keyword
MENU ▼
Read by QxMD icon Read
search

Logic

keyword
https://www.readbyqxmd.com/read/29454038/dendritic-cells-as-cancer-therapeutics
#1
REVIEW
Christian E Bryant, Sarah Sutherland, Benjamin Kong, Michael S Papadimitrious, Derek N J Hart
The ability of immune therapies to control cancer has recently generated intense interest. This therapeutic outcome is reliant on T cell recognition of tumour cells. The natural function of dendritic cells (DC) is to generate adaptive responses, by presenting antigen to T cells, hence they are a logical target to generate specific anti-tumour immunity. Our understanding of the biology of DC is expanding, and they are now known to be a family of related subsets with variable features and function. Most clinical experience to date with DC vaccination has been using monocyte-derived DC vaccines...
February 14, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29453994/land-use-change-and-conversion-effects-on-ground-water-quality-trends-an-integration-of-land-change-modeler-in-gis-and-a-new-ground-water-quality-index-developed-by-fuzzy-multi-criteria-group-decision-making-models
#2
Mohammad Reza Shooshtarian, Mansooreh Dehghani, Ferrante Margherita, Oliveri Conti Gea, Shima Mortezazadeh
This study aggregated Land Change Modeller (LCM) as a useful model in GIS with an extended Groundwater Quality Index (GWQI) developed by fuzzy Multi-Criteria Group Decision-Making models to investigate the effect of land use change and conversion on groundwater quality being supplied for drinking. The model's performance was examined through an applied study in Shiraz, Iran, in a five year period (2011 to 2015). Four land use maps including urban, industrial, garden, and bare were employed in LCM model and the impact of change in area and their conversion to each other on GWQI changes was analysed...
February 14, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29453616/laser-induced-plasma-spectroscopy-lips-use-of-a-geological-tool-in-assessing-bone-mineral-content
#3
László Andrássy, Izabella Gomez, Ágnes Horváth, Katalin Gulyás, Zsófia Pethö, Balázs Juhász, Harjit Pal Bhattoa, Zoltan Szekanecz
Bone may be similar to geological formulations in many ways. Therefore, it may be logical to apply laser-based geological techniques in bone research. The mineral and element oxide composition of bioapatite can be estimated by mathematical models. Laser-induced plasma spectrometry (LIPS) has long been used in geology. This method may provide a possibility to determine the composition and concentration of element oxides forming the inorganic part of bones. In this study, we wished to standardize the LIPS technique and use mathematical calculations and models in order to determine CaO distribution and bone homogeneity using bovine shin bone samples...
February 17, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29452443/gender-comparison-of-medical-student-microsurgical-skills-in-a-laboratory-model
#4
Rowena Sudario-Lumague, Yuan-Cheng Chiang, Tsan-Shiun Lin
BACKGROUND: Perceived gender-related differences in surgical skills could limit opportunities available for any aspiring surgeon. There should be more available literature and logical analysis of these observations. The objective of this study is to evaluate the microsurgical skills of male and female medical students using a standard scale in the laboratory. METHODS: This study included medical students enrolled in the Kaohsiung Chang Gung Memorial Hospital from 2002 to 2015 who were evaluated by a senior consultant for their microsurgical skills...
February 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29452426/open-access-data-capitalism-and-academic-publishing
#5
Michael Hagner
Open Access (OA) is widely considered a breakthrough in the history of academic publishing, rendering the knowledge produced by the worldwide scientific community accessible to all. In numerous countries, national governments, funding institutions and research organisations have undertaken enormous efforts to establish OA as the new publishing standard. The benefits and new perspectives, however, cause various challenges. This essay addresses several issues, including that OA is deeply embedded in the logic and practices of data capitalism...
February 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29452063/getting-started-an-empirically-derived-logic-model-for-age-friendly-community-initiatives-in-the-early-planning-phase
#6
Emily A Greenfield
Age-friendly community initiatives (AFCIs) foster efforts across stakeholders to make localities more supportive and inclusive of older adults, and potentially better for residents of all ages. This study drew on in-depth interviews with leaders of nine newly forming AFCIs in northern New Jersey to develop an empirically based logic model for the initiatives in the early planning phase. The results obtained from a conventional content analysis indicated three main activities in the early planning phase: assessing the community; meeting; and communicating with stakeholders; and facilitating communitywide communications...
February 16, 2018: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/29450828/the-role-of-excipients-in-the-stability-of-triamcinolone-acetonide-in-ointments
#7
Anton J P van Heugten, Wouter S de Vries, Marian M A Markesteijn, Roland J Pieters, H Vromans
Degradation of triamcinolone acetonide (TCA) in an ointment was investigated. TCA appeared to be concentrated in propylene glycol (PG) which in turn is dispersed in a lanolin-petrolatum mixture. Two predominant degradation products were identified: a 21-aldehyde and a 17-carboxylic acid. The 21-aldehyde is formed after TCA is oxidized by O 2 , a reaction that is catalyzed by trace metals. Logically, the content of trace metals has a profound effect on the degradation rate. It was shown that trace metals are extracted from lanolin and petrolatum by PG, increasing the concentration in PG...
