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https://www.readbyqxmd.com/read/28922900/grass-pollen-affects-survival-and-development-of-larval-anopheles-arabiensis-diptera-culicidae
#1
Yelfwagash Asmare, Richard J Hopkins, Habte Tekie, Sharon R Hill, Rickard Ignell
Nutrients in breeding sites are critical for the survival and development of malaria mosquitoes, having a direct impact on vectorial capacity. Yet, there is a limited understanding about the natural larval diet and its impact on the individual fitness of mosquitoes. Recent studies have shown that gravid Anopheles arabiensis Patton (Diptera: Culicidae) are attracted by and oviposit in grass-associated habitats. The pollen provided by these grasses is a potential source of nutrients for the larvae. Here, we assess the effect of Typha latifolia L...
September 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28922879/intraparenchymal-cysts-following-deep-brain-stimulation-variable-presentations-and-clinical-courses
#2
Kalman Katlowitz, Michael H Pourfar, Zvi Israel, Alon Y Mogilner
BACKGROUND: The development of cysts at the electrode lead is a rare complication of deep brain stimulation (DBS), with only 3 cases reported in the literature. A better understanding of the variable clinical presentations and courses of these cysts may help increase awareness of this potentially life-threatening complication. OBJECTIVE: To review the clinical presentation of patients with intraparenchymal cysts following DBS implantations. METHODS: We report 3 patients who developed a cyst along the course of the DBS lead...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28922876/visual-deficit-from-laser-interstitial-thermal-therapy-for-temporal-lobe-epilepsy-anatomical-considerations
#3
Walter J Jermakowicz, Michael E Ivan, Iahn Cajigas, Ramses Ribot, Ignacio Jusue-Torres, Mehul B Desai, Armando Ruiz, Pierre-Francois D'Haese, Andres M Kanner, Jonathan R Jagid
BACKGROUND: Laser interstitial thermal therapy (LITT) is quickly emerging as an effective surgical therapy for temporal lobe epilepsy (TLE). One of the most frequent complications of the procedure is postoperative visual field cuts, but the physiopathology of these deficits is unknown. OBJECTIVE: To evaluate potential causes of visual deficits after LITT for TLE in an attempt to minimize this complication. METHODS: This retrospective chart review compares the case of a 24-year-old male who developed homonymous hemianopsia following LITT for TLE to 17 prior patients who underwent the procedure and suffered no visual deficit...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28922856/building-up-absence-seizures-in-the-somatosensory-cortex-from-network-to-cellular-epileptogenic-processes
#4
Guillaume Jarre, Tristan Altwegg-Boussac, Mark S Williams, Florian Studer, Mathilde Chipaux, Olivier David, Stéphane Charpier, Antoine Depaulis, Séverine Mahon, Isabelle Guillemain
The epileptogenic processes leading to recurrent seizures in Genetic Epilepsies are largely unknown. Using the Genetic Absence Epilepsy Rat from Strasbourg, we investigated in vivo the network and single neuron mechanisms responsible for the early emergence of epileptic activity. Local field potential recordings in the primary somatosensory cortex (SoCx), from the second post-natal week to adulthood, showed that immature cortical discharges progressively evolved into typical spike-and-wave discharges following a 3-step maturation process...
September 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922830/connectivity-neurofeedback-training-can-differentially-change-functional-connectivity-and-cognitive-performance
#5
Ayumu Yamashita, Shunsuke Hayasaka, Mitsuo Kawato, Hiroshi Imamizu
Advances in functional magnetic resonance imaging have made it possible to provide real-time feedback on brain activity. Neurofeedback has been applied to therapeutic interventions for psychiatric disorders. Since many studies have shown that most psychiatric disorders exhibit abnormal brain networks, a novel experimental paradigm named connectivity neurofeedback, which can directly modulate a brain network, has emerged as a promising approach to treat psychiatric disorders. Here, we investigated the hypothesis that connectivity neurofeedback can induce the aimed direction of change in functional connectivity, and the differential change in cognitive performance according to the direction of change in connectivity...
October 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28922829/the-threshold-of-the-state-civil-defence-the-blackout-and-the-home-in-second-world-war-britain
#6
James Greenhalgh
This article reconsiders the way that the British state extended its control of the home during the Second World War, using the implementation of air raid precautions and the blackout as a lens through which to view the state's developing attitudes to domestic space. Presented here is not the familiar story of pitch-dark, dangerous streets or altered cityscapes of fear and destruction; instead, by examining personal testimony the article inverts traditional treatments of the blackout to look at the interior of dwellings, demonstrating how the realities of total warfare impinged upon the psychological elements that constituted the home...
June 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922824/in-quest-of-the-antique-the-bazaar-exchange-and-mart-and-the-democratization-of-collecting-1926-42
#7
Heidi Egginton
The popularization of antique collecting is typically located in the second half of the twentieth century, with the rise of 'retrochic' and the emergence of new markets and online trading websites for anonymously exchanging second-hand goods. Close study of the printed literature connected with the inter-war second-hand trade, however, challenges conventional chronologies in the history of consumer culture, and can provide a new perspective on the role of collecting in British social and cultural life. This article examines the period, after the late 1920s, during which The Bazaar, Exchange and Mart reinvented itself as a forum for antique and decorative art enthusiasts...
