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https://www.readbyqxmd.com/read/28744722/temporal-encoding-strategies-result-in-boosts-to-final-free-recall-performance-comparable-to-spatial-ones
#1
Nichole Bouffard, Jared Stokes, Hannah J Kramer, Arne D Ekstrom
The method of loci is a highly effective mnemonic that recruits existing salient memory for spatial locations and uses the information as a scaffold for remembering a list of items (Yates, 1966). One possible account for the effectiveness of the spatial method of loci comes from the perspective that it utilizes evolutionarily preserved mechanisms for spatial navigation within the hippocampus (Maguire et al. in Proceedings of the National Academy of Sciences, 97(8), 4398-4403, 2000; O'Keefe & Nadel, 1978; Rodriguez et al...
July 25, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28743952/scaling-relations-and-self-similarity-of-3-dimensional-reynolds-averaged-navier-stokes-equations
#2
Ali Ercan, M Levent Kavvas
Scaling conditions to achieve self-similar solutions of 3-Dimensional (3D) Reynolds-Averaged Navier-Stokes Equations, as an initial and boundary value problem, are obtained by utilizing Lie Group of Point Scaling Transformations. By means of an open-source Navier-Stokes solver and the derived self-similarity conditions, we demonstrated self-similarity within the time variation of flow dynamics for a rigid-lid cavity problem under both up-scaled and down-scaled domains. The strength of the proposed approach lies in its ability to consider the underlying flow dynamics through not only from the governing equations under consideration but also from the initial and boundary conditions, hence allowing to obtain perfect self-similarity in different time and space scales...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743087/quinoline-containing-acetyl-hydrazone-an-easily-accessible-switch-on-optical-chemosensor-for-zn-2
#3
Wei-Na Wu, Pan-Dong Mao, Yuan Wang, Xiao-Lei Zhao, Zhou-Qing Xu, Zhi-Hong Xu, Yuan Xue
A simple chemosensor, namely, N-((quinolin-8-yl)methylene)acetohydrazide (1) was synthesized and used as an off-on fluorescence sensor, which exhibits high selectivity toward Zn(2+) in aqueous media. The probe has large Stokes shift of >200nm, and its detection limit for Zn(2+) is 89.3nM. The binding process was confirmed through UV-vis absorption analysis, fluorescence measurements, mass spectroscopy study, (1)H NMR spectra and density functional theory calculation. The crystal structures of Zn(2+), Ni(2+), and Cu(2+) complexes based on 1 were determined through X-ray crystallographic analysis...
July 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28742922/intracellular-imaging-of-docosanol-in-living-cells-by-coherent-anti-stokes-raman-scattering-microscopy
#4
Sixian You, Yuan Liu, Zane Arp, Youbo Zhao, Eric J Chaney, Marina Marjanovic, Stephen A Boppart
No abstract text is available yet for this article.
July 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28741145/thigh-muscle-and-subcutaneous-tissue-thickness-measured-using-ultrasound-imaging-in-older-females-living-in-extended-care-a-preliminary-study
#5
Daniella Welch, Laetitia Sungu Ndanyo, Simon Brown, Sandra Agyapong-Badu, Martin Warner, Maria Stokes, Dinesh Samuel
BACKGROUND: Thigh tissue thickness has not been examined in older females living in extended care in UK as an indicator of musculoskeletal health. This study examined the feasibility of using ultrasound imaging to measure the thickness of superficial (fat) and deep layers (muscle) of the thigh in older females living in extended care. METHODS: In ten older females in extended care (aged 80-98 years, mean 88 ± 6.8; body mass: 56.5 ± 12.6 kg) images of the anterior thigh (dominant) were taken in supine using B-mode ultrasound imaging...