February 15, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29449797/dual-deep-modeling-multi-level-modeling-with-dual-potencies-and-its-formalization-in-f-logic
#8
Bernd Neumayr, Christoph G Schuetz, Manfred A Jeusfeld, Michael Schrefl
An enterprise database contains a global, integrated, and consistent representation of a company's data. Multi-level modeling facilitates the definition and maintenance of such an integrated conceptual data model in a dynamic environment of changing data requirements of diverse applications. Multi-level models transcend the traditional separation of class and object with clabjects as the central modeling primitive, which allows for a more flexible and natural representation of many real-world use cases. In deep instantiation, the number of instantiation levels of a clabject or property is indicated by a single potency...
2018: Software and Systems Modeling
https://www.readbyqxmd.com/read/29448329/minimum-energy-dissipation-required-for-a-logically-irreversible-operation
#9
Naoki Takeuchi, Nobuyuki Yoshikawa
According to Landauer's principle, the minimum heat emission required for computing is linked to logical entropy, or logical reversibility. The validity of Landauer's principle has been investigated for several decades and was finally demonstrated in recent experiments by showing that the minimum heat emission is associated with the reduction in logical entropy during a logically irreversible operation. Although the relationship between minimum heat emission and logical reversibility is being revealed, it is not clear how much free energy is required to be dissipated for a logically irreversible operation...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29446498/simultaneous-g-quadruplex-dna-logic
#10
Antoine Bader, Scott Lee Cockroft
A fundamental principle of digital computer operation is Boolean logic, where inputs and outputs are described by binary integer voltages. Similarly, inputs and outputs may be processed on the molecular level as exemplified by synthetic circuits that exploit the programmability of DNA base-pairing. Unlike modern computers, which execute large numbers of logic gates in parallel, most implementations of molecular logic have been limited to single computing tasks, or sensing applications. Here we report three G-quadruplex-based logic gates that operate simultaneously in a single reaction vessel...
February 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29446199/light-dependent-cytoplasmic-recruitment-enhances-the-dynamic-range-of-a-nuclear-import-photoswitch
#11
Hayretin Yumerefendi, Hui Wang, Daniel J Dickinson, Andrew Lerner, Per Malkus, Bob Goldstein, Klaus Hahn, Brian Kuhlman
Cellular signal transduction is often regulated at multiple steps in order to achieve more complex logic or precise control of a pathway. For instance, some signaling mechanisms couple allosteric activation with localization to achieve high signal to noise. Here, we create a system for light activated nuclear import that incorporates two levels of control. It consists of a nuclear import photoswitch, Light Activated Nuclear Shuttle (LANS), and a protein engineered to preferentially interact with LANS in the dark, Zdk2...
February 14, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29445602/uniportal-video-assisted-thoracoscopic-surgery-vats-sleeve-resections-for-non-small-cell-lung-cancer-patients-an-observational-prospective-study-and-technique-analysis
#12
Aris Koryllos, Erich Stoelben
Bronchus sleeve resection for operative treatment of non-small cell lung cancer (NSCLC) is a gold standard in modern thoracic surgery in cases of centrally located tumors or hilär lymph node metastases. Advanced instruments and growing surgical experience allowed surgeons to reduce the required incisions (from 3-port to uniportal) and to resect larger and more centrally located malignancies minimal invasively. It is a logical and expected advance in thoracic surgery that video-assisted thoracoscopic surgery (VATS) would be ultimately used also for complex bronchial resections...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29444698/using-owl-reasoning-to-support-the-generation-of-novel-gene-sets-for-enrichment-analysis
#13
David J Osumi-Sutherland, Enrico Ponta, Melanie Courtot, Helen Parkinson, Laura Badi
BACKGROUND: The Gene Ontology (GO) consists of over 40,000 terms for biological processes, cell components and gene product activities linked into a graph structure by over 90,000 relationships. It has been used to annotate the functions and cellular locations of several million gene products. The graph structure is used by a variety of tools to group annotated genes into sets whose products share function or location. These gene sets are widely used to interpret the results of genomics experiments by assessing which sets are significantly over- or under-represented in results lists...
