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https://www.readbyqxmd.com/read/29143423/treatment-and-biology-of-pediatric-acute-lymphoblastic-leukemia
#1
REVIEW
Motohiro Kato, Atsushi Manabe
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. In the past ALL was intractable but now the survival probability is as high as 80-90%. Improved supportive care, treatment stratification based on relapse risk, biological features of leukemic cells, and optimization of treatment regimens by nationwide and international collaboration have contributed to this dramatic improvement. While including traditional risk factors (e.g., age and leukocyte count at diagnosis), the treatment has been modified based on biological characteristics (aneuploidy and translocation) and treatment response (assessed by minimal residual disease)...
November 16, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29081634/a-novel-finite-time-average-consensus-protocol-based-on-event-triggered-nonlinear-control-strategy-for-multiagent-systems
#2
Xiaobo Wang, Juelong Li, Jianchun Xing, Ronghao Wang
We present a novel finite-time average consensus protocol based on event-triggered control strategy for multiagent systems. The system stability is proved. The lower bound of the interevent time is obtained to guarantee that there is no Zeno behavior. Moreover, the upper bound of the convergence time is obtained. The relationship between the convergence time and protocol parameter with initial state is analyzed. Lastly, simulations are conducted to verify the effectiveness of the results.
2017: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/29061655/public-mental-health-crisis-management-and-section-136-of-the-mental-health-act
#3
Aileen O'Brien, Faisil Sethi, Mark Smith, Annie Bartlett
The interface between mental health services and the criminal justice system presents challenges both for professionals and patients. Both systems are stressed and inherently complex. Section 136 of the Mental Health Act is unusual being both an aspect of the Mental Health Act and a power of arrest. It has a long and controversial history related to concerns about who has been detained and how the section was applied. More recently, Section 136 has had a public profile stemming from the use of police cells as places of safety for young, mentally disturbed individuals...
October 23, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29053463/cooperative-fault-tolerant-tracking-control-for-multiagent-systems-an-intermediate-estimator-based-approach
#4
Jun-Wei Zhu, Guang-Hong Yang, Wen-An Zhang, Li Yu
This paper studies the observer based fault tolerant tracking control problem for linear multiagent systems with multiple faults and mismatched disturbances. A novel distributed intermediate estimator based fault tolerant tracking protocol is presented. The leader's input is nonzero and unavailable to the followers. By applying a projection technique, the mismatched disturbances are separated into matched and unmatched components. For each node, a tracking error system is established, for which an intermediate estimator driven by the relative output measurements is constructed to estimate the sensor faults and a combined signal of the leader's input, process faults, and matched disturbance component...
October 17, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/29050407/layer-chicken-embryo-survival-to-hatch-when-administered-an-in-ovo-vaccination-of-strain-f-mycoplasma-gallisepticum-and-locations-of-bacteria-prevalence-in-the-newly-hatched-chick
#5
K E C Elliott, S L Branton, J D Evans, P D Gerard, E D Peebles
Mycoplasma gallisepticum (MG) is a bacterial pathogen that causes production losses in layer chickens. To combat MG, multiage layer facilities vaccinate pullets by either spray or eye-drop vaccination. The objective in this study was to evaluate the use of in ovo vaccination as a potential alternative for MG vaccination. Layer embryos at 18 d of incubation were either not-injected (control), or were hand-injected with either commercial Marek's disease vaccine diluent alone or with a high, medium, low, or very low dosage of a live attenuated strain F (FMG) vaccine suspended in the commercial diluent...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29045165/asparaginase-activity-levels-and-monitoring-in-patients-with-acute-lymphoblastic-leukemia
#6
Wanda Salzer, Bruce Bostrom, Yoav Messinger, Anthony J Perissinotti, Bernard Marini
Asparaginase is an integral component of multiagent chemotherapy regimens for the treatment of acute lymphoblastic leukemia (ALL). Adequate asparagine depletion is believed to be an important factor in achieving optimal therapeutic outcomes. Measurement of asparaginase activity allows practitioners to evaluate the potential effectiveness of therapy in real time. Asparaginase activity levels can be used to identify patients with silent inactivation and modify therapy in these patients. Patients with silent inactivation to asparaginase who are switched to therapy with an immunologically distinct asparaginase exhibit outcomes similar to patients who never developed silent inactivation...
