keyword
MENU ▼
Read by QxMD icon Read
search

Agent

keyword
https://www.readbyqxmd.com/read/29054083/modulation-of-valence-band-maximum-edge-and-photocatalytic-activity-of-biox-by-incorporation-of-halides
#1
Jiaxin Lv, Qingsong Hu, Chengjin Cao, Yaping Zhao
To better know the photocatalytic performance of bismuth oxyhalides (BiOX, X = Cl, Br, I) regulated by incorporation of halides within nanostructures, BiOX nanosheets were synthesized through morphology controllable solvothermal method and characterized systematically. The organic structural property greatly influences the photocatalytic activity of BiOX: 1) as for neutral molecular phenol, BiOX shows photocatalytic activity in the order of BiOCl > BiOBr > BiOI under simulated sun light irradiation, and the photo-oxidation kinetics follow Eley-Rideal mechanism; and 2) for adsorbed anionic orange II (OII) and cationic methylene blue (MB), BiOX shows photocatalytic activity in the order of BiOCl > BiOBr > BiOI, and the photo-oxidation kinetics follow Langmuir-Hinshelwood mechanism...
October 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/29054075/evaluation-of-immunological-markers-of-ovine-vaginal-irritation-implications-for-preclinical-assessment-of-non-vaccine-hiv-preventive-agents
#2
Gregg N Milligan, Gracie Vargas, Kathleen L Vincent, Yong Zhu, Nigel Bourne, Massoud Motamedi
The presence of genital inflammatory responses and a compromised vaginal epithelial barrier have been linked to an increased risk of HIV acquisition. It is important to assure that application of candidate microbicides designed to limit HIV transmission will not cause these adverse events. We previously developed high resolution in vivo imaging methodologies in sheep to assess epithelial integrity following vaginal application of a model microbicide, however characterization of genital inflammation in sheep has not been previously possible...
October 13, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29054025/antibacterial-activity-against-cariogenic-bacteria-and-cytotoxic-and-genotoxic-potential-of-anacardium-occidentale-l-and-anadenanthera-macrocarpa-benth-brenan-extracts
#3
Josenildo Segundo Chaves de Araújo, Aline Rogéria Freire de Castilho, Andressa Brito Lira, Andréia Vieira Pereira, Tatiane Kelly Barbosa de Azevêdo, Edja Maria de Melo de Brito Costa, Maria do Socorro Vieira Pereira, Hilzeth Freire Luna Pessoa, Jozinete Vieira Pereira
OBJECTIVES: The present study aimed to assess the antibacterial activity against bacteria with cariogenic relevance, toxic and genotoxic potential of the plants Anacardium occidentale L. and Anadenanthera macrocarpa (Benth.) Bernam. DESIGN: Using a microdilution technique, the extracts were submitted to minimum inhibitory concentration (MIC) testing against Streptococcus mitis (ATCC 903), Streptococcus mutans (ATCC 25175), Streptococcus oralis (ATCC 10557), Streptococcus salivarius (ATCC 7073), Streptococcus sanguinis (ATCC 15300) and Streptococcus sobrinus (ATCC 27609)...
October 14, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29053932/the-patterns-of-in-vitro-cell-death-and-inflammatory-cytokines-induced-by-distinct-bcg-vaccine-strains-are-differentially-induced-in-human-mononuclear-cells
#4
C Ponte, M Hacker, M Moraes, L Castello-Branco, F Silva, P Antas
Tuberculosis (TB) remains among the world's leading cause of mortality. For its control, studies of TB vaccines are needed. Since live-attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only TB vaccine currently in use, studies on the protective role of BCG are required. In this study, we analyzed host cells purified directly from whole blood of human immunodeficiency virus (HIV)-negative volunteers, comprising adult healthy donors (HD) and neonates (umbilical cord bloods, UCB), with the aim to directly compare in vitro immune responses with distinct BCG strains in human mononuclear cells...
October 20, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29053889/optimization-of-mass-spectrometry-acquisition-parameters-for-determination-of-polycarbonate-additives-degradation-products-and-colorants-migrating-from-food-contact-materials-to-chocolate
#5
Chiara Bignardi, Antonella Cavazza, Carmen Laganà, Paola Salvadeo, Claudio Corradini
The interest towards the so-called "substances of emerging concerns", in particular referred to objects intended to come into contact with food is recently growing. Such substances can be found in traces in simulants and in food products put in contact with plastic materials. In this context, it is important to set up analytical systems characterized by high sensitivity, and to improve detection parameters to enhance signals. This work was aimed at optimizing a method based on UHPLC coupled to High Resolution Mass Spectrometry to quantify the most common plastic additives, and able to detect the presence of polymers degradation products and coloring agents migrating from plastic re-usable containers...
