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Master cell disease

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https://www.readbyqxmd.com/read/29129353/impact-of-lymph-node-dissection-at-the-time-of-radical-nephrectomy-with-tumor-thrombectomy-on-oncological-outcomes-results-from-the-international-renal-cell-carcinoma-venous-thrombus-consortium-ircc-vtc
#1
Derya Tilki, Thenappan Chandrasekar, Umberto Capitanio, Gaetano Ciancio, Siamak Daneshmand, Paolo Gontero, Javier Gonzalez, Axel Haferkamp, Markus Hohenfellner, William C Huang, Estefania Linares Espinós, Adam Lorentz, Juan I Martinez-Salamanca, Viraj A Master, James M McKiernan, Francesco Montorsi, Giacomo Novara, Sascha Pahernik, Juan Palou, Raj S Pruthi, Oscar Rodriguez-Faba, Paul Russo, Douglas S Scherr, Shahrokh F Shariat, Martin Spahn, Carlo Terrone, Cesar Vera-Donoso, Richard Zigeuner, John A Libertino, Christopher P Evans
OBJECTIVES: To study the effect of lymph node dissection (LND) at the time of nephrectomy and tumor thrombectomy on oncological outcomes in patients with renal cell carcinoma (RCC) and tumor thrombus. PATIENTS AND METHODS: The records of 1,978 patients with RCC and tumor thrombus who underwent radical nephrectomy and tumor thrombectomy from 1985 to 2014 at 24 centers were analyzed. None of the patients had distant metastases. Extent and pathologic results of LND were compared with respect to cancer-specific survival (CSS)...
November 9, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29125549/klf2-in-regulation-of-nf-%C3%AE%C2%BAb-mediated-immune-cell-function-and-inflammation
#2
REVIEW
Prerana Jha, Hiranmoy Das
KLF2 (Kruppel-like factor 2) is a member of the zinc finger transcription factor family, which critically regulates embryonic lung development, function of endothelial cells and maintenance of quiescence in T-cells and monocytes. It is expressed in naïve T-cells and monocytes, however its level of expression decreases during activation and differentiation. KLF2 also plays critical regulatory role in various inflammatory diseases and their pathogenesis. Nuclear factor-kappaB (NF-κB) is an important inducer of inflammation and the inflammation is mediated through the transcription of several proinflammatory cytokines, chemokines and adhesion molecules...
November 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29125499/mast-cells-in-the-brain%C3%A2-old-cells-new-target
#3
Giovanna Traina
Mast cells (MCs) are mainly known for their involvement on allergic reactions through degranulation and release of vasoactive, inflammatory and nociceptive mediators. Upon encountering an allergen, MCs are first responders, true sensors of the environment, actually they respond to a wide range of "danger" signals both immunological and non-immunological in rapid and selective manner. They secrete both preformed and newly synthesized mediators acting as effectors in relationship between nervous, vascular and immune systems...
November 7, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/29123414/low-grade-central-osteosarcoma-in-proximal-humerus-a-rare-entity
#4
Fan Tang, Li Min, Yong Zhou, Yi Luo, Chongqi Tu
Low-grade central osteosarcoma is a rare subtype of tumor with low-grade malignancy. Currently, wide resection with negative resection margin is the standard treatment for this disease. The role of neoadjuvant chemotherapy in low-grade central osteosarcoma was controversial and was mostly considered for tumors containing high-grade focal areas. Local tumor recurrences often exhibited a tumor with higher histologic grade or differentiation with the potential for metastases. In low-grade central osteosarcoma, timely wide resection after definite diagnosis can result in 5-year survival for almost 90%...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29121799/pueraria-lobate-inhibits-rankl-mediated-osteoclastogenesis-via-downregulation-of-creb-pgc1%C3%AE-c-fos-nfatc1-signaling
#5
Keun Ha Park, Dong Ryun Gu, Su Hyun Jin, Chi-Su Yoon, Wonmin Ko, Youn Chul Kim, Seoung Hoon Lee
Puerariae radix, the dried root of Pueraria lobate Ohwi, is known to prevent bone loss in ovariectomized mice; however, the precise molecular mechanisms are not understood. In this study, we investigated the effects and underlying mechanisms of action of Puerariae radix extract (PRE) on receptor activator of NF-[Formula: see text]B ligand (RANKL)-induced osteoclastogenesis. PRE dose-dependently inhibited osteoclast differentiation and formation, decreased the bone-resorbing activity of osteoclasts, and downregulated the expression of osteoclast differentiation marker genes...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29118380/delivery-of-the-gene-encoding-the-tumor-suppressor-sef-into-prostate-tumors-by-therapeutic-ultrasound-inhibits-both-tumor-angiogenesis-and-growth
#6
Sabrin Mishel, Boris Shneyer, Lina Korsensky, Orit Goldshmidt-Tran, Tom Haber, Marcelle Machluf, Dina Ron
