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https://www.readbyqxmd.com/read/29774169/phase-2-study-of-everolimus-for-relapsed-or-refractory-classical-hodgkin-lymphoma
#1
Patrick B Johnston, Lauren C Pinter-Brown, Ghulam Warsi, Kristen White, Radhakrishnan Ramchandren
Background: The current standard of care for classical Hodgkin lymphoma (HL) is multiagent chemotherapy with or without radiation. In patients who relapse or fail to respond, additional high-dose chemotherapy with autologous hematopoietic stem cell transplantation (AHSCT) can improve progression-free survival (PFS). Novel therapies are required for patients refractory to chemotherapy and AHSCT. The mammalian target of rapamycin inhibitor everolimus has shown preliminary activity in preclinical models of HL and promising efficacy in patients with relapsed or refractory HL...
2018: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29771667/leader-follower-output-synchronization-of-linear-heterogeneous-systems-with-active-leader-using-reinforcement-learning
#2
Yongliang Yang, Hamidreza Modares, Donald C Wunsch, Yixin Yin
This paper develops optimal control protocols for the distributed output synchronization problem of leader-follower multiagent systems with an active leader. Agents are assumed to be heterogeneous with different dynamics and dimensions. The desired trajectory is assumed to be preplanned and is generated by the leader. Other follower agents autonomously synchronize to the leader by interacting with each other using a communication network. The leader is assumed to be active in the sense that it has a nonzero control input so that it can act independently and update its control to keep the followers away from possible danger...
June 2018: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29771662/optimal-and-autonomous-control-using-reinforcement-learning-a-survey
#3
Bahare Kiumarsi, Kyriakos G Vamvoudakis, Hamidreza Modares, Frank L Lewis
This paper reviews the current state of the art on reinforcement learning (RL)-based feedback control solutions to optimal regulation and tracking of single and multiagent systems. Existing RL solutions to both optimal and control problems, as well as graphical games, will be reviewed. RL methods learn the solution to optimal control and game problems online and using measured data along the system trajectories. We discuss Q-learning and the integral RL algorithm as core algorithms for discrete-time (DT) and continuous-time (CT) systems, respectively...
June 2018: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/29730281/radiation-pneumonitis-in-pediatric-hodgkin-lymphoma-patients-receiving-radiation-therapy-to-the-chest
#4
Gary D Lewis, Jennifer E Agrusa, Bin S Teh, Maria M Gramatges, Viral Kothari, Carl E Allen, Arnold C Paulino
PURPOSE: The purpose of this study is to determine the incidence of radiation pneumonitis (RP) in children receiving radiation therapy (RT) for Hodgkin lymphoma (HL). METHODS AND PATIENTS: A retrospective chart review was conducted of pediatric HL patients who received multiagent chemotherapy followed by RT to any part of the chest. The National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.03, was used to determine the RP grade. Parameters analyzed included sex; age; bleomycin dose; and RT dosimetric variables such as mean lung dose (MLD), mean individual (i; right vs left) lung dose or iMLD, V5 to V25, and individual lung V5 to V25...
February 4, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29697579/acid-suppressing-drugs-and-a-low-1-level-of-antithrombin-as-risk-factors-for-l-asparaginase-associated-pancreatitis-a-case-control-study-in-the-japan-association-of-childhood-leukemia-study-jacls
#5
Yoshiko Hashii, Makoto Yoshida, Junichi Hara, Shinichiro Nishimura, Keiko Yumura-Yagi, Keizo Horibe, Tatsutoshi Nakahata
L-Asparaginase has significantly improved outcome for children with acute lymphoblastic leukemia and has become an essential component of multiagent chemotherapy. However, there are many adverse events due to L-asparaginase, including acute pancreatitis. The pathology of L-asparaginase-associated pancreatitis (AAP) remains unclear. We compared patients who developed AAP (n=29) and random matched controls (n=36) who had been enrolled in the Japan Association of Childhood Leukemia Study of the ALL-02 protocol...
