODS: Thirty-four patients with histopathologically proven primary brain low-grade gliomas (n = 15) and high-grade gliomas (n = 19) underwent pre-operative or pre-biopsy MET/PET, fluid-attenuated inversion recovery, dynamic susceptibility contrast perfusion-weighted magnetic resonance imaging, and contrast-enhanced T1-weighted at 3...
October 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28825948/11c-methionine-avid-plasmablastic-lymphoma
#8
Salvatore Annunziata, Annarosa Cuccaro, Carmelo Caldarella, Lucia Leccisotti, Stefan Hohaus
A 73-year-old woman had a diagnosis of a plasmablastic lymphoma by the excision of the right parotid gland. Two years after the diagnosis, the patient underwent a whole-body C-methionine PET/CT in order to evaluate the amino acid avidity of a scalp metastasis and for plasmablastic lymphoma restaging. C-methionine uptake was detected in the scalp, in several bone sites, and in the cricoid cartilage. Plasmablastic lymphoma is a subtype of B-cell lymphoma with an aggressive behavior and a poor prognosis. C-methionine appears to be a promising tracer for paraprotein-producing neoplasms...
August 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28721805/automated-one-pot-radiosynthesis-of-11c-s-adenosyl-methionine
#9
Florencia Zoppolo, Williams Porcal, Patricia Oliver, Eduardo Osvaldo Savio, Henry Engler
BACKGROUND: Glycine-N-methyl transferase is an enzyme overexpressed in some neoplastic tissues. It catalyses the methylation of glycine using S-adenosyl methionine (SAM) as co-enzyme. SAM is involved in a great variety of biochemical processes, including transmethylation reactions. Thus, [11C]SAM could be used to evaluate transmethylation activity in tumours. The only method reported for [11C]SAM synthesis is an enzymatic process with several limitations. We propose a new chemical method to obtain [11C]SAM, through a one-pot synthesis...
July 18, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28708598/the-performance-of-11c-methionine-pet-in-the-differential-diagnosis-of-glioma-recurrence
#10
Weilin Xu, Liansheng Gao, Anwen Shao, Jingwei Zheng, Jianmin Zhang
Despite the advancement of neuroimaging techniques, it often remains a diagnostic challenge to distinguish recurrent glioma from lesions representing treatment effect. Preliminary reports suggest that 11C-methionine Positron emission tomography (PET) can assist in diagnosing true glioma recurrence. We present here a meta-analysis to assess the accuracy of 11C-methionine PET in identifying recurrent glioma in patients who had undergone prior therapy. A comprehensive search of the PubMed, Embase and Chinese Biomedical (CBM) databases yielded 23 eligible articles comprising 29 studies listed prior to November 20, 2016, representing 891 patients...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28319499/developmental-venous-anomalies-mimicking-neoplasm-on-11c-methionine-pet-and-dsc-perfusion-mri
#11
Julie H Harreld, Mikhail Doubrovin, Elizabeth R Butch, Angela Edwards, Barry Shulkin
Elevated relative cerebral blood volume on perfusion MRI and increased uptake on C-methionine PET can be used to diagnose and guide biopsy of brain tumors but are not specific. We report increased uptake on C-methionine PET associated with 4 developmental venous anomalies (DVAs) in 3 children with brain tumors, which could potentially mimic tumor and misdirect biopsy. Because DVAs are not readily visible on CT, prevention of misdirected biopsy in patients with focally elevated C-methionine uptake and relative cerebral blood volume relies on close correlation with contrast-enhanced anatomic MRI to exclude DVA or other nonneoplastic etiology...
May 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28245294/amino-acid-transport-system-a-substrate-predicts-the-therapeutic-effects-of-particle-radiotherapy
#12
Tomoya Uehara, Mariko Watanabe, Hiroyuki Suzuki, Yoshiya Furusawa, Yasushi Arano
L-[methyl-11C]Methionine (11C-Met) is useful for estimating the therapeutic efficacy of particle radiotherapy at early stages of the treatment. Given the short half-life of 11C, the development of longer-lived 18F- and 123I-labeled probes that afford diagnostic information similar to 11C-Met, are being sought. Tumor uptake of 11C-Met is involved in many cellular functions such as amino acid transport System-L, protein synthesis, and transmethylation. Among these processes, since the energy-dependent intracellular functions involved with 11C-Met are more reflective of the radiotherapeutic effects, we evaluated the activity of the amino acid transport System-A as an another energy-dependent cellular function in order to estimate radiotherapeutic effects...
2017: PloS One
https://www.readbyqxmd.com/read/27922862/improved-detection-of-minimal-residual-disease-by-11c-methionine-pet-ct-in-a-young-patient-with-unusual-extramedullary-presentation-of-recurrent-multiple-myeloma
#13
Carmelo Caldarella, Salvatore Annunziata, Livio Pagano, Valerio De Stefano, Vittoria Rufini
Extramedullary relapse of multiple myeloma (MM) is uncommon. A 40-year-old woman with history of MM underwent PET/CT using C-methionine (C-MET) after the detection of a vulvar lesion on MRI, biopsy proven to be extramedullary relapse of MM. The vulvar lesion was negative at the F-FDG PET/CT but showed high uptake of C-MET; focal uptake of both F-FDG and C-MET was shown within the muscles of the left leg, histologically confirmed as extramedullary relapse of MM. F-FDG PET/CT performed after chemotherapy showed no uptake in both sites, whereas posttreatment C-MET PET/CT showed persistence of residual uptake within the vulvar lesion...