July 24, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28738657/a-new-strategy-for-fabrication-of-water-dispersible-and-biodegradable-fluorescent-organic-nanoparticles-with-aie-and-esipt-characteristics-and-their-utilization-for-bioimaging
#6
Dazhuang Xu, Meiying Liu, Hui Zou, Jianwen Tian, Hongye Huang, Qing Wan, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Fluorescence probes play a crucial role in optical imaging for visualization of complex biological processes. As compared with conventional organic fluorogens, the probes with aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) characteristics show significant advantages in high quantum yield at concentrated and aggregated state, large Stokes shift and low cytotoxicity. However, the synthesis of AIE-active fluorescent probes through the ESIPT mechanism has received only very limited attention...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738627/a-novel-ph-probe-based-on-ratiometric-fluorescent-properties-of-dicyanomethylene-4h-chromene-platform
#7
Xiaolei Liu, Jixun Han, Yan Zhang, Xiaofeng Yang, Yu Cui, Guoxin Sun
We report here a ratiometric pH probe (Z)-2-(2-(2-(4-hydroxyphenyl)-2-(pyrrolidin-1-yl)vinyl) -4H-chromen-4-ylidene)-malononitrile over the pH range of 2.44-6.00. It was synthesized by Knoevenagel Reaction from dicyanomethylene-4H-chromene and pyrrolidine. This is the first example of pyrrolidine as a part of the product structure in Knoevenagel condensation. High selectivity and sensitivity for pH variation were observed with significant fluorescent ratiometric responses and a remarkable Stokes shift (about 138nm)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738610/a-novel-donor-%C3%AF-acceptor-type-fluorescence-probe-for-sensing-ph-mechanism-and-application-in-vivo
#8
Jianbin Chao, Huijuan Wang, Yongbin Zhang, Caixia Yin, Fangjun Huo, Kailun Song, Zhiqing Li, Ting Zhang, Yaqin Zhao
A novel pH fluorescent probe 1-(pyren-1-yl)-3-(6-methoxypridin-3-yl)-acrylketone, (PMPA), which had a pyrene structure attached to methoxypyridine, was synthesized for monitoring extremely acidic and alkaline pH. The pH titrations indicated that PMPA displayed a remarkable emission enhancement with a pKa of 2.70 and responded linearly to minor pH fluctuations within the extremely acidic range of 1.26-3.97. Interestingly, PMPA also exhibited strong pH-dependent characteristics with pKa 9.32 and linear response to extreme-alkalinity range of 8...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738606/a-label-free-fluorometric-assay-for-actin-detection-based-on-enzyme-responsive-dna-templated-copper-nanoparticles
#9
Quanwei Song, Lixia Yang, Hongkun Chen, Rong Zhang, Na Na, Jin Ouyang
Herein, we develop a fluorescent strategy for label-free detection of actin by the in situ formation of double-stranded DNA (dsDNA) templated copper nanoparticles (CuNPs) and the digestion capability of deoxyribonuclease I (DNase I). In this design, the introduction of actin can effectively hinder the enzymic digestion owing to the exceptional target-mediated conformational structure between actin and DNase I. Consequently, the remaining adenine-thymine-rich dsDNA can act as an efficient template for fluorescent CuNPs (λex = 340nm, λem = 585nm) with a Mega-Stokes shifting (245nm)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28737786/fluorescence-emission-originated-from-the-h-aggregated-cyanine-dye-with-chiral-gemini-surfactant-assemblies-having-a-narrow-absorption-band-and-a-remarkably-large-stokes-shift
#10
Naoya Ryu, Yutaka Okazaki, Emilie Pouget, Makoto Takafuji, Shoji Nagaoka, Hirotaka Ihara, Reiko Oda
We demonstrate that the fluorescence emission that originated from a cyanine dye forming H-aggregates with a narrow absorption band and a remarkably large Stokes shift can be induced by symmetry breaking. The H-aggregate formation was successfully induced using chirally assembled cationic gemini surfactants with enantiomeric tartrate counterions as templates in water.
July 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28737182/micro-and-nano-patterned-elastin-like-polypeptide-hydrogels-for-stem-cell-culture
#11
A Paul, M Stührenberg, S Chen, D Rhee, W-K Lee, T W Odom, S C Heilshorn, A Enejder
We show that submicron-sized patterns can be imprinted into soft, recombinant-engineered protein hydrogels (here elastin-like proteins, ELP) by transferring wavy patterns from polydimethylsiloxane (PDMS) molds. The high-precision topographical tunability of the relatively stiff PDMS is translated to a bio-responsive, soft material, enabling topographical cell response studies at elastic moduli matching those of tissues. Aligned and unaligned wavy patterns with mold periodicities of 0.24-4.54 μm were imprinted and characterized by coherent anti-Stokes Raman scattering and atomic force microscopy...