October 20, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29053830/friedreich-s-ataxia-clinical-features-pathogenesis-and-management
#6
A Cook, P Giunti
Introduction: Friedreich's ataxia is the most common inherited ataxia. Sources of data: Literature search using PubMed with keywords Friedreich's ataxia together with published papers known to the authors. Areas of agreement: The last decade has seen important advances in our understanding of the pathogenesis of disease. In particular, the genetic and epigenetic mechanisms underlying the disease now offer promising novel therapeutic targets...
October 19, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/29053790/the-hippo-signaling-pathway-in-pancreatic-%C3%AE-cells-functions-and-regulations
#7
Amin Ardestani, Kathrin Maedler
Hippo signaling is an evolutionarily conserved pathway that critically regulates development and homeostasis of various tissues in response to a wide range of extracellular and intracellular signals. As an emerging significant player in many diseases, the Hippo pathway is also involved in the pathophysiology of diabetes on the level of the pancreatic islets. Multiple lines of evidence uncover the importance of Hippo signaling in pancreas development as well as in the regulation of β-cell survival, proliferation and regeneration...
October 18, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/29053743/in-vitro-modeling-of-experimental-succinic-semialdehyde-dehydrogenase-deficiency-ssadhd-using-brain-derived-neural-stem-cells
#8
Kara R Vogel, Garrett R Ainslie, Erwin E Jansen, Gajja S Salomons, Jean-Baptiste Roullet, K Michael Gibson
We explored the utility of neural stem cells (NSCs) as an in vitro model for evaluating preclinical therapeutics in succinic semialdehyde dehydrogenase-deficient (SSADHD) mice. NSCs were obtained from aldh5a1+/+ and aldh5a1-/- mice (aldh5a1 = aldehyde dehydrogenase 5a1 = SSADH). Multiple parameters were evaluated including: (1) production of GHB (γ-hydroxybutyrate), the biochemical hallmark of SSADHD; (2) rescue from cell death with the dual mTOR (mechanistic target of rapamycin) inhibitor, XL-765, an agent previously shown to rescue aldh5a1-/- mice from premature lethality; (3) mitochondrial number, total reactive oxygen species, and mitochondrial superoxide production, all previously documented as abnormal in aldh5a1-/- mice; (4) total ATP levels and ATP consumption; and (5) selected gene expression profiles associated with epilepsy, a prominent feature in both experimental and human SSADHD...
2017: PloS One
https://www.readbyqxmd.com/read/29053717/gpr40-partial-agonists-and-agopams-differentiating-effects-on-glucose-and-hormonal-secretions-in-the-rodent
#9
Michele J Pachanski, Melissa E Kirkland, Daniel T Kosinski, Joel Mane, Boonlert Cheewatrakoolpong, Jiyan Xue, Daphne Szeto, Gail Forrest, Corin Miller, Michelle Bunzel, Christopher W Plummer, Harry R Chobanian, Michael W Miller, Sarah Souza, Brande S Thomas-Fowlkes, Aimie M Ogawa, Adam B Weinglass, Jerry Di Salvo, Xiaoyan Li, Yue Feng, Daniel A Tatosian, Andrew D Howard, Steven L Colletti, Maria E Trujillo
GPR40 agonists are effective antidiabetic agents believed to lower glucose through direct effects on the beta cell to increase glucose stimulated insulin secretion. However, not all GPR40 agonists are the same. Partial agonists lower glucose through direct effects on the pancreas, whereas GPR40 AgoPAMs may incorporate additional therapeutic effects through increases in insulinotrophic incretins secreted by the gut. Here we describe how GPR40 AgoPAMs stimulate both insulin and incretin secretion in vivo over time in diabetic GK rats...
