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https://www.readbyqxmd.com/read/28331342/spotlight-on-atezolizumab-and-its-potential-in-the-treatment-of-advanced-urothelial-bladder-cancer
#1
REVIEW
Ahmet Murat Aydin, Solomon L Woldu, Ryan C Hutchinson, Martin Boegemann, Aditya Bagrodia, Yair Lotan, Vitaly Margulis, Laura-Maria Krabbe
Metastatic urothelial carcinoma of the bladder is an aggressive malignancy with poor prognosis, reflecting a lack of effective systemic therapies. The current standard of care includes multiagent platinum-based chemotherapy; however a majority of patients do not respond to treatment and most eventually succumb to disease. Recently, renewed interest in immunotherapy in the form of immune-checkpoint inhibition has gained widespread attention for a number of malignancies. Atezolizumab, an anti-PDL1 antibody, has been shown to be effective in a subset of patients previously treated with or unfit for platinum-based chemotherapy, and has shown durable responses with a good tolerability profile...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28321348/spontaneous-remission-of-an-untreated-myc-and-bcl2-coexpressing-high-grade-b-cell-lymphoma-a-case-report-and-literature-review
#2
D Alan Potts, Jonathan R Fromm, Ajay K Gopal, Ryan D Cassaday
Non-Hodgkin lymphomas (NHL) are a heterogeneous group of hematologic malignancies typically treated with multiagent chemotherapy. Rarely, spontaneous remissions can be observed, particularly in more indolent subtypes. The prognosis of aggressive NHL can be predicted using clinical and histopathologic factors. In aggressive B-cell NHL, the importance of MYC and BCL2 proto-oncogene coexpression (as assessed by immunohistochemistry) and high-grade histologic features are particularly noteworthy. We report a unique case of spontaneous remission in a patient with an aggressive B-cell NHL which harbored high-risk histopathologic features, including MYC protein expression at 70-80%, BCL2 protein expression, and morphologic features suggestive of high-grade B-cell lymphoma, NOS (formerly B-cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma [BCLU])...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28320680/data-driven-multiagent-systems-consensus-tracking-using-model-free-adaptive-control
#3
Xuhui Bu, Zhongsheng Hou, Hongwei Zhang
This paper investigates the data-driven consensus tracking problem for multiagent systems with both fixed communication topology and switching topology by utilizing a distributed model free adaptive control (MFAC) method. Here, agent's dynamics are described by unknown nonlinear systems and only a subset of followers can access the desired trajectory. The dynamical linearization technique is applied to each agent based on the pseudo partial derivative, and then, a distributed MFAC algorithm is proposed to ensure that all agents can track the desired trajectory...
March 14, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28318642/stage-i-uterine-carcinosarcoma-matched-cohort-analyses-for-lymphadenectomy-chemotherapy-and-brachytherapy
#4
Brandon-Luke L Seagle, Margaux Kanis, Masha Kocherginsky, Jonathan B Strauss, Shohreh Shahabi
OBJECTIVE: To determine if lymphadenectomy, chemotherapy and radiotherapy are associated with survival benefit among women with stage I uterine carcinosarcoma. METHODS: Women with stage I uterine carcinosarcoma (n=5614) were identified from the 1998-2013 National Cancer Data Base. Kaplan-Meier survival estimates and Cox proportional-hazards regression models were used to evaluate predictors of overall survival. Effects of these predictors were also estimated using propensity score matched analyses for lymphadenectomy, adjuvant chemotherapy, and radiotherapy...
January 12, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28317560/stage-i-uterine-carcinosarcoma-matched-cohort-analyses-for-lymphadenectomy-chemotherapy-and-brachytherapy
#5
Brandon-Luke L Seagle, Margaux Kanis, Masha Kocherginsky, Jonathan B Strauss, Shohreh Shahabi
OBJECTIVE: To determine if lymphadenectomy, chemotherapy and radiotherapy are associated with survival benefit among women with stage I uterine carcinosarcoma. METHODS: Women with stage I uterine carcinosarcoma (n=5614) were identified from the 1998-2013 National Cancer Data Base. Kaplan-Meier survival estimates and Cox proportional-hazards regression models were used to evaluate predictors of overall survival. Effects of these predictors were also estimated using propensity score matched analyses for lymphadenectomy, adjuvant chemotherapy, and radiotherapy...
April 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28288774/intravenous-vs-intraosseous-access-and-return-of-spontaneous-circulation-during-out-of-hospital-cardiac-arrest
#6
Brian Clemency, Kaori Tanaka, Paul May, Johanna Innes, Sara Zagroba, Jacqueline Blaszak, David Hostler, Derek Cooney, Kevin McGee, Heather Lindstrom
INTRODUCTION: Guidelines endorse intravenous (IV) and intraosseous (IO) medication administration for cardiac arrest treatment. Limited clinical evidence supports this recommendation. A multiagency, retrospective study was performed to determine the association between parenteral access type and return of spontaneous circulation (ROSC) in out of hospital cardiac arrest. METHODS: This was a structured, retrospective chart review of emergency medical services (EMS) records from three agencies...
