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https://www.readbyqxmd.com/read/28324955/identifying-important-regions-in-eeg-epilepsy-brain-networks
#1
Nantia D Iakovidou, Manolis Christodoulakis, Eleftherios S Papathanasiou, Savvas S Papacostas, Georgios D Mitsis
The human brain has been called the most complex object in the known universe and in many ways it constitutes the final frontier of science. Lately, the functional connectivity in human brain has been regarded and studied as a complex network using electroencephalography (EEG) signals. This means that the brain is studied as a connected system, where nodes represent different specialized brain regions and links or connections, represent communication pathways between the nodes. It is also fairly established that graph theory provides a variety of measures, methods and tools that can be useful to efficiently model, analyze and study an EEG network...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324758/dynamics-of-complex-valued-fractional-order-neural-networks
#2
Eva Kaslik, Ileana Rodica Rădulescu
The dynamics of complex-valued fractional-order neuronal networks are investigated, focusing on stability, instability and Hopf bifurcations. Sufficient conditions for the asymptotic stability and instability of a steady state of the network are derived, based on the complex system parameters and the fractional order of the system, considering simplified neuronal connectivity structures (hub and ring). In some specific cases, it is possible to identify the critical values of the fractional order for which Hopf bifurcations may occur...
March 6, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28324507/using-protein-fragment-complementation-assays-pca-and-peptide-arrays-to-study-telomeric-protein-protein-interactions
#3
Wenbin Ma, Ok-Hee Lee, Hyeung Kim, Zhou Songyang
Studying protein-protein interactions is critical to our understanding of signaling pathways. Telomere Interactome is assembled around telomeres and consists of proteins and factors from diverse pathways. Dissecting how this protein network contributes to telomere protection and length regulation requires the elucidation of the complex and dynamic interactions between the proteins within the interactome. Here, we focus on three assays, Bi-molecular Fluorescence Complementation (BiFC), Gaussia Luciferase Protein-fragment Complementation Assay (GLuc PCA), and OPAL peptide array, which have proven vital in our studies of telomere protein interaction networks...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28324193/hemodynamic-characterization-of-peripheral-arterio-venous-malformations
#4
Sabrina Frey, A Haine, R Kammer, H von Tengg-Kobligk, D Obrist, I Baumgartner
Peripheral arterio-venous malformations (pAVMs) are congenital vascular anomalies that require treatment, due to their severe clinical consequences. The complexity of lesions often leads to misdiagnosis and ill-planned treatments. To improve disease management, we developed a computational model to quantify the hemodynamic effects of key angioarchitectural features of pAVMs. Hemodynamic results were used to predict the transport of contrast agent (CA), which allowed us to compare our findings to digital subtraction angiography (DSA) recordings of patients...
March 21, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28323429/is-high-density-amorphous-ice-simply-a-derailed-state-along-the-ice-i-to-ice-iv-pathway
#5
Jacob James Shephard, Sanliang Ling, Gabriele Cesare Sosso, Angelos Michaelides, Ben Slater, Christoph G Salzmann
The structural nature of high-density amorphous ice (HDA), which forms through low-temperature pressure-induced amorphization of the 'ordinary' ice I, is heavily debated. Clarifying this question is not only important for understanding the complex condensed states of H2O but also in the wider context of pressure-induced amorphization processes, which are encountered across the entire materials spectrum. We first show that ammonium fluoride (NH4F), which has a similar hydrogen-bonded network to ice I, also undergoes a pressure collapse upon compression at 77 K...
March 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28319908/the-sociology-of-space-as-a-catalyst-for-innovation-in-the-health-sector
#6
Trust Saidi, Katusha de Villiers, Tania S Douglas
This paper reviews the role of space in facilitating innovation. It draws on the sociology of space in exploring the social practices, institutional forces and material complexity of how people and spaces interact. We assess how space influences the development of innovative solutions to challenges in the health sector. Our aim is to advance an understanding of the social production of space for healthcare innovation. We draw empirical examples from the Innovation Hub at Groote Schuur Hospital in Cape Town to illustrate that innovation does not take place in an institutional vacuum, but requires space that facilitates interaction of different players...
March 9, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28319783/development-of-an-evaluation-framework-for-publicly-funded-r-d-projects-the-case-of-korea-s-next-generation-network
#7
Eungdo Kim, Soyoung Kim, Hongbum Kim
For decades, efforts have been made globally to measure the performance of large-scale public projects and to develop a framework to perform such measurements due to the complexity and dynamics of R&D and stakeholder interests. Still, limitations such as the use of a simply modified model and the lack of a comprehensive viewpoint are prevalent in existing approaches. In light of these research gaps, this study suggests a practical model to evaluate the performance of large-scale and publicly funded projects...