April 24, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29692919/case-based-review-pediatric-medulloblastoma
#6
REVIEW
Cassie N Kline, Roger J Packer, Eugene I Hwang, David R Raleigh, Steve Braunstein, Corey Raffel, Pratiti Bandopadhayay, David A Solomon, Mariam Aboian, Soonmee Cha, Sabine Mueller
Medulloblastoma is the most common malignant brain tumor affecting children. These tumors are high grade with propensity to metastasize within the central nervous system and, less frequently, outside the neuraxis. Recent advancements in molecular subgrouping of medulloblastoma refine diagnosis and improve counseling in regards to overall prognosis. Both are predicated on the molecular drivers of each subgroup-WNT-activated, SHH-activated, group 3, and group 4. The traditional therapeutic mainstay for medulloblastoma includes a multimodal approach with surgery, radiation, and multiagent chemotherapy...
September 2017: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29626139/manchester-arena-bombing-lessons-learnt-from-a-mass-casualty-incident
#7
Ross J Craigie, P J Farrelly, R Santos, S R Smith, J S Pollard, D J Jones
On 22 May 2017 Salman Abedi detonated an improvised explosive device in the Manchester Arena resulting in 23 deaths (including the attacker). This was the deadliest terrorist attack on UK soil since the 2005 London bombings, but was only one of five mass casualty terrorist attacks in the UK in 2017. Preparation for mass casualty incidents (MCI) is obligatory, involving such methods as multiagency tabletop exercises, mock hospital exercises, as well as simulation and training for clinicians in managing the injuries that would be anticipated in such an event...
April 6, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29620671/intraplacental-choriocarcinoma-coexisting-with-fetomaternal-hemorrhage-case-report-chemotherapy-management-and-literature-review
#8
Qin She, Zhi Cheng, Darine El-Chaar, Feng Luo, Xiaoyan Guo, Shi Wu Wen
RATIONALE: Near-term intraplacental choriocarcinoma (IC) coexisting with massive fetomaternal hemorrhage (FMH) is rare, and its clinical course is poorly understood. Here, we report a new case from our hospital, with detailed discussion and literature review. PATIENT CONCERNS: A 21-year-old Chinese female at 35 weeks gestation was admitted to our hospital due to reduced fetal movement. Near-term IC coexisting with massive FMH was diagnosed after delivery. INTERVENTION: The mother and infant were followed 3 months after delivery...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29609802/tracking-control-of-nonholonomic-mobile-agents-with-external-disturbances-and-input-delay
#9
Ahmadreza Jenabzadeh, Behrouz Safarinejadian
This paper investigates the tracking control problem of chained-form nonholonomic multiagent systems (MASs). In contrast to the existing works in which some algorithms have been designed for ideal conditions, the destructive factors including external disturbances and input delay are considered in the dynamics of the agents in this work. Two distributed controllers are proposed such that the states of the controlled agents can track the states of the target in the presence of external disturbances and input delay...
March 30, 2018: ISA Transactions
https://www.readbyqxmd.com/read/29582233/economic-evaluation-of-the-juvenile-drug-court-reclaiming-futures-jdc-rf-model
#10
Kathryn McCollister, Pamela Baumer, Monica Davis, Alison Greene, Sally Stevens, Michael Dennis
Juvenile drug court (JDC) programs are an increasingly popular option for rehabilitating juvenile offenders with substance problems, but research has found inconsistent evidence regarding their effectiveness and economic impact. While assessing client outcomes such as reduced substance use and delinquency is necessary to gauge program effectiveness, a more comprehensive understanding of program success and sustainability can be attained by examining program costs and economic benefits. As part of the National Cross-Site Evaluation of JDC and Reclaiming Futures (RF), an economic analysis of five JDC/RF programs was conducted from a multisystem and multiagency perspective...
