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https://www.readbyqxmd.com/read/28096698/burkitt-lymphoma-in-adolescents-and-young-adults-management-challenges
#1
REVIEW
Massimo Dozzo, Francesca Carobolante, Pietro Maria Donisi, Annamaria Scattolin, Elena Maino, Rosaria Sancetta, Piera Viero, Renato Bassan
About one-half of all Burkitt lymphoma (BL) patients are younger than 40 years, and one-third belong to the adolescent and young adult (AYA) subset, defined by an age between 15 and 25-40 years, based on selection criteria used in different reports. BL is an aggressive B-cell neoplasm displaying highly characteristic clinico-diagnostic features, the biologic hallmark of which is a translocation involving immunoglobulin and c-MYC genes. It presents as sporadic, endemic, or epidemic disease. Endemicity is pathogenetically linked to an imbalance of the immune system which occurs in African children infected by malaria parasites and Epstein-Barr virus, while the epidemic form strictly follows the pattern of infection by HIV...
2017: Adolescent Health, Medicine and Therapeutics
https://www.readbyqxmd.com/read/28096105/the-value-of-paediatric-assessment-in-historic-child-sexual-abuse
#2
Sarah Al-Jilaihawi, Kevin Borg, Sabine Maguire, Deborah Hodes
INTRODUCTION: A perception exists that there are few benefits of a paediatric assessment in historic child sexual abuse (CSA), as the likelihood of finding forensic evidence is low. AIM: To determine the value of a comprehensive paediatric assessment in a dedicated clinic for children and young people who present following suspicion or allegation of historic CSA. METHOD: All children with suspected or alleged historic CSA, defined as >7 days after the last episode of sexual assault in pubertal girls, or >3 days for prepubertal girls and all boys, were assessed in a specialised paediatric clinic...
January 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28092592/adaptive-fuzzy-bounded-control-for-consensus-of-multiple-strict-feedback-nonlinear-systems
#3
Wei Wang, Shaocheng Tong
This paper studies the adaptive fuzzy bounded control problem for leader-follower multiagent systems, where each follower is modeled by the uncertain nonlinear strict-feedback system. Combining the fuzzy approximation with the dynamic surface control, an adaptive fuzzy control scheme is developed to guarantee the output consensus of all agents under directed communication topologies. Different from the existing results, the bounds of the control inputs are known as a priori, and they can be determined by the feedback control gains...
January 10, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28092586/consensus-problem-over-high-order-multiagent-systems-with-uncertain-nonlinearities-under-deterministic-and-stochastic-topologies
#4
Hamed Rezaee, Farzaneh Abdollahi
The leaderless consensus problem over a class of high-order nonlinear multiagent systems (MASs) is studied. A robust protocol is proposed which guarantees achieving consensus in the network in the presences of uncertainties in agents models. Achieving consensus in the case of stochastic links failure is studied as well. Based on the concept super-martingales, it is shown that if the probability of the network connectivity is not zero, under some conditions, achieving almost sure consensus in the network can be guaranteed...
December 6, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28092579/cooperative-adaptive-output-regulation-for-second-order-nonlinear-multiagent-systems-with-jointly-connected-switching-networks
#5
Wei Liu, Jie Huang
This paper studies the cooperative global robust output regulation problem for a class of heterogeneous second-order nonlinear uncertain multiagent systems with jointly connected switching networks. The main contributions consist of the following three aspects. First, we generalize the result of the adaptive distributed observer from undirected jointly connected switching networks to directed jointly connected switching networks. Second, by performing a new coordinate and input transformation, we convert our problem into the cooperative global robust stabilization problem of a more complex augmented system via the distributed internal model principle...
January 11, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28092312/synchronous-presentation-of-renal-cell-carcinoma-and-hodgkin-lymphoma-in-an-adolescent
#6
Mohamed Y Elsaid, Kara G Gill, Ankush Gosain, Peter F Nichol, Charles M Leys, Darya Buehler, Catherine P Leith, Neha J Patel
BACKGROUND: Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adults but not in children. OBSERVATION: We report a case of a 16-year-old girl in whom RCC was incidentally discovered on the computed tomography scan that was performed to stage her underlying Hodgkin lymphoma. Analysis of constitutional cytogenetics for common genetic aberrations that predispose to RCC did not reveal any mutations or genetic variations. However, cytogenetics on the RCC tumor demonstrated a rare reciprocal translocation between chromosomes 6 and 11, t(6;11)(p21;q12)...