Carcinomas constitute over 80% of all human cancer types with no effective therapy for metastatic disease. Here, we demonstrate, for the first time, the efficacy of therapeutic-ultrasound (TUS) to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. Sef is downregulated in various human carcinomas, in a manner correlating with tumor aggressiveness. In vitro, hSef-b inhibited proliferation of TRAMP C2 cells and attenuated activation of ERK/MAPK and the master transcription factor NF-κB in response to FGF and IL-1/TNF, respectively...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115435/human-umbilical-cord-mesenchymal-stem-cells-alleviate-interstitial-fibrosis-and-cardiac-dysfunction-in-a-dilated-cardiomyopathy-rat-model-by-inhibiting-tnf%C3%A2-%C3%AE-and-tgf%C3%A2-%C3%AE-1-erk1-2-signaling-pathways
#7
Changyi Zhang, Guichi Zhou, Yezeng Chen, Sizheng Liu, Fen Chen, Lichun Xie, Wei Wang, Yonggang Zhang, Tianyou Wang, Xiulan Lai, Lian Ma
Dilated cardiomyopathy (DCM) is a disease of the heart characterized by pathological remodeling, including patchy interstitial fibrosis and degeneration of cardiomyocytes. In the present study, the beneficial role of human umbilical cord‑derived mesenchymal stem cells (HuMSCs) derived from Wharton's jelly was evaluated in the myosin‑induced rat model of DCM. Male Lewis rats (aged 8‑weeks) were injected with porcine myosin to induce DCM. Cultured HuMSCs (1x106 cells/rat) were intravenously injected 28 days after myosin injection and the effects on myocardial fibrosis and the underlying signaling pathways were investigated and compared with vehicle‑injected and negative control rats...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115381/proliferation-of-vascular-smooth-muscle-cells-under-inflammation-is-regulated-by-nf-%C3%AE%C2%BAb-p65-microrna-17-rb-pathway-activation
#8
Dong Yang, Chen Sun, Jing Zhang, Shu Lin, Lin Zhao, Lun Wang, Ruoran Lin, Junyuan Lv, Shijie Xin
Inflammation and excessive proliferation of vascular smooth muscle cells (VSMCs) have key roles in various vascular disorders, including restenosis, atherosclerosis and pulmonary artery hypertension. However, the underlying mechanism remains unclear. The present study investigated the role of nuclear factor-κB (NF-κB) and microRNA (miRNA) in the regulation of VSMC proliferation under inflammatory conditions. It was demonstrated that miR‑17 stimulated the proliferation of VSMCs, enhanced cell cycle G1/S transition, and increased levels of proliferating cell nuclear antigen and E2F1...
October 25, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29113993/pxr-more-than-just-a-master-xenobiotic-receptor
#9
Peter Oladimeji, Taosheng Chen
Pregnane X receptor (PXR) is a nuclear receptor considered to be a master xenobiotic receptor that coordinately regulates the expression of genes encoding drug-metabolizing enzymes and drug transporters, to essentially detoxify and eliminate xenobiotics and endotoxins from the body. In the past several years, the function of PXR in the regulation of xenobiotic metabolism has been extensively studied, and the role of PXR as a xenobiotic sensor has been well-established. It is now clear, however, that PXR plays many other roles in addition to its xenobiotic sensing function...
November 7, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29111206/functional-mutant-gata4-identification-and-potential-application-in-preimplantation-diagnosis-of-congenital-heart-diseases
#10
REVIEW
You Yu, Wei Lei, Junjie Yang, Yan-Chang Wei, Zhen-Ling Zhao, Zhen-Ao Zhao, Shijun Hu
Congenital heart diseases (CHDs) affect nearly 1% of all neonates and show an increasing tendency. The complex inheritance patterns and multifactorial etiologies make these defects difficult to be identified before complete manifestation. Genetic screening has identified hundreds of specific mutant sites for CHDs based on cardiac transcriptional factors. GATA4 is a master regulator required for ventral morphogenesis and heart tube formation. Its mutation is most widely studied in CHDs. In the past decades, over 100 GATA4 mutant sites have been reported, but only a few functional sites have been identified...
October 27, 2017: Gene
https://www.readbyqxmd.com/read/29107144/osteon-myospalacem-baileyi-attenuates-osteoclast-differentiation-through-rankl-induced-nfat-pathways
#11
Yulei Cui, Xiaoying Zhao, Lijuan Mei, Jinjin Pei, Shuo Wang, Yun Shao, Yanduo Tao, Xiaoling Zhang, Lei Jiang
ETHNOPHARMACOLOGICAL RELEVANCE: Osteon Myospalacem Baileyi, known as Sai long gu (Tibetan language, means "blind rat bone"), is the whole skeleton of Tibet plateau rodentia animal Myospalacem Baileyi. Osteon Myospalacem Baileyi had been widely used in the Tibet region as an anti-osteoporosis drug and since 1991 Osteon Myospalacem Baileyi has been listed in the Pharmacopoeia of People's Republic of China as the first-class animal new medical material. However, the mechanism of its anti-osteoporosis activities is still unclear...