2017: PloS One
https://www.readbyqxmd.com/read/29053683/new-application-of-an-atmospheric-pressure-plasma-jet-as-a-neuro-protective-agent-against-glucose-deprivation-induced-injury-of-sh-sy5y-cells
#10
Xu Yan, Zhaozhong Meng, Jiting Ouyang, Yajun Qiao, Fang Yuan
The atmospheric pressure plasma jet (APPJ) has attracted the attention of many researchers from multiple disciplines in recent years because its emissions include multiple types of reactive nitrogen species (RNS) and reactive oxygen species (ROS). Our previous study has shown the cytoprotective effect of the APPJ against oxidative stress-induced injuries. The aim of the present study is to provide a detailed in vitro treatment protocol regarding the neuroprotective applications of helium APPJs on glucose deprivation-induced injury in SH-SY5Y cells...
October 9, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053680/evaluating-in-vitro-dna-damage-using-comet-assay
#11
Yanxin Lu, Yang Liu, Chunzhang Yang
DNA damage is a common phenomenon for each cell during its lifespan, and is defined as an alteration of the chemical structure of genomic DNA. Cancer therapies, such as radio- and chemotherapy, introduce enormous amount of additional DNA damage, leading to cell cycle arrest and apoptosis to limit cancer progression. Quantitative assessment of DNA damage during experimental cancer therapy is a key step to justify the effectiveness of a genotoxic agent. In this study, we focus on a single cell electrophoresis assay, also known as the comet assay, which can quantify single and double-strand DNA breaks in vitro...
October 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053678/assay-for-phosphorylation-and-microtubule-binding-along-with-localization-of-tau-protein-in-colorectal-cancer-cells
#12
Md Nazmul Huda, Erdenedolgor Erdene-Ochir, Cheol-Ho Pan
The microtubule-associated protein tau is a neuronal protein that localizes mostly in axons. Generally tau is essential for normal neuronal functioning because it is involved in microtubule assembly and stabilization. Besides neurons, tau is expressed in human breast, prostate, gastric, colorectal, and pancreatic cancers where it shows nearly similar structure and exerts similar functions as the neuronal tau. The amount of tau and its phosphorylation can change its function as a stabilizer of microtubules, and lead to the development of paired helical filaments in different neurodegenerative disorders, such as Alzheimer's disease...
October 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053656/is-it-necessary-to-alter-anticoagulation-therapy-for-tooth-extraction-in-patients-taking-direct-oral-anticoagulants
#13
M Caliskan, H-C Tükel, E Benlidayi, A Deniz
BACKGROUND: The number of patients using direct oral anticoagulants (DOACs) instead of vitamin K antagonists (VKA) is increasing and there is limited data on the safety of tooth extractions in patients taking DOACs. The aim of this study was to compare the amount of bleeding (AOB) and postoperative complications after tooth extractions between patients taking VKAs and patients taking DOACs without altering the anticoaguation therapy. MATERIAL AND METHODS: The study consisted of four groups: Direct thrombin inhibitor group, factor Xa inhibitor group, warfarin group and a control group...
October 20, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29053638/neuroprotective-surgical-strategies-in-parkinson-s-disease-role-of-preclinical-data
#14
REVIEW
Napoleon Torres, Jenny Molet, Cecile Moro, John Mitrofanis, Alim Louis Benabid
Although there have been many pharmacological agents considered to be neuroprotective therapy in Parkinson's disease (PD) patients, neurosurgical approaches aimed to neuroprotect or restore the degenerative nigrostriatal system have rarely been the focus of in depth reviews. Here, we explore the neuroprotective strategies involving invasive surgical approaches (NSI) using neurotoxic models 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA), which have led to clinical trials. We focus on several NSI approaches, namely deep brain stimulation of the subthalamic nucleus, glial neurotrophic derived factor (GDNF) administration and cell grafting methods...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29053600/detection-and-management-of-mango-dieback-disease-in-the-united-arab-emirates
#15
Esam Eldin Saeed, Arjun Sham, Ayah AbuZarqa, Khawla A Al Shurafa, Tahra S Al Naqbi, Rabah Iratni, Khaled El-Tarabily, Synan F AbuQamar