January 13, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28056112/association-of-delayed-adjuvant-chemotherapy-with-survival-after-lung-cancer-surgery
#7
Michelle C Salazar, Joshua E Rosen, Zuoheng Wang, Brian N Arnold, Daniel C Thomas, Roy S Herbst, Anthony W Kim, Frank C Detterbeck, Justin D Blasberg, Daniel J Boffa
Importance: Adjuvant chemotherapy offers a survival benefit to a number of staging scenarios in non-small-cell lung cancer. Variable recovery from lung cancer surgery may delay a patient's ability to tolerate adjuvant chemotherapy, yet the urgency of chemotherapy initiation is unclear. Objective: To assess differences in survival according to the time interval between non-small-cell lung cancer resection and the initiation of postoperative chemotherapy to determine the association between adjuvant treatment timing and efficacy...
January 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28042620/summarizing-simulation-results-using-causally-relevant-states
#8
Nidhi Parikh, Madhav Marathe, Samarth Swarup
As increasingly large-scale multiagent simulations are being implemented, new methods are becoming necessary to make sense of the results of these simulations. Even concisely summarizing the results of a given simulation run is a challenge. Here we pose this as the problem of simulation summarization: how to extract the causally-relevant descriptions of the trajectories of the agents in the simulation. We present a simple algorithm to compress agent trajectories through state space by identifying the state transitions which are relevant to determining the distribution of outcomes at the end of the simulation...
May 2016: Multiagent Based Simul
https://www.readbyqxmd.com/read/28040140/gestational-choriocarcinoma-with-renal-and-pulmonary-metastases-lacking-a-primary-uterine-origin
#9
Hao-Ming Li, Wen-Chien Hou, Yu-Ju Lai, Chien-Chang Kao, Tai-Kuang Chao, Mu-Hsien Yu, Her-Young Su
OBJECTIVE: We describe a case of gestational choriocarcinoma metastasized to the kidney and lung, which presented initially as refractory hematuria after a term pregnancy 5 years earlier. CASE REPORT: A 35-year-old woman, G2P1, with a previous history of full-term pregnancy in 2009, presented to the emergency department complaining of intermittent gross hematuria for 2 months. Abdominal computed tomography showed a suspicious arteriovenous malformation in the right kidney and a thrombus within the right renal vein...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28035754/sinusoidal-cd30-diffuse-large-b-cell-lymphoma-can-masquerade-as-anaplastic-large-cell-lymphoma-in-pediatric-posttransplant-lymphoproliferative-disorders
#10
Neel S Bhatt, Michael E Kelly, Bjorn Batdorf, Gabriela Gheorghe
Posttransplant lymphoproliferative disorder (PTLD) is a known complication of solid organ transplantation. Diffuse large B-cell lymphoma (DLBCL) is frequently seen in this setting. However, CD30+ DLBCL with sinusoidal pattern of involvement has not been reported in pediatric PTLD. We are reporting a 9-year-old female child presented with diffuse lymphadenopathy postheart transplantation. The pattern of involvement was suggestive of anaplastic large cell lymphoma, but the malignant cells were positive for B-cell markers and negative for anaplastic lymphoma kinase...
December 30, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28032089/impact-of-treatment-protocol-on-outcome-of-localized-ewing-s-sarcoma
#11
Srividya Nasaka, Sadashivudu Gundeti, Ranga Raman Ganta, Ravi Sankar Arigela, Vijay Gandhi Linga, Lakshmi Srinivas Maddali
BACKGROUND: The outcome of localized Ewing's sarcoma has improved with multi-disciplinary approach. Survivals of Ewing's sarcoma from the Asian countries differed between centers. METHODS: We retrospectively analyzed the records of newly diagnosed localized Ewing's sarcoma patients from 2002 to 2012. The patients were analyzed in three groups; Group 1(2002-2004) who received non-ifosfomide based regimens, Group 2(2005-2008) who received VDC/IE for 12 cycles, and Group 3(2009-2012), who received VDC/IE for 17 cycles...
October 2016: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28029635/ergodicity-based-cooperative-multiagent-area-coverage-via-a-potential-field
#12
Stefan Ivic, Bojan Crnkovic, Igor Mezic
This paper considers a problem of area coverage where the objective is to achieve given coverage density by use of multiple mobile agents. We present an ergodicity-based coverage algorithm which enables a centralized feedback control for multiagent system based on radial basis function (RBF) representation of the ergodicity problem and a solution of an appropriately designed stationary heat equation for the potential field. The heat equation uses a source term that depends on the difference between the given goal density distribution and the current coverage density (time average of RBFs along trajectories)...
December 16, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28029634/heuristics-based-trust-estimation-in-multiagent-systems-using-temporal-difference-learning
#13
G Rishwaraj, S G Ponnambalam, Chu Kiong Loo
The application of multiagent system (MAS) is becoming increasing popular as it allows agents in a system to pool resources together to achieve a common objective. A vital part of the MAS is the teamwork cooperation through the sharing of information and resources among the agents to optimize their efforts in accomplishing given objectives. A critical part of the teamwork effort is the ability to trust each other when executing any task to ensure efficient and successful cooperation. This paper presents the development of a trust estimation model that could empirically evaluate the trust of an agent in MAS...