February 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28282014/planning-for-the-leicester-city-football-club-victory-parade
#7
Martin Halse
This paper details the multiagency planning for and delivery of the Leicester City Football Club victory parade at the end of the 2015/16 football season to celebrate the team winning the Barclays Premier League. This is compared and contrasted with the planning and delivery of the reinterment of the mortal remains of King Richard III, which took place in Leicester a little more than 12 months prior. Both events were unprecedentedly high-profile for a comparatively small city and the routes involved had much in common...
January 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28275036/predictors-of-nonadherence-to-nccn-guideline-recommendations-for-the-management-of-stage-i-anal-canal-cancer
#8
Adam J Kole, John M Stahl, Henry S Park, Sajid A Khan, Kimberly L Johung
Background: Definitive chemoradiotherapy (CRT) is recommended by the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Anal Carcinoma for all patients with stage I anal canal cancer. Because these patients were not well represented in clinical trials establishing CRT as standard therapy, it is unclear whether NCCN recommendations are being closely followed for stage I disease. This study identified factors that predict for NCCN Guideline-concordant versus NCCN Guideline-discordant care. Methods: Using the National Cancer Data Base, we identified patients diagnosed with anal canal carcinoma from 2004 to 2012 who received concurrent CRT (radiotherapy [RT] 45...
March 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28222846/planning-for-the-leicester-city-football-club-victory-parade
#9
Martin Halse
This paper details the multiagency planning for and delivery of the Leicester City Football Club victory parade at the end of the 2015/16 football season to celebrate the team winning the Barclays Premier League. This is compared and contrasted with the planning and delivery of the reinterment of the mortal remains of King Richard III, which took place in Leicester a little more than 12 months prior. Both events were unprecedentedly high-profile for a comparatively small city and the routes involved had much in common...
January 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28221781/the-relationship-between-organic-loading-and-effects-on-fish-reproduction-for-pulp-mill-effluents-across-canada
#10
Pierre H Martel, Brian I O'Connor, Tibor G Kovacs, Michael R van den Heuvel, Joanne L Parrott, Mark E McMaster, Deborah L MacLatchy, Glen J Van Der Kraak, L Mark Hewitt
This study builds upon the work of a multiagency consortium tasked with determining cost-effective solutions for the effects of pulp mill effluents on fish reproduction. A laboratory fathead minnow egg production test and chemical characterization tools were used to benchmark 81 effluents from 20 mills across Canada, representing the major pulping, bleaching, and effluent treatment technologies. For Kraft and mechanical pulp mills, effluents containing less than 20 mg/L BOD5 were found to have the greatest probability of having no effects...
March 9, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28192039/endemic-infection-of-stranded-southern-sea-otters-enhydra-lutris-nereis-with-novel-parvovirus-polyomavirus-and-adenovirus
#11
Juliana D Siqueira, Terry Ng, Melissa Miller, Linlin Li, Xutao Deng, Erin Dodd, Francesca Batac, Eric Delwart
Over the past century, the southern sea otter (SSO; Enhydra lutris nereis) population has been slowly recovering from near extinction due to overharvest. The SSO is a threatened species under federal law and a fully protected species under California law. Through a multiagency collaborative program, stranded animals are rehabilitated and released, while deceased animals are necropsied and tissues are cryopreserved to facilitate scientific study. Here, we processed archival tissues to enrich particle-associated viral nucleic acids, which we randomly amplified and deeply sequenced to identify viral genomes through sequence similarities...
February 13, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28190712/effect-of-antiplatelet-therapy-on-aneurysmal-sac-expansion-associated-with-type-ii-endoleaks-after-endovascular-aneurysm-repair
#12
Francisco Álvarez Marcos, José Manuel Llaneza Coto, Francisco José Franco Meijide, Ahmad Amer Zanabili Al-Sibbai, Jorge Vilariño Rico, Manuel Alonso Pérez, Santiago Caeiro Quinteiro
OBJECTIVE: Endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAAs) has gained widespread use through a solid reputation of safety and effectiveness. However, some issues, such as endoleaks and sac growth over time, still arise as important concerns. Antiplatelet therapy, mandatory as secondary prevention of cardiovascular disease, may play a role in both phenomena by interfering with blood clotting properties and the inflammatory process associated with AAA. We analyzed whether different antiplatelet therapies were independent risk factors for type II endoleak (T2E) persistence and midterm sac growth after EVAR...
February 9, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28188985/3d-ssf-a-bio-inspired-approach-for-dynamic-multi-subject-clustering-of-white-matter-tracts
#13
REVIEW
A Chekir, S Hassas, M Descoteaux, M Côté, E Garyfallidis, F Oulebsir-Boumghar
There is growing interest in the study of white matter (WM) variation across subjects, and in particular the analysis of specific WM bundles, to better understand brain development and aging, as well as to improve early detection of some diseases. Several WM multi-subject clustering methods have been proposed to study WM bundles. These methods aim to overcome the complexity of the problem, which includes the huge size of the WM tractography datasets generated from multiple subjects, the existence of various streamlines with different positions, lengths and geometric forms, as well as the presence of outliers...
