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https://www.readbyqxmd.com/read/27925603/consensus-control-of-nonlinear-multiagent-systems-with-time-varying-state-constraints
#1
Wenchao Meng, Qinmin Yang, Jennie Si, Youxian Sun
In this paper, we present a novel adaptive consensus algorithm for a class of nonlinear multiagent systems with time-varying asymmetric state constraints. As such, our contribution is a step forward beyond the usual consensus stabilization result to show that the states of the agents remain within a user defined, time-varying bound. To prove our new results, the original multiagent system is transformed into a new one. Stabilization and consensus of transformed states are sufficient to ensure the consensus of the original networked agents without violating of the predefined asymmetric time-varying state constraints...
December 1, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27908531/chemotherapy-delay-after-primary-debulking-surgery-for-ovarian-cancer
#2
Brandon-Luke L Seagle, Sharlay K Butler, Anna E Strohl, Wilberto Nieves-Neira, Shohreh Shahabi
OBJECTIVE: To determine the association of chemotherapy delay with overall survival (OS) and investigate predictors of delay among a population-representative American ovarian cancer cohort. METHODS: An observational retrospective cohort analysis of women with ovarian cancer who received National Comprehensive Cancer Network guideline-consistent care was performed with the 1998-2011 National Cancer Data Base. Chemotherapy delay was defined as initiation of multiagent chemotherapy >28days from primary debulking surgery...
November 28, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27900363/integration-of-genomics-and-histology-revises-diagnosis-and-enables-effective-therapy-of-refractory-cancer-of-unknown-primary-with-pdl1-amplification
#3
Stefan Gröschel, Martin Bommer, Barbara Hutter, Jan Budczies, David Bonekamp, Christoph Heining, Peter Horak, Martina Fröhlich, Sebastian Uhrig, Daniel Hübschmann, Christina Geörg, Daniela Richter, Nicole Pfarr, Katrin Pfütze, Stephan Wolf, Peter Schirmacher, Dirk Jäger, Christof von Kalle, Benedikt Brors, Hanno Glimm, Wilko Weichert, Albrecht Stenzinger, Stefan Fröhling
Identification of the tissue of origin in cancer of unknown primary (CUP) poses a diagnostic challenge and is critical for directing site-specific therapy. Currently, clinical decision-making in patients with CUP primarily relies on histopathology and clinical features. Comprehensive molecular profiling has the potential to contribute to diagnostic categorization and, most importantly, guide CUP therapy through identification of actionable lesions. We here report the case of an advanced-stage malignancy initially mimicking poorly differentiated soft-tissue sarcoma that did not respond to multiagent chemotherapy...
November 2016: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/27893535/cytoplasmic-hur-status-predicts-disease-free-survival-in-resected-pancreatic-cancer-a-post-hoc-analysis-from-the-international-phase-iii-espac-3-clinical-trial
#4
Talar Tatarian, Wei Jiang, Benjamin E Leiby, Amanda Grigoli, Masaya Jimbo, Nooreen Dabbish, John P Neoptolemos, William Greenhalf, Eithne Costello, Paula Ghaneh, Christopher Halloran, Daniel Palmer, Markus Buchler, Charles J Yeo, Jordan M Winter, Jonathan R Brody
OBJECTIVES: We tested cytoplasmic HuR (cHuR) as a predictive marker for response to chemotherapy by examining tumor samples from the international European Study Group of Pancreatic Cancer-3 trial, in which patients with resected pancreatic ductal adenocarcinoma (PDA) received either gemcitabine (GEM) or 5-fluorouracil (5-FU) adjuvant monotherapy. BACKGROUND: Previous studies have implicated the mRNA-binding protein, HuR (ELAVL1), as a predictive marker for PDA treatment response in the adjuvant setting...
November 23, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27893408/betweenness-centrality-based-consensus-protocol-for-second-order-multiagent-systems-with-sampled-data
#5
Myeong-Jin Park, Seung-Hoon Lee, Oh-Min Kwon, Ju H Park, Seong-Gon Choi
This paper designs a new leader-following consensus protocol for second-order multiagent systems with time-varying sampling. For the first time in designing a leader-following protocol, the concept of betweenness centrality is adopted to analyze the information flow in the consensus problem for multiagent systems. By construction of a suitable Lyapunov-Krasovskii functional, some criteria for designing consensus protocols of such systems are established in terms of linear matrix inequalities which can be easily solved by various effective optimization algorithms...
