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https://www.readbyqxmd.com/read/28742955/bayesian-one-step-ipd-network-meta-analysis-of-time-to-event-data-using-royston-parmar-models
#1
Suzanne C Freeman, James R Carpenter
Network meta-analysis (NMA) combines direct and indirect evidence from trials to calculate and rank treatment estimates. While modelling approaches for continuous and binary outcomes are relatively well developed, less work has been done with time-to-event outcomes. Such outcomes are usually analysed using Cox proportional hazard (PH) models. However, in oncology with longer follow-up time, and time-dependent effects of targeted treatments, this may no longer be appropriate. Network meta-analysis conducted in the Bayesian setting has been increasing in popularity...
July 25, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/28742858/reduction-of-endoplasmic-reticulum-mitochondria-interactions-in-beta-cells-from-patients-with-type-2-diabetes
#2
Charles Thivolet, Guillaume Vial, Romeo Cassel, Jennifer Rieusset, Anne-Marie Madec
Type 2 diabetes develops when beta cells are not able to fulfill insulin needs. The role of the endoplasmic reticulum-mitochondria junction in coordinating the functions of these two organelles throughout the natural history of type 2 diabetes is determinant and may explain the alterations of insulin biosynthesis. Our goal was to study endoplasmic reticulum and mitochondrial interactions in human beta cells from organ donors with type 2 diabetes. Pancreas samples were obtained via the network for pancreatic organ donors with diabetes (nPOD) based on disease status with 12 subjects with type 2 diabetes and 9 non-diabetic controls...
2017: PloS One
https://www.readbyqxmd.com/read/28742460/resistance-genes-in-global-crop-breeding-networks
#3
Karen A Garrett, Kelsey F Andersen, Frank Asche, Robert Bowden, Greg Forbes, Peter Kulakow, Bo Zhou
Resistance genes are a major tool for managing crop diseases. The networks of crop breeders who exchange resistance genes and deploy them in varieties help to determine the global landscape of resistance and epidemics, an important system for maintaining food security. These networks function as a complex adaptive system, with associated strengths and vulnerabilities, and implications for policies to support resistance gene deployment strategies. Extensions of epidemic network analysis can be used to evaluate the multilayer agricultural networks that support and influence crop breeding networks...
July 25, 2017: Phytopathology
https://www.readbyqxmd.com/read/28742159/%C3%AE-adrenergic-signaling-broadly-contributes-to-ltp-induction
#4
Joanna Jȩdrzejewska-Szmek, Vincent Luczak, Ted Abel, Kim T Blackwell
Long-lasting forms of long-term potentiation (LTP) represent one of the major cellular mechanisms underlying learning and memory. One of the fundamental questions in the field of LTP is why different molecules are critical for long-lasting forms of LTP induced by diverse experimental protocols. Further complexity stems from spatial aspects of signaling networks, such that some molecules function in the dendrite and some are critical in the spine. We investigated whether the diverse experimental evidence can be unified by creating a spatial, mechanistic model of multiple signaling pathways in hippocampal CA1 neurons...
July 24, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28742069/nematode-grazing-promotes-bacterial-community-dynamics-in-soil-at-the-aggregate-level
#5
Yuji Jiang, Manqiang Liu, Jiabao Zhang, Yan Chen, Xiaoyun Chen, Lijun Chen, Huixin Li, Xue-Xian Zhang, Bo Sun
Nematode predation has important roles in determining bacterial community composition and dynamics, but the extent of the effects remains largely rudimentary, particularly in natural environment settings. Here, we investigated the complex microbial-microfaunal interactions in the rhizosphere of maize grown in red soils, which were derived from four long-term fertilization regimes. Root-free rhizosphere soil samples were separated into three aggregate fractions whereby the abundance and community composition were examined for nematode and total bacterial communities...