January 27, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28183347/application-of-incident-command-structure-to-clinical-trial-management-in-the-academic-setting-principles-and-lessons-learned
#14
Penny S Reynolds, Mary J Michael, Bruce D Spiess
BACKGROUND: Clinical trial success depends on appropriate management, but practical guidance to trial organisation and planning is lacking. The Incident Command System (ICS) is the 'gold standard' management system developed for managing diverse operations in major incident and public health arenas. It enables effective and flexible management through integration of personnel, procedures, resources, and communications within a common hierarchical organisational structure. Conventional ICS organisation consists of five function modules: Command, Planning, Operations, Logistics, and Finance/Administration...
February 9, 2017: Trials
https://www.readbyqxmd.com/read/28167373/extraskeletal-osteosarcoma-a-european-musculoskeletal-oncology-society-study-on-266-patients
#15
A Longhi, S S Bielack, R Grimer, J Whelan, R Windhager, A Leithner, A Gronchi, D Biau, P Jutte, A H Krieg, F M Klenke, G Grignani, D M Donati, R Capanna, J Casanova, C Gerrand, G Bisogno, S Hecker-Nolting, M De Lisa, L D'Ambrosio, M Willegger, G Scoccianti, S Ferrari
PURPOSE: Prognosis of extraskeletal osteosarcoma (ESOS) is reported to be poorer than that of skeletal osteosarcoma. This multicenter retrospective study aimed to evaluate factors influencing ESOS prognosis. PATIENTS AND METHODS: Members of the European Musculoskeletal Oncology Society (EMSOS) submitted institutional data on patients with ESOS. RESULTS: Data from 274 patients treated from 1981 to 2014 were collected from 16 EMSOS centres; 266 patients were eligible...
February 3, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28166516/output-feedback-distributed-containment-control-for-high-order-nonlinear-multiagent-systems
#16
Yafeng Li, Changchun Hua, Shuangshuang Wu, Xinping Guan
In this paper, we study the problem of output feedback distributed containment control for a class of high-order nonlinear multiagent systems under a fixed undirected graph and a fixed directed graph, respectively. Only the output signals of the systems can be measured. The novel reduced order dynamic gain observer is constructed to estimate the unmeasured state variables of the system with the less conservative condition on nonlinear terms than traditional Lipschitz one. Via the backstepping method, output feedback distributed nonlinear controllers for the followers are designed...
January 31, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28141536/consensus-of-hybrid-multi-agent-systems
#17
Yuanshi Zheng, Jingying Ma, Long Wang
In this brief, we consider the consensus problem of hybrid multiagent systems. First, the hybrid multiagent system is proposed, which is composed of continuous-time and discrete-time dynamic agents. Then, three kinds of consensus protocols are presented for the hybrid multiagent system. The analysis tool developed in this brief is based on the matrix theory and graph theory. With different restrictions of the sampling period, some necessary and sufficient conditions are established for solving the consensus of the hybrid multiagent system...
January 27, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28134666/epithelioid-trophoblastic-tumor-around-an-abdominal-cesarean-scar-a-pathologic-and-molecular-genetic-analysis
#18
Emily Han-Chung Hsiue, Chiun Hsu, Li-Hui Tseng, Tzu-Pin Lu, Kuan-Ting Kuo
Epithelioid trophoblastic tumor (ETT) is a rare chemoresistant gestational trophoblastic neoplasm that typically presents as an intrauterine lesion. To our knowledge, no isolated abdominal wall ETT around a Cesarean scar has been reported. Here we describe a 54-yr-old woman with a complex obstetric history who presented with a solitary abdominal wall tumor adjacent to the abdominal Cesarean section scar. The tumor demonstrated typical morphologic and immunophenotypic features of ETT. The gestational origin of the tumor was confirmed by microsatellite genotyping...
January 27, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28129199/asynchronous-periodic-edge-event-triggered-control-for-double-integrator-networks-with-communication-time-delays
#19
Gaopeng Duan, Feng Xiao, Long Wang
This paper focuses on the average consensus of double-integrator networked systems based on the asynchronous periodic edge-event triggered control. The asynchronous property lies in the edge event-detecting procedure. For different edges, their event detections are performed at different times and the corresponding events occur independently of each other. When an event is activated, the two adjacent agents connected by the corresponding link sample their relative state information and update their controllers...
January 23, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28129198/leader-following-consensus-for-high-order-nonlinear-stochastic-multiagent-systems
#20
Changchun Hua, Yafeng Li, Xinping Guan
This paper considers the distributed consensus tracking problem for a class of high-order stochastic multiagent systems with uncertain nonlinear functions under a fixed undirected graph. Through the recursive method, the novel nonlinear distributed controllers are designed. By constructing a kind of special form for the virtual controller in the first step of recursive design, we realize that the state variables of every agent are separated except the outputs of the adjacency agents. The designed controller of each agent only depends on its own state variables and the outputs of the adjacent multiagents...
January 24, 2017: IEEE Transactions on Cybernetics
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