October 18, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29021144/metastatic-primary-seminal-vesicle-adenocarcinoma-management-of-a-rare-tumour-with-multiagent-chemotherapy-and-hormonal-therapy
#7
Hira Lal, Priyank Yadav, Rahul Jena, Manoj Jain
Primary seminal vesicle adenocarcinoma is one of the rarest genitourinary cancers. The pathogenesis is unknown and clinical manifestations are protean. There is no defined treatment for this disease and various combinations of surgery, chemotherapy, radiation therapy and hormonal therapy have been used in the past. Here, we have reported a primary seminal vesicle adenocarcinoma with hepatic metastases, managed with multiagent chemotherapy (oxaliplatin and 5-fluorouracil based) and androgen ablation (with triptorelin)...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28991757/an-adaptive-primal-dual-subgradient-algorithm-for-online-distributed-constrained-optimization
#8
Deming Yuan, Daniel W C Ho, Guo-Ping Jiang
In this paper, we consider the problem of solving distributed constrained optimization over a multiagent network that consists of multiple interacting nodes in online setting, where the objective functions of nodes are time-varying and the constraint set is characterized by an inequality. Through introducing a regularized convex-concave function, we present a consensus-based adaptive primal-dual subgradient algorithm that removes the need for knowing the total number of iterations T in advance. We show that the proposed algorithm attains an $O (T1/2 + c) [where c∈(0,1/2)] regret bound and an O (T1 - c/2) bound on the violation of constraints; in addition, we show an improvement to an $O (Tc) regret bound when the objective functions are strongly convex...
October 5, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28976791/adjuvant-chemoradiotherapy-with-epirubicin-cisplatin-and-fluorouracil-compared-with-adjuvant-chemoradiotherapy-with-fluorouracil-and-leucovorin-after-curative-resection-of-gastric-cancer-results-from-calgb-80101-alliance
#9
RANDOMIZED CONTROLLED TRIAL
Charles S Fuchs, Donna Niedzwiecki, Harvey J Mamon, Joel E Tepper, Xing Ye, Richard S Swanson, Peter C Enzinger, Daniel G Haller, Tomislav Dragovich, Steven R Alberts, Georg A Bjarnason, Christopher G Willett, Leonard L Gunderson, Richard M Goldberg, Alan P Venook, David Ilson, Eileen O'Reilly, Kristen Ciombor, David J Berg, Jeffrey Meyerhardt, Robert J Mayer
Purpose After curative resection of gastric or gastroesophageal junction adenocarcinoma, Intergroup Trial 0116 (Phase III trial of postoperative adjuvant radiochemotherapy for high risk gastric and gastroesophageal junction adenocarcinoma: Demonstrated superior survival for patients who received postoperative chemoradiotherapy with bolus fluorouracil (FU) and leucovorin (LV) compared with surgery alone. CALGB 80101 (Alliance; Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastroesophageal Adenocarcinoma) assessed whether a postoperative chemoradiotherapy regimen that replaced FU plus LV with a potentially more active systemic therapy could further improve overall survival...
November 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28976329/adaptive-output-regulation-of-heterogeneous-multiagent-systems-under-markovian-switching-topologies
#10
Min Meng, Lu Liu, Gang Feng
This paper investigates the adaptive output regulation problem for heterogeneous linear multiagent systems under randomly switching communication topologies. The switching mechanism is governed by a time-homogeneous Markov process, whose states correspond to all possible communication topologies among agents. A novel distributed adaptive cooperative controller is presented, where the dynamic compensators are utilized to estimate the exogenous signal for all the agents in mean square sense. The distributed control law is based upon the local information of agents, without using the global information of the communication topologies...
September 29, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28976242/persistent-positive-metaiodobenzylguanidine-scans-after-autologous-peripheral-blood-stem-cell-transplantation-may-indicate-maturation-of-stage-4-neuroblastoma
#11
Yasuhiro Okamoto, Yuichi Kodama, Takuro Nishikawa, Almitra Rindiarti, Takayuki Tanabe, Shunsuke Nakagawa, Takako Yoshioka, Koji Takumi, Tatsuru Kaji, Yoshifumi Kawano
Metaiodobenzylguanidine (MIBG) scans are sensitive testing tools for neuroblastoma. Persistent positive MIBG scans in patients with stage 3 neuroblastoma have previously been found to indicate maturation rather than regression. We assessed the significance of this finding in stage 4 neuroblastoma in the present study. Fifteen consecutive pediatric patients with stage 4 neuroblastoma treated between 2004 and 2014 at the Kagoshima University Hospital were retrospectively examined. Treatment involved a combination of multiagent chemotherapy, resection, autologous peripheral blood stem cell transplantation (PBSCT), radiotherapy, and maintenance therapy with retinoic acid...
April 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/28962512/erratum-to-ecomment-management-of-deep-sternal-wound-infections-after-cardiac-surgery-towards-development-of-new-substrates-for-sustained-multiagent-delivery-release-profiles-interact-cardiovasc-thorac-surg-2017-25-1-11-doi-10-1093-icvts-ivx176
#12
Ekaterini Christina Tampaki, Didier Lardinois, Athanasios Tampakis
No abstract text is available yet for this article.
October 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28952952/applying-distributed-constraint-optimization-approach-to-the-user-association-problem-in-heterogeneous-networks
#13
Peibo Duan, Changsheng Zhang, Guoqiang Mao, Bin Zhang
User association has emerged as a distributed resource allocation problem in the heterogeneous networks (HetNets). Although an approximate solution is obtainable using the approaches like combinatorial optimization and game theory-based schemes, these techniques can be easily trapped in local optima. Furthermore, the lack of exploring the relation between the quality of the solution and the parameters in the HetNet [e.g., the number of users and base stations (BSs)], at what levels, impairs the practicability of deploying these approaches in a real world environment...
