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https://www.readbyqxmd.com/read/28923224/an-update-on-randomized-clinical-trials-in-metastatic-colorectal-carcinoma
#1
REVIEW
Naruhiko Ikoma, Kanwal Raghav, George Chang
There have been remarkable advances in the treatment of metastatic colorectal cancer over the past 20 years, chiefly achieved by development of new active drugs and establishment of effective systemic therapy regimens. Multidisciplinary care of resectable liver disease with use of perioperative systemic therapy and superior liver resection has resulted in prolonged survival of select patients. Median overall survival has significantly improved with the modern multiagent regimens. This article reviews recent high-quality randomized clinical trials that were conducted to address optimal treatment of advanced and metastatic colorectal carcinoma, mainly focused on initially inoperable metastatic disease...
October 2017: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/28890617/prevalence-of-oral-complications-occurring-in-a-population-of-pediatric-cancer-patients-receiving-chemotherapy
#2
Kapil Gandhi, Geetika Datta, Shilpa Ahuja, Tanvi Saxena, Ankush G Datta
Multiagent chemotherapy, radiotherapy, or a combination of both are the contemporary methods of cancer treatment. With medical advancements, though cure rates have increased considerably, focus is now shifted to the potential early and late complications of the same. The aim of this study was to assess the early oral complications in pediatric patients receiving chemotherapy. Sixty-two children with cancer undergoing chemotherapy with the mean age of 7.42 ± 3.6 years were included in the study. The various types of malignancies and oral problems during chemotherapy were recorded in the subjects...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28881945/ecomment-management-of-deep-sternal-wound-infections-after-cardiac-surgery-towards-development-of-new-substrates-for-sustained-multiagent-delivery-release-profiles
#3
Ekaterini Christina Tampakia, Didier Lardinois, Athanasios Tampakis
No abstract text is available yet for this article.
July 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28872614/aberrant-signaling-pathways-in-t-cell-acute-lymphoblastic-leukemia
#4
REVIEW
Deborah Bongiovanni, Valentina Saccomani, Erich Piovan
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the malignant transformation of immature progenitors primed towards T-cell development. Clinically, T-ALL patients present with diffuse infiltration of the bone marrow by immature T-cell blasts high blood cell counts, mediastinal involvement, and diffusion to the central nervous system. In the past decade, the genomic landscape of T-ALL has been the target of intense research. The identification of specific genomic alterations has contributed to identify strong oncogenic drivers and signaling pathways regulating leukemia growth...
September 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28870277/lessons-learned-from-implementing-an-incident-command-system-during-a-local-multiagency-response-to-a-legionnaires-disease-cluster-in-sydney-nsw
#5
Emma Quinn, Travers Johnstone, Zeina Najjar, Toni Cains, Geoff Tan, Essi Huhtinen, Sven Nilsson, Stuart Burgess, Matthew Dunn, Leena Gupta
The incident command system (ICS) provides a common structure to control and coordinate an emergency response, regardless of scale or predicted impact. The lessons learned from the application of an ICS for large infectious disease outbreaks are documented. However, there is scant evidence on the application of an ICS to manage a local multiagency response to a disease cluster with environmental health risks. The Sydney Local Health District Public Health Unit (PHU) in New South Wales, Australia, was notified of 5 cases of Legionnaires' disease during 2 weeks in May 2016...
September 5, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28866604/scaled-group-consensus-in-multiagent-systems-with-first-second-order-continuous-dynamics
#6
Junyan Yu, Yang Shi
We investigate scaled group consensus problems of multiagent systems with first/second-order linear continuous dynamics. For a complex network consisting of two subnetworks with different physical quantities or task distributions, it is concerned with this case that the agents' states in one subnetwork converge to a consistent value asymptotically, while the states in the other subnetwork approach another value with a ratio of the former. For the case of the information exchange being directed, novel consensus protocols are designed for both first-order and second-order dynamics to solve the scaled group consensus problems...
August 29, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28863036/clinical-activity-of-eribulin-in-advanced-desmoplastic-small-round-cell-tumor
#7
Sheik Emambux, Michele Kind, Francois Le Loarer, Maud Toulmonde, Eberhard Stoeckle, Antoine Italiano
Desmoplastic small round-cell tumor is a rare but highly aggressive tumor occurring mainly in adolescents and young adults. Prolonged progression-free survival has been documented in patients who have undergone aggressive multimodality therapy - that is, multiagent intensive chemotherapy, debulking surgery, and radiation therapy. Eribulin is a microtubule-dynamics inhibitor, and it has recently been shown to be active in liposarcomas. In preclinical models, eribulin activities have also been shown to occur in Ewing's sarcoma cell lines, rhabdomyosarcomas and osteosarcomas...
