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Anna R Reynolds, Justin C Strickland, William W Stoops, Joshua A Lile, Craig R Rush
BACKGROUND: Medications development efforts for methamphetamine-use disorder have targeted central monoamines because these systems are directly involved in the effects of methamphetamine. Buspirone is a dopamine autoreceptor and D3 receptor antagonist and partial agonist at serotonin 1A receptors, making it a logical candidate medication for methamphetamine-use disorder. Buspirone effects on abuse-related behaviors of methamphetamine have been mixed in clinical and preclinical studies...
September 22, 2017: Drug and Alcohol Dependence
Hongwei Tan, Gang Liu, Huali Yang, Xiaohui Yi, Liang Pan, Jie Shang, Shibing Long, Ming Liu, Yihong Wu, Run-Wei Li
Memristive devices are able to store and process information which offer several key advantages over the transistor-based architectures. However, most of the two-terminal memristive devices have fixed functions once made and cannot be reconfigured for other situations. Here, we propose and demonstrate a memristive device 'memlogic' (memory-logic) as a non-volatile switch of logic operations integrated with memory function in a single light-gated memristor. Based on non-volatile light-modulated memristive switching behavior, a single memlogic cell is able to achieve optical and electrical mixed basic Boolean logic of reconfigurable 'AND' , 'OR' and 'NOT' operations...
October 13, 2017: ACS Nano
Zhen Qu, Yao Li, Weiyang Mo, Mingwei Yang, Shengxiang Zhu, Daniel C Kilper, Ivan B Djordjevic
We experimentally demonstrate self-adaptive coded 5×100  Gb/s WDM polarization multiplexed 16 quadrature amplitude modulation transmission over a 100 km fiber link, which is enabled by a real-time control plane. The real-time optical signal-to-noise ratio (OSNR) is measured using an optical performance monitoring device. The OSNR measurement is processed and fed back using control plane logic and messaging to the transmitter side for code adaptation, where the binary data are adaptively encoded with three types of low-density parity-check (LDPC) codes with code rates of 0...
October 15, 2017: Optics Letters
Andres Riofrio, Susana Sanz, Maria Jesus L Boada, Beatriz L Boada
In this article, a Linear Quadratic Regulator (LQR) lateral stability and rollover controller has been developed including as the main novelty taking into account the road bank angle and using exclusively active suspension for both lateral stability and rollover control. The main problem regarding the road bank is that it cannot be measured by means of on-board sensors. The solution proposed in this article is performing an estimation of this variable using a Kalman filter. In this way, it is possible to distinguish between the road disturbance component and the vehicle's roll angle...
October 13, 2017: Sensors
Navika D Shukla, Allen L Ho, Arjun V Pendharkar, Eric S Sussman, Casey H Halpern
Medically intractable epilepsy is associated with increased morbidity and mortality. For those with focal epilepsy and correlated electrophysiological or radiographic features, open surgical resection can achieve high rates of seizure control, but can be associated with neurologic deficits and cognitive effects. Recent innovations have allowed for more minimally invasive methods of surgical seizure control such as magnetic resonance-guided laser interstitial therapy (MRgLITT). MRgLITT achieves the goal of ablating seizure foci while preserving neuropsycho-logical function and offering real-time feedback and monitoring of tissue ablation...
2017: Neuropsychiatric Disease and Treatment
Lu Li, Pallavi G Patki, Young B Kwon, Veronika Stelmakh, Brandon D Campbell, Muthiah Annamalai, Taras I Lakoba, Michael Vasilyev
One of the main reasons why nonlinear-optical signal processing (regeneration, logic, etc.) has not yet become a practical alternative to electronic processing is that the all-optical elements with nonlinear input-output relationship have remained inherently single-channel devices (just like their electronic counterparts) and, hence, cannot fully utilise the parallel processing potential of optical fibres and amplifiers. The nonlinear input-output transfer function requires strong optical nonlinearity, e.g...