October 26, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29106591/comprehensive-characterization-of-alternative-polyadenylation-in-human-cancer
#12
Yu Xiang, Youqiong Ye, Yanyan Lou, Yang Yang, Chunyan Cai, Zhao Zhang, Tingting Mills, Ning-Yuan Chen, Yoonjin Kim, Fatma Muge Ozguc, Lixia Diao, Harry Karmouty-Quintana, Yang Xia, Rodney E Kellems, Zheng Chen, Michael R Blackburn, Seung-Hee Yoo, Ann-Bin Shyu, Gordon B Mills, Leng Han
Background: Alternative polyadenylation (APA) is emerging as a major post-transcriptional mechanism for gene regulation, and dysregulation of APA contributes to several human diseases. However, the functional consequences of APA in human cancer are not fully understood. Particularly, there is no large-scale analysis in cancer cell lines. Methods: We characterized the global APA profiles of 6398 patient samples across 17 cancer types from The Cancer Genome Atlas and 739 cancer cell lines from the Cancer Cell Line Encyclopedia...
November 2, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29104620/expression-of-and-correlation-between-bcl6-and-zeb-family-members-in-patients-with-breast-cancer
#13
Lin Ang, Li Zheng, Jin Wang, Jin Huang, Hong-Guang Hu, Qiang Zou, Yang Zhao, Qiang-Ming Liu, Min Zhao, Zheng-Sheng Wu
B-cell lymphoma 6 (BCL6), a proto-oncogene, is an evolutionarily conserved zinc finger protein that functions as a transcriptional repressor. BCL6 is the master regulator of B-lymphocyte development, and it has been reported that BCL6 may serve an important role in breast cancer progression. The aim of the present study was to investigate the expression of BCL6, zinc finger E-box-binding homeobox (ZEB)1 and ZEB2 and their associations in breast cancer. The mRNA and protein expression of BCL6, ZEB1 and ZEB2 was assessed using in situ hybridization and immunohistochemistry, respectively, in 228 patients with breast cancer and 80 patients with benign breast disease...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29100092/mutations-in-fibronectin-cause-a-subtype-of-spondylometaphyseal-dysplasia-with-corner-fractures
#14
Chae Syng Lee, He Fu, Nissan Baratang, Justine Rousseau, Heena Kumra, V Reid Sutton, Marcello Niceta, Andrea Ciolfi, Guilherme Yamamoto, Débora Bertola, Carlo L Marcelis, Dorien Lugtenberg, Andrea Bartuli, Choel Kim, Julie Hoover-Fong, Nara Sobreira, Richard Pauli, Carlos Bacino, Deborah Krakow, Jillian Parboosingh, Patrick Yap, Ariana Kariminejad, Marie T McDonald, Mariana I Aracena, Ekkehart Lausch, Sheila Unger, Andrea Superti-Furga, James T Lu, Dan H Cohn, Marco Tartaglia, Brendan H Lee, Dieter P Reinhardt, Philippe M Campeau
Fibronectin is a master organizer of extracellular matrices (ECMs) and promotes the assembly of collagens, fibrillin-1, and other proteins. It is also known to play roles in skeletal tissues through its secretion by osteoblasts, chondrocytes, and mesenchymal cells. Spondylometaphyseal dysplasias (SMDs) comprise a diverse group of skeletal dysplasias and often manifest as short stature, growth-plate irregularities, and vertebral anomalies, such as scoliosis. By comparing the exomes of individuals with SMD with the radiographic appearance of "corner fractures" at metaphyses, we identified three individuals with fibronectin (FN1) variants affecting highly conserved residues...
November 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29095649/loss-of-smad3-promotes-vascular-remodeling-in-pulmonary-arterial-hypertension-via-mrtf-disinhibition
#15
Diana Zabini, Elise Granton, Yijie Hu, Maria Zena Miranda, Ulrike Weichelt, Sandra Breuils Bonnet, Sébastien Bonnet, Nicholas W Morrell, Kim A Connelly, Steeve Provencher, Bahil Ghanim, Walter Klepetko, Andrea Olschewski, Andras Kapus, Wolfgang M Kuebler
INTRODUCTION: Vascular remodeling in pulmonary arterial hypertension (PAH) results from smooth muscle cell hypertrophy and proliferation of vascular cells. Loss of bone morphogenetic protein receptor 2 (BMPR-II) signaling and increased signaling via transforming growth factor β (TGF-β) and its downstream mediators SMAD2/3 has been proposed to drive lung vascular remodeling; yet, proteomic analyses indicate a loss of SMAD3 in PAH. OBJECTIVE: We proposed that SMAD3 may be dysregulated in PAH, and that loss of SMAD3 may present a master switch in the disease process by disinhibiting its interaction partner myocardin-related transcription factor (MRTF) which drives muscle protein expression...
