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Alex Herskovic, Elizabeth Mauer, Paul Christos, Himanshu Nagar
BACKGROUND: The role of postoperative radiotherapy (PORT) in the treatment of pathologic stage IIIA (N2) non-small cell lung cancer (NSCLC) remains controversial. We investigated practice patterns and outcomes for these patients in a prospectively maintained nationwide oncology outcomes database. METHODS: Patients with known histologies of pathologic stage IIIA (N2) NSCLC who underwent surgery with negative margins and received adjuvant multiagent chemotherapy from 2004-2013 were identified from the National Cancer DataBase (NCDB) and stratified by the use of PORT...
October 13, 2016: Journal of Thoracic Oncology
Jiahu Qin, Weiming Fu, Wei Xing Zheng, Huijun Gao
The bipartite consensus problem for a group of homogeneous generic linear agents with input saturation under directed interaction topology is examined. It is established that if each agent is asymptotically null controllable with bounded controls and the interaction topology described by a signed digraph is structurally balanced and contains a spanning tree, then the semi-global bipartite consensus can be achieved for the linear multiagent system by a linear feedback controller with the control gain being designed via the low gain feedback technique...
October 11, 2016: IEEE Transactions on Cybernetics
Lantao Xing, Changyun Wen, Fanghong Guo, Zhitao Liu, Hongye Su
In this paper, we propose a new distributed event-trigger consensus protocol for linear multiagent systems with external disturbances. Two consensus problems are considered: one is a leader-follower case and the other is a nonleader case. Different from the existing results, our proposed scheme enables each agent to decide when to transmit its state signals to its neighbors such that continuous communication between neighboring agents is avoided. Clearly, this can largely decrease the communication burden of the whole communication network...
October 4, 2016: IEEE Transactions on Cybernetics
Guoxing Wen, C L Philip Chen, Yan-Jun Liu, Zhi Liu
Compared with the existing neural network (NN) or fuzzy logic system (FLS) based adaptive consensus methods, the proposed approach can greatly alleviate the computation burden because it needs only to update a few adaptive parameters online. In the multiagent agreement control, the system uncertainties derive from the unknown nonlinear dynamics are counteracted by employing the adaptive NNs; the state delays are compensated by designing a Lyapunov-Krasovskii functional. Finally, based on Lyapunov stability theory, it is demonstrated that the proposed consensus scheme can steer a multiagent system synchronizing to the predefined reference signals...
October 11, 2016: IEEE Transactions on Cybernetics
William A Stokes, Bernard L Jones, Shilpa Bhatia, Ayman J Oweida, Daniel W Bowles, David Raben, Julie A Goddard, Jessica D McDermott, Sana D Karam
BACKGROUND: Although laryngectomy is the treatment of choice for patients with T4 larynx cancer, many patients are unable or unwilling to undergo laryngectomy and instead pursue larynx-preservation strategies combining radiotherapy (RT) and chemotherapy. Herein, the authors analyzed the National Cancer Data Base to evaluate overall survival (OS) between patients treated with surgical and organ-preserving modalities. METHODS: The National Cancer Data Base was queried for patients diagnosed from 2004 through 2012 with T4M0 laryngeal cancer who underwent either laryngectomy (surgery) with adjuvant RT (SRT), chemotherapy starting concurrently within 7 days of RT (CCRT), or multiagent induction chemotherapy starting 43 to 98 days before RT (ICRT)...
October 11, 2016: Cancer
Ahitagni Biswas, Lakhan Kashyap, Aanchal Kakkar, Chitra Sarkar, Pramod Kumar Julka
Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal central nervous system tumor commonly affecting children <3 years of age. It roughly constitutes 1%-2% of all pediatric central nervous system tumors. Recent data show that it is the most common malignant central nervous system tumor in children <6 months of age. Management of this aggressive tumor is associated with a myriad of diagnostic and therapeutic challenges. On the basis of radiology and histopathology alone, distinction of AT/RT from medulloblastoma or primitive neuroectodermal tumor is difficult, and hence this tumor has been commonly misdiagnosed as primitive neuroectodermal tumor for decades...
2016: Cancer Management and Research
Stephanie Miller, Peter Eldred, Ariel Muldoon, Kara Anlauf-Dunn, Charlie Stein, Shannon Hubler, Lesley Merrick, Nick Haxton, Chad Larson, Andrew Rehn, Peter Ode, Jake Vander Laan
Aquatic monitoring programs vary widely in objectives and design. However, each program faces the unifying challenge of assessing conditions and quantifying reasonable expectations for measured indicators. A common approach for setting resource expectations is to define reference conditions that represent areas of least human disturbance or most natural state of a resource characterized by the range of natural variability across a region of interest. Identification of reference sites often relies heavily on professional judgment, resulting in varying and unrepeatable methods...