December 20, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27998231/hypothalamic-pituitary-axis-dysfunction-in-survivors-of-childhood-cns-tumors-importance-of-systematic-follow-up-and-early-endocrine-consultation
#14
Wassim Chemaitilly, Gregory T Armstrong, Amar Gajjar, Melissa M Hudson
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
December 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27992356/consensus-problem-over-high-order-multiagent-systems-with-uncertain-nonlinearities-under-deterministic-and-stochastic-topologies
#15
Hamed Rezaee, Farzaneh Abdollahi
The leaderless consensus problem over a class of high-order nonlinear multiagent systems (MASs) is studied. A robust protocol is proposed which guarantees achieving consensus in the network in the presences of uncertainties in agents models. Achieving consensus in the case of stochastic links failure is studied as well. Based on the concept super-martingales, it is shown that if the probability of the network connectivity is not zero, under some conditions, achieving almost sure consensus in the network can be guaranteed...
December 6, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27992355/collectively-rotating-formation-and-containment-deployment-of-multiagent-systems-a-polar-coordinate-based-finite-time-approach
#16
Yujuan Wang, Yongduan Song, Miroslav Krstic
This paper investigates the problem of achieving rotating formation and containment simultaneously via finite time control schemes for multiagent systems. It is nontrivial to maintain rotating formation where the desired formation structure is time-varying and only neighboring information is available. The underlying problem becomes even more complicated if containment is imposed yet finite time convergence is required at the same time. To tackle this problem, a polar coordinate-based approach is exploited in this paper...
December 14, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27975063/a-multiagent-system-for-dynamic-data-aggregation-in-medical-research
#17
Alevtina Dubovitskaya, Visara Urovi, Imanol Barba, Karl Aberer, Michael Ignaz Schumacher
The collection of medical data for research purposes is a challenging and long-lasting process. In an effort to accelerate and facilitate this process we propose a new framework for dynamic aggregation of medical data from distributed sources. We use agent-based coordination between medical and research institutions. Our system employs principles of peer-to-peer network organization and coordination models to search over already constructed distributed databases and to identify the potential contributors when a new database has to be built...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27925603/consensus-control-of-nonlinear-multiagent-systems-with-time-varying-state-constraints
#18
Wenchao Meng, Qinmin Yang, Jennie Si, Youxian Sun
In this paper, we present a novel adaptive consensus algorithm for a class of nonlinear multiagent systems with time-varying asymmetric state constraints. As such, our contribution is a step forward beyond the usual consensus stabilization result to show that the states of the agents remain within a user defined, time-varying bound. To prove our new results, the original multiagent system is transformed into a new one. Stabilization and consensus of transformed states are sufficient to ensure the consensus of the original networked agents without violating of the predefined asymmetric time-varying state constraints...
December 1, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/27908531/chemotherapy-delay-after-primary-debulking-surgery-for-ovarian-cancer
#19
Brandon-Luke L Seagle, Sharlay K Butler, Anna E Strohl, Wilberto Nieves-Neira, Shohreh Shahabi
OBJECTIVE: To determine the association of chemotherapy delay with overall survival (OS) and investigate predictors of delay among a population-representative American ovarian cancer cohort. METHODS: An observational retrospective cohort analysis of women with ovarian cancer who received National Comprehensive Cancer Network guideline-consistent care was performed with the 1998-2011 National Cancer Data Base. Chemotherapy delay was defined as initiation of multiagent chemotherapy >28days from primary debulking surgery...
November 28, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27900363/integration-of-genomics-and-histology-revises-diagnosis-and-enables-effective-therapy-of-refractory-cancer-of-unknown-primary-with-pdl1-amplification
#20
Stefan Gröschel, Martin Bommer, Barbara Hutter, Jan Budczies, David Bonekamp, Christoph Heining, Peter Horak, Martina Fröhlich, Sebastian Uhrig, Daniel Hübschmann, Christina Geörg, Daniela Richter, Nicole Pfarr, Katrin Pfütze, Stephan Wolf, Peter Schirmacher, Dirk Jäger, Christof von Kalle, Benedikt Brors, Hanno Glimm, Wilko Weichert, Albrecht Stenzinger, Stefan Fröhling
Identification of the tissue of origin in cancer of unknown primary (CUP) poses a diagnostic challenge and is critical for directing site-specific therapy. Currently, clinical decision-making in patients with CUP primarily relies on histopathology and clinical features. Comprehensive molecular profiling has the potential to contribute to diagnostic categorization and, most importantly, guide CUP therapy through identification of actionable lesions. We here report the case of an advanced-stage malignancy initially mimicking poorly differentiated soft-tissue sarcoma that did not respond to multiagent chemotherapy...
November 2016: Cold Spring Harbor Molecular Case Studies
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