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https://www.readbyqxmd.com/read/29159199/dna-mediated-gene-therapy-in-a-mouse-model-of-limb-girdle-muscular-dystrophy-2b
#1
Julia Ma, Christophe Pichavant, Haley du Bois, Mital Bhakta, Michele P Calos
Mutations in the gene for dysferlin cause a degenerative disorder of skeletal muscle known as limb girdle muscular dystrophy 2B. To achieve gene delivery of plasmids encoding dysferlin to hind limb muscles of dysferlin knockout mice, we used a vascular injection method that perfused naked plasmid DNA into all major muscle groups of the hind limb. We monitored delivery by luciferase live imaging and western blot, confirming strong dysferlin expression that persisted over the 3-month time course of the experiment...
December 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29151008/suture-anchor-repair-of-complete-proximal-hamstring-ruptures-a-cadaveric-biomechanical-evaluation
#2
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/29145673/imaging-characteristics-predict-operative-difficulty-mobilizing-the-sciatic-nerve-for-proximal-hamstring-repair
#3
Thomas J Wilson, B Matthew Howe, Robert J Spinner, Aaron J Krych
BACKGROUND: Repair of proximal hamstring avulsions requires mobilization of the sciatic nerve away from the tendon stump, which can be achieved with varying difficulty depending on the degree of scar formation and adherence. Predicting when a scarred, adherent, difficult-to-mobilize nerve will be encountered has been difficult. OBJECTIVE: To identify clinical and/or radiological factors predictive of a difficult intraoperative dissection of the sciatic nerve during proximal hamstring repair...
November 14, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29081863/chronic-achilles-tendon-rupture
#4
REVIEW
Nicola Maffulli, Alessio Giai Via, Francesco Oliva
BACKGROUND: The Achilles tendon, the largest and strongest tendon in the human body, is nevertheless one of the tendons which most commonly undergoes a complete subcutaneous tear. Achilles tendon ruptures are especially common in middle aged men who occasionally participate in sport. Even though Achilles tendon ruptures are frequent, up to 25% of acute injuries are misdiagnosed, and present as chronic injuries. METHODS: This is a review article about diagnosis and management of chronic Achilles tendon ruptures...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29065270/medial-meniscus-resection-increases-and-medial-meniscus-repair-preserves-anterior-knee-laxity-a-cohort-study-of-4497-patients-with-primary-anterior-cruciate-ligament-reconstruction
#5
Riccardo Cristiani, Erik Rönnblad, Björn Engström, Magnus Forssblad, Anders Stålman
BACKGROUND: There are still controversies regarding the effects on knee laxity of additional meniscus resection or repair in the setting of anterior cruciate ligament reconstruction (ACLR). Hypothesis/Purpose: The purpose was to determine the effects on knee laxity of resection or repair of medial meniscus (MM) or lateral meniscus (LM) injuries in the ACLR knee. The hypothesis was that patients with an additional meniscus resection would have significantly increased postoperative knee laxity versus that of an isolated ACLR, whereas patients with meniscus repair would have laxity comparable to that of an isolated ACLR...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29051899/surgical-treatment-of-segond-fractures-in-acute-anterior-cruciate-ligament-reconstruction
#6
Andrea Ferretti, Edoardo Monaco, Megan Rianne Wolf, Matteo Guzzini, Angelo De Carli, Daniele Mazza
BACKGROUND: The Segond fracture is an avulsion-type fracture located on the anterolateral aspect of the tibia associated with a ligament recently termed the anterolateral ligament. This injury has been described as pathognomonic for an anterior cruciate ligament (ACL) tear and is associated with a higher grade pivot shift. PURPOSE: To present and report 2-year clinical outcomes of a surgical technique for acute ACL reconstruction with fixation of a concomitant Segond fracture...
October 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29051869/case-of-acute-concomitant-rupture-of-anterior-cruciate-ligament-and-patellar-tendon-of-knee-surgical-decision-making-and-outcome
#7
Jithin Orville Lobo, Joe Joseph Cherian, Arnav Sahu
INTRODUCTION: Acute concomitant rupture of both anterior cruciate ligament (ACL) and patellar tendon is a rare injury. The diagnosis of either of the injuries may be missed on clinical examination in the emergency room. A high index of suspicion is necessary when active extension is absent, and necessary investigations like ultrasound or magnetic resonance imaging (MRI) should be done to confirm the diagnosis. There are no fixed treatment protocols in these injuries. The options include immediate repair of patellar tendon with either simultaneous or delayed reconstruction of ACL...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29023278/surgical-approach-impacts-posterior-femoral-cutaneous-nerve-outcomes-after-proximal-hamstring-repair
#8
Thomas J Wilson, Robert J Spinner, Aaron J Krych
OBJECTIVE: The goal of this study was to characterize the risk of intraoperative injury to the posterior femoral cutaneous nerve and to evaluate potential risk factors for injury during surgical repair of proximal hamstring injuries. DESIGN: Retrospective cohort study. SETTING: Single tertiary referral center. PATIENTS: The cohort consisted of all patients presenting to a single institution with a proximal hamstring avulsion injury who were managed with surgical repair between January 1, 2000 and August 1, 2016...