September 22, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28945721/asparaginase-toxicities-identification-and-management-in-patients-with-acute-lymphoblastic-leukemia%C3%A2
#14
Van Thu Huynh, Sharon Bergeron
BACKGROUND: Acute lymphoblastic leukemia (ALL) is a common cancer in children, and outcomes have greatly improved because of the refinement of multiagent chemotherapy regimens that include intensified asparaginase therapy. Asparaginase, a cornerstone of modern pediatric chemotherapy regimens for ALL and asparaginase-containing protocols, is increasingly used in adolescent and adult patients historically treated with asparaginase-free regimens. 
. OBJECTIVES: This article is an overview of commonly encountered asparaginase-
associated toxicities and offers recommendations for treatment management...
October 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28923224/an-update-on-randomized-clinical-trials-in-metastatic-colorectal-carcinoma
#15
REVIEW
Naruhiko Ikoma, Kanwal Raghav, George Chang
There have been remarkable advances in the treatment of metastatic colorectal cancer over the past 20 years, chiefly achieved by development of new active drugs and establishment of effective systemic therapy regimens. Multidisciplinary care of resectable liver disease with use of perioperative systemic therapy and superior liver resection has resulted in prolonged survival of select patients. Median overall survival has significantly improved with the modern multiagent regimens. This article reviews recent high-quality randomized clinical trials that were conducted to address optimal treatment of advanced and metastatic colorectal carcinoma, mainly focused on initially inoperable metastatic disease...
October 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28890617/prevalence-of-oral-complications-occurring-in-a-population-of-pediatric-cancer-patients-receiving-chemotherapy
#16
Kapil Gandhi, Geetika Datta, Shilpa Ahuja, Tanvi Saxena, Ankush G Datta
Multiagent chemotherapy, radiotherapy, or a combination of both are the contemporary methods of cancer treatment. With medical advancements, though cure rates have increased considerably, focus is now shifted to the potential early and late complications of the same. The aim of this study was to assess the early oral complications in pediatric patients receiving chemotherapy. Sixty-two children with cancer undergoing chemotherapy with the mean age of 7.42 ± 3.6 years were included in the study. The various types of malignancies and oral problems during chemotherapy were recorded in the subjects...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28881945/ecomment-management-of-deep-sternal-wound-infections-after-cardiac-surgery-towards-development-of-new-substrates-for-sustained-multiagent-delivery-release-profiles
#17
Ekaterini Christina Tampakia, Didier Lardinois, Athanasios Tampakis
No abstract text is available yet for this article.
July 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28872614/aberrant-signaling-pathways-in-t-cell-acute-lymphoblastic-leukemia
#18
REVIEW
Deborah Bongiovanni, Valentina Saccomani, Erich Piovan
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the malignant transformation of immature progenitors primed towards T-cell development. Clinically, T-ALL patients present with diffuse infiltration of the bone marrow by immature T-cell blasts high blood cell counts, mediastinal involvement, and diffusion to the central nervous system. In the past decade, the genomic landscape of T-ALL has been the target of intense research. The identification of specific genomic alterations has contributed to identify strong oncogenic drivers and signaling pathways regulating leukemia growth...
September 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28870277/lessons-learned-from-implementing-an-incident-command-system-during-a-local-multiagency-response-to-a-legionnaires-disease-cluster-in-sydney-nsw
#19
Emma Quinn, Travers Johnstone, Zeina Najjar, Toni Cains, Geoff Tan, Essi Huhtinen, Sven Nilsson, Stuart Burgess, Matthew Dunn, Leena Gupta
The incident command system (ICS) provides a common structure to control and coordinate an emergency response, regardless of scale or predicted impact. The lessons learned from the application of an ICS for large infectious disease outbreaks are documented. However, there is scant evidence on the application of an ICS to manage a local multiagency response to a disease cluster with environmental health risks. The Sydney Local Health District Public Health Unit (PHU) in New South Wales, Australia, was notified of 5 cases of Legionnaires' disease during 2 weeks in May 2016...
September 5, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28866604/scaled-group-consensus-in-multiagent-systems-with-first-second-order-continuous-dynamics
#20
Junyan Yu, Yang Shi
We investigate scaled group consensus problems of multiagent systems with first/second-order linear continuous dynamics. For a complex network consisting of two subnetworks with different physical quantities or task distributions, it is concerned with this case that the agents' states in one subnetwork converge to a consistent value asymptotically, while the states in the other subnetwork approach another value with a ratio of the former. For the case of the information exchange being directed, novel consensus protocols are designed for both first-order and second-order dynamics to solve the scaled group consensus problems...
August 29, 2017: IEEE Transactions on Cybernetics
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