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pancreatic cystic lesions

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https://www.readbyqxmd.com/read/29777233/visceral-adiposity-and-high-adiponectin-levels-are-associated-with-the-prevalence-of-pancreatic-cystic-lesions
#1
Suguru Mizuno, Yousuke Nakai, Hiroyuki Isayama, Takeharu Yoshikawa, Kei Saito, Naminatsu Takahara, Hirofumi Kogure, Minoru Tada, Naoto Hayashi, Kazuhiko Koike
OBJECTIVES: Obesity is increasing in developed countries and is a risk factor for pancreatic cancer (PaC). We previously reported that obesity was associated with pancreatic cystic lesions (PCLs), which are both precursors of, and risk factors for, PaC. In the present study, we further investigated the relationship between visceral adiposity and adiponectin levels and the extent of PCLs. METHODS: Individuals who underwent comprehensive health screening at our institution between January 2008 and March 2013 were analyzed...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29736662/serous-pancreatic-cystadenoma-with-compression-of-wirsung-s-duct
#2
Enio Campos Amico, José Roberto Alves, Adriano de Araújo Lima Liguori, Rogério Lacerda Sousa
Serous cystadenoma of the pancreas is a common cystic neoplasm typically of benign evolution that rarely communicates with the pancreatic ductal system. We present several images originating from two cases of serous cystadenoma of the pancreas which led to compression and dilatation of Wirsung's duct. These cases suggest that when the diagnosis of pancreatic microcystic lesion is detected, associated, or not associated with a central fibrous scar and a low carcinoembryonic antigen level in the aspirated fluid, the presence of dilatation of Wirsung's duct does not exclude the diagnosis of serous pancreatic cystadenoma...
May 7, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29732356/clinical-significance-of-pancreatic-intraepithelial-neoplasia-in-resectable-pancreatic-cancer-on-survivals
#3
Da-Young Yu, Young-Dong Yu, Wan-Bae Kim, Hyung-Joon Han, Sae-Byul Choi, Dong-Sik Kim, Sang-Yong Choi, Joo-Young Kim, Hyeyoon Chang, Baek-Hui Kim
Purpose: Noninvasive precursor lesions for pancreatic adenocarcinoma include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. PanIN is often found synchronously adjacent to resected pancreatic ductal adenocarcinoma (PDAC) tumors. However, its prognostic significance on outcome after PDAC resection is unknown. The purpose of the current study was to determine if the presence of PanIN has a prognostic or predictive effect on survival after resection for PDAC with curative intent...
May 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29725744/imaging-and-clinical-features-of-xanthogranulomatous-pancreatitis-an-analysis-of-10-cases-at-a-single-institution
#4
Ji Hye Kwon, Jin Hee Kim, So Yeon Kim, Jae Ho Byun, Hyoung Jung Kim, Seung-Mo Hong, Moon-Gyu Lee, Seung Soo Lee
PURPOSE: The purpose of the study was to investigate the imaging and clinical features of xanthogranulomatous pancreatitis (XGP). METHODS: This retrospective series study included 10 patients with pathology-proven XGP. Two radiologists reviewed the computed tomography (CT) and magnetic resonance imaging (MRI) in consensus to determine the morphological features of XGP. The lesion enhancement pattern on dynamic contrast-enhanced scans and the MR signal intensity were also evaluated...
May 3, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29713060/pre-neoplastic-pancreas-cells-enter-a-partially-mesenchymal-state-following-transient-tgf-%C3%AE-exposure
#5
Jesse Handler, Jane Cullis, Antonina Avanzi, Emily A Vucic, Dafna Bar-Sagi
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease and a major health problem in the United States. While the cytokine TGF-β has been implicated in PDAC development, it can exert both pro-tumorigenic and anti-tumorigenic effects that are highly context dependent and incompletely understood. Using three-dimensional (3D) cultures of Kras G12D -expressing mouse pancreatic epithelial cells we demonstrated that while exposure to exogenous TGF-β induced growth arrest of the Kras G12D cells, its subsequent removal allowed the cells to enter a hyper-proliferative, partially mesenchymal (PM), and progenitor-like state...
May 1, 2018: Oncogene
https://www.readbyqxmd.com/read/29703250/a-case-report-of-giant-pancreatic-pseudocyst-following-acute-pancreatitis-experience-with-endoscopic-internal-drainage
#6
W A E Udeshika, H M M T B Herath, S U B Dassanayake, S P Pahalagamage, Aruna Kulatunga
BACKGROUND: Pancreatic cysts are being diagnosed more frequently because of the increasing usage of imaging techniques. A pseudocyst with the major diameter of 10 cm is termed as a giant cyst. Asymptomatic pseudo-cysts up to 6 cm in diameter can be safely observed and monitored without intervention, but larger and symptomatic pseudocysts require intervention. CASE PRESENTATION: A 27-year-old Sri Lankan male, with history of heavy alcohol use, presented with progressive abdominal distension following an episode of acute pancreatitis...