March 26, 2018: Journal of Behavioral Health Services & Research
https://www.readbyqxmd.com/read/29547493/10-years-of-nephrogenic-systemic-fibrosis-a-comprehensive-analysis-of-nephrogenic-systemic-fibrosis-reports-received-by-a-pharmaceutical-company-from-2006-to-2016
#11
Jan Endrikat, Susan Dohanish, Nicolas Schleyer, Susanne Schwenke, Sheela Agarwal, Thomas Balzer
OBJECTIVES: The aim of this study was to critically assess the evaluation and categorization process for nephrogenic systemic fibrosis (NSF) based on reports received by Bayer from 2006 to 2016. MATERIALS AND METHODS: A total of 779 NSF reports received by Bayer globally from 2006 to 2016 were included in the analysis. Arlington Medical Resources provided gadolinium-based contrast agent (GBCA) market share. Reports were conservatively categorized based on the Cowper/Girardi criteria...
March 16, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29545256/epidemiology-clinical-features-and-outcome-of-htlv-1-related-atll-in-an-area-of-prevalence-in-the-united-states
#12
Luis Malpica, Agustin Pimentel, Isildinha M Reis, Eduardo Gotuzzo, Lazaros Lekakis, Krishna Komanduri, Thomas Harrington, Glen N Barber, Juan C Ramos
Adult T-cell leukemia/lymphoma (ATLL) is a fatal disease caused by human T-cell leukemia virus type 1 (HTLV-1). We retrospectively analyzed 195 patients with ATLL (lymphomatous n = 96, acute n = 80, unfavorable chronic n = 7, chronic n = 5, smoldering n = 3, and unclassified n = 4) diagnosed between 1987 and 2016 (median age 52 years, 77% Afro-Caribbean). Hypercalcemia was associated with acute ATLL (65%, vs 23% lymphomatous) ( P = .012). The median survival for patients treated with modern therapies between 2000 and 2016 was 4...
March 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29541391/acute-myeloid-leukemia-with-t-4-12-q12-p13-an-aggressive-disease-with-frequent-involvement-of-pdgfra-and-etv6
#13
Jingyi Li, Jie Xu, Lynne V Abruzzo, Guilin Tang, Shaoying Li, M James You, Gary Lu, Elias J Jabbour, Qi Deng, Carlos E Bueso-Ramos, L Jeffrey Medeiros, C Cameron Yin
We describe the clinical, morphologic, immunophenotypic and molecular genetic features of 15 cases of acute myeloid leukemia (AML) with t(4;12)(q12;p13). There were 9 men and 6 women, with a median age of 50 years (range, 17-76). Most patients had hypercellular bone marrow with a median blast count of 58% and multilineage dysplasia. Flow cytometry analysis showed myeloid lineage with blasts positive for CD13, CD33, CD34, CD38, CD117 and HLA-DR. Interestingly, aberrant CD7 expression was detected in 12/14 cases, and myeloperoxidase was either negative (3/15) or positive in only a small subset of the blasts (12/15)...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29535877/topical-imiquimod-for-the-treatment-of-relapsed-cutaneous-langerhans-cell-histiocytosis-after-chemotherapy-in-an-elderly-patient
#14
Shinsaku Imashuku, Miyako Kobayashi, Yoichi Nishii, Keisuke Nishimura
Diagnosis and treatment of Langerhans cell histiocytosis (LCH) in elderly patients are often difficult. We report here a 61-year-old female suffering from a refractory axillary ulcer for nearly a year, whose biopsy revealed LCH. It was also noted that the patient had other cutaneous papulovesicular eruptions of LCH as well as central diabetes insipidus. The patient was first successfully treated with multiagent chemotherapy (cytosine arabinoside/vinblastine/prednisolone). DDAVP also well controlled diabetes insipidus; however, the axillary ulcer and cutaneous LCH relapsed...
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29533897/an-overview-of-recent-advances-in-event-triggered-consensus-of-multiagent-systems
#15
Lei Ding, Qing-Long Han, Xiaohua Ge, Xian-Ming Zhang
Event-triggered consensus of multiagent systems (MASs) has attracted tremendous attention from both theoretical and practical perspectives due to the fact that it enables all agents eventually to reach an agreement upon a common quantity of interest while significantly alleviating utilization of communication and computation resources. This paper aims to provide an overview of recent advances in event-triggered consensus of MASs. First, a basic framework of multiagent event-triggered operational mechanisms is established...