August 31, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28854301/understanding-hearing-and-hearing-loss-in-children-with-down-syndrome
#8
Emily Nightengale, Patricia Yoon, Kristy Wolter-Warmerdam, Dee Daniels, Fran Hickey
Purpose: This study evaluated the prevalence of permanent and transient hearing loss, the use of hearing aids as a recommendation, and middle ear dysfunction in children with Down syndrome (DS) through a large multiage and ethnically diverse sample, using current audiologic testing practices. Method: Retrospective analysis of data collected on 308 children with DS (168 boys, 140 girls; average age = 5.99 ± 4.88 years) who received an audiological evaluation during 2013 as part of their medical care at a large pediatric hospital...
September 18, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28838180/monitoring-results-in-routine-immunization-development-of-routine-immunization-dashboard-in-selected-african-countries-in-the-context-of-the-polio-eradication-endgame-strategic-plan
#9
Alain Poy, Maya M V X van den Ent, Stephen Sosler, Alan R Hinman, Sidney Brown, Samir Sodha, Daniel C Ehlman, Aaron S Wallace, Richard Mihigo
Background: To monitor immunization-system strengthening in the Polio Eradication Endgame Strategic Plan 2013-2018 (PEESP), the Global Polio Eradication Initiative identified 1 indicator: 10% annual improvement in third dose of diphtheria- tetanus-pertussis-containing vaccine (DTP3) coverage in polio high-risk districts of 10 polio focus countries. Methods: A multiagency team, including staff from the African Region, developed a comprehensive list of outcome and process indicators measuring various aspects of the performance of an immunization system...
July 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28816678/adaptive-consensus-control-of-nonlinear-multiagent-systems-with-unknown-control-directions-under-stochastic-topologies
#10
Hamed Rezaee, Farzaneh Abdollahi
The consensus problem over high-order nonlinear multiagent systems with the Brunovsky-type model is studied. The model parameters and control directions of agents are supposed to be unknown. Hence, based on Nussbaum-type functions, an adaptive protocol is proposed, which guarantees achieving consensus in the network when the parameters and control directions of the agents are unknown and unidentical. The main contribution of this paper (compared with the existing similar results in the literature) is to guarantee achieving consensus in networks of agents when the communication topology is not connected constantly, and communication links stochastically switch over time...
August 15, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28809720/aperiodic-robust-model-predictive-control-for-constrained-continuous-time-nonlinear-systems-an-event-triggered-approach
#11
Changxin Liu, Jian Gao, Huiping Li, Demin Xu
The event-triggered control is a promising solution to cyber-physical systems, such as networked control systems, multiagent systems, and large-scale intelligent systems. In this paper, we propose an event-triggered model predictive control (MPC) scheme for constrained continuous-time nonlinear systems with bounded disturbances. First, a time-varying tightened state constraint is computed to achieve robust constraint satisfaction, and an event-triggered scheduling strategy is designed in the framework of dual-mode MPC...
August 14, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28809714/avoiding-congestion-in-cluster-consensus-of-the-second-order-nonlinear-multiagent-systems
#12
Yi Wang, Zhongjun Ma, Guanrong Chen
In order to avoid congestion in the second-order nonlinear leader-following multiagent systems over capacity-limited paths, an approach called cluster lag consensus is proposed, which means that the agents in different clusters will pass through the same positions with the same velocities but lag behind the leader at different times. Lyapunov functionals and matrix theory are applied to analyze such cluster lag consensus. It is shown that when the graphic roots of clusters are influenced by the leader and the intracoupling of cluster agents is larger than a threshold, the cluster lag consensus can be achieved...
August 11, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28800058/effectiveness-of-mifamurtide-in-addition-to-standard-chemotherapy-for-high-grade-osteosarcoma-a-systematic-review
#13
Rincy Jimmy, Cindy Stern, Karolina Lisy, Sarahlouise White
BACKGROUND: Osteosarcoma mostly occurs during the period of rapid bone growth in children and adolescents as high-grade osteosarcomas. Current treatment recommended for high-grade non-metastatic and metastatic and/or relapsed osteosarcoma involves neoadjuvant multiagent conventional chemotherapy, followed by surgical resection of macroscopically detected tumor and postoperative adjuvant chemotherapy. However, residual micrometastatic deposits that develop following surgery have shown resistance to postoperative/adjuvant chemotherapy...
August 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28792513/cooperative-vehicles-for-robust-traffic-congestion-reduction-an-analysis-based-on-algorithmic-environmental-and-agent-behavioral-factors
#14
Prajakta Desai, Seng W Loke, Aniruddha Desai
Traffic congestion continues to be a persistent problem throughout the world. As vehicle-to-vehicle communication develops, there is an opportunity of using cooperation among close proximity vehicles to tackle the congestion problem. The intuition is that if vehicles could cooperate opportunistically when they come close enough to each other, they could, in effect, spread themselves out among alternative routes so that vehicles do not all jam up on the same roads. Our previous work proposed a decentralized multiagent based vehicular congestion management algorithm entitled Congestion Avoidance and Route Allocation using Virtual Agent Negotiation (CARAVAN), wherein the vehicles acting as intelligent agents perform cooperative route allocation using inter-vehicular communication...