July 25, 2017: ISME Journal
https://www.readbyqxmd.com/read/28742036/study-of-temporal-effects-on-subjective-video-quality-of-experience
#6
Christos G Bampis, Zhi Li, Anush K Moorthy, Ioannis Katsavounidis, Anne Aaron, Alan C Bovik
HTTP adaptive streaming is being increasingly deployed by network content providers such as Netflix and YouTube. By dividing video content into data chunks encoded at different bitrates, a client is able to request the appropriate bitrate for the segment to be played next based on the estimated network conditions. However, this can introduce a number of impairments, including compression artifacts and rebuffering events which can severely impact an end-user's quality of experience (QoE). We have recently created a new video quality database which simulates a typical video streaming application, using long video sequences and interesting Netflix content...
July 20, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28741908/research-capacity-for-childhood-obesity-prevention-in-latin-america-an-area-for-growth
#7
Diana C Parra, Susan Vorkoper, Harold W Kohl, Benjamin Caballero, Carolina Batis, Alejandra Jauregui, Jessica Mason, Michael Pratt
BACKGROUND: The rise of childhood obesity in Latin America calls for research capacity to understand, monitor and implement strategies, policies and programmes to address it. OBJECTIVE: The objective of the study was to assess current research capacity in Latin America related to childhood obesity, nutrition and physical activity. METHODS: We conducted a search of peer-reviewed articles on childhood obesity in Latin America with at least one Latin American author from 2010 to May 2015...
July 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28741612/an-information-theoretic-framework-reveals-a-tunable-allosteric-network-in-group-ii-chaperonins
#8
Tom Lopez, Kevin Dalton, Anthony Tomlinson, Vijay Pande, Judith Frydman
ATP-dependent allosteric regulation of the ring-shaped group II chaperonins remains ill defined, in part because their complex oligomeric topology has limited the success of structural techniques in suggesting allosteric determinants. Further, their high sequence conservation has hindered the prediction of allosteric networks using mathematical covariation approaches. Here, we develop an information theoretic strategy that is robust to residue conservation and apply it to group II chaperonins. We identify a contiguous network of covarying residues that connects all nucleotide-binding pockets within each chaperonin ring...
July 24, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28741361/3d-printed-shape-memory-objects-based-on-olefin-ionomer-of-zinc-neutralized-poly-ethylene-co-methacrylic-acid
#9
Zhiyang Zhao, Fang Peng, Kevin A Cavicchi, Mukerrem Miko Cakmak, Robert A Weiss, Bryan D Vogt
3D printing enables the net shape manufacturing of objects with minimal material waste and low tooling costs, but the functionality is generally limited by available materials, especially for extrusion based printing such as Fused Deposition Modeling (FDM). Here we demonstrate shape memory behavior of 3D printed objects with FDM using a commercially available olefin ionomer, Surlyn 9520, which is zinc neutralized poly(ethylene-co-methacrylic acid). The initial fixity for 3D printed and compression molded samples was similar, but the initial recovery was much lower for the 3D printed sample (R=58%) than the compression molded sample (R=83%)...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28741055/effects-of-tunable-excitation-in-carotenoids-explained-by-the-vibrational-energy-relaxation-approach
#10
Vytautas Balevičius, Craig N Lincoln, Daniele Viola, Giulio Cerullo, Jürgen Hauer, Darius Abramavicius
Carotenoids are fundamental building blocks of natural light harvesters with convoluted and ultrafast energy deactivation networks. In order to disentangle such complex relaxation dynamics, several studies focused on transient absorption measurements and their dependence on the pump wavelength. However, such findings are inconclusive and sometimes contradictory. In this study, we compare internal conversion dynamics in [Formula: see text]-carotene, pumped at the first, second, and third vibronic progression peak...