October 6, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29016194/outcomes-after-operative-and-nonoperative-treatment-of-proximal-hamstring-avulsions-a-systematic-review-and-meta-analysis
#9
Blake M Bodendorfer, Andrew J Curley, Joshua A Kotler, James M Ryan, Neha S Jejurikar, Anagha Kumar, William F Postma
BACKGROUND: No meta-analysis has compared outcomes of operative and nonoperative proximal hamstring avulsion treatment. PURPOSE: To compare outcomes of operative and nonoperative proximal hamstring avulsion treatment, including acute, chronic, partial, and complete repairs. STUDY DESIGN: Meta-analysis. METHODS: PubMed, CINAHL, SPORTdiscus, Cochrane Library, EMBASE, and Web of Science were searched up to July 2016. Three authors screened the studies and performed quality assessment using criteria from the Methodologic Index for Nonrandomized Studies...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28990574/an-evidence-based-evaluation-on-the-use-of-platelet-rich-plasma-in-orthopedics-a-review-of-the-literature
#10
Nasir Hussain, Herman Johal, Mohit Bhandari
Within orthopedics, the use of platelet-rich plasma (PRP) has been rapidly increasing in popularity, however, its true effectiveness has yet to be fully established. Several studies find that injecting PRP to the site of injury does not provide any significant benefit with respect to clinical outcomes; however, many others report the contrary. Due to the conflicting evidence and multiple meta-analyses conducted on the topic, a literature review of high-quality evidence on the use of PRP for common orthopaedic conditions was performed...
2017: SICOT-J
https://www.readbyqxmd.com/read/28894756/relationships-between-tibiofemoral-contact-forces-and-cartilage-morphology-at-2-to-3-years-after-single-bundle-hamstring-anterior-cruciate-ligament-reconstruction-and-in-healthy-knees
#11
David John Saxby, Adam L Bryant, Xinyang Wang, Luca Modenese, Pauline Gerus, Jason M Konrath, Kim L Bennell, Karine Fortin, Tim Wrigley, Flavia M Cicuttini, Christopher J Vertullo, Julian A Feller, Tim Whitehead, Price Gallie, David G Lloyd
BACKGROUND: Prevention of knee osteoarthritis (OA) following anterior cruciate ligament (ACL) rupture and reconstruction is vital. Risk of postreconstruction knee OA is markedly increased by concurrent meniscal injury. It is unclear whether reconstruction results in normal relationships between tibiofemoral contact forces and cartilage morphology and whether meniscal injury modulates these relationships. HYPOTHESES: Since patients with isolated reconstructions (ie, without meniscal injury) are at lower risk for knee OA, we predicted that relationships between tibiofemoral contact forces and cartilage morphology would be similar to those of normal, healthy knees 2 to 3 years postreconstruction...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28884093/hamstring-injuries-update-article
#12
Lucio Ernlund, Lucas de Almeida Vieira
Hamstring (HS) muscle injuries are the most common injury in sports. They are correlated to long rehabilitations and have a great tendency to recur. The HS consist of the long head of the biceps femoris, semitendinosus, and semimembranosus. The patient's clinical presentation depends on the characteristics of the lesion, which may vary from strain to avulsions of the proximal insertion. The most recognized risk factor is a previous injury. Magnetic resonance imaging is the method of choice for the injury diagnosis and classification...
June 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28857901/two-unique-cases-of-ciprofloxacin-associated-avulsion-of-ligament-and-tendon
#13
Jeffrey David Smith, Robert W Irwin, Erin T Wolff
Ciprofloxacin is recognized to have a deleterious relationship with tendons, particularly Achilles tendinopathy, which makes up most case reports. Tendinopathy seems to occur because of induction of collagen-degrading enzymes causing damage and ischemia of the poorly vascularized regions preventing repair. The focus on the relationship of ciprofloxacin and the Achilles tendon leaves patients on fluoroquinolones with non-Achilles tendinopathy symptoms at risk of misdiagnosis. There have not been any documented instances of ligament damage with ciprofloxacin administration in the literature, although ligament and tendon compositions are similar and should have similar susceptibility...
August 25, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28803035/bone-tunnel-change-develops-within-two-weeks-of-double-bundle-anterior-cruciate-ligament-reconstruction-using-hamstring-autograft-a-comparison-of-different-postoperative-immobilization-periods-using-computed-tomography
#14
Ryo Shimizu, Nobuo Adachi, Minoru Ishifuro, Atsuo Nakamae, Masakazu Ishikawa, Masataka Deie, Mitsuo Ochi
BACKGROUND: The purpose of this study was to evaluate bone tunnel changes following anterior cruciate ligament (ACL) reconstruction during the early postoperative period using computed tomography (CT), and to understand the impact of postoperative immobilization on these changes. METHODS: Twenty patients who underwent double-bundle ACL reconstruction using hamstring tendon autografts were included. We subcategorized patients into two groups: patients who underwent isolated ACL reconstruction and had three days of knee immobilization (Group A, n=10); and patients with concomitant meniscus injuries who underwent ACL reconstruction and meniscus repair simultaneously (Group B, n=10) had their knees immobilized for two weeks after surgery...