February 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27907162/simultaneous-11c-methionine-positron-emission-tomography-magnetic-resonance-imaging-of-suspected-primary-brain-tumors
#14
Cornelius Deuschl, Sophia Goericke, Johannes Grueneisen, Lino Morris Sawicki, Juliane Goebel, Nicolai El Hindy, Karsten Wrede, Ina Binse, Thorsten Poeppel, Harald Quick, Michael Forsting, Joerg Hense, Lale Umutlu, Marc Schlamann
INTRODUCTION: The objective of this study was to assess the diagnostic value of integrated 11C- methionine PET/MRI for suspected primary brain tumors, in comparison to MRI alone. MATERIAL AND METHODS: Forty-eight consecutive patients with suspected primary brain tumor were prospectively enrolled for an integrated 11C-methionine PET/MRI. Two neuro-radiologists separately evaluated the MRI alone and the integrated PET/MRI data sets regarding most likely diagnosis and diagnostic confidence on a 5-point scale...
2016: PloS One
https://www.readbyqxmd.com/read/27846727/-current-progresses-in-developing-pet-radiopharmaceuticals-for-patients-in-the-czech-republic
#15
J Adam, R Demlová, Z Řehák
BACKGROUND: In Masaryk Memorial Cancer Institute (MMCI), there is a long-running intensive joint effort of the RECAMO project and commercial entities, involving mainly clinical evaluations of state-of-the-art PET radiopharmaceuticals leading to their future availability for Czech physicians and their patients. Recently, the PET tracers [11C]methionine and [18F]fluorocholine, among others, were developed in this cooperation, both of them tracers with high importance for oncologic positron emission tomography diagnostics...
December 0: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/27835793/differences-in-accumulation-and-the-transport-mechanism-of-l-and-d-methionine-in-high-and-low-grade-human-glioma-cells
#16
Masato Kobayashi, Asuka Mizutani, Kodai Nishi, Syuichi Nakajima, Naoto Shikano, Ryuichi Nishii, Kazuki Fukuchi, Keiichi Kawai
INTRODUCTION: Although [S-methyl-11C]-labeled L-methionine and D-methionine ((11)C-L-MET and (11)C-D-MET) are useful radiotracers for positron emission tomography imaging of brain tumors, it is not known whether the accumulation and transport mechanisms underlying uptake of (11)C-D-MET and (11)C-L-MET are the same. (11)C-L-MET is mainly taken up by the amino acid transport system L. We evaluated accumulation and the transport mechanism of D-MET in high- and low-grade human glioma cells in vitro...
January 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27673782/pseudoprogression-of-glioblastoma-multiforme-after-chemoradiation-therapy-diagnosis-by-11c-methionine-positron-emission-tomography-pet
#17
M Matsuo, H Tanaka, T Yamaguchi, H Nishibori, S Ogawa
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27648703/mri-and-11c-methyl-l-methionine-pet-differentiate-bevacizumab-true-responders-after-initiating-therapy-for-recurrent-glioblastoma
#18
Takaaki Beppu, Kazunori Terasaki, Toshiaki Sasaki, Yuichi Sato, Makiko Tomabechi, Kenichi Kato, Makoto Sasaki, Kuniaki Ogasawara
PURPOSE: Normalization of tumor vasculature after administering bevacizumab (BEV) makes assessment of therapeutic response using MRI difficult. The aim of this study was to clarify whether PET with C-methyl-L-methionine (MET-PET) would supplement MRI assessing of response after initiating BEV in glioblastoma. METHODS: Twenty patients with recurrent glioblastoma were treated with biweekly BEV plus temozolomide. Both MRI and MET-PET were performed before treatment (baseline) and at 4 and 8 weeks after starting treatment...
November 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27609791/comparison-of-11-c-methionine-and-18-f-fdg-pet-ct-for-staging-and-follow-up-of-pediatric-lymphoma
#19
COMPARATIVE STUDY
Sue C Kaste, Scott E Snyder, Monika L Metzger, John T Sandlund, Scott C Howard, Matthew Krasin, Barry L Shulkin
Methionine transport across plasma membranes occurs via the large amino acid transporter, which is overexpressed in malignant cells, leading to tracer accumulation within tumors. We investigated the uptake of (11)C-methionine ((11)C-MET) in children and young adults with Hodgkin lymphoma (HL) or non-Hodgkin lymphoma (NHL) and compared the biodistribution of (11)C-MET PET/CT with that of (18)F-FDG PET/CT. Methods: Conducted under an investigational new drug authorization, we prospectively enrolled patients with newly diagnosed HL (n = 19) and NHL (n = 2) onto the Institutional Review Board-approved investigation of (11)C-MET PET/CT...
March 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27589877/the-diagnostic-value-of-11c-methionine-pet-in-hyperparathyroidism-with-negative-99mtc-mibi-spect-a-meta-analysis
#20
Leilei Yuan, Jun Liu, Ying Kan, Jigang Yang, Xufu Wang
Background 99mTc-sestamibi (MIBI) parathyroid SPECT is generally regarded as the best preoperative localizing method in patients with hyperparathyroidism (HPT). However, 99mTc-MIBI SPECT is false negative in approximately 25% of adenomas. 11C-methionine positron emission tomography (PET) has been used in HPT with negative 99mTc-MIBI SPECT scan results. Purpose To systematically review and conduct a meta-analysis of published data on the performance of 11C-methionine PET in patients with HPT with negative 99mTc-MIBI SPECT...
May 2017: Acta Radiologica
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