July 24, 2017: Soft Matter
https://www.readbyqxmd.com/read/28736661/brain-tumor-delineation-enhanced-by-moxifloxacin-based-two-photon-cars-combined-microscopy
#12
Viet-Hoan Le, Su Woong Yoo, Yeoreum Yoon, Taejun Wang, Bumju Kim, Seunghun Lee, Kyung-Hwa Lee, Ki Hean Kim, Euiheon Chung
Delineating brain tumor margin is critical for maximizing tumor removal while sparing adjacent normal tissue for better clinical outcome. We describe the use of moxifloxacin-based two-photon (TP)/coherent anti-Stokes Raman scattering (CARS) combined microscopy for differentiating normal mouse brain tissue from metastatic brain tumor tissue based on histoarchitectural and biochemical differences. Moxifloxacin, an FDA-approved compound, was used to label cells in the brain, and moxifloxacin-based two-photon microscopy (TPM) revealed tumor lesions with significantly high cellular density and invading edges in a metastatic brain tumor model...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28735539/strong-size-dependency-on-the-carrier-and-photon-dynamics-in-ingan-gan-single-nanowalls-determined-using-photoluminescence-and-ultrafast-transient-absorption-spectroscopy
#13
S Chouksey, S Sankaranarayanan, V Pendem, P K Saha, S Ganguly, D Saha
Here, we have demonstrated strong size dependency of quasi-equilibrium and nonequilibrium carrier and photon dynamics in InGaN/GaN single nanowalls using photoluminescence and transient absorption spectroscopy. We demonstrate that two-dimensional carrier confinement, strain relaxation, and modified density of states lead to a reduced Stokes shift, smaller full width at half-maxima, increased exciton binding energy, and reduced nonradiative recombination. The ultrafast transient spectroscopy shows that carrier capture is a two-step process dominated by optical phonons and carrier-carrier scattering in succession...
July 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28735415/cfd-simulation-of-aerosol-delivery-to-a-human-lung-via-surface-acoustic-wave-nebulization
#14
Morteza Yousefi, Oveis Pourmehran, Mofid Gorji-Bandpy, Kiao Inthavong, Leslie Yeo, Jiyuan Tu
Administration of drug in the form of particles through inhalation is generally preferable in the treatment of respiratory disorders. Conventional inhalation therapy devices such as inhalers and nebulizers, nevertheless, suffer from low delivery efficiencies, wherein only a small fraction of the inhaled drug reaches the lower respiratory tract. This is primarily because these devices are not able to produce a sufficiently fine drug mist that has aerodynamic diameters on the order of a few microns. This study employs computational fluid dynamics to investigate the transport and deposition of the drug particles produced by a new aerosolization technique driven by surface acoustic waves (SAWs) into an in silico lung model geometrically reconstructed using computed tomography scanning...
July 22, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28735354/transplantation-sites-for-human-and-murine-islets
#15
Rebecca A Stokes, Kim Cheng, Amit Lalwani, Michael M Swarbrick, Helen E Thomas, Thomas Loudovaris, Tom W Kay, Wayne J Hawthorne, Philip J O'Connell, Jenny E Gunton
AIMS/HYPOTHESIS: Beta cell replacement is a potential cure for type 1 diabetes. In humans, islet transplants are currently infused into the liver via the portal vein, although this site has disadvantages. Here, we investigated alternative transplantation sites for human and murine islets in recipient mice, comparing the portal vein with quadriceps muscle and kidney, liver and spleen capsules. METHODS: Murine islets were isolated from C57BL6/J mice and transplanted into syngeneic recipients...