February 14, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29444602/evaluating-integrative-cancer-clinics-with-the-claim-assessment-profile-an-example-with-the-inspirehealth-clinic
#14
Lara Hilton, Pamela Elfenbaum, Shamini Jain, Meredith Sprengel, Wayne B Jonas
BACKGROUND: The evaluation of freestanding integrative cancer clinical programs is challenging and is rarely done. We have developed an approach called the Claim Assessment Profile (CAP) to identify whether evaluation of a practice is justified, feasible, and likely to provide useful information. OBJECTIVES: A CAP was performed in order to (1) clarify the healing claims at InspireHealth, an integrative oncology treatment program, by defining the most important impacts on its clients; (2) gather information about current research capacity at the clinic; and (3) create a program theory and path model for use in prospective research...
March 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29444577/classification-of-scapular-body-fractures
#15
J Bartonicek, D Klika, M Tucek
INTRODUCTION: The aim of this study is to present, on the basis of 3D CT reconstructions of 187 of scapular body fractures, a clinically oriented classification respecting the biomechanical architecture of the scapula. METHODS: In a series of 375 scapula fractures we identified 187 body fractures in187 patients (157 men, 30 women) with the mean age of 48 years (range; 16100 years). 3D CT reconstructions were obtainedof all fractures, to allow an objective evaluation of the fracture pattern...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29444491/piecing-together-nonribosomal-peptide-synthesis
#16
REVIEW
Janice M Reimer, Asfarul S Haque, Michael J Tarry, T Martin Schmeing
Nonribosomal peptide synthetases (NRPSs) produce peptide products with wide-ranging biological activities. NRPSs are macromolecular machines with modular assembly-line logic, a complex catalytic cycle, moving parts and multiple active sites. They are organized into repeating sets of domains, called modules. Each module contains all functionality to introduce a building block into the growing peptide, many also perform cosynthetic tailoring. Structures of individual domains have provided insights into their catalytic mechanisms, but with one exception, larger NRPS proteins were refractory to structure determination...
February 11, 2018: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29444407/phase-tunable-josephson-thermal-router
#17
GiulianoFrancesco Timossi, Antonio Fornieri, Federico Paolucci, Claudio Puglia, Francesco Giazotto
A fundamental aspect of electronics is the ability to distribute a charge current among different terminals. On the other hand, despite the great interest in dissipation, storage and conversion of heat in solid state structures, the control of thermal currents at the nanoscale is still in its infancy. Here, we show the experimental realization of a phase-tunable thermal router able to control the spatial distribution of an incoming heat current, thus providing the possibility of tuning the electronic temperatures of two output terminals...
February 14, 2018: Nano Letters
https://www.readbyqxmd.com/read/29440766/a-cnot-gate-between-multiphoton-qubits-encoded-in-two-cavities
#18
S Rosenblum, Y Y Gao, P Reinhold, C Wang, C J Axline, L Frunzio, S M Girvin, Liang Jiang, M Mirrahimi, M H Devoret, R J Schoelkopf
Entangling gates between qubits are a crucial component for performing algorithms in quantum computers. However, any quantum algorithm must ultimately operate on error-protected logical qubits encoded in high-dimensional systems. Typically, logical qubits are encoded in multiple two-level systems, but entangling gates operating on such qubits are highly complex and have not yet been demonstrated. Here we realize a controlled NOT (CNOT) gate between two multiphoton qubits in two microwave cavities. In this approach, we encode a qubit in the high-dimensional space of a single cavity mode, rather than in multiple two-level systems...
February 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29440328/evaluation-of-california-s-tobacco-21-law
#19
Xueying Zhang, Tam D Vuong, Elizabeth Andersen-Rodgers, April Roeseler
INTRODUCTION: California's law raising the minimum tobacco sales age to 21 went into effect on 9 June 2016. This law, known as 'Tobacco 21' or 'T21', also expanded the definition of tobacco to include electronic smoking devices. This paper describes the T21 evaluation plan and initial evaluation results. METHODS: An evaluation plan and logic model were created to evaluate T21. A tobacco retailer poll was conducted 7 months after the law went into effect to assess awareness, support and implementation; an online survey of California adults was fielded to provide data on tobacco use and attitudinal changes before and after T21 implementation; and tobacco purchase surveys were conducted to assess the retailer violation rate (RVR)...
February 13, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29440017/patient-involvement-in-diagnosing-cancer-in-primary-care-a-systematic-review-of-current-interventions
#20
Jane Heyhoe, Caroline Reynolds, Alice Dunning, Olivia Johnson, Alex Howat, Rebecca Lawton
BACKGROUND: Patients can play a role in achieving an earlier diagnosis of cancer by monitoring and re-appraising symptoms after initially presenting to primary care. It is not clear what interventions exist, or what the components of an intervention to engage patients at this diagnostic stage are. AIM: The review had two aims: 1) to identify interventions that involve patients, and 2) to establish key components for engaging patients in the diagnosis of cancer in primary care at the post-presentation stage...
February 12, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
keyword
keyword
26755
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"