June 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922820/justifying-british-advertising-in-war-and-austerity-1939-51
#8
Philippa Haughton
Drawing together institutional papers, the trade- and national-press, and Mass-Observation documents, this article examines the changing ways that the Advertising Association justified commercial advertising from 1939 to 1951. It argues that the ability to repeatedly re-conceptualize the social and economic purposes of advertising was central to the industry's survival and revival during the years of war and austerity. This matters because the survival and revival of commercial advertising helps to explain the composition of the post-war mixed economy and the emergence of a consumer culture that became the 'golden age' of capitalism...
September 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922817/children-class-and-the-search-for-security-writing-the-future-in-1930s-britain
#9
Hester Barron, Claire Langhamer
This article is based on 269 essays written in 1937 by Middlesbrough schoolboys aged 12-16 years on the topic 'When I leave school', which were collected by the social research organization Mass Observation. The essays provide a counterpoint to social scientific surveys of ordinary people and allow us to work with the boys' own understandings of the world they inhabited. They offer an alternative lens on a period which, at least in relation to the industrial areas of Britain, is often characterized by poverty and unemployment...
September 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922805/failure-of-the-azithromycin-and-ethambutol-combination-regimen-in-the-hollow-fibre-system-model-of-pulmonary-mycobacterium-avium-infection-is-due-to-acquired-resistance
#10
Shashikant Srivastava, Devyani Deshpande, Tawanda Gumbo
Objectives: To investigate the performance of the two backbone drugs in the standard combination therapy regimen in the hollow-fibre system (HFS) model of pulmonary Mycobacterium avium complex (MAC) infection. Methods: Six HFS were inoculated with human-derived monocytes infected with MAC, and treated with 15 mg/kg of ethambutol and 500 mg of azithromycin daily for 28 days to recapitulate the concentration-time profiles seen in the lungs of humans treated with these drugs and doses...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28922779/targeting-the-myofibroblastic-cancer-associated-fibroblast-phenotype-through-inhibition-of-nox4
#11
Christopher J Hanley, Massimiliano Mellone, Kirsty Ford, Steve M Thirdborough, Toby Mellows, Steven J Frampton, David M Smith, Elena Harden, Cedric Szyndralewiez, Marc Bullock, Fergus Noble, Karwan A Moutasim, Emma V King, Pandurangan Vijayanand, Alex H Mirnezami, Timothy J Underwood, Christian H Ottensmeier, Gareth J Thomas
Background: Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as potential therapeutic targets. However, effective methods to manipulate these cells clinically have yet to be developed. Methods: CAF accumulation and prognostic significance in head and neck cancer (oral, n = 260; oropharyngeal, n = 271), and colorectal cancer (n = 56) was analyzed using immunohistochemistry...
January 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28922664/patchy-particles-made-by-colloidal-fusion
#12
Zhe Gong, Theodore Hueckel, Gi-Ra Yi, Stefano Sacanna
Patches on the surfaces of colloidal particles provide directional information that enables the self-assembly of the particles into higher-order structures. Although computational tools can make quantitative predictions and can generate design rules that link the patch motif of a particle to its internal microstructure and to the emergent properties of the self-assembled materials, the experimental realization of model systems of particles with surface patches (or 'patchy' particles) remains a challenge. Synthetic patchy colloidal particles are often poor geometric approximations of the digital building blocks used in simulations and can only rarely be manufactured in sufficiently high yields to be routinely used as experimental model systems...
September 18, 2017: Nature
https://www.readbyqxmd.com/read/28922654/student-s-perception-about-innovative-teaching-learning-practices-in-forensic-medicine
#13
Sanjay Gupta, Utsav N Parekh, Jaishree D Ganjiwale
BACKGROUND: Since decades, Forensic Medicine is mainly taught by didactic methods but in last couple of years some other teachinglearning and assessment methods are also introduced at some places which also lacks uniformity. Feedback from learners is most fundamental aspect to assess effectiveness of applied methods, but is not implemented in practice at most medical schools in India. Unfortunately, medical students are deprived of this practical empowerment and thus may not be efficient enough to contribute potentially to the justice system during their professional life...
September 11, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28922625/living-and-dying-with-advanced-dementia-a-prospective-cohort-study-of-symptoms-service-use-and-care-at-the-end-of-life
#14
Elizabeth L Sampson, Bridget Candy, Sarah Davis, Anna Buylova Gola, Jane Harrington, Michael King, Nuriye Kupeli, Gerry Leavey, Kirsten Moore, Irwin Nazareth, Rumana Z Omar, Victoria Vickerstaff, Louise Jones
BACKGROUND: Increasing number of people are dying with advanced dementia. Comfort and quality of life are key goals of care. AIMS: To describe (1) physical and psychological symptoms, (2) health and social care service utilisation and (3) care at end of life in people with advanced dementia. DESIGN: 9-month prospective cohort study. SETTING AND PARTICIPANTS: Greater London, England, people with advanced dementia (Functional Assessment Staging Scale 6e and above) from 14 nursing homes or their own homes...