April 2018: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/29528932/manual-compared-with-electric-vacuum-aspiration-for-treatment-of-molar-pregnancy
#16
Lilian Padrón, Jorge Rezende Filho, Joffre Amim Junior, Sue Yazaki Sun, Rafael Cortés Charry, Izildinha Maestá, Kevin M Elias, Neil Horowitz, Antonio Braga, Ross S Berkowitz
OBJECTIVE: To evaluate uterine evacuation of patients with molar pregnancy, comparing manual with electric vacuum aspiration. METHODS: This is a retrospective cohort study of patients with molar pregnancy followed at the Rio de Janeiro Trophoblastic Disease Center from January 2007 to December 2016. The individual primary study outcomes were incomplete uterine evacuation, uterine perforation, development of uterine synechia, and development of postmolar gestational trophoblastic neoplasia...
April 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29515628/pediatric-germ-cell-tumors-a-developmental-perspective
#17
REVIEW
Joshua L Pierce, A Lindsay Frazier, James F Amatruda
Germ cell tumors (GCTs) arising in infants, children, and adolescents present a set of special challenges. GCTs make up about 3% of malignancies in children aged 0-18 and nearly 15% of cancers in adolescents. Epidemiologic and molecular evidence suggests that GCTs in young children likely represent a distinct biologic group as compared to GCTs of older adolescents and adults. Despite this difference, pediatric GCTs are typically treated with cisplatin-based multiagent regimens similar to those used in adults...
2018: Advances in Urology
https://www.readbyqxmd.com/read/29480636/an-evidence-based-oral-health-promotion-programme-lessons-from-leicester
#18
J M Murphy, T E Burch, A J Dickenson, J Wong, R Moore
OBJECTIVES: To provide an overview and draw lessons from the establishment of a local oral health promotion programme for preschool children in Leicester, England (2013-2017). The article provides information on the strategic approach taken in Leicester, one of the most ethnically diverse cities in England, and also one of the most deprived. Over a third of children aged 3 years, and half of those aged 5 years, have experience of obvious dental decay. METHODS: A description of the evolution and development of the programme is provided along with commentary by the authors...
March 2018: Oral Diseases
https://www.readbyqxmd.com/read/29477553/does-a-human-chorionic-gonadotropin-level-of-over-20-000-iu-l-four-weeks-after-uterine-evacuation-for-complete-hydatidiform-mole-constitute-an-indication-for-chemotherapy-for-gestational-trophoblastic-neoplasia
#19
Antonio Braga, Andressa Biscaro, Jessye Melgarejo do Amaral Giordani, Maurício Viggiano, Kevin M Elias, Ross S Berkowitz, Michael J Seckl
OBJECTIVE: To evaluate whether a human chorionic gonadotropin (hCG) level ≥20,000 IU/L four weeks after uterine evacuation for complete hydatidiform mole (CHM) is an appropriate indicator for initiating chemotherapy for the treatment of gestational trophoblastic neoplasia (GTN). STUDY DESIGN: Historical database review of 1228 women with CHM who received treatment and follow-up between January 2000 and June 2013 at four Brazilian trophoblastic disease centers...
April 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29465639/multi-state-syphilis-outbreak-among-american-indians-2013-2015
#20
Virginia B Bowen, Thomas A Peterman, Dinorah L Calles, Antoine Thompson, Robert Kirkcaldy, Melanie Taylor
This article summarizes a multi-state outbreak of heterosexual syphilis, including 134 cases of syphilis in adults and adolescents and at least two cases of congenital syphilis, which occurred on an American Indian reservation in the United States during 2013-2015. In addition to providing salient details about the outbreak, the article seeks to document the case-finding and treatment activities undertaken, their relative success or failure, and the lessons learned from a coordinated, multiagency response. Of 134 adult cases of syphilis, 40% were identified by enhanced, interagency contact tracing and partner services; 26% through symptomatic testing; and 16% through screening of asymptomatic individuals as the result of an electronic medical record (EMR) screening prompt...
February 13, 2018: Sexually Transmitted Diseases
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