July 24, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28740978/synthesis-and-photo-electro-catalytic-properties-of-a-3d-pomof-material-based-on-an-interpenetrated-copper-coordination-polymer-linked-by-in-situ-dual-ligands-and-dawson-type-phosphotungstates
#11
Ling-Yu Fan, Kai Yu, Jing-Hua Lv, He Zhang, Zhan-Hua Su, Lu Wang, Chun-Mei Wang, Bai-Bin Zhou
A novel 3D polyoxometalate metal organic framework (POMOF), [{CuCu (H2O)5(pzc)10(pz)6}{P2W18O62}2]·4H2O (1) (Hpzc = pyrazine-2-carboxylic acid, pz = pyrazine) has been hydrothermally synthesized and characterized by IR, TG, XRD, UV-vis and elemental analyses. In compound 1, the pzc and pz ligands are generated through in situ transformation from pyrazine-2,3-dicarboxylic acid (pzdc) to remove one or two CO2 molecules. The ligands with four coordination modes connect nine crystallographically independent Cu atoms to form a super-big circle unit...
July 25, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28739525/state-dependent-alpha-peak-frequency-shifts-experimental-evidence-potential-mechanisms-and-functional-implications
#12
REVIEW
Andreas Mierau, Wolfgang Klimesch, Jérémie Lefebvre
Neural populations produce complex oscillatory patterns thought to implement brain function. The dominant rhythm in the healthy adult human brain is formed by alpha oscillations with a typical power peak most commonly found between 9 and 11 Hz. This alpha peak frequency has been repeatedly discussed as a highly heritable and stable neurophysiological "trait" marker reflecting anatomical properties of the brain, and individuals' general cognitive capacity. However, growing evidence suggests that the alpha peak frequency is highly volatile at shorter time scales, dependent on the individuals' "state"...
July 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/28739495/the-deep-thioredoxome-in-chlamydomonas-reinhardtii-new-insights-into-redox-regulation
#13
María Esther Pérez-Pérez, Adeline Mauriès, Alexandre Maes, Nicolas J Tourasse, Marion Hamon, Stéphane D Lemaire, Christophe H Marchand
Thiol-based redox post-translational modifications have emerged as important mechanisms of signaling and regulation in all organisms and thioredoxin plays a key role by controlling the thiol-disulfide status of target proteins. Recent redox proteomic studies revealed hundreds of proteins regulated by glutathionylation and nitrosylation in the unicellular green alga Chlamydomonas reinhardtii while much less is known about the thioredoxin interactome in this organism. By combining qualitative and quantitative proteomic analyses, we have investigated comprehensively the Chlamydomonas thioredoxome and 1188 targets have been identified...
July 21, 2017: Molecular Plant
https://www.readbyqxmd.com/read/28739135/cytokinins-in-symbiotic-nodulation-when-where-what-for
#14
REVIEW
Pascal Gamas, Mathias Brault, Marie-Françoise Jardinaud, Florian Frugier
Substantial progress has been made in the understanding of early stages of the symbiotic interaction between legume plants and rhizobium bacteria. Those include the specific recognition of symbiotic partners, the initiation of bacterial infection in root hair cells, and the inception of a specific organ in the root cortex, the nodule. Increasingly complex regulatory networks have been uncovered in which cytokinin (CK) phytohormones play essential roles in different aspects of early symbiotic stages. Intriguingly, these roles can be either positive or negative, cell autonomous or non-cell autonomous, and vary, depending on time, root tissues, and possibly legume species...
July 21, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28739119/structural-and-functional-empirical-and-modeled-connectivity-in-the-cerebral-cortex-of-the-rat
#15
Antonio Díaz-Parra, Zachary Osborn, Santiago Canals, David Moratal, Olaf Sporns
Connectomics data from animal models provide an invaluable opportunity to reveal the complex interplay between structure and function in the mammalian brain. In this work, we investigate the relationship between structural and functional connectivity in the rat brain cortex using a directed anatomical network generated from a carefully curated meta-analysis of published tracing data, along with resting-state functional MRI data obtained from a group of 14 anesthetized Wistar rats. We found a high correspondence between the strength of functional connections, measured as blood oxygen level dependent (BOLD) signal correlations between cortical regions, and the weight of the corresponding anatomical links in the connectome graph (maximum Spearman rank-order correlation ρ=0...