August 9, 2017: Knee
https://www.readbyqxmd.com/read/28758137/sciatic-nerve-injury-after-proximal-hamstring-avulsion-and-repair
#15
Thomas J Wilson, Robert J Spinner, Rohith Mohan, Christopher M Gibbs, Aaron J Krych
BACKGROUND: Muscle bellies of the hamstring muscles are intimately associated with the sciatic nerve, putting the sciatic nerve at risk of injury associated with proximal hamstring avulsion. There are few data informing the magnitude of this risk, identifying risk factors for neurologic injury, or determining neurologic outcomes in patients with distal sciatic symptoms after surgery. PURPOSE: To characterize the frequency and nature of sciatic nerve injury and distal sciatic nerve-related symptoms after proximal hamstring avulsion and to characterize the influence of surgery on these symptoms...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28717624/ipsilateral-hamstring-tendon-graft-reconstruction-for-chronic-patellar-tendon-ruptures-surgical-technique
#16
Nicola Maffulli, Angelo Del Buono, Francesco Oliva
BACKGROUND: Patellar tendon chronic ruptures are more debated to manage that acute injuries as the patella tends to retract proximally (after 2 weeks), and surrounding soft tissues may make the repair more complicate. PURPOSE: We propose a novel technique in which the patellar tendon is reconstructed using ipsilateral hamstring tendons. This surgical procedure implies to drill a single tunnel through the patella and another through the tibia to reduce the risk of bony breakage...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28580247/repair-of-proximal-hamstring-tears-a-surgical-technique
#17
Gilbert Moatshe, Jorge Chahla, Alexander R Vap, Marcio Ferrari, George Sanchez, Justin J Mitchell, Robert F LaPrade
Proximal hamstring tears are among the most common sports-related injuries. These injuries often occur as strains or partial tears at the proximal muscle belly or the musculotendinous junction, with avulsion injuries of the proximal attachment occurring less frequently. Regardless of the mechanism, they produce functional impairment and negatively affect an athlete's performance. Various classifications for these injuries are reported in the literature. Early surgical treatment is recommended for patients with either a 2-tendon tear/avulsion with more than 2 cm retraction or those with complete 3-tendon tears...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28532890/fascial-manipulation-%C3%A2-for-persistent-knee-pain-following-acl-and-meniscus-repair
#18
Sannasi Rajasekar, Aurélie Marie Marchand
Fascial Manipulation(®) (FM) is a manual therapy approach for the treatment of musculoskeletal pain. Anomalous fascial tension is common following surgery due to surgical scar, inadequate mobility and fear of movement. Fascial tension may result in pain and loss of mobility. This case report aims at investigating the effectiveness of FM(®) on pain and function in a patient following knee surgery. A 32 years old male patient, with persisting knee pain following anterior cruciate ligament reconstruction (hamstring graft) and meniscal repair, underwent the systematic FM(®) assessment process, the selected centers of coordination of myofascial units were treated...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28466182/trends-and-incidences-of-ligament-surgeries-and-osteotomies-of-the-knee-an-analysis-of-german-inpatient-records-2005-2013
#19
Christoph Domnick, Patric Garcia, Michael J Raschke, Johannes Glasbrenner, Georg Lodde, Christian Fink, Mirco Herbort
INTRODUCTION: In Germany most surgical procedures of the ligaments of the knee and correcting osteotomies of the knees are performed within an inpatient setting. The purpose of this study was to analyze the available data to assess epidemiological trends and incidences in inpatient knee joint surgery. MATERIALS AND METHODS: Approximately 154 million anonymized DRG inpatient records were collected by the German Federal Statistical Office between 2005 and 2013. These data were screened and analyzed for knee joint surgical ligamental procedures and osteotomies...
May 2, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28451864/prolotherapy-induces-an-inflammatory-response-in-human-tenocytes-in-vitro
#20
Emmanuel C Ekwueme, Mahir Mohiuddin, Jazmin A Yarborough, P Gunnar Brolinson, Denitsa Docheva, Hugo A M Fernandes, Joseph W Freeman
BACKGROUND: Proliferative therapy, or prolotherapy, is a controversial treatment method for many connective tissue injuries and disorders. It involves the injection of a proliferant, or irritant solution, into the site of injury, which causes small-scale cell death. This therapeutic trauma is theorized to initiate the body's wound-healing cascade, perhaps leading to tissue repair. The immediate effects of many of these proliferants are poorly characterized, as are the cellular responses to them; here, we sought to evaluate the immediate effects of two common proliferants (dextrose and P2G, a combination of phenol, glucose, and glycerin) on the cellular response of human tenocytes, and begin to explicate the mechanisms with which each proliferant functions...
August 2017: Clinical Orthopaedics and related Research
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