September 29, 2016: Environmental Management
Timothy F Jones, Nupur Sashti, Amanda Ingram, Quyen Phan, Hillary Booth, Joshua Rounds, Cyndy S Nicholson, Shaun Cosgrove, Kia Crocker, L Hannah Gould
INTRODUCTION: Molecular subtyping of pathogens is critical for foodborne disease outbreak detection and investigation. Many clusters initially identified by pulsed-field gel electrophoresis (PFGE) are not confirmed as point-source outbreaks. We evaluated characteristics of clusters that can help prioritize investigations to maximize effective use of limited resources. MATERIALS AND METHODS: A multiagency collaboration (FoodNet) collected data on Salmonella and Escherichia coli O157 clusters for 3 years...
September 27, 2016: Foodborne Pathogens and Disease
L M Rosati, A Hacker-Prietz, A D Rao, A Narang, A De Jesus-Acosta, D T Le, L Zheng, D A Laheru, J M Herman
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Bivas Biswas, Sameer Bakhshi
Ewing sarcoma family tumors (ESFT) are heterogeneous, aggressive group of disease with peak incidence in adolescent and young adults. The outcome has been improved dramatically from 10% with surgery and radiotherapy alone to 65%-70% now, in localized disease, with the introduction of chemotherapy. Chemotherapy regimen evolved from single agent to multiagent with effort of many cooperative clinical trials over decades. The usual treatment protocol include introduction of multi-agent chemotherapy in neoadjuvant setting to eradicate systemic disease with timely incorporation of surgery and/or radiotherapy as local treatment modality and further adjuvant chemotherapy to prevent recurrence...
September 18, 2016: World Journal of Orthopedics
Ryan A Wilcox
DISEASE OVERVIEW: Approximately one-fourth of cutaneous lymphomas are B-cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT). DIAGNOSIS: Diagnosis and disease classification is based on histologic review and immunohistochemical staining of an appropriate skin biopsy. Pathologic review and an appropriate staging evaluation are necessary to distinguish primary cutaneous B-cell lymphomas from systemic B-cell lymphomas with secondary skin involvement...
October 2016: American Journal of Hematology
Antonio Braga, Berenice Torres, Marcelo Burlá, Izildinha Maestá, Sue Yazaki Sun, Lawrence Lin, José Mauro Madi, Elza Uberti, Maurício Viggiano, Kevin M Elias, Ross S Berkowitz
OBJECTIVE: To compare the outcomes of Brazilian patients with molar pregnancy who continue human chorionic gonadotropin (hCG) surveillance with those treated with chemotherapy when hCG was still positive, but falling at 6months after uterine evacuation. METHODS: Retrospective chart review of 12,526 patients with hydatidiform mole treated at one of nine Brazilian reference centers from January 1990 to May 2016. RESULTS: At 6months from uterine evacuation, 96 (0...
September 15, 2016: Gynecologic Oncology
Lei Ding, Wei Xing Zheng
This paper studies network-based practical leader-following consensus problem of heterogeneous multiagent systems with Lipschitz nonlinear dynamics under both fixed and switching topologies. Considering the effect of network-induced delay, a network-based leader-following consensus protocol with heterogeneous gain matrix is proposed for each follower agent. By employing Lyapunov-Krasovskii method, a sufficient condition for designing the network-based consensus controller gain is derived such that the leader-following consensus error exponentially converges to a bounded region under a fixed topology...
September 7, 2016: IEEE Transactions on Cybernetics
Rosmarie Kelly, Fred Koehle, Oscar P Flite, R Chris Rustin
The Richmond County Mosquito Control program's mission statement is to incorporate strategies of integrated mosquito control management that are effective, practical, and environmentally safe and protect the health of Richmond County residents, as well as promote public education, in order to prevent large mosquito populations and the diseases that they transmit. To this end, the program coordinates efforts with other county agencies in order to provide better service. This is a small program with limited resources, so in an effort to provide better integrated mosquito management, the mosquito control program and the Phinizy Center for Water Sciences joined efforts to trap mosquitoes at sites across the county, identify the species, and send the mosquitoes off for viral testing...
October 2016: U.S. Army Medical Department Journal
Marc H Bornstein, Chun-Shin Hahn, Diane L Putnick
BACKGROUND: Command of language is a fundamental skill, a cornerstone of multiple cognitive and socioemotional aspects of development, and a necessary ingredient of successful adjustment and functioning in society. Little is known about the developmental stability of language in at-risk youth or which biological and social risk factors moderate stability. METHODS: This four-wave 10-year prospective longitudinal study evaluated stability of core language skill in 1,780 children in varying categories of biological and social risk in a multiage, multidomain, multimeasure, and multireporter framework...