November 22, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27893405/second-order-consensus-in-multiagent-systems-via-distributed-sliding-mode-control
#6
Wenwu Yu, He Wang, Fei Cheng, Xinghuo Yu, Guanghui Wen
In this paper, the new decoupled distributed sliding-mode control (DSMC) is first proposed for second-order consensus in multiagent systems, which finally solves the fundamental unknown problem for sliding-mode control (SMC) design of coupled networked systems. A distributed full-order sliding-mode surface is designed based on the homogeneity with dilation for reaching second-order consensus in multiagent systems, under which the sliding-mode states are decoupled. Then, the SMC is applied to the decoupled sliding-mode states to reach their origin in finite time, which is the sliding-mode surface...
November 22, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27852581/management-of-children-and-young-people-with-vision-impairment-diagnosis-developmental-challenges-and-outcomes
#7
REVIEW
Sue Keil, Alistair Fielder, Jenefer Sargent
Vision impairment (VI) has a significant impact on an individual's ability to engage with everyday tasks. Severe early-onset VI presents different challenges to adult onset visual loss since reduced visual input presents a major obstacle to the acquisition and development of fundamental developmental skills in early and later childhood. Early referral of the child with reduced vision is vital to ensure accurate diagnosis and prompt treatment of any modifiable aspects of the condition. Guidance to ensure optimisation of developmental opportunity through adaptation of play and care is vital from the earliest stages...
November 16, 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27851822/tumor-activated-mesenchymal-stromal-cells-promote-osteosarcoma-stemness-and-migratory-potential-via-il-6-secretion
#8
Margherita Cortini, Annamaria Massa, Sofia Avnet, Gloria Bonuccelli, Nicola Baldini
Osteosarcoma (OS) is an aggressive bone malignancy with a high relapse rate despite combined treatment with surgery and multiagent chemotherapy. As for other cancers, OS-associated microenvironment may contribute to tumor initiation, growth, and metastasis. We consider mesenchymal stromal cells (MSC) as a relevant cellular component of OS microenvironment, and have previously found that the interaction between MSC and tumor cells is bidirectional: tumor cells can modulate their peripheral environment that in turn becomes more favorable to tumor growth through metabolic reprogramming...
2016: PloS One
https://www.readbyqxmd.com/read/27820136/paraneoplastic-galactorrhea-in-childhood-t-all-an-evaluation-of-tumor-derived-prolactin
#9
Allison Grimes, Nooshin Mirkheshti, Bandana Chatterjee, Gail Tomlinson, Chatchawin Assanasen
T-cell acute lymphoblastic leukemia (T-ALL) comprises 15% of childhood leukemia. Although multiagent pulse chemotherapy has improved event-free survival in recent decades, the lack of reliable prognosticators and high rate of relapse remain a challenge. Described is a novel discovery of tumor-derived hyperprolactinemia in childhood T-ALL through a case associated with paraneoplastic galactorrhea. Prolactin production by tumor cells, although a rare phenomenon, is previously demonstrated in several adult cancers and 2 pediatric malignancies with unknown implications...
November 4, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27780854/t-cell-receptor-signaling-activates-an-itk-nf-%C3%AE%C2%BAb-gata-3-axis-in-t-cell-lymphomas-facilitating-resistance-to-chemotherapy
#10
Tianjiao Wang, Ye Lu, Avery Polk, Pinki Chowdhury, Carlos Murga-Zamalloa, Hiroshi Fujiwara, Koichiro Suemori, Niklas Beyersdorf, Alexandra C Hristov, Megan S Lim, Nathanael G Bailey, Ryan A Wilcox
PURPOSE: T-cell lymphomas are a molecularly heterogeneous group of non-Hodgkin lymphomas (NHL) that account for a disproportionate number of NHL disease-related deaths due to their inherent and acquired resistance to standard multiagent chemotherapy regimens. Despite their molecular heterogeneity and frequent loss of various T-cell specific receptors, the T-cell antigen receptor is retained in the majority of these lymphomas. As T-cell receptor (TCR) engagement activates a number of signaling pathways and transcription factors that regulate T-cell growth and survival, we examined the TCR's role in mediating resistance to chemotherapy...