April 27, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29695287/the-importance-of-endoscopic-ultrasound-fine-needle-aspiration-in-the-diagnosis-of-solid-pseudopapillary-tumor-of-the-pancreas-two-case-reports
#7
Diogo Turiani Hourneaux De Moura, Martin Coronel, Igor Braga Ribeiro, Galileu Ferreira Ayala Farias, Maria Auxiliadora Choez, Rodrigo Rocha, Marcello Pecoraro Toscano, Eduardo Guimarães Hourneaux De Moura
BACKGROUND: Solid pseudopapillary tumor of the pancreas, otherwise known as solid and cystic tumor or Frantz tumor, is an unusual form of pancreatic carcinoma, with unknown etiopathogenesis, that accounts for 0.2 to 2.7% of all pancreatic tumors. It is defined as an exocrine pancreatic neoplasia that mainly affects women between the second and third decade of life, and its management is not well defined. Endoscopic ultrasound offers a key anatomical advantage in accessing the pancreas and endoscopic ultrasound fine-needle aspiration has become the gold standard method for the diagnosis of pancreatic lesions...
April 26, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29685110/wirsung-atraumatic-rupture-in-patient-with-pancreatic-pseudocysts-a-case-presentation
#8
Martino Gerosa, Marco Chiarelli, Angelo Guttadauro, Matilde De Simone, Fulvio Tagliabue, Melchiorre Costa, Sabina Terragni, Ugo Cioffi
BACKGROUND: Pancreatic duct disruption is a challenging condition leading to pancreatic juice leakage and consequently to pancreatic fluid collections. The manifestations of pancreatic main duct leak include pseudocysts, walled-off necrosis, pancreatic fistulas, ascites, pleural and pericardial effusions. Pseudocyst formation is the most frequent outcome of a pancreatic duct leak. CASE PRESENTATION: We describe a case of a 64-year old man with large multiple pancreatic cysts discovered for progressive jaundice and significant weight loss in the absence of a previous episode of acute pancreatitis...
April 23, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29685048/endoscopic-ultrasound-cytologic-brushing-vs-endoscopic-ultrasound-fine-needle-aspiration-for-cytological-diagnosis-of-cystic-pancreatic-lesions-a-multicenter-randomized-open-label-trial
#9
José Lariño-Noia, Daniel de la Iglesia, Julio Iglesias-García, Manuel Macías, Aurelio López Martín, María Luisa Legaz, Juan Vila, Antonio Reyes, Ihab Abdulkader, J Enrique Domínguez-Muñoz
INTRODUCTION: the incidence of cystic pancreatic lesions (CPL) in the asymptomatic population is increasing. Achieving a preoperative diagnosis of CPL still remains a challenge. OBJECTIVES: to evaluate the diagnostic accuracy of the cytological diagnosis of CPL from samples obtained by cytology brush versus standard endoscopic ultrasound fine needle aspiration (EUS-FNA). METHODS: a multicenter, randomized, open-label trial was performed of EUS-cytology brush (EUS-EB) versus EUS-FNA for the cytological diagnosis of CPL...
April 24, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29683969/diagnostic-accuracy-of-preoperative-imaging-for-differentiation-of-branch-duct-versus-mixed-duct-intraductal-papillary-mucinous-neoplasms
#10
Emmanuel E Ugbarugba, Carmen Grieco, Phil A Hart, Feng Li, Brett Sklaw, Kevin Cronley, Veeral M Oza, Benjamin J Swanson, Jon P Walker, Samer El-Dika, Darwin L Conwell, Somashekar G Krishna
OBJECTIVE: The aim of this study is to determine the diagnostic accuracy of preoperative evaluation to detect main pancreatic duct involvement in pancreatic cystic lesions thus differentiating mixed intraductal papillary mucinous neoplasm (IPMN) from branch duct (BD)-IPMN. METHODS: The pathology database of pancreatic resections from 2000 to 2014 was reviewed. Main pancreatic duct-IPMNs and IPMNs with intracystic mass/nodules were excluded. The preoperative test characteristics were analyzed using surgical histopathology as the "gold standard...