July 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28739098/effects-of-bariatric-surgery-on-energy-homeostasis
#16
REVIEW
Wei Li, Denis Richard
Bariatric surgery represents the most efficient therapy for severe obesity. It reduces the size of fat stores or the amount of body fat gain. The bariatric surgery procedures currently used include Roux-en-Y gastric bypass and sleeve gastrectomy, which are the most commonly performed procedures. Other procedures are laparoscopic adjustable gastric banding and biliopancreatic diversion. The latter represents the most effective surgery for treatment of severe obesity as well as type 2 diabetes. Bariatric surgery reduces energy intake by restricting the size of the stomach reservoir and causing malabsorption, as in the case of biliopancreatic diversion...
August 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28738264/evidence-of-anomalous-behavior-of-intermolecular-interactions-at-low-concentration-of-methanol-in-ethanol-methanol-binary-system
#17
K Nilavarasi, Thejus R Kartha, V Madhurima
At low concentrations of methanol in a binary system of ethanol and methanol, uniquely complex molecular interactions are reported here. Previous studies indicate that ethanol molecules form aggregates held together by hydrogen bonding (O-H-O) and also dispersive forces. Addition of small amount of methanol tends to break the hydrogen bond network of ethanol due to the larger polarity of methanol. This leads to the ethanol molecules becoming somewhat isolated from each other within a scaffolding network of methanol molecules, as seen from the present molecular dynamics simulations...
July 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28737728/neighbor-affinity-based-core-attachment-method-to-detect-protein-complexes-in-dynamic-ppi-networks
#18
Xiujuan Lei, Jing Liang
Protein complexes play significant roles in cellular processes. Identifying protein complexes from protein-protein interaction (PPI) networks is an effective strategy to understand biological processes and cellular functions. A number of methods have recently been proposed to detect protein complexes. However, most of methods predict protein complexes from static PPI networks, and usually overlook the inherent dynamics and topological properties of protein complexes. In this paper, we proposed a novel method, called NABCAM (Neighbor Affinity-Based Core-Attachment Method), to identify protein complexes from dynamic PPI networks...
July 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28737705/emotion-recognition-from-chinese-speech-for-smart-affective-services-using-a-combination-of-svm-and-dbn
#19
Lianzhang Zhu, Leiming Chen, Dehai Zhao, Jiehan Zhou, Weishan Zhang
Accurate emotion recognition from speech is important for applications like smart health care, smart entertainment, and other smart services. High accuracy emotion recognition from Chinese speech is challenging due to the complexities of the Chinese language. In this paper, we explore how to improve the accuracy of speech emotion recognition, including speech signal feature extraction and emotion classification methods. Five types of features are extracted from a speech sample: mel frequency cepstrum coefficient (MFCC), pitch, formant, short-term zero-crossing rate and short-term energy...
July 24, 2017: Sensors
https://www.readbyqxmd.com/read/28737684/angular-rate-sensing-with-gyrowheel-using-genetic-algorithm-optimized-neural-networks
#20
Yuyu Zhao, Hui Zhao, Xin Huo, Yu Yao
GyroWheel is an integrated device that can provide three-axis control torques and two-axis angular rate sensing for small spacecrafts. Large tilt angle of its rotor and de-tuned spin rate lead to a complex and non-linear dynamics as well as difficulties in measuring angular rates. In this paper, the problem of angular rate sensing with the GyroWheel is investigated. Firstly, a simplified rate sensing equation is introduced, and the error characteristics of the method are analyzed. According to the analysis results, a rate sensing principle based on torque balance theory is developed, and a practical way to estimate the angular rates within the whole operating range of GyroWheel is provided by using explicit genetic algorithm optimized neural networks...
July 22, 2017: Sensors
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