October 12, 2017: Nature Communications
Steven R Cohen, Sierra Hewett, Lauren Ross, Flore Delaunay, Ashley Goodacre, Char Ramos, Tracy Leong, Ahmad Saad
Zuk et al in 2001 identified stem and regenerative cells within the stromal vascular fraction of fat. In preclinical studies, these cells appeared to stimulate angiogenesis and reduce inflammation, and soon thereafter, clinical use of stromal vascular fraction (SVF) evolved as researchers such as Rigotti, Coleman, Mojallal, our group, and others demonstrated that fat can be used for both therapeutic and aesthetic indications. The regenerative effects of fat and its contents on facial aesthetics have been shown at the histologic and cellular level...
July 1, 2017: Aesthetic Surgery Journal
Walter S Campbell, Daniel Karlsson, Daniel J Vreeman, Audrey J Lazenby, Geoffrey A Talmon, James R Campbell
Background: The College of American Pathologists (CAP) introduced the first cancer synoptic reporting protocols in 1998. However, the objective of a fully computable and machine-readable cancer synoptic report remains elusive due to insufficient definitional content in Systematized Nomenclature of Medicine - Clinical Terms (SNOMED CT) and Logical Observation Identifiers Names and Codes (LOINC). To address this terminology gap, investigators at the University of Nebraska Medical Center (UNMC) are developing, authoring, and testing a SNOMED CT observable ontology to represent the data elements identified by the synoptic worksheets of CAP...
September 13, 2017: Journal of the American Medical Informatics Association: JAMIA
Xiaojuan Gong, Zengbo Li, Qin Hu, Ruixin Zhou, Shaomin Shuang, Chuan Dong
A novel fluorescent probe based on N,S,P co-doped carbon nanodots (N,S,P-CNDSac) has been facile and fast fabricated by a one-step hydrothermal pyrolysis of Saccharomyces cerevisiae and utilized for label-free and "on-off-on" sequential detection manganese(VII) and ʟ-ascorbic acid (ʟ-AA). The fluorescence of N,S,P-CNDSac can be effectively quenched by Mn(VII) based on inner filter effect (IFE) and recovered upon the addition of ʟ-AA due to the easy-conversion of Mn(VII) to reduced states (i.e. Mn(IV), Mn(II) and Mn(0)) by ʟ-AA...
October 12, 2017: ACS Applied Materials & Interfaces
Yen-Hung Lin, Pichaya Pattanasattayavong, Thomas D Anthopoulos
Following the unprecedented rise in photovoltaic power conversion efficiencies during the past five years, metal-halide perovskites (MHPs) have emerged as a new and highly promising class of solar-energy materials. Their extraordinary electrical and optical properties combined with the abundance of the raw materials, the simplicity of synthetic routes, and processing versatility make MHPs ideal for cost-efficient, large-volume manufacturing of a plethora of optoelectronic devices that span far beyond photovoltaics...
October 12, 2017: Advanced Materials
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0183393.].
2017: PloS One
Paul R Ward, Katie Attwell, Samantha B Meyer, Philippa Rokkas, Julie Leask
In terms of public health, childhood vaccination programs have benefits that far outweigh risks. However, some parents decide not to vaccinate their children. This paper explores the ways in which such parents talked about the perceived risks and benefits incurred by vaccinating (or not vaccinating) their children. Between 2013-2016 we undertook 29 in-depth interviews with non-vaccinating and/or 'vaccine hesitant' parents in Australia. Interviews were conducted in an open and non-judgmental manner, akin to empathic neutrality...
2017: PloS One
Paul J Read, Pablo Jimenez, Jon L Oliver, Rhodri S Lloyd
Forty-one practitioners inclusive of physiotherapists, sports scientists and strength and conditioning coaches from the academies of elite soccer clubs in the United Kingdom completed an on-line questionnaire which examined their: (1) background information; (2) perceptions of injury occurrence and risk factors; (3) screening and return to play; and (4) approach to designing and delivering injury prevention programmes with a response rate of 55% (41/75). Contact injuries were the most common mechanism reported and players between 13-16 years of age were perceived to be at the greatest risk...