February 28, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28319090/a-single-copy-sleeping-beauty-transposon-mutagenesis-screen-identifies-new-pten-cooperating-tumor-suppressor-genes
#8
Jorge de la Rosa, Julia Weber, Mathias Josef Friedrich, Yilong Li, Lena Rad, Hannes Ponstingl, Qi Liang, Sandra Bernaldo de Quirós, Imran Noorani, Emmanouil Metzakopian, Alexander Strong, Meng Amy Li, Aurora Astudillo, María Teresa Fernández-García, María Soledad Fernández-García, Gary J Hoffman, Rocío Fuente, George S Vassiliou, Roland Rad, Carlos López-Otín, Allan Bradley, Juan Cadiñanos
The overwhelming number of genetic alterations identified through cancer genome sequencing requires complementary approaches to interpret their significance and interactions. Here we developed a novel whole-body insertional mutagenesis screen in mice, which was designed for the discovery of Pten-cooperating tumor suppressors. Toward this aim, we coupled mobilization of a single-copy inactivating Sleeping Beauty transposon to Pten disruption within the same genome. The analysis of 278 transposition-induced prostate, breast and skin tumors detected tissue-specific and shared data sets of known and candidate genes involved in cancer...
March 20, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28318522/prognostic-stratification-and-healthcare-approach-in-patients-with-multiple-pathologies
#9
M Bernabeu-Wittel, B Barón-Franco, D Nieto-Martín, L Moreno-Gaviño, N Ramírez-Duque, M Ollero-Baturone
Polypathological patients constitute a prevalent, fairly homogeneous population, which is characterised by high clinical complexity, substantial vulnerability and significant resource consumption, in addition to high mortality and the need for comprehensive, coordinated care. It is particularly important to establish a reliable prognosis in these patients. It is also extremely useful for professionals involved in the decision-making process for patients and their families in vital planning and their preferences, for strategic health planning in management fields, and for clinical research, by facilitating their incorporation into clinical trials and other intervention studies...
March 16, 2017: Revista Clínica Española
https://www.readbyqxmd.com/read/28318372/white-blood-cell-counts-insulin-resistance-vitamin-d-levels-and-sarcopenia-in-korean-elderly-men
#10
Sang-Hwan Kim, Hyun Seok Kwon, Hee-Jin Hwang
Sarcopenia is a major determinant of frailty, disability and mortality in the elderly. Whether low-grade inflammation, insulin resistance and vitamin D are independently associated with sarcopenia remains unclear. In our study, sarcopenia was defined as an appendicular skeletal muscle mass divided by height squared (ASM/Ht(2)) that was <2 SD below the normal means for young adults. Insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR) index [(insulin (IU/mL) × fasting glucose (mg/dL)/18)/22...
May 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28318268/mechanistic-insights-into-the-directed-assembly-of-hydrogel-blocks-mediated-by-polyelectrolytes-or-microgels
#11
Nicolas Hanauer, Pierre Luc Latreille, Xavier Banquy
In this study, we report the directed assembly of hydrogel blocks mediated by electrostatic interactions. We compared two different assembly mechanisms, one mediated by microgel particles and another mediated by direct interaction between oppositely charged blocks. The system consisted in hydrogel blocks made of an interpenetrated network of (hydroxyethyl)methacrylate-poly(ethyleneglycol)dimethacrylate (HEMA-PEGDMA) and either positively charged polyethyleneimine (PEI) or negatively charged hyaluronic acid (HA)...
March 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28318184/preventing-childhood-obesity-contributions-from-the-social-sciences-to-intervention
#12
Muriel Lamarque, Alicia Bibiana Orden
Programming and implementation of health policies for the prevention of overweight and obesity have traditionally focused on the dissemination of specific messages identifying healthy foods and pointing out the importance of physical activity. Despite recurrent efforts, the prevalence of obesity in both adult and children populations continues to rise. The configuration of preventive proposals seems to neglect the more complex reality of the eating phenomenon, whose nature goes beyond its biological basis. Behind the presence of overweight or obesity, there are factors that exceed individual behaviors, which are constituted as elements of social order...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28317894/swim-a-computational-tool-to-unveiling-crucial-nodes-in-complex-biological-networks
#13
Paola Paci, Teresa Colombo, Giulia Fiscon, Aymone Gurtner, Giulio Pavesi, Lorenzo Farina
SWItchMiner (SWIM) is a wizard-like software implementation of a procedure, previously described, able to extract information contained in complex networks. Specifically, SWIM allows unearthing the existence of a new class of hubs, called "fight-club hubs", characterized by a marked negative correlation with their first nearest neighbors. Among them, a special subset of genes, called "switch genes", appears to be characterized by an unusual pattern of intra- and inter-module connections that confers them a crucial topological role, interestingly mirrored by the evidence of their clinic-biological relevance...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317777/preparation-characterization-and-stability-of-curcumin-loaded-zein-shellac-composite-colloidal-particles
#14
Cuixia Sun, Chenqi Xu, Like Mao, Di Wang, Jie Yang, Yanxiang Gao
Curcumin-loaded zein-shellac composite particles were prepared by the antisolvent co-precipitation method. The encapsulation efficiency of curcumin was significantly improved from 82.7% in zein particles to 93.2% in zein-shellac complex particles. The result of differential scanning calorimetry suggested that curcumin in the polymeric matrix was in an amorphous state. Fourier transform infrared spectroscopy analysis revealed that curcumin had non-covalently interacted with zein and shellac, mainly through hydrogen bonding and hydrophobic interaction...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28316353/cassava-postharvest-physiological-deterioration-a-complex-phenomenon-involving-calcium-signaling-reactive-oxygen-species-and-programmed-cell-death
#15
REVIEW
Astride S M Djabou, Luiz J C B Carvalho, Qing X Li, Nicolas Niemenak, Songbi Chen
Postharvest physiological deterioration (PPD) of cassava (Manihot esculenta) storage roots is a complex physiological and biochemical process which involve many regulatory networks linked with specific proteins modulation and signaling transduction pathways. However, it is poorly understood regarding biological regulation, and the interactions among protein groups and signals to determine PPD syndrome in cassava storage roots. This review sheds some light on the possible molecular mechanisms involved in reactive oxygen species (ROS), calcium signaling transduction, and programmed cell death (PCD) in cassava PPD syndrome...