Mango is affected by different decline disorders causing significant losses to mango growers. In the United Arab Emirates (UAE), the pathogen was isolated from all tissues sampled from diseased trees affected by Lasiodiplodia theobromae. Symptoms at early stages of the disease included general wilting appearance of mango trees, and dieback of twigs. In advanced stages, the disease symptoms were also characterized by the curling and drying of leaves, leading to complete defoliation of the tree and discolouration of vascular regions of the stems and branches...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29053584/lomefloxacin-induces-oxidative-stress-and-apoptosis-in-colo829-melanoma-cells
#16
Artur Beberok, Dorota Wrześniok, Martyna Szlachta, Jakub Rok, Zuzanna Rzepka, Michalina Respondek, Ewa Buszman
Although some fluoroquinolones have been found to exert anti-tumor activity, studies on the effect of these drugs on melanoma cells are relatively rare. The aim of this study was to examine the effect of lomefloxacin on cell viability, reactive oxygen species production, redox balance, cell cycle distribution, DNA fragmentation, and apoptosis in COLO829 melanoma cells. Lomefloxacin decreases the cell viability in a dose- and time-dependent manner. For COLO829 cells treated with the drug for 24, 48, and 72 h, the values of IC50 were found to be 0...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29053565/a-synthetic-analogue-of-neopeltolide-8-9-dehydroneopeltolide-is-a-potent-anti-austerity-agent-against-starved-tumor-cells
#17
Haruhiko Fuwa, Mizuho Sato
Neopeltolide, an antiproliferative marine macrolide, is known to specifically inhibit complex III of the mitochondrial electron transport chain (mETC). However, details of the biological mode-of-action(s) remain largely unknown. This work demonstrates potent cytotoxic activity of synthetic neopeltolide analogue, 8,9-dehydroneopeltolide (8,9-DNP), against starved human pancreatic adenocarcinoma PANC-1 cells and human non-small cell lung adenocarcinoma A549 cells. 8,9-DNP induced rapid dissipation of the mitochondrial membrane potential and depletion of intracellular ATP level in nutrient-deprived medium...
October 20, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29053522/immediate-enhancement-of-nerve-function-using-a-novel-axonal-fusion-device-after-neurotmesis
#18
David Colton Riley, Richard B Boyer, Curt A Deister, Alonda C Pollins, Nancy L Cardwell, Nathaniel D Kelm, Mark D Does, Richard D Dortch, Ravinder Bamba, Robert Bruce Shack, Wesley P Thayer
BACKGROUND: The management of peripheral nerve injuries remains a large challenge for plastic surgeons. With the inability to fuse axonal endings, results after microsurgical nerve repair have been inconsistent. Our current nerve repair strategies rely upon the slow and lengthy process of axonal regeneration (~1 mm/d). Polyethylene glycol (PEG) has been investigated as a potential axonal fusion agent; however, the percentage of axonal fusion has been inconsistent. The purpose of this study was to identify a PEG delivery device to standardize outcomes after attempted axonal fusion with PEG...
October 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29053453/distributed-continuous-time-algorithms-for-resource-allocation-problems-over-weight-balanced-digraphs
#19
Zhenhua Deng, Shu Liang, Yiguang Hong
In this paper, a distributed resource allocation problem with nonsmooth local cost functions is considered, where the interaction among agents is depicted by strongly connected and weight-balanced digraphs. Here the decision variable of each agent is within a local feasibility constraint described as a convex set, and all the decision variables have to satisfy a network resource constraint, which is the sum of available resources. To solve the problem, a distributed continuous-time algorithm is developed by virtue of differentiated projection operations and differential inclusions, and its convergence to the optimal solution is proved via the set-valued LaSalle invariance principle...
October 17, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/29053429/house-finch-haemorhous-mexicanus-associated-mycoplasma-gallisepticum-identified-in-lesser-goldfinch-spinus-psaltria-and-western-scrub-jay-aphelocoma-californica-using-strain-specific-quantitative-pcr
#20
Catherine R Allen, Arlind Mara, Edan R Tulman, David H Ley, Steven J Geary
In 1994 Mycoplasma gallisepticum was found to be the etiologic agent of House Finch (Haemorhous mexicanus) conjunctivitis, a rapidly expanding epidemic caused by a genetically discrete, House Finch-associated strain of M. gallisepticum (HFMG). While most prominent in House Finches, HFMG has been reported in other members of the family Fringillidae, including American Goldfinches (Spinus tristis), Purple Finches (Haemorhous purpureus), Pine Grosbeaks (Pinicola enucleator), and Evening Grosbeaks (Coccothraustes vespertinus)...
October 20, 2017: Journal of Wildlife Diseases
keyword
keyword
26749
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"