October 25, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27780316/can-we-eliminate-neoadjuvant-chemoradiotherapy-in-favor-of-neoadjuvant-multiagent-chemotherapy-for-select-stage-ii-iii-rectal-adenocarcinomas-analysis-of-the-national-cancer-database
#11
Richard J Cassidy, Yuan Liu, Kirtesh Patel, Jim Zhong, Conor E Steuer, David A Kooby, Maria C Russell, Theresa W Gillespie, Jerome C Landry
BACKGROUND: Stage II and III rectal cancers have been effectively treated with neoadjuvant chemoradiotherapy (NCRT) followed by definitive resection. Advancements in surgical technique and systemic therapy have prompted investigation of neoadjuvant multiagent chemotherapy (NMAC) regimens with the elimination of radiation (RT). The objective of the current study was to investigate factors that predict for the use of NCRT versus NMAC and compare outcomes using the National Cancer Data Base (NCDB) for select stage II and III rectal cancers...
October 25, 2016: Cancer
https://www.readbyqxmd.com/read/27775915/necessary-and-sufficient-conditions-for-consensus-of-second-order-multiagent-systems-under-directed-topologies-without-global-gain-dependency
#12
Kaien Liu, Zhijian Ji, Wei Ren
The consensus problem for second-order multiagent systems with absolute velocity damping under directed topologies is investigated. In contrast to the existing results, which rely on a sufficiently large common absolute velocity damping gain above a lower bound dependent on global information, this paper focuses on novel algorithms to overcome this limitation. A novel consensus algorithm, where different agents use different absolute velocity damping gains, is first proposed. In the absence of delays, based on a system transformation method, the consensus problem for second-order multiagent systems is converted into that for first-order multiagent systems with the agent number doubled...
October 21, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27746190/role-of-postoperative-radiotherapy-in-pathologic-stage-iiia-n2-non-small-cell-lung-cancer-in-a-prospective-nationwide-oncology-outcomes-database
#13
Alex Herskovic, Elizabeth Mauer, Paul Christos, Himanshu Nagar
BACKGROUND: The role of postoperative radiotherapy (PORT) in the treatment of pathologic stage IIIA (N2) non-small cell lung cancer (NSCLC) remains controversial. We investigated practice patterns and outcomes for these patients in a prospectively maintained nationwide oncology outcomes database. METHODS: Patients with known histologies of pathologic stage IIIA (N2) NSCLC who underwent surgery with negative margins and received adjuvant multiagent chemotherapy from 2004-2013 were identified from the National Cancer DataBase (NCDB) and stratified by the use of PORT...
October 13, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27740508/on-the-bipartite-consensus-for-generic-linear-multiagent-systems-with-input-saturation
#14
Jiahu Qin, Weiming Fu, Wei Xing Zheng, Huijun Gao
The bipartite consensus problem for a group of homogeneous generic linear agents with input saturation under directed interaction topology is examined. It is established that if each agent is asymptotically null controllable with bounded controls and the interaction topology described by a signed digraph is structurally balanced and contains a spanning tree, then the semi-global bipartite consensus can be achieved for the linear multiagent system by a linear feedback controller with the control gain being designed via the low gain feedback technique...
October 11, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27740505/event-based-consensus-for-linear-multiagent-systems-without-continuous-communication
#15
Lantao Xing, Changyun Wen, Fanghong Guo, Zhitao Liu, Hongye Su
In this paper, we propose a new distributed event-trigger consensus protocol for linear multiagent systems with external disturbances. Two consensus problems are considered: one is a leader-follower case and the other is a nonleader case. Different from the existing results, our proposed scheme enables each agent to decide when to transmit its state signals to its neighbors such that continuous communication between neighboring agents is avoided. Clearly, this can largely decrease the communication burden of the whole communication network...