October 11, 2017: Journal of Sports Sciences
Niamh Appleby, Daniel Angelov
Elevated platelet counts are frequently encountered in hospital medicine and arise from both physiological and pathological mechanisms. Thrombocytosis may be secondary, reflecting an inflammatory state, iron deficiency, recent surgery or point towards an underlying neoplasm. Thrombocytosis may be the presenting sign of solid tumours and haematological conditions. The discovery of the activating mutations affecting thrombopoiesis led to greater understanding of the pathobiology of essential thrombocythaemia and other myeloproliferative neoplasms...
October 2, 2017: British Journal of Hospital Medicine
Han-Seung Ko, Yeongjun Lee, Sung-Yong Min, Sung-Joo Kwon, Tae-Woo Lee
Nanowire (NW) complementary inverters based on NW channels and NW electrodes are a promising core logic unit of future subminiature, high density and textile-type configured electronic circuits. However, existing approaches based on short NWs (<150 μm) or non-woven nanofibers cannot provide precisely-coordinated NW inverters due to the difficulty in the position and alignment control of each NW. In particular, the large-scale fabrication of highly-aligned metal nanoelectrode (NE) arrays with low resistivity is a challenging issue...
October 11, 2017: Nanoscale
Uday Yanamandra, Shaji K Kumar
The primary hurdle in the path to curing multiple myeloma (MM) is defining a validated minimal residual disease (MRD) and its utility in the therapeutic decision making. A better definition of MRD will aid in tailoring MM therapy further to address the clonal heterogeneity and genomic instability and overcome patient's ineffective immune surveillance. MRD analysis can define the logical endpoint for maintenance therapy, in addition also aids in providing a better clinical end point for studies comparing novel agents in myeloma...
October 11, 2017: Leukemia & Lymphoma
Anand R Nair, Nithya Mariappan, April J Stull, Joseph Francis
BACKGROUND: Blueberries (BB) have been shown to improve insulin sensitivity and endothelial function in obese and pre-diabetic humans, and decrease oxidative stress and inflammation, and ameliorate cardio-renal damage in rodents. This indicates that blueberries have a systemic effect and are not limited to a particular organ system. In order for blueberries to exert beneficial effects on the whole body, the mechanism would logically have to operate through modulation of cellular humoral factors...
October 11, 2017: Food & Function
Eliza L Y Wong, Juan Manuel Ramos-Goñi, Annie W L Cheung, Amy Y K Wong, Oliver Rivero-Arias
BACKGROUND: An international valuation protocol exists for obtaining societal values for each of the 3125 health states of the five-level EuroQol-five dimensions (EQ-5D-5L) questionnaire. A feedback module (FM) that can be related to theoretical models used in behavioral economics was recently included in this protocol. OBJECTIVES: Our objective was to assess the impact of using an FM to estimate an EQ-5D-5L value set in Hong Kong. METHODS: EQ-5D-5L health states were elicited using a composite time trade-off (C-TTO) and a discrete-choice (DC) experiment...
October 10, 2017: Patient
N Binkley, R Besuyen, T Fuerst, L Skillern, D Hans
Premenopausal bone loss increases fracture risk later in life. Depending on peak values, varying degrees of bone mass and microarchitectural loss can be tolerated. We suggest that risk-benefit assessments of drugs that cause premenopausal bone loss be individualized considering baseline status and subsequent BMD and TBS loss. INTRODUCTION: It is logical that drug-induced loss of bone mass and microarchitecture in young adults increase fracture risk later in life. However, no existing data quantify how drug-induced bone loss in younger adults impacts fracture risk later in life...
October 10, 2017: Osteoporosis International
Guillermo Rodrigo, Djordje Bajić, Ignacio Elola, Juan F Poyatos
Many essential bacterial responses present complex transcriptional regulation of gene expression. To what extent can the study of these responses substantiate the logic of their regulation? Here, we show how the input function of the genes constituting the response, i.e., the information of how their transcription rates change as function of the signals acting on the regulators, can serve as a quantitative tool to deconstruct the corresponding regulatory logic. To demonstrate this approach, we consider the multiple antibiotic resistance (mar) response in Escherichia coli...
2017: NPJ Systems Biology and Applications
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