November 2, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29089978/tp53-gene-mediates-distinct-dopaminergic-neuronal-damage-in-different-dopaminergic-neurotoxicant-models
#16
REVIEW
Tao Lu, Paul Kim, Yu Luo
Tp53, a stress response gene, is involved in diverse cell death pathways and its activation is implicated in the pathogenesis of Parkinson's disease. However, whether the neuronal Tp53 protein plays a direct role in regulating dopaminergic (DA) neuronal cell death or neuronal terminal damage in different neurotoxicant models is unknown. In our recent studies, in contrast to the global inhibition of Tp53 function by pharmacological inhibitors and in traditional Tp53 knock-out mice, we examined the effects of DA-specific Tp53 gene deletion after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and methamphetamine exposure...
September 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29070831/inhibition-of-lobuloalveolar-development-by-foxc1-overexpression-in-the-mouse-mammary-gland
#17
Bowen Gao, Ying Qu, Bingchen Han, Yoshiko Nagaoka, Makoto Katsumata, Nan Deng, Shikha Bose, Liting Jin, Armando E Giuliano, Xiaojiang Cui
The forkhead box transcription factor FOXC1 plays a critical role in embryogenesis and the development of many organs. Its mutations and high expression are associated with many human diseases including breast cancer. Although FOXC1 knockout mouse studies showed that it is not required for mammary gland development during puberty, it is not clear whether its overexpression alters normal mammary development in vivo. To address this question, we generated transgenic mice with mammary-specific FOXC1 overexpression...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29065888/a-comprehensive-data-mining-study-shows-that-most-nuclear-receptors-act-as-newly-proposed-homeostasis-associated-molecular-pattern-receptors
#18
Luqiao Wang, Gayani Nanayakkara, Qian Yang, Hongmei Tan, Charles Drummer, Yu Sun, Ying Shao, Hangfei Fu, Ramon Cueto, Huimin Shan, Teodoro Bottiglieri, Ya-Feng Li, Candice Johnson, William Y Yang, Fan Yang, Yanjie Xu, Hang Xi, Weiqing Liu, Jun Yu, Eric T Choi, Xiaoshu Cheng, Hong Wang, Xiaofeng Yang
BACKGROUND: Nuclear receptors (NRs) can regulate gene expression; therefore, they are classified as transcription factors. Despite the extensive research carried out on NRs, still several issues including (1) the expression profile of NRs in human tissues, (2) how the NR expression is modulated during atherosclerosis and metabolic diseases, and (3) the overview of the role of NRs in inflammatory conditions are not fully understood. METHODS: To determine whether and how the expression of NRs are regulated in physiological/pathological conditions, we took an experimental database analysis to determine expression of all 48 known NRs in 21 human and 17 murine tissues as well as in pathological conditions...
October 24, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29059153/nutrient-sensor-o-glcnac-transferase-controls-cancer-lipid-metabolism-via-srebp-1-regulation
#19
V L Sodi, Z A Bacigalupa, C M Ferrer, J V Lee, W A Gocal, D Mukhopadhyay, K E Wellen, M Ivan, M J Reginato
Elevated O-GlcNAcylation is associated with disease states such as diabetes and cancer. O-GlcNAc transferase (OGT) is elevated in multiple cancers and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis. Here we show that O-GlcNAcylation modulates lipid metabolism in cancer cells. OGT regulates expression of the master lipid regulator the transcription factor sterol regulatory element binding protein 1 (SREBP-1) and its transcriptional targets both in cancer and lipogenic tissue...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/29056898/mitochondrial-bioenergetics-is-altered-in-fibroblasts-from-patients-with-sporadic-alzheimer-s-disease
#20
María J Pérez, Daniela P Ponce, Cesar Osorio-Fuentealba, Maria I Behrens, Rodrigo A Quintanilla
The identification of an early biomarker to diagnose Alzheimer's disease (AD) remains a challenge. Neuropathological studies in animal and AD patients have shown that mitochondrial dysfunction is a hallmark of the development of the disease. Current studies suggest the use of peripheral tissues, like skin fibroblasts as a possibility to detect the early pathological alterations present in the AD brain. In this context, we studied mitochondrial function properties (bioenergetics and morphology) in cultured fibroblasts obtained from AD, aged-match and young healthy patients...
2017: Frontiers in Neuroscience
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