September 8, 2016: Journal of Child Psychology and Psychiatry, and Allied Disciplines
Shanaaz Mathews, Lorna J Martin, David Coetzee, Chris Scott, Threnesan Naidoo, Yasheen Brijmohun, Karisha Quarrie
BACKGROUND: Child mortality trends in South Africa (SA) show a decrease, but remain high and appear to have plateaued. To attain the new sustainable development goals, we need a better understanding of causes of death and the associated factors. OBJECTIVES: To describe the SA child death review (CDR) pilot, the pattern of child deaths reviewed and the factors associated with these deaths. METHODS: CDR teams were established at two pilot sites, Salt River mortuary (Western Cape Province) and Phoenix mortuary (KwaZulu-Natal Province)...
September 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Shanaaz Mathews, Lorna J Martin, David Coetzee, Chris Scott, Yasheen Brijmohun
South Africa (SA) has not met the child mortality target for the Millennium Development Goals, despite having invested substantially in programmes and policies to achieve these targets. The scale-up of the prevention of mother-to-child transmission programmes reduced HIV transmission from mother to child, but this has not been sustained owing to limitations in community-based child health services. Child mortality has declined, but has now plateaued. Children continue to die from preventable and treatable causes of death...
September 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Steven M Horwitz, Andrew D Zelenetz, Leo I Gordon, William G Wierda, Jeremy S Abramson, Ranjana H Advani, C Babis Andreadis, Nancy Bartlett, John C Byrd, Luis E Fayad, Richard I Fisher, Martha J Glenn, Thomas M Habermann, Nancy Lee Harris, Francisco Hernandez-Ilizaliturri, Richard T Hoppe, Mark S Kaminski, Christopher R Kelsey, Youn H Kim, Susan Krivacic, Ann S LaCasce, Matthew Lunning, Auayporn Nademanee, Oliver Press, Rachel Rabinovitch, Nishitha Reddy, Erin Reid, Kenneth Roberts, Ayman A Saad, Lubomir Sokol, Lode J Swinnen, Julie M Vose, Joachim Yahalom, Nadeem Zafar, Mary Dwyer, Hema Sundar, Pierluigi Porcu
Peripheral T-cell lymphomas (PTCLs) represent a relatively uncommon heterogeneous group of non-Hodgkin's lymphomas (NHLs) with an aggressive clinical course and poor prognosis. Anthracycline-based multiagent chemotherapy with or without radiation therapy followed by first-line consolidation with high-dose therapy followed by autologous stem cell rescue (HDT/ASCR) is the standard approach to most of the patients with newly diagnosed PTCL. Relapsed or refractory disease is managed with second-line systemic therapy followed by HDT/ASCR or allogeneic stem cell transplant, based on the patient's eligibility for transplant...
September 2016: Journal of the National Comprehensive Cancer Network: JNCCN
Jesús M Sánchez, Álvaro Carrera, Carlos Á Iglesias, Emilio Serrano
Indoor evacuation systems are needed for rescue and safety management. One of the challenges is to provide users with personalized evacuation routes in real time. To this end, this project aims at exploring the possibilities of Google Glass technology for participatory multiagent indoor evacuation simulations. Participatory multiagent simulation combines scenario-guided agents and humans equipped with Google Glass that coexist in a shared virtual space and jointly perform simulations. The paper proposes an architecture for participatory multiagent simulation in order to combine devices (Google Glass and/or smartphones) with an agent-based social simulator and indoor tracking services...
2016: Sensors
Arya Amini, Timothy V Waxweiler, Jeffrey V Brower, Bernard L Jones, Jessica D McDermott, David Raben, Debashis Ghosh, Daniel W Bowles, Sana D Karam
Importance: Data on adjuvant concurrent chemoradiotherapy (CRT) after resection of salivary gland carcinomas (SGCs) are limited. Objective: To examine overall survival (OS) outcomes of patients who receive CRT vs radiotherapy (RT) alone after resection of SGCs. Design, Setting, and Participants: The National Cancer Data Base (NCDB), a hospital-based registry that represents 70% of all cancer cases in the United States, was queried for patients who underwent resection of major SGCs with at least 1 high-risk feature (T3-T4 stage, N1-N3 stage, or positive margins)...
August 18, 2016: JAMA Otolaryngology—Head & Neck Surgery
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