2017: PloS One
https://www.readbyqxmd.com/read/28783647/distributed-optimal-consensus-control-for-nonlinear-multiagent-system-with-unknown-dynamic
#15
Jilie Zhang, Huaguang Zhang, Tao Feng
This paper focuses on the distributed optimal cooperative control for continuous-time nonlinear multiagent systems (MASs) with completely unknown dynamics via adaptive dynamic programming (ADP) technology. By introducing predesigned extra compensators, the augmented neighborhood error systems are derived, which successfully circumvents the system knowledge requirement for ADP. It is revealed that the optimal consensus protocols actually work as the solutions of the MAS differential game. Policy iteration algorithm is adopted, and it is theoretically proved that the iterative value function sequence strictly converges to the solution of the coupled Hamilton-Jacobi-Bellman equation...
August 1, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28770352/primary-ovarian-burkitt-s-lymphoma-a-rare-oncological-problem-in-gynaecology-a-review-of-literature
#16
REVIEW
Anna Stepniak, Piotr Czuczwar, Piotr Szkodziak, Ewa Wozniakowska, Slawomir Wozniak, Tomasz Paszkowski
PURPOSE: This review presents the information about epidemiology, clinical manifestation, diagnosis and treatment of primary ovarian Burkitt's lymphoma (BL), including a literature search of available BL cases. The purpose of this review is to draw clinicians' attention to the possibility of ovarian BL occurrence, which may be important in the differential diagnosis of ovarian tumours. METHODS: PubMed and Web of Science databases were searched using the keywords ''Burkitt's'', ''Lymphoma'', ''Ovarian'', ''Primary'', ''Burkitt's lymphoma''...
August 2, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28767379/composite-backstepping-consensus-algorithms-of-leader-follower-higher-order-nonlinear-multiagent-systems-subject-to-mismatched-disturbances
#17
Xiangyu Wang, Shihua Li, Michael Z Q Chen
This paper is devoted to solving the output consensus problem of leader-follower higher-order nonlinear multiagent systems subject to mismatched disturbances. The disturbances are allowed to be in higher-order forms. First, by constructing a generalized proportional-integral observer for each follower, estimates of the disturbances and their derivatives are obtained. At the same time, a distributed observer is also developed for the followers to estimate the leader state information. Second, based on the estimates of the disturbances and the leader state, together with the backstepping technique, a feedforward-feedback composite consensus control scheme is proposed...
July 27, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28763362/survival-after-primary-debulking-surgery-compared-with-neoadjuvant-chemotherapy-in-advanced-ovarian-cancer-a-national-cancer-database-study
#18
Brandon-Luke L Seagle, Stephen Graves, Anna E Strohl, Shohreh Shahabi
OBJECTIVE: The aim of this study was to compare overall survival (OS) of women with advanced ovarian cancer treated with primary debulking surgery (PDS) or neoadjuvant chemotherapy (NAC) using a large national cohort. METHODS: The 1998-2011 National Cancer Database was queried to identify women with stage III or IV ovarian cancer treated with multiagent chemotherapy and stage-appropriate surgery. Overall survival was estimated and compared using Kaplan-Meier analysis between women who received PDS followed by multiagent chemotherapy or NAC followed by interval surgery...
August 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28749363/distributed-parametric-consensus-optimization-with-an-application-to-model-predictive-consensus-problem
#19
Xinli Shi, Jinde Cao, Wei Huang
In this paper, we study a special class of distributed convex optimization problems--distributed parametric consensus optimization problem (DPCOP), for which a two-stage optimization method including primal decomposition and distributed consensus is provided. Different from traditional distributed optimization problems driving all the local states to a common value, DPCOP aims to solve a system-wide problem with partial common parameters shared amongst local agents in a distributed way. To relax the restriction on the topology, a distributed projected subgradient method is applied in distributed consensus stage to achieve the consensus of local estimated parameters, while the subgradients can be obtained by solving a multiparametric problem locally...
July 25, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28739136/coordinated-tracking-of-linear-multiagent-systems-with-input-saturation-and-stochastic-disturbances
#20
Qingling Wang, Changyin Sun
This paper addresses the coordinated tracking problem for linear multiagent systems with input saturation and stochastic disturbances. The objective is to construct a class of tracking control laws that achieve consensus tracking in the absence of disturbances, while guaranteeing a bounded variance of the state difference between the follower agent and the leader in the present of disturbances, under the assumptions that each agent is asymptotically null controllable with bounded controls (ANCBC) and the network is connected...
July 21, 2017: ISA Transactions
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