October 4, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27740504/neural-network-based-adaptive-leader-following-consensus-control-for-a-class-of-nonlinear-multiagent-state-delay-systems
#16
Guoxing Wen, C L Philip Chen, Yan-Jun Liu, Zhi Liu
Compared with the existing neural network (NN) or fuzzy logic system (FLS) based adaptive consensus methods, the proposed approach can greatly alleviate the computation burden because it needs only to update a few adaptive parameters online. In the multiagent agreement control, the system uncertainties derive from the unknown nonlinear dynamics are counteracted by employing the adaptive NNs; the state delays are compensated by designing a Lyapunov-Krasovskii functional. Finally, based on Lyapunov stability theory, it is demonstrated that the proposed consensus scheme can steer a multiagent system synchronizing to the predefined reference signals...
October 11, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27727461/a-comparison-of-overall-survival-for-patients-with-t4-larynx-cancer-treated-with-surgical-versus-organ-preservation-approaches-a-national-cancer-data-base-analysis
#17
William A Stokes, Bernard L Jones, Shilpa Bhatia, Ayman J Oweida, Daniel W Bowles, David Raben, Julie A Goddard, Jessica D McDermott, Sana D Karam
BACKGROUND: Although laryngectomy is the treatment of choice for patients with T4 larynx cancer, many patients are unable or unwilling to undergo laryngectomy and instead pursue larynx-preservation strategies combining radiotherapy (RT) and chemotherapy. Herein, the authors analyzed the National Cancer Data Base to evaluate overall survival (OS) between patients treated with surgical and organ-preserving modalities. METHODS: The National Cancer Data Base was queried for patients diagnosed from 2004 through 2012 with T4M0 laryngeal cancer who underwent either laryngectomy (surgery) with adjuvant RT (SRT), chemotherapy starting concurrently within 7 days of RT (CCRT), or multiagent induction chemotherapy starting 43 to 98 days before RT (ICRT)...
October 11, 2016: Cancer
https://www.readbyqxmd.com/read/27695363/atypical-teratoid-rhabdoid-tumors-challenges-and-search-for-solutions
#18
Ahitagni Biswas, Lakhan Kashyap, Aanchal Kakkar, Chitra Sarkar, Pramod Kumar Julka
Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal central nervous system tumor commonly affecting children <3 years of age. It roughly constitutes 1%-2% of all pediatric central nervous system tumors. Recent data show that it is the most common malignant central nervous system tumor in children <6 months of age. Management of this aggressive tumor is associated with a myriad of diagnostic and therapeutic challenges. On the basis of radiology and histopathology alone, distinction of AT/RT from medulloblastoma or primitive neuroectodermal tumor is difficult, and hence this tumor has been commonly misdiagnosed as primitive neuroectodermal tumor for decades...
2016: Cancer Management and Research
https://www.readbyqxmd.com/read/27688255/a-large-scale-multiagency-approach-to-defining-a-reference-network-for-pacific-northwest-streams
#19
Stephanie Miller, Peter Eldred, Ariel Muldoon, Kara Anlauf-Dunn, Charlie Stein, Shannon Hubler, Lesley Merrick, Nick Haxton, Chad Larson, Andrew Rehn, Peter Ode, Jake Vander Laan
Aquatic monitoring programs vary widely in objectives and design. However, each program faces the unifying challenge of assessing conditions and quantifying reasonable expectations for measured indicators. A common approach for setting resource expectations is to define reference conditions that represent areas of least human disturbance or most natural state of a resource characterized by the range of natural variability across a region of interest. Identification of reference sites often relies heavily on professional judgment, resulting in varying and unrepeatable methods...
September 29, 2016: Environmental Management
https://www.readbyqxmd.com/read/27676287/characteristics-of-clusters-of-salmonella-and-escherichia-coli-o157-detected-by-pulsed-field-gel-electrophoresis-that-predict-identification-of-outbreaks
#20
Timothy F Jones, Nupur Sashti, Amanda Ingram, Quyen Phan, Hillary Booth, Joshua Rounds, Cyndy S Nicholson, Shaun Cosgrove, Kia Crocker, L Hannah Gould
INTRODUCTION: Molecular subtyping of pathogens is critical for foodborne disease outbreak detection and investigation. Many clusters initially identified by pulsed-field gel electrophoresis (PFGE) are not confirmed as point-source outbreaks. We evaluated characteristics of clusters that can help prioritize investigations to maximize effective use of limited resources. MATERIALS AND METHODS: A multiagency collaboration (FoodNet) collected data on Salmonella and Escherichia coli O157 clusters for 3 years...
September 27, 2016: Foodborne Pathogens and Disease
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