2017: Acta Physiologiae Plantarum
https://www.readbyqxmd.com/read/28316259/the-adipose-stromal-vascular-fraction-as-a-complex-cellular-source-for-tissue-engineering-applications
#16
Venkat M Ramakrishnan, Nolan L Boyd
A major challenge in tissue engineering is the generation of sufficient volumes of viable tissue for organ transplant. The development of a stable, mature vasculature is required to sustain the metabolic and functional activities of engineered tissues. Adipose stromal vascular fraction (SVF) cells are an easily accessible, heterogeneous cell system comprised of endothelial cells, macrophages, pericytes, and various stem cell populations. Collectively, SVF has been shown to spontaneously form vessel-like networks in vitro and robust, patent, and functional vasculatures in vivo...
March 19, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28315679/charged-groups-at-binding-interfaces-of-the-psbo-subunit-of-photosystem-ii-a-combined-bioinformatics-and-simulation-study
#17
Coral Del Val, Ana-Nicoleta Bondar
PsbO is an extrinsic subunit of photosystem II engaged in complex binding interactions within photosystem II. At the interface between PsbO, D1 and D2 subunits of photosystem II, a cluster of charged and polar groups of PsbO is part of an extended hydrogen-bond network thought to participate in proton transfer. The precise role of specific amino acid residues at this complex binding interface remains a key open question. Here, we address this question by carrying out extensive bioinformatics analyses and molecular dynamics simulations of PsbO proteins with mutations at the binding interface...
March 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28315631/network-analysis-of-urocortins
#18
(no author information available yet)
OBJECTIVES: Urocortins (Ucns), members of corticotropin releasing factor family, play critical roles in a number of pathological and physiological conditions. Many proteins have been reported to participate in Ucns signaling pathways, which formed complex interaction networks. METHODS: STITCH ('search tool for interactions of chemicals') is an interaction network database that provides exploration of the known and predicted interactions among large sets of chemicals and proteins...
November 19, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28315459/dynamic-reorganization-of-intrinsic-functional-networks-in-the-mouse-brain
#19
Joanes Grandjean, Maria Giulia Preti, Thomas Aw Bolton, Michaela Buerge, Erich Seifritz, Christopher R Pryce, Dimitri Van De Ville, Markus Rudin
Functional connectivity (FC) derived from resting-state functional magnetic resonance imaging (rs-fMRI) allows for the integrative study of neuronal processes at a macroscopic level. The majority of studies to date have assumed stationary interactions between brain regions, without considering the dynamic aspects of network organization. Only recently has the latter received increased attention, predominantly in human studies. Applying dynamic FC (dFC) analysis to mice is attractive given the relative simplicity of the mouse brain and the possibility to explore mechanisms underlying network dynamics using pharmacological, environmental or genetic interventions...
March 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28315308/target-specific-alterations-in-the-vip-inhibitory-drive-to-hippocampal-gabaergic-cells-after-status-epilepticus
#20
Linda Suzanne David, Lisa Topolnik
Status epilepticus (SE) is associated with complex reorganization of hippocampal circuits involving a significant loss of specific subtypes of GABAergic interneurons. While adaptive circuit plasticity may increase the chances for recruitment of surviving interneurons, the underlying mechanisms remain largely unknown. We studied the alterations in the inhibitory tone received by the hippocampal CA1 oriens/alveus (O/A) interneurons from the vasoactive intestinal peptide (VIP)- and calretinin (CR)-expressing interneurons using the pilocarpine-induced status epilepticus (SE) model of epilepsy...
March 14, 2017: Experimental Neurology
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