May 2018: Pancreas
https://www.readbyqxmd.com/read/29670173/overexpression-of-her2-in-the-pancreas-promotes-development-of-intraductal-papillary-mucinous-neoplasms-in-mice
#11
Wataru Shibata, Hiroto Kinoshita, Yohko Hikiba, Takeshi Sato, Yasuaki Ishii, Soichiro Sue, Makoto Sugimori, Nobumi Suzuki, Kosuke Sakitani, Hideaki Ijichi, Ryutaro Mori, Itaru Endo, Shin Maeda
Pancreatic ductal adenocarcinoma (PDA) has a 5-year survival rate of less than 5% and is the sixth leading cause of cancer death. Although KRAS mutations are one of the major driver mutations in PDA, KRAS mutation alone is not sufficient to induce invasive pancreatic cancer in mice model. HER2, also known as ERBB2, is a receptor tyrosine kinase, and overexpression of HER2 is associated with poor clinical outcomes in pancreatic cancer. However, no report has shown whether HER2 and its downstream signaling contributes to the pancreatic cancer development...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667626/eus-fna-in-cystic-pancreatic-lesions-where-are-we-now-and-where-are-we-headed-in-the-future
#12
REVIEW
Jose Lariño-Noia, Julio Iglesias-Garcia, Daniel de la Iglesia-Garcia, J Enrique Dominguez-Muñoz
EUS-FNA is often performed in the evaluation of Cystic Pancreatic Lesions (CPL) for a better preoperative characterization. The objective is to identify premalignant lesions as Mucinous Cystic Neoplasms, and/or a malignant transformation of them (adenocarcinoma). The role of cytological evaluation in this setting is discouraging and intracystic markers analysis, mainly CEA, lacks of a good specificity for the detection of mucinous neoplasms. New devices and approaches have emerged to overcome these problems as the cytology brush (Echobrush), the small mini-biopsy foceps, the cystoscopy and the needle Confocal LASER Endomicroscopy (nCLE), showing in some studies good rates of accuracy for distinguishing among mucinosus and non-mucinous neoplasms...
March 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29650941/-a-case-of-an-intraductal-papillary-mucinous-neoplasm-which-rapidly-worsened-and-penetrated-into-the-stomach-and-the-transverse-colon
#13
Akira Sogawa, Kei Nakamura, Tomoyuki Nagata, Satoshi Mochizuki, Yuen Nakase, Shozo Kitai, Seishirou Inaba, Keiji Shimada
We report a case of a 71-year-old woman.She visited our hospital with a complaint of high fever and abdominal distention. She has been pointed out intraductal papillary mucinous neoplasm(IPMN)4 years ago.Abdominal CT showed cystic legion, 80mm in diameter, on the pancreas.The lesion was unclear at the boundary between the main pancreatic duct and in contact with the stomach, transverse colon.Upper endoscopic and colonoscopic examination revealed the exhaustion image from the intestional tract but not pointed out the malignant findings...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650930/-a-case-of-early-gastric-cancer-with-multiple-lymph-node-metastases-revealed-by-additional-surgical-resection-after-esd
#14
Yoshitaka Nakamura, Masayuki Yubakami, Yutaka Kondo, Yukihisa Nishimura, Momoko Todo, Kiyoto Atsuji, Akihiro Yamaguchi, Naoki Kakihara, Osamu Ikawa, Hiroki Taniguchi
A 74-year-old man was referred to our hospital for further investigation of a cystic lesion in the pancreatic body, which had been detected by ultrasonography at a local hospital. He was diagnosed as intraductal papillary mucinous neoplasm(IPMN) and further preoperative examinations were conducted. Upper gastrointestinal endoscopy demonstrated a type 0-II c tumor of the greater curvature in the upper third of the stomach. Endoscopic ultrasonography showed no sign of submucosal invasion. Endoscopic submucosal dissection(ESD)was carried out and pathological examination of a specimen revealed well differentiated adenocarcinoma with submucosal invasion, which fulfilled the indication for additional gastrectomy with lymph node dissection...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29623746/synchronous-pancreatic-serous-cystic-neoplasm-and-duodenal-neuroendocrine-tumor-case-report-and-review-of-the-literature
#15
Ann Brinch Madelung, Sönke Detlefsen
Simultaneous presence of pancreatic serous cystic neoplasms and neuroendocrine neoplasms is rare. We present a case with the incidental finding of a duodenal neuroendocrine tumor (NET) with 2 lymph node metastases in a Whipple resection specimen performed to remove a pancreatic cystic neoplasm that postoperatively turned out to represent a serous cystic neoplasm (SCN). The patient was a 75-year-old female. She presented with loss of appetite and weight. Preoperative contrast-enhanced computed tomography scan of the abdomen showed a multicystic lesion in the head of pancreas...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29606941/a-surgically-resected-pancreatic-schwannoma-with-obstructive-jaundice-with-special-reference-to-differential-diagnosis-from-other-cystic-lesions-in-the-pancreas
#16
Takayoshi Watanabe, Kenichiro Araki, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Hiroyuki Kuwano, Ken Shirabe
Pancreatic schwannomas are uncommon. About 60% of pancreatic schwannomas develop cystic lesions, and the differential diagnosis from other cystic pancreatic tumors is difficult. A 43-year-old man presented for evaluation of liver dysfunction detected during a medical checkup. Blood testing detected obstructive jaundice. A computed tomography scan revealed a well-defined polycystic tumor of about 5 cm at the pancreatic head. We performed surgical resection to treat the patient's symptoms and facilitate long-term management...