July 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/28731349/improved-metrological-traceability-of-particle-size-values-measured-with-line-start-incremental-centrifugal-liquid-sedimentation
#16
Vikram Kestens, Victoria A Coleman, Pieter-Jan De Temmerman, Caterina Minelli, Holger Woehlecke, Gert Roebben
Line-start incremental centrifugal liquid sedimentation (disc-CLS) is a powerful method to determine particle size. It is based on Stokes' law and on the measurement of particle sedimentation rate through a liquid with a density gradient. Because several of the input quantities of the Stokes' equation cannot be easily determined for this case of a rotating disc, the usual disc-CLS approach relies on calibrating the sedimentation time scale with commercially available PVC reference particles. To use these calibrant particles for establishing metrological traceability, they must fulfil the same requirements as those imposed on a certified reference material, i...
July 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28730558/transplantation-sites-for-porcine-islets
#17
Rebecca A Stokes, Denbigh M Simond, Heather Burns, Anita T Patel, Philip J O'Connell, Jenny E Gunton, Wayne J Hawthorne
AIMS/HYPOTHESIS: Xenotransplantation has great potential to provide beta cell replacement and thereby provide a cure for large numbers of people with type 1 diabetes. Crucial to the success of xenotransplantation is establishment of the most viable sites for transplantation. METHODS: We compared porcine islet tissue transplanted into kidney, liver and spleen in pig recipients as assessed by blood glucose levels and IVGTT. RESULTS: Kidney was the superior site for porcine islet tissue transplantation, followed by liver then spleen...
July 21, 2017: Diabetologia
https://www.readbyqxmd.com/read/28729006/a-representative-assessment-of-the-management-of-open-fractures-of-the-lower-limb-within-uk-orthoplastic-centres-a-two-centre-audit-of-compliance-with-national-standards
#18
B Rymer, E O F Dimovska, D T S Chou, R Choa, B Davis, S Huq
BACKGROUND: Open fractures of the lower limb represent a complex and varied array of injuries. The BOAST 4 document produced by BAPRAS and the BOA provides standards on how to manage these patients, and NICE have recently produced additional guidance. We aimed to assess concordance with these standards in a large cohort representative of UK orthoplastic centres. METHODS: Patients admitted to the orthoplastic units at Norfolk and Norwich University Hospital and Royal Stoke University Hospital with open lower limb fractures between 2009 and 2014 were included...
July 11, 2017: Injury
https://www.readbyqxmd.com/read/28728004/effects-of-aspect-ratio-of-multi-walled-carbon-nanotubes-on-coal-washery-waste-water-treatment
#19
Ahmed Aliyu, Ishaq Kariim, Saka Ambali Abdulkareem
The dependency of adsorption behaviour on the aspect ratio of multi-walled carbon nanotubes (MWCNTs) has been explored. In this study, effect of growth temperature on yield and aspect ratio of MWCNTs by catalytic chemical vapour deposition (CCVD) method is reported. The result revealed that yield and aspect ratio of synthesised MWCNTs strongly depend on the growth temperature during CCVD operation. The resulting MWCNTs were characterized by High Resolution Transmission Electron Microscope (HRTEM), Dynamic Light Scattering (DLS) and X-ray diffraction (XRD) techniques to determine it diameter, hydrodynamic diameter and crystallinity respectively...
July 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28727418/combining-tof-sims-imaging-mass-spectrometry-and-cars-microspectroscopy-reveals-lipid-patterns-reminiscent-of-gene-expression-patterns-in-the-wing-imaginal-disc-of-drosophila-melanogaster
#20
Florian Marty, Gianluca Rago, Donald F Smith, Xiaoli Gao, Gert B Eijkel, Luke MacAleese, Mischa Bonn, Erich Brunner, Konrad Basler, Ron M A Heeren
Using label-free ToF-SIMS imaging mass spectrometry, we generated a map of small molecules differentially expressed in the Drosophila wing imaginal disc. The distributions of these moieties were in line with gene expression patterns observed during wing imaginal disc development. Combining ToF-SIMS imaging and coherent anti-Stokes Raman spectroscopy (CARS) microspectroscopy allowed us to locally identify acylglycerols as the main constituents of the pattern differentiating the future body wall tissue from the wing blade tissue...
July 20, 2017: Analytical Chemistry
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