August 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28922608/j-si-h-coupling-constants-of-activated-si-h-bonds
#15
Petra Meixner, Kilian Batke, Andreas Fischer, Dominik Schmitz, Georg Eickerling, Marcel Kalter, Klaus Ruhland, Klaus Eichele, José E Barquera-Lozada, Nicola P M Casati, Fabio Montisci, Piero Macchi, Wolfgang Scherer
We outline in this combined experimental and theoretical NMR study that sign and magnitude of J(Si,H) coupling constants provide reliable indicators to evaluate the extent of the oxidative addition of Si-H bonds in hydrosilane complexes. In combination with experimental electron density studies and MO analyses a simple structure-property relationship emerges: positive J(Si,H) coupling constants are observed in cases where M → L π-back-donation (M = transition metal; L = hydrosilane ligand) dominates. The corresponding complexes are located close to the terminus of the respective oxidative addition trajectory...
September 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28922568/spectral-libraries-for-swath-ms-assays-for-drosophila-melanogaster-and-solanum-lycopersicum
#16
Bertrand Fabre, Dagmara Korona, Clara I Mata-Martinez, Harriet T Parsons, Michael J Deery, Maarten L A T M Hertog, Bart M Nicolaï, Steven Russell, Kathryn S Lilley
Quantitative proteomics methods have emerged as powerful tools for measuring protein expression changes at the proteome level. Using mass-spectrometry (MS) based approaches, it is now possible to routinely quantify thousands of proteins. However, pre-fractionation of the samples at the protein or peptide level is usually necessary to go deep into the proteome, increasing both MS analysis time and technical variability. Recently, a new MS acquisition method named SWATH was introduced with the potential to provide good coverage of the proteome as well as a good measurement precision without prior sample fractionation...
September 18, 2017: Proteomics
https://www.readbyqxmd.com/read/28922559/quarantine-isolation-and-the-duty-of-easy-rescue-in-public
#17
Alberto Giubilini, Thomas Douglas, Hannah Maslen, Julian Savulescu
We address the issue of whether, why and under what conditions, quarantine and isolation are morally justified, with a particular focus on measures implemented in the developing world. We argue that the benefits of quarantine and isolation justify some level of coercion or compulsion by the state, but that the state should be able to provide the strongest justification possible for implementing such measures. While a constrained form of consequentialism might provide a justification for such public health interventions, we argue that a stronger justification is provided by a principle of State Enforced Easy Rescue: a state may permissibly compel individuals to engage in activities that entail a small cost to them but a large benefit to others, because individuals have a moral duty of easy rescue to engage in those activities...
September 18, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28922544/flexible-photodetectors-based-on-novel-functional-materials
#18
REVIEW
Chao Xie, Feng Yan
Flexible photodetectors have attracted a great deal of research interest in recent years due to their great possibilities for application in a variety of emerging areas such as flexible, stretchable, implantable, portable, wearable and printed electronics and optoelectronics. Novel functional materials, including materials with zero-dimensional (0D) and one-dimensional (1D) inorganic nanostructures, two-dimensional (2D) layered materials, organic semiconductors and perovskite materials, exhibit appealing electrical and optoelectrical properties, as well as outstanding mechanical flexibility, and have been widely studied as building blocks in cost-effective flexible photodetection...
September 18, 2017: Small
https://www.readbyqxmd.com/read/28922488/isolation-of-rhodotorula-mucilaginosa-from-blood-cultures-in-a-tertiary-care-hospital
#19
Iker Falces-Romero, Emilio Cendejas-Bueno, María Pilar Romero-Gómez, Julio García-Rodríguez
BACKGROUND: Rhodotorula species have traditionally been considered as one of common non-virulent environmental inhabitant. They have emerged as an opportunistic pathogen, particularly in immunocompromised hosts and most infections have been associated with intravenous catheters in these patients. OBJECTIVE: We review the isolates in blood cultures of Rhodotorula mucilaginosa in our Hospital. We describe the demographic and clinical features of the cases and the antifungal susceptibility profiles of the isolates...
September 18, 2017: Mycoses
https://www.readbyqxmd.com/read/28922487/pcr-based-detection-of-a-fumigatus-and-absence-of-azole-resistance-due-to-tr34-l98h-in-a-french-multicenter-cohort-of-137-patients-with-fungal-rhinosinusitis
#20
Florent Morio, Eric Dannaoui, Taieb Chouaki, Estelle Cateau, Olivier Malard, Pierre Bonfils, Cyril Page, Xavier Dufour, Claire Cottrel, Tamic Erwan, Rose-Anne Lavergne, Patrice Le Pape
BACKGROUND: Fungal rhinosinusitis has a worldwide distribution, comprises distinct clinical entities but is mostly due to Aspergillus among which A. fumigatus plays a major role in European countries. Although, there is accumulating evidence for the emergence of environmentally acquired-azole resistance in A. fumigatus (such as TR34 /L98H) in various clinical settings, there is few data for patients with fungal rhinosinusitis. OBJECTIVES: To investigate the prevalence of A...
September 18, 2017: Mycoses
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