January 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29589164/progression-patterns-in-the-remnant-pancreas-after-resection-of-non-invasive-or-micro-invasive-intraductal-papillary-mucinous-neoplasms-ipmn
#17
Mohammad Al Efishat, Marc A Attiyeh, Anne A Eaton, Mithat Gönen, Olca Basturk, David Klimstra, Michael I D'Angelica, Ronald P DeMatteo, T Peter Kingham, Vinod Balachandran, William R Jarnagin, Peter J Allen
BACKGROUND: Although IPMN are thought to represent a whole-gland disease, segmental resection remains the most frequently performed treatment. We sought to determine the rates, patterns, and predictors of IPMN progression in the pancreatic remnant following segmental resection of noninvasive or microinvasive IPMN. METHODS: A prospectively maintained database was queried to identify all patients who underwent resection of noninvasive or microinvasive IPMN (≤ 10 mm of invasive component) between 1989 and 2015...
March 27, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29589102/dilemmas-for-the-pathologist-in-the-oncologic-assessment-of-pancreatoduodenectomy-specimens-an-overview-of-different-grossing-approaches-and-the-relevance-of-the-histopathological-characteristics-in-the-oncologic-assessment-of-pancreatoduodenectomy-specimens
#18
REVIEW
Eline Soer, Lodewijk Brosens, Marc van de Vijver, Frederike Dijk, Marie-Louise van Velthuysen, Arantza Farina-Sarasqueta, Hans Morreau, Johan Offerhaus, Lianne Koens, Joanne Verheij
A pancreatoduodenectomy specimen is complex, and there is much debate on how it is best approached by the pathologist. In this review, we provide an overview of topics relevant for current clinical practice in terms of gross dissection, and macro- and microscopic assessment of the pancreatoduodenectomy specimen with a suspicion of suspected pancreatic cancer. Tumor origin, tumor size, degree of differentiation, lymph node status, and resection margin status are universally accepted as prognostic for survival...
March 27, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29571176/intraoperative-ultrasound-appearance-of-a-pancreatic-cerebral-metastasis-a-case-report
#19
Carmine Antonio Donofrio, Lina Raffaella Barzaghi, Jody Filippo Capitanio, Andrea Cavalli, Pietro Panni, Silvia Snider, Pietro Mortini
BACKGROUND:  Brain metastases (BMs) derived from pancreatic adenocarcinoma (PAC) have an extremely low incidence (0.1-0.4%) and are usually associated with a very poor prognosis. The treatment strategy is palliative and includes conventional radiotherapy, stereotactic radiosurgery, chemotherapy, and surgical resection. CASE DESCRIPTION:  A 39-year-old man with a history of PAC developed a systemic tumor relapse with intracranial progression. Magnetic resonance imaging (MRI) documented a right rolandic, cortical, and cystic lesion with leptomeningeal intrasulcular extension...
March 23, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29561526/three-primary-carcinomas-on-18f-fdg-pet-ct-intrahepatic-cholangiocarcinoma-papillary-renal-cell-carcinoma-and-clear-cell-renal-cell-carcinoma
#20
Dayong Wu, Yujing Hu, Qiang Wei, Congna Tian, Yanzhu Bian
A CT scan was performed on a 67-year-old man newly diagnosed with acute pancreatitis. The scan revealed a low-density lesion in the liver, a left renal nodule, and a right renal cystic mass. Intense F-FDG uptake was observed in the liver lesion and left renal nodule. No abnormal uptake was observed in the right renal mass. In addition, another focal intense uptake was observed in segment VII of the liver. Biopsies revealed intrahepatic cholangiocarcinomas in the 2 liver lesions, papillary renal cell carcinoma in the left renal lesion and clear cell renal cell carcinoma in the right renal lesion...
March 20, 2018: